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Found 271 with Last Name = 'jarvie' and Initial = 'em'
TargetSomatostatin receptor type 4(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50095116((R)-1-(3-Amino-propyl)-6-(1H-indol-3-ylmethyl)-10-...)
Affinity DataIC50:  41nMAssay Description:Inhibitory concentration required for somatostatin 4 receptor in radioligand binding assay ([125I]-Tyr11-SRIF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 5(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50095116((R)-1-(3-Amino-propyl)-6-(1H-indol-3-ylmethyl)-10-...)
Affinity DataIC50:  41nMAssay Description:Inhibitory concentration required for somatostatin 5 receptor in radioligand binding assay ([125I]-Tyr11-SRIF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 5(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50095115((1R,9R)-5-(4-Amino-butyl)-2-(1H-indol-3-ylmethyl)-...)
Affinity DataIC50:  87nMAssay Description:Inhibitory concentration required for somatostatin 5 receptor in radioligand binding assay ([125I]-Tyr11-SRIF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50311424(7-((3',4'-difluorobiphenyl-4-ylsulfonyl)methyl)-2,...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50344942(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
Affinity DataIC50:  190nMAssay Description:Inhibition of human CYP3A4 expressed in Escherichia coli using diethoxyfluorescein substrate measured in 25 to 30 mins by time dependent inhibition a...More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50254851(3-Cyclohexyl-1-[4'-((3R,5S)-3,5-dimethyl-piperazin...)
Affinity DataIC50:  200nMAssay Description:Inhibition of CYP3A4 (unknown origin) using diethoxyfluorescein substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50311425(7-((4'-fluorobiphenyl-4-ylsulfonyl)methyl)-2,3,4,5...)
Affinity DataIC50:  200nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50311414(CHEMBL1078492 | N-(3-((1H-pyrazol-3-yl)methyl)-2,3...)
Affinity DataIC50:  200nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50311413(CHEMBL1078595 | N-(3-((1H-pyrazol-3-yl)methyl)-2,3...)
Affinity DataIC50:  200nMAssay Description:Inhibition of human recombinant CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50095116((R)-1-(3-Amino-propyl)-6-(1H-indol-3-ylmethyl)-10-...)
Affinity DataIC50:  275nMAssay Description:Inhibitory concentration required for somatostatin 2 receptor in radioligand binding assay ([125I]-Tyr11-SRIF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50311419(CHEMBL1078464 | N-(4-fluorophenyl)-5-((2,3,4,5-tet...)
Affinity DataIC50:  300nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 5(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50450804(CHEMBL123190)
Affinity DataIC50:  316nMAssay Description:Compound was tested for inhibition of specific [125I]Tyr11-SRIF binding to human recombinant SST5 (somatostatin) receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 5(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50450803(CHEMBL332512)
Affinity DataIC50:  316nMAssay Description:Compound was tested for inhibition of specific [125I]Tyr11-SRIF binding to human recombinant SST5 (somatostatin) receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 5(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50450806(CHEMBL324511)
Affinity DataIC50:  398nMAssay Description:Compound was tested for inhibition of specific [125I]Tyr11-SRIF binding to human recombinant SST5 (somatostatin) receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50254851(3-Cyclohexyl-1-[4'-((3R,5S)-3,5-dimethyl-piperazin...)
Affinity DataIC50:  400nMAssay Description:Inhibition of CYP3A4 (unknown origin) using phenylpiperazinylmethylbenzylresofurin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50311414(CHEMBL1078492 | N-(3-((1H-pyrazol-3-yl)methyl)-2,3...)
Affinity DataIC50:  400nMAssay Description:Inhibition of human recombinant CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50095116((R)-1-(3-Amino-propyl)-6-(1H-indol-3-ylmethyl)-10-...)
Affinity DataIC50:  407nMAssay Description:Inhibitory concentration required for somatostatin 1 receptor in radioligand binding assay ([125I]-Tyr11-SRIF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50311415(CHEMBL1078490 | N-(3-((1H-pyrazol-3-yl)methyl)-2,3...)
Affinity DataIC50:  500nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50254968(CHEMBL479418 | [4'-((3R,5S)-3,5-Dimethyl-piperazin...)
Affinity DataIC50:  500nMAssay Description:Inhibition of CYP3A4 (unknown origin) using phenylpiperazinylmethylbenzylresofurin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 5(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50450805(CHEMBL332786)
Affinity DataIC50:  501nMAssay Description:Compound was tested for inhibition of specific [125I]Tyr11-SRIF binding to human recombinant SST5 (somatostatin) receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50095115((1R,9R)-5-(4-Amino-butyl)-2-(1H-indol-3-ylmethyl)-...)
Affinity DataIC50:  501nMAssay Description:Inhibitory concentration required for somatostatin 1 receptor in radioligand binding assay ([125I]-Tyr11-SRIF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50254968(CHEMBL479418 | [4'-((3R,5S)-3,5-Dimethyl-piperazin...)
Affinity DataIC50:  600nMAssay Description:Inhibition of CYP3A4 (unknown origin) using diethoxyfluorescein substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50311423(7-((6-(4-fluorophenyl)pyridin-3-ylsulfonyl)methyl)...)
Affinity DataIC50:  600nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50311412(CHEMBL1080046 | N-(3-((1H-pyrazol-3-yl)methyl)-2,3...)
Affinity DataIC50:  600nMAssay Description:Inhibition of human recombinant CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50311412(CHEMBL1080046 | N-(3-((1H-pyrazol-3-yl)methyl)-2,3...)
Affinity DataIC50:  800nMAssay Description:Inhibition of human recombinant CYP3A4 using diethoxyfluorescein as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50254931(4'-((3R,5S)-3,5-Dimethyl-piperazin-1-ylmethyl)-bip...)
Affinity DataIC50:  900nMAssay Description:Inhibition of CYP3A4 (unknown origin) using diethoxyfluorescein substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 4(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50095115((1R,9R)-5-(4-Amino-butyl)-2-(1H-indol-3-ylmethyl)-...)
Affinity DataIC50:  1.05E+3nMAssay Description:Inhibitory concentration required for somatostatin 4 receptor in radioligand binding assay ([125I]-Tyr11-SRIF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50311420(7-((6-(piperidin-1-yl)pyridin-3-ylsulfonyl)methyl)...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 3(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50095116((R)-1-(3-Amino-propyl)-6-(1H-indol-3-ylmethyl)-10-...)
Affinity DataIC50:  1.26E+3nMAssay Description:Inhibitory concentration required for somatostatin 3 receptor in radioligand binding assay ([125I]-Tyr11-SRIF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50311416(CHEMBL1078208 | N-(3-((1H-pyrazol-3-yl)methyl)-2,3...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50254892(2-(3-Chloro-phenyl)-N-[4'-((3R,5S)-3,5-dimethyl-pi...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using diethoxyfluorescein substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50247157((3-(4-(((3R,5S)-3,5-dimethylpiperazin-1-yl)methyl)...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of human CYP3A4 expressed in Escherichia coli using diethoxyfluorescein substrate measured in 25 to 30 mins by time dependent inhibition a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 5(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50450802(CHEMBL120607)
Affinity DataIC50:  1.41E+3nMAssay Description:Compound was tested for inhibition of specific [125I]Tyr11-SRIF binding to human recombinant SST5 (somatostatin) receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50254892(2-(3-Chloro-phenyl)-N-[4'-((3R,5S)-3,5-dimethyl-pi...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using phenylpiperazinylmethylbenzylresofurin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50254931(4'-((3R,5S)-3,5-Dimethyl-piperazin-1-ylmethyl)-bip...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using phenylpiperazinylmethylbenzylresofurin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50095115((1R,9R)-5-(4-Amino-butyl)-2-(1H-indol-3-ylmethyl)-...)
Affinity DataIC50:  1.59E+3nMAssay Description:Inhibitory concentration required for somatostatin 2 receptor in radioligand binding assay ([125I]-Tyr11-SRIF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50311421(7-((6-isopropoxypyridin-3-ylsulfonyl)methyl)-2,3,4...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50311422(7-((6-(4-fluorophenoxy)pyridin-3-ylsulfonyl)methyl...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50311412(CHEMBL1080046 | N-(3-((1H-pyrazol-3-yl)methyl)-2,3...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of human recombinant CYP3A4 using 7-{3-(4-phenylpiperazin-1-ylmethyl)benzyl}resorufin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50344942(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of human CYP3A4 expressed in Escherichia coli using diethoxyfluorescein substrate measured in 0 to 5 mins by time dependent inhibition ass...More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50311417(CHEMBL1081860 | N-(3-((1H-pyrazol-3-yl)methyl)-2,3...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of human recombinant CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50311412(CHEMBL1080046 | N-(3-((1H-pyrazol-3-yl)methyl)-2,3...)
Affinity DataIC50:  2.51E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50254893(2-Benzenesulfonyl-N-[4'-((3R,5S)-3,5-dimethyl-pipe...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using diethoxyfluorescein substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 3(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50095115((1R,9R)-5-(4-Amino-butyl)-2-(1H-indol-3-ylmethyl)-...)
Affinity DataIC50:  3.09E+3nMAssay Description:Inhibitory concentration required for somatostatin 3 receptor in radioligand binding assay ([125I]-Tyr11-SRIF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50254971(CHEMBL481575 | [4-(4-Chloro-phenylamino)-piperidin...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using phenylpiperazinylmethylbenzylresofurin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50254999(CHEMBL480210 | [4'-((3R,5S)-3,5-Dimethyl-piperazin...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using phenylpiperazinylmethylbenzylresofurin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50292984(1-[2-(4-([(3R,5S)-3,5-Dimethyl-1-piperazinyl]methy...)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibition of human CYP3A4 expressed in Escherichia coli using diethoxyfluorescein substrate by time dependent inhibition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50254999(CHEMBL480210 | [4'-((3R,5S)-3,5-Dimethyl-piperazin...)
Affinity DataIC50:  4.80E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using diethoxyfluorescein substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50292981(CHEMBL489094 | N-(4-Fluorophenyl)-1-[(4-([(3S)-3-m...)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibition of human CYP3A4 expressed in Escherichia coli using diethoxyfluorescein substrate by time dependent inhibition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50254971(CHEMBL481575 | [4-(4-Chloro-phenylamino)-piperidin...)
Affinity DataIC50:  5.20E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using diethoxyfluorescein substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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