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Found 141 with Last Name = 'kamath' and Initial = 'av'
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50:  1nMAssay Description:Inhibition of PAF mediated human eosinophil chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50:  1nMAssay Description:Inhibition of C5a mediated human eosinophil chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50: <1nMAssay Description:Inhibition of PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50:  2nMAssay Description:Inhibition of release of LTE4 in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50:  3nMAssay Description:Inhibition of Eotaxin mediated by human eosinophil chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50113041((2R,5R)-5-Hydroxy-1-[4-(2-trifluoromethyl-benzylox...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50113040((2R,4R)-1-[4-(4-Fluoro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50113028((2R,4S)-4-Hydroxy-1-[4-(2-methyl-benzyloxy)-benzen...)
Affinity DataIC50:  6nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50113048((2R,5R)-1-(4-Benzyloxy-benzenesulfonyl)-5-hydroxy-...)
Affinity DataIC50:  7nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50113046((2R,5R)-5-Hydroxy-1-[4-(2-iodo-benzyloxy)-benzenes...)
Affinity DataIC50:  7nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50113035((2R,4S)-1-[4-(4-Chloro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50:  7nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50113044((2R,5R)-5-Hydroxy-1-[4-(2-methyl-benzyloxy)-benzen...)
Affinity DataIC50:  8nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50113029((2R,4R)-1-[4-(4-Fluoro-phenoxy)-benzenesulfonyl]-2...)
Affinity DataIC50:  8.5nMAssay Description:Inhibitory concentration of the compound against Matrix metalloproteinase-1 was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50113038((2R,4S)-1-(4-Benzyloxy-benzenesulfonyl)-4-hydroxy-...)
Affinity DataIC50:  9nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50113045((2R,5R)-1-[4-(2-Ethyl-benzyloxy)-benzenesulfonyl]-...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50113034((2R,4S)-1-[4-(3-Chloro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50113037((2R,5R)-5-Hydroxy-1-[4-(4-trifluoromethyl-benzylox...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  11nMAssay Description:Inhibition of PDE4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50113039((2R,5R)-5-Hydroxy-1-[4-(2-isopropyl-benzyloxy)-ben...)
Affinity DataIC50:  11nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50113024((2R,4S)-1-[4-(4-Fluoro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50:  14nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50113047((2R,4S)-4-Hydroxy-1-[4-(2-methoxy-benzyloxy)-benze...)
Affinity DataIC50:  14nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50113021((2R,4S)-1-[4-(3-Cyano-benzyloxy)-benzenesulfonyl]-...)
Affinity DataIC50:  15nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50113033((2R,5R)-5-Hydroxy-1-[4-(3-trifluoromethyl-benzylox...)
Affinity DataIC50:  15nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50113027((2R,4S)-4-Hydroxy-1-[4-(2-trifluoromethyl-benzylox...)
Affinity DataIC50:  16nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50113025((2R,5R)-5-Hydroxy-1-[4-(naphthalen-1-ylmethoxy)-be...)
Affinity DataIC50:  16nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50113023((2R,4S)-4-Hydroxy-1-[4-(3-methyl-benzyloxy)-benzen...)
Affinity DataIC50:  18nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50113049((2R,4R)-2-Hydroxycarbamoyl-1-(4-methoxy-benzenesul...)
Affinity DataIC50:  19nMAssay Description:Inhibitory concentration of the compound against Matrix metalloproteinase-1 was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50113030((2R,4S)-4-Hydroxy-1-[4-(4-methyl-benzyloxy)-benzen...)
Affinity DataIC50:  20nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50113043((2R,4S)-1-[4-(3-Fluoro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50:  21nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50113042((2R,4S)-1-[4-(4-Cyano-benzyloxy)-benzenesulfonyl]-...)
Affinity DataIC50:  25nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50113036((2R,4S)-4-Hydroxy-1-[4-(3-methoxy-benzyloxy)-benze...)
Affinity DataIC50:  27nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  33nMAssay Description:Inhibition of PDE4DMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  34nMAssay Description:Inhibition of PDE4BMore data for this Ligand-Target Pair
LigandPNGBDBM50113022((2R,4S)-1-[4-(2-Chloro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50:  36nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50113031((2R,5R)-1-[4-(2-Cyano-benzyloxy)-benzenesulfonyl]-...)
Affinity DataIC50:  39nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176521(5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...)
Affinity DataIC50:  40nMAssay Description:Inhibitory activity against PDE2 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  41nMAssay Description:Inhibition of release of LTE4 in human whole bloodMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  41nMAssay Description:Inhibition of release of LTE4 in human whole bloodMore data for this Ligand-Target Pair
LigandPNGBDBM50113026((2R,5R)-1-[4-(3-Cyano-benzyloxy)-benzenesulfonyl]-...)
Affinity DataIC50:  49nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50113020((2R,4S)-1-[4-(Biphenyl-2-ylmethoxy)-benzenesulfony...)
Affinity DataIC50:  67nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50113032((2R,4S)-1-[4-(2-Fluoro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50:  67nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50:  107nMAssay Description:Inhibition of PDE4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50113029((2R,4R)-1-[4-(4-Fluoro-phenoxy)-benzenesulfonyl]-2...)
Affinity DataIC50:  120nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50:  185nMAssay Description:Inhibition of PDE4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  625nMAssay Description:Inhibition of release of TNF alpha in human whole bloodMore data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM28393((+)-EHNA | (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...)
Affinity DataIC50:  635nMAssay Description:Inhibitory activity against PDE2 by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50:  925nMAssay Description:Inhibition of release of TNF alpha in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50113045((2R,5R)-1-[4-(2-Ethyl-benzyloxy)-benzenesulfonyl]-...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of TNF-alpha release was determined in LPS-stimulated human whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50113046((2R,5R)-5-Hydroxy-1-[4-(2-iodo-benzyloxy)-benzenes...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of TNF-alpha release was determined in LPS-stimulated human whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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