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Found 39 with Last Name = 'kaplan' and Initial = 'f'
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59229(Pyrazolopyrimidone analog, RGB-286331)
Affinity DataIC50:  4nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM10890(1-N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonam...)
Affinity DataIC50:  7nM EC50:  80nMAssay Description:CAII assays were performed at CEREP (paris). All other kinase assays were performed at Upstate (Dundee, UK).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59228(Pyrazolopyrimidone analog, RGB-285940)
Affinity DataIC50:  7nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 3/G1/S-specific cyclin-E1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  9nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59230(Pyrazolopyrimidone analog, RGB-285960)
Affinity DataIC50:  9nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  10nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM10881(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Affinity DataIC50:  14nM EC50:  40nMAssay Description:CAII assays were performed at CEREP (paris). All other kinase assays were performed at Upstate (Dundee, UK).More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  15nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59253(RGB-285961)
Affinity DataIC50:  20nM EC50:  70nMAssay Description:CAII assays were performed at CEREP (paris). All other kinase assays were performed at Upstate (Dundee, UK).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59235(PEGylated derivative, RGB-286276)
Affinity DataIC50:  22nMAssay Description:In vitro kinase activity of PEGylated pyrazolopyrimidone CDK inhibitor or a 5 PEG-amine was coupled to ReactiGel agarose beads (Pierce, No. 20259).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM6568(6-(2,6-dichlorophenyl)-8-methyl-2-{[3-(methylsulfa...)
Affinity DataIC50:  28nM EC50: <3nMAssay Description:CAII assays were performed at CEREP (paris). All other kinase assays were performed at Upstate (Dundee, UK).More data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59235(PEGylated derivative, RGB-286276)
Affinity DataIC50:  34nMAssay Description:Inhibition of HCT116 cell proliferation with compounds using calcein AM Assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59229(Pyrazolopyrimidone analog, RGB-286331)
Affinity DataIC50:  43nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  48nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  51nMAssay Description:Inhibition of HCT116 cell proliferation after 72hr of incubation with compounds was determined by SRB Assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59230(Pyrazolopyrimidone analog, RGB-285960)
Affinity DataIC50:  64nMAssay Description:Inhibition of HCT116 cell proliferation after 72hr of incubation with compounds was determined by SRB Assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCDK-activating kinase assembly factor MAT1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  71nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59235(PEGylated derivative, RGB-286276)
Affinity DataIC50:  84nMAssay Description:In vitro kinase activity of PEGylated pyrazolopyrimidone CDK inhibitor or a 5 PEG-amine was coupled to ReactiGel agarose beads (Pierce, No. 20259).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM50079331(2-(2-Chloro-phenyl)-5,7-dihydroxy-8-(3-hydroxy-1-m...)
Affinity DataIC50:  155nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59229(Pyrazolopyrimidone analog, RGB-286331)
Affinity DataIC50:  220nMAssay Description:Inhibition of HCT116 cell proliferation after 72hr of incubation with compounds was determined by SRB Assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM50079331(2-(2-Chloro-phenyl)-5,7-dihydroxy-8-(3-hydroxy-1-m...)
Affinity DataIC50:  221nMAssay Description:Inhibition of HCT116 cell proliferation after 72hr of incubation with compounds was determined by SRB Assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59228(Pyrazolopyrimidone analog, RGB-285940)
Affinity DataIC50:  230nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  282nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59230(Pyrazolopyrimidone analog, RGB-285960)
Affinity DataIC50:  310nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataIC50:  372nM EC50:  70nMAssay Description:CAII assays were performed at CEREP (paris). All other kinase assays were performed at Upstate (Dundee, UK).More data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59228(Pyrazolopyrimidone analog, RGB-285940)
Affinity DataIC50:  410nMAssay Description:Inhibition of HCT116 cell proliferation after 72hr of incubation with compounds was determined by SRB Assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM50079331(2-(2-Chloro-phenyl)-5,7-dihydroxy-8-(3-hydroxy-1-m...)
Affinity DataIC50:  485nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM50079331(2-(2-Chloro-phenyl)-5,7-dihydroxy-8-(3-hydroxy-1-m...)
Affinity DataIC50:  663nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  754nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  839nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59228(Pyrazolopyrimidone analog, RGB-285940)
Affinity DataIC50:  858nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59235(PEGylated derivative, RGB-286276)
Affinity DataIC50:  890nMAssay Description:In vitro kinase activity of PEGylated pyrazolopyrimidone CDK inhibitor or a 5 PEG-amine was coupled to ReactiGel agarose beads (Pierce, No. 20259).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM50079331(2-(2-Chloro-phenyl)-5,7-dihydroxy-8-(3-hydroxy-1-m...)
Affinity DataIC50:  1.34E+3nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59230(Pyrazolopyrimidone analog, RGB-285960)
Affinity DataIC50:  1.75E+3nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59233(Pyrazolopyrimidone analog, RGB-310590)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of HCT116 cell proliferation after 72hr of incubation with compounds was determined by SRB Assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59232(Pyrazolopyrimidone analog, RGB-310595)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HCT116 cell proliferation after 72hr of incubation with compounds was determined by SRB Assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59231(Pyrazolopyrimidone analog, RGB-310596)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HCT116 cell proliferation after 72hr of incubation with compounds was determined by SRB Assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59234(Pyrazolopyrimidone analog, RGB-310591)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HCT116 cell proliferation after 72hr of incubation with compounds was determined by SRB Assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Gpc Biotech

LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataEC50:  1nMAssay Description:CAII assays were performed at CEREP (paris). All other kinase assays were performed at Upstate (Dundee, UK).More data for this Ligand-Target Pair