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Found 1078 with Last Name = 'keller' and Initial = 'th'
TargetDihydrofolate reductase(Homo sapiens (Human))
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program

Curated by ChEMBL
LigandPNGBDBM18793(6,6-dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]...)
Affinity DataKi:  7.70nMAssay Description:Binding affinity to human recombinant DHFR expressed in Escherichia coli BL21(DE3) by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166735(3-[5-(2-Methyl-imidazol-1-yl)-2-(pyrazin-2-ylamino...)
Affinity DataKi:  10nMAssay Description:Inhibition of luciferase production elicited by NECA by compound in CHO cells transfected with human adenosine A2b receptor and a luciferase expressi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program

Curated by ChEMBL
LigandPNGBDBM50035483(5-Chloro-N*6*-(2,5-dimethoxy-benzyl)-quinazoline-2...)
Affinity DataKi:  10.2nMAssay Description:Binding affinity to human recombinant DHFR expressed in Escherichia coli BL21(DE3) by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166742(3-[2-(3-Methyl-pyridin-2-ylamino)-5-[1,2,4]triazol...)
Affinity DataKi:  20nMAssay Description:Inhibition of luciferase production elicited by NECA by compound in CHO cells transfected with human adenosine A2b receptor and a luciferase expressi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166739(3-[2-(Pyridin-2-ylamino)-5-[1,2,4]triazol-1-yl-thi...)
Affinity DataKi:  24nMAssay Description:Displacement of [125I]-AB-MECA from human adenosine A3 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program

Curated by ChEMBL
LigandPNGBDBM18512(5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)
Affinity DataKi:  30.8nMAssay Description:Binding affinity to human recombinant DHFR expressed in Escherichia coli BL21(DE3) by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAdenosine receptor A3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166742(3-[2-(3-Methyl-pyridin-2-ylamino)-5-[1,2,4]triazol...)
Affinity DataKi:  37nMAssay Description:Displacement of [125I]-AB-MECA from human adenosine A3 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus 2)
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50175864(Bz-Nle-Lys-Arg-Arg-B(OH)2 | CHEMBL199845)
Affinity DataKi:  43nMAssay Description:Inhibitory activity against CF40.NS3pro from Dengue virus type 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166739(3-[2-(Pyridin-2-ylamino)-5-[1,2,4]triazol-1-yl-thi...)
Affinity DataKi:  53nMAssay Description:Inhibition of luciferase production elicited by NECA by compound in CHO cells transfected with human adenosine A2b receptor and a luciferase expressi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program

Curated by ChEMBL
LigandPNGBDBM18792(1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-...)
Affinity DataKi:  55.6nMAssay Description:Binding affinity to human recombinant DHFR expressed in Escherichia coli BL21(DE3) by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166745(3-[2-(Pyridin-4-ylamino)-5-[1,2,4]triazol-1-yl-thi...)
Affinity DataKi:  62nMAssay Description:Inhibition of luciferase production elicited by NECA by compound in CHO cells transfected with human adenosine A2b receptor and a luciferase expressi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166737(3-[2-(Pyridin-3-ylamino)-5-[1,2,4]triazol-1-yl-thi...)
Affinity DataKi:  86nMAssay Description:Inhibition of luciferase production elicited by NECA by compound in CHO cells transfected with human adenosine A2b receptor and a luciferase expressi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166743(3-[5-Imidazol-1-yl-2-(pyridin-3-ylamino)-thiazol-4...)
Affinity DataKi:  92nMAssay Description:Inhibition of luciferase production elicited by NECA by compound in CHO cells transfected with human adenosine A2b receptor and a luciferase expressi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166743(3-[5-Imidazol-1-yl-2-(pyridin-3-ylamino)-thiazol-4...)
Affinity DataKi:  124nMAssay Description:Displacement of [125I]-AB-MECA from human adenosine A3 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166741(4-(3-cyanophenyl)-5-(1H-1,2,4-triazol-1-yl)-1,3-th...)
Affinity DataKi:  134nMAssay Description:Displacement of [125I]-AB-MECA from human adenosine A3 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166735(3-[5-(2-Methyl-imidazol-1-yl)-2-(pyrazin-2-ylamino...)
Affinity DataKi:  175nMAssay Description:Displacement of [3H]ZM-241,385 from human adenosine A2a receptors transfected in HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166735(3-[5-(2-Methyl-imidazol-1-yl)-2-(pyrazin-2-ylamino...)
Affinity DataKi:  224nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166745(3-[2-(Pyridin-4-ylamino)-5-[1,2,4]triazol-1-yl-thi...)
Affinity DataKi:  304nMAssay Description:Displacement of [125I]-AB-MECA from human adenosine A3 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166741(4-(3-cyanophenyl)-5-(1H-1,2,4-triazol-1-yl)-1,3-th...)
Affinity DataKi:  365nMAssay Description:Inhibition of luciferase production elicited by NECA by compound in CHO cells transfected with human adenosine A2b receptor and a luciferase expressi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166735(3-[5-(2-Methyl-imidazol-1-yl)-2-(pyrazin-2-ylamino...)
Affinity DataKi:  419nMAssay Description:Displacement of [125I]-AB-MECA from human adenosine A3 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Experimental Drug Development Centre

Curated by ChEMBL
LigandPNGBDBM50502427(CHEMBL4542517)
Affinity DataKi:  440nMAssay Description:Irreversible inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate pretreated for 5 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166743(3-[5-Imidazol-1-yl-2-(pyridin-3-ylamino)-thiazol-4...)
Affinity DataKi:  560nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166737(3-[2-(Pyridin-3-ylamino)-5-[1,2,4]triazol-1-yl-thi...)
Affinity DataKi:  698nMAssay Description:Displacement of [125I]-AB-MECA from human adenosine A3 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus 2)
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50175863(Bz-Nle-Lys-Arg-Arg-CF3 | CHEMBL200294)
Affinity DataKi:  850nMAssay Description:Inhibitory activity against CF40.NS3pro from Dengue virus type 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus 2)
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50175982(Bz-Lys-Arg-Arg-H | CHEMBL199510)
Affinity DataKi:  1.50E+3nMAssay Description:Inhibitory activity against dengue 2 NS3 protease fused via a linker to region of NS2BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166737(3-[2-(Pyridin-3-ylamino)-5-[1,2,4]triazol-1-yl-thi...)
Affinity DataKi:  1.53E+3nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166739(3-[2-(Pyridin-2-ylamino)-5-[1,2,4]triazol-1-yl-thi...)
Affinity DataKi:  1.76E+3nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166739(3-[2-(Pyridin-2-ylamino)-5-[1,2,4]triazol-1-yl-thi...)
Affinity DataKi:  2.02E+3nMAssay Description:Displacement of [3H]ZM-241,385 from human adenosine A2a receptors transfected in HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207120(3-isobutyl-8-((6-methoxyisoquinolin-4-yl)methyl)-1...)
Affinity DataKi:  2.30E+3nMAssay Description:Inhibition of adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166737(3-[2-(Pyridin-3-ylamino)-5-[1,2,4]triazol-1-yl-thi...)
Affinity DataKi:  2.57E+3nMAssay Description:Displacement of [3H]ZM-241,385 from human adenosine A2a receptors transfected in HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166743(3-[5-Imidazol-1-yl-2-(pyridin-3-ylamino)-thiazol-4...)
Affinity DataKi:  2.70E+3nMAssay Description:Displacement of [3H]ZM-241,385 from human adenosine A2a receptors transfected in HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus 2)
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50175984(BZ-Nle-Lys-Arg-(4-guanidinyl)-Phe-H | Bz-Nle-Lys-A...)
Affinity DataKi:  2.80E+3nMAssay Description:Inhibitory activity against dengue 2 NS3 protease fused via a linker to region of NS2BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166741(4-(3-cyanophenyl)-5-(1H-1,2,4-triazol-1-yl)-1,3-th...)
Affinity DataKi:  2.84E+3nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Experimental Drug Development Centre

Curated by ChEMBL
LigandPNGBDBM50502433(CHEMBL4575866)
Affinity DataKi:  3.06E+3nMAssay Description:Irreversible inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate pretreated for 5 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166745(3-[2-(Pyridin-4-ylamino)-5-[1,2,4]triazol-1-yl-thi...)
Affinity DataKi:  3.78E+3nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Experimental Drug Development Centre

Curated by ChEMBL
LigandPNGBDBM50502434(CHEMBL4551647)
Affinity DataKi:  3.90E+3nMAssay Description:Irreversible inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate pretreated for 5 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetAdenosine receptor A2a(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166745(3-[2-(Pyridin-4-ylamino)-5-[1,2,4]triazol-1-yl-thi...)
Affinity DataKi:  4.16E+3nMAssay Description:Displacement of [3H]ZM-241,385 from human adenosine A2a receptors transfected in HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus 2)
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50175976(Bz-Ala-Lys-Arg-Arg-H | CHEMBL197765)
Affinity DataKi:  5.30E+3nMAssay Description:Inhibitory activity against dengue 2 NS3 protease fused via a linker to region of NS2BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166741(4-(3-cyanophenyl)-5-(1H-1,2,4-triazol-1-yl)-1,3-th...)
Affinity DataKi:  5.61E+3nMAssay Description:Displacement of [3H]ZM-241,385 from human adenosine A2a receptors transfected in HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus 2)
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM33259(Bz-NKRR-H | Bz-Nle-Lys-Arg-Arg-H | CHEMBL256877)
Affinity DataKi:  5.80E+3nMAssay Description:Inhibitory activity against dengue 2 NS3 protease fused via a linker to region of NS2BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus 2)
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM33259(Bz-NKRR-H | Bz-Nle-Lys-Arg-Arg-H | CHEMBL256877)
Affinity DataKi:  5.80E+3nMAssay Description:Inhibitory activity against CF40.NS3pro from Dengue virus type 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus 2)
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50175988(Bz-Nle-Lys-Arg-(p-Me)Phe-H | CHEMBL199396)
Affinity DataKi:  6.00E+3nMAssay Description:Inhibitory activity against dengue 2 NS3 protease fused via a linker to region of NS2BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus 2)
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50175987(Bz-Phe-Lys-Arg-Arg-H | CHEMBL199736)
Affinity DataKi:  6.80E+3nMAssay Description:Inhibitory activity against dengue 2 NS3 protease fused via a linker to region of NS2BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus 2)
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50175974(Bz-Nle-Lys-Arg-Trp-H | CHEMBL433993)
Affinity DataKi:  7.50E+3nMAssay Description:Inhibitory activity against dengue 2 NS3 protease fused via a linker to region of NS2BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus 2)
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50175993(Bz-D-Nle-Lys-Arg-Arg-H | CHEMBL201775)
Affinity DataKi:  9.40E+3nMAssay Description:Inhibitory activity against dengue 2 NS3 protease fused via a linker to region of NS2BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166742(3-[2-(3-Methyl-pyridin-2-ylamino)-5-[1,2,4]triazol...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166742(3-[2-(3-Methyl-pyridin-2-ylamino)-5-[1,2,4]triazol...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]ZM-241,385 from human adenosine A2a receptors transfected in HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus 2)
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50175978(Bz-Nle-Lys-Arg-(p-Ph)Phe-H | CHEMBL381854)
Affinity DataKi:  1.16E+4nMAssay Description:Inhibitory activity against dengue 2 NS3 protease fused via a linker to region of NS2BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus 2)
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50175981(Bz-Arg-Arg-H | CHEMBL197766)
Affinity DataKi:  1.20E+4nMAssay Description:Inhibitory activity against dengue 2 NS3 protease fused via a linker to region of NS2BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus 2)
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50175985(Bz-Nle-Phe-Arg-Arg-H | CHEMBL199582)
Affinity DataKi:  1.58E+4nMAssay Description:Inhibitory activity against dengue 2 NS3 protease fused via a linker to region of NS2BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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