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Found 441 with Last Name = 'kelly' and Initial = 'mg'
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099016(CHEMBL275964 | Cyclohexanecarboxylic acid {(S)-1-b...)
Affinity DataKi:  0.800nMAssay Description:Ability to displace [3H]-8-OH-DPAT from CHO cells stably transfected with human 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM86708(CAS_146714-97-8 | CHEMBL31354 | CHEMBL514874 | CHE...)
Affinity DataKi:  0.900nMAssay Description:Displacement of 8-OH-DPAT from human 5-hydroxytryptamine 1A receptor expressed in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50166904(CHEMBL193206 | N-{(R)-2-[4-(2,3-Dihydro-benzo[1,4]...)
Affinity DataKi:  1nMAssay Description:Displacement of 8-OH-DPAT from human 5-hydroxytryptamine 1A receptor expressed in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50166901(4-Chloro-N-{(R)-2-[4-(2,3-dihydro-benzo[1,4]dioxin...)
Affinity DataKi:  1.20nMAssay Description:Displacement of 8-OH-DPAT from human 5-hydroxytryptamine 1A receptor expressed in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099015(CHEMBL10796 | Cyclohexanecarboxylic acid {(R)-1-be...)
Affinity DataKi:  1.5nMAssay Description:Ability to displace [3H]-8-OH-DPAT from CHO cells stably transfected with human 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50166903(4-Cyano-N-{(R)-2-[4-(2,3-dihydro-benzo[1,4]dioxin-...)
Affinity DataKi:  1.60nMAssay Description:Displacement of 8-OH-DPAT from human 5-hydroxytryptamine 1A receptor expressed in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50166899(CHEMBL435111 | N-{(R)-2-[4-(2,3-Dihydro-benzo[1,4]...)
Affinity DataKi:  1.90nMAssay Description:Displacement of 8-OH-DPAT from human 5-hydroxytryptamine 1A receptor expressed in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM21393(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Affinity DataKi:  3nMAssay Description:Displacement of 8-OH-DPAT from human 5-hydroxytryptamine 1A receptor expressed in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099011(1-Methyl-cyclohexanecarboxylic acid {(R)-2-[4-(4-m...)
Affinity DataKi:  3nMAssay Description:Ability to displace [3H]-8-OH-DPAT from CHO cells stably transfected with human 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50166902(CHEMBL195425 | N-{(S)-2-[4-(2,3-Dihydro-benzo[1,4]...)
Affinity DataKi:  3.40nMAssay Description:Displacement of 8-OH-DPAT from human 5-hydroxytryptamine 1A receptor expressed in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099014(CHEMBL10793 | Cyclohexanecarboxylic acid {(R)-1-be...)
Affinity DataKi:  4.5nMAssay Description:Ability to displace [3H]-8-OH-DPAT from CHO cells stably transfected with human 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50166900(4-Chloro-N-{(S)-2-[4-(2,3-dihydro-benzo[1,4]dioxin...)
Affinity DataKi:  5.10nMAssay Description:Displacement of 8-OH-DPAT from human 5-hydroxytryptamine 1A receptor expressed in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50166906(CHEMBL365350 | N-{(S)-2-[4-(2,3-Dihydro-benzo[1,4]...)
Affinity DataKi:  8.60nMAssay Description:Displacement of 8-OH-DPAT from human 5-hydroxytryptamine 1A receptor expressed in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50166905(4-Cyano-N-{(S)-2-[4-(2,3-dihydro-benzo[1,4]dioxin-...)
Affinity DataKi:  9.20nMAssay Description:Displacement of 8-OH-DPAT from human 5-hydroxytryptamine 1A receptor expressed in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099013(CHEMBL10603 | N-{(R)-1-Benzyl-2-[4-(4-methoxy-[1,2...)
Affinity DataKi:  9.90nMAssay Description:Ability to displace [3H]-8-OH-DPAT from CHO cells stably transfected with human 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099012(CHEMBL10764 | N-{(S)-1-Benzyl-2-[4-(4-chloro-[1,2,...)
Affinity DataKi:  425nMAssay Description:Ability to displace [3H]-8-OH-DPAT from CHO cells stably transfected with human 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50223719(CHEMBL3348530)
Affinity DataIC50:  0.0600nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50138293((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Affinity DataIC50: <0.100nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20464((2E)-3-[2-(piperidin-1-yl)-6-(trifluoromethyl)pyri...)
Affinity DataIC50:  0.420nMAssay Description:Inhibition of capsaicin-induced calcium uptake by transient receptor potential vanilloid type 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20464((2E)-3-[2-(piperidin-1-yl)-6-(trifluoromethyl)pyri...)
Affinity DataIC50:  1nMAssay Description:Inhibition of pH-induced calcium uptake by transient receptor potential vanilloid type 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50158665((E)-3-(4-tert-Butyl-phenyl)-N-quinolin-7-yl-acryla...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of capsaicin-induced calcium uptake by transient receptor potential vanilloid type 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50158658((E)-3-(2-Morpholin-4-yl-6-trifluoromethyl-pyridin-...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of pH-induced calcium uptake by transient receptor potential vanilloid type 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50223719(CHEMBL3348530)
Affinity DataIC50:  1.40nMAssay Description:Inhibitory activity against [125I]-NDP-alpha-MSH binding to the human melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50138288(4-((S)-3-(4-Chloro-benzyl)-4-{4-[2-(2-cyclopropyl-...)
Affinity DataIC50:  1.40nMAssay Description:Inhibitory activity against [125I]-NDP-alpha-MSH binding to the human melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50158658((E)-3-(2-Morpholin-4-yl-6-trifluoromethyl-pyridin-...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of capsaicin-induced calcium uptake by transient receptor potential vanilloid type 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50138301(4-[(S)-4-(4-{2-[1-(Acetyl-ethyl-amino)-ethyl]-phen...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against [125I]-NDP-alpha-MSH binding to the human melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50158665((E)-3-(4-tert-Butyl-phenyl)-N-quinolin-7-yl-acryla...)
Affinity DataIC50:  2nMAssay Description:Inhibition of pH-induced calcium uptake by transient receptor potential vanilloid type 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50158681((E)-3-(4-tert-Butyl-phenyl)-N-(2-oxo-1,2,3,4-tetra...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of capsaicin-induced calcium uptake by transient receptor potential vanilloid type 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50130009((4S,15R,18S,21S,24S)-5-((S)-2-Acetylamino-hexanoyl...)
Affinity DataIC50:  3nMAssay Description:Binding affinity towards human melanocortin 4 receptor (hMC4R) using [125I]NDP-alpha-MSH as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50138290((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against [125I]-NDP-alpha-MSH binding to the human melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50138294(4-((S)-3-(4-Chloro-benzyl)-4-{4-[2-(2-cyclopropyl-...)
Affinity DataIC50:  3.30nMAssay Description:Inhibitory activity against [125I]-NDP-alpha-MSH binding to the human melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50138303((S)-4-(4-Benzoyl-piperazin-1-yl)-2-(4-chloro-benzy...)
Affinity DataIC50:  4.40nMAssay Description:Inhibitory activity against [125I]-NDP-alpha-MSH binding to the human melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50138305((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Affinity DataIC50:  4.80nMAssay Description:Inhibitory activity against [125I]-NDP-alpha-MSH binding to the human melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50138296((S)-4-(4-{2-[1-(Acetyl-ethyl-amino)-ethyl]-phenyl}...)
Affinity DataIC50:  5.80nMAssay Description:Inhibitory activity against human melanocortin 3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50158679((E)-3-(4-tert-Butyl-phenyl)-N-(3-oxo-3,4-dihydro-2...)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of capsaicin-induced calcium uptake by transient receptor potential vanilloid type 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50130014((R)-2-Acetylamino-N-(4-{acetyl-[2-(1H-indol-3-yl)-...)
Affinity DataIC50:  7.70nMAssay Description:Binding affinity towards human melanocortin 4 receptor (hMC4R) using [125I]NDP-alpha-MSH as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM86708(CAS_146714-97-8 | CHEMBL31354 | CHEMBL514874 | CHE...)
Affinity DataIC50:  8.40nMAssay Description:In vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50138292((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Affinity DataIC50:  8.90nMAssay Description:Inhibitory activity against [125I]-NDP-alpha-MSH binding to the human melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50138302(CHEMBL125079 | N-[1-(2-{4-[(S)-2-(4-Chloro-benzyl)...)
Affinity DataIC50:  9.40nMAssay Description:Inhibitory activity against [125I]-NDP-alpha-MSH binding to the human melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50138291((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Affinity DataIC50:  9.5nMAssay Description:Inhibitory activity against [125I]-NDP-alpha-MSH binding to the human melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50138299((S)-4-(4-Acetyl-piperazin-1-yl)-2-(4-chloro-benzyl...)
Affinity DataIC50:  11nMAssay Description:Inhibitory activity against [125I]-NDP-alpha-MSH binding to the human melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50138304((S)-4-(4-{2-[1-(Acetyl-ethyl-amino)-ethyl]-phenyl}...)
Affinity DataIC50:  13nMAssay Description:Inhibitory activity against [125I]-NDP-alpha-MSH binding to the human melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50158678((E)-3-(4-tert-Butyl-phenyl)-4-phenyl-but-2-enoic a...)
Affinity DataIC50:  14nMAssay Description:Inhibition of capsaicin-induced calcium uptake by transient receptor potential vanilloid type 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50158628(5-tert-Butyl-2-[(E)-2-(2,3-dihydro-benzo[1,4]dioxi...)
Affinity DataIC50:  15nMAssay Description:Inhibition of capsaicin-induced calcium uptake by transient receptor potential vanilloid type 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
Evotec

US Patent
LigandPNGBDBM118155(US8653091, 50)
Affinity DataIC50:  15nMAssay Description:The purinergic receptors P2X2 and P2X3 are expressed in a variety of tissues including various sensory and sympathetic ganglia, such as the dorsal ro...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50158647((E)-N-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-3-(2-mor...)
Affinity DataIC50:  15nMAssay Description:Inhibition of capsaicin-induced calcium uptake by transient receptor potential vanilloid type 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50158633((E)-3-(4-tert-Butyl-phenyl)-5-methyl-hex-2-enoic a...)
Affinity DataIC50:  16nMAssay Description:Inhibition of capsaicin-induced calcium uptake by transient receptor potential vanilloid type 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50158683((E)-3-(4-tert-Butyl-phenyl)-N-(3,4-dihydro-2H-benz...)
Affinity DataIC50:  16nMAssay Description:Inhibition of capsaicin-induced calcium uptake by transient receptor potential vanilloid type 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
Evotec

US Patent
LigandPNGBDBM118169(US8653091, 64)
Affinity DataIC50:  17nMAssay Description:The purinergic receptors P2X2 and P2X3 are expressed in a variety of tissues including various sensory and sympathetic ganglia, such as the dorsal ro...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetP2X purinoceptor 3(Homo sapiens (Human))
Evotec

US Patent
LigandPNGBDBM118154(US8653091, 49)
Affinity DataIC50:  19nMAssay Description:The purinergic receptors P2X2 and P2X3 are expressed in a variety of tissues including various sensory and sympathetic ganglia, such as the dorsal ro...More data for this Ligand-Target Pair
In DepthDetails US Patent
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