TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbvie
Curated by ChEMBL
Abbvie
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbvie
Curated by ChEMBL
Abbvie
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbvie
Curated by ChEMBL
Abbvie
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbvie
Curated by ChEMBL
Abbvie
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbvie
Curated by ChEMBL
Abbvie
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbvie
Curated by ChEMBL
Abbvie
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbvie
Curated by ChEMBL
Abbvie
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbvie
Curated by ChEMBL
Abbvie
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbvie
Curated by ChEMBL
Abbvie
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbvie
Curated by ChEMBL
Abbvie
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbvie
Curated by ChEMBL
Abbvie
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbvie
Curated by ChEMBL
Abbvie
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbvie
Curated by ChEMBL
Abbvie
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbvie
Curated by ChEMBL
Abbvie
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of mouse DGAT1 using [1-14C]decanoyl-CoA substrate by phospholipid flash plate assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of N-terminal His6-tagged human recombinant DGAT1 expressed in insect cell membrane using [1-14C]decanoyl-CoA substrate by phospholipid fl...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbvie
Curated by ChEMBL
Abbvie
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbvie
Curated by ChEMBL
Abbvie
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbvie
Curated by ChEMBL
Abbvie
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbvie
Curated by ChEMBL
Abbvie
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbvie
Curated by ChEMBL
Abbvie
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbvie
Curated by ChEMBL
Abbvie
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbvie
Curated by ChEMBL
Abbvie
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbvie
Curated by ChEMBL
Abbvie
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbvie
Curated by ChEMBL
Abbvie
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbvie
Curated by ChEMBL
Abbvie
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbvie
Curated by ChEMBL
Abbvie
Curated by ChEMBL
Affinity DataIC50: 34nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbvie
Curated by ChEMBL
Abbvie
Curated by ChEMBL
Affinity DataIC50: 36nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbvie
Curated by ChEMBL
Abbvie
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 44nMAssay Description:Inhibition of N-terminal His6-tagged human recombinant DGAT1 expressed in insect cell membrane using [1-14C]decanoyl-CoA substrate by phospholipid fl...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbvie
Curated by ChEMBL
Abbvie
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbvie
Curated by ChEMBL
Abbvie
Curated by ChEMBL
Affinity DataIC50: 74nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 78nMAssay Description:Inhibition of human DGAT1 expressed in human HeLa cells assessed as reduction in triglyceride synthesisMore data for this Ligand-Target Pair
Affinity DataIC50: <80nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using AMMC substrate and NADPH incubated up to 2 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using AMMC substrate and NADPH incubated up to 2 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: <80nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using AMMC substrate and NADPH incubated up to 2 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: <80nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using AMMC substrate and NADPH incubated up to 2 hrsMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbvie
Curated by ChEMBL
Abbvie
Curated by ChEMBL
Affinity DataIC50: 97nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of N-terminal His6-tagged human recombinant DGAT1 expressed in insect cell membrane using [1-14C]decanoyl-CoA substrate by phospholipid fl...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbvie
Curated by ChEMBL
Abbvie
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Inhibition of N-terminal His6-tagged human recombinant DGAT1 expressed in insect cell membrane using [1-14C]decanoyl-CoA substrate by phospholipid fl...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbvie
Curated by ChEMBL
Abbvie
Curated by ChEMBL
Affinity DataIC50: 350nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 660nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using 7-benzyloxyquiniline substrate and NADPH incubated up to 2 hrsMore data for this Ligand-Target Pair