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Found 440 with Last Name = 'kitano' and Initial = 'y'
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM145285(US8952169, 64 | US9771376, Example 64)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human Nav1.7/beta1/2 transfected in HEK293-A cells assessed as inhibition of channel current incubated for 5.5 mins by high-throughput ...More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50257179(CHEMBL2325622)
Affinity DataIC50:  0.550nMAssay Description:Inhibition of mouse NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM70937(US9546164, 100 | US9694002, 100)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human Nav1.7/beta1/2 transfected in HEK293-A cells assessed as inhibition of channel current incubated for 5.5 mins by high-throughput ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50222422(6,7-diethoxy-4-(2-(3-(4-fluorophenyl)-1H-pyrazol-4...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of partially purified EGFR tyrosine kinase from human A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50240277(CHEMBL4061793)
Affinity DataIC50:  1.80nMAssay Description:Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombinMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM50257179(CHEMBL2325622)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50222428((R)-4-(6,7-dimethoxyquinazolin-4-yl)-N,N-diethyl-2...)
Affinity DataIC50:  3nMAssay Description:Inhibition of partially purified EGFR tyrosine kinase from human A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50240277(CHEMBL4061793)
Affinity DataIC50:  3.10nMAssay Description:Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombinMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM217483(US9212182, 477 | US9212182, 478)
Affinity DataIC50:  3.20nMAssay Description:Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombinMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM76858(US9546164, 580 | US9694002, 580)
Affinity DataIC50:  3.20nMAssay Description:Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombinMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50240277(CHEMBL4061793)
Affinity DataIC50:  3.90nMAssay Description:Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombinMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50222430((E)-6,7-dimethoxy-4-(4-phenylbut-1-enyl)quinazolin...)
Affinity DataIC50:  4nMAssay Description:Inhibition of partially purified EGFR tyrosine kinase from human A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50222431((R)-1-(4-(6,7-diethoxyquinazolin-4-yl)-2-methyl-1-...)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of partially purified EGFR tyrosine kinase from human A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Mus musculus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50240267(CHEMBL2325014)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of mouse NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50222418(6,7-diethoxy-4-(4-phenylbut-1-enyl)quinazoline | C...)
Affinity DataIC50:  5nMAssay Description:Inhibition of partially purified EGFR tyrosine kinase from human A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50240267(CHEMBL2325014)
Affinity DataIC50:  8nMAssay Description:Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombinMore data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM217483(US9212182, 477 | US9212182, 478)
Affinity DataIC50:  8.5nMAssay Description:Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombinMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50222434((R)-4-(6,7-dimethoxyquinazolin-4-yl)-2-methyl-1-ph...)
Affinity DataIC50:  9nMAssay Description:Inhibition of partially purified EGFR tyrosine kinase from human A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50222439(6,7-diethoxy-4-(2-(3-phenyl-1H-pyrrol-2-yl)ethynyl...)
Affinity DataIC50:  10nMAssay Description:Inhibition of partially purified EGFR tyrosine kinase from human A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM145285(US8952169, 64 | US9771376, Example 64)
Affinity DataIC50:  11nMAssay Description:Inhibition of human Nav1.1/beta1/2 transfected in HEK293-A cells assessed as inhibition of channel current incubated for 5.5 mins by high-throughput ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50222437(1-(4-(6,7-diethoxyquinazolin-4-yl)-2-methyl-1-phen...)
Affinity DataIC50:  11.7nMAssay Description:Inhibition of partially purified EGFR tyrosine kinase from human A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM258102(US9493448, 4 | US9845313, Example 4)
Affinity DataIC50:  12nMAssay Description:Inhibition of human NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50222438(6,7-diethoxy-4-(2-(1-phenyl-1H-imidazol-2-yl)ethyn...)
Affinity DataIC50:  12nMAssay Description:Inhibition of partially purified EGFR tyrosine kinase from human A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM50240267(CHEMBL2325014)
Affinity DataIC50:  13nMAssay Description:Inhibition of human NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50222417(4-(3,3-dimethyl-4-phenylbut-1-ynyl)-6,7-dimethoxyq...)
Affinity DataIC50:  13nMAssay Description:Inhibition of partially purified EGFR tyrosine kinase from human A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM50613335(CHEMBL5288162)
Affinity DataIC50:  14nMAssay Description:Inhibition of human Nav1.7/beta1/2 transfected in HEK293-A cells assessed as inhibition of channel current incubated for 5.5 mins by high-throughput ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50222435(6,7-dimethoxy-4-(4-phenylbut-1-ynyl)quinazoline | ...)
Affinity DataIC50:  14nMAssay Description:Inhibition of partially purified EGFR tyrosine kinase from human A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM258219(US9493448, 126 | US9597330, Example 37 | US9845313...)
Affinity DataIC50:  14nMAssay Description:Current recording was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50222432(6,7-dimethoxy-4-(3-phenoxyprop-1-ynyl)quinazoline ...)
Affinity DataIC50:  15nMAssay Description:Inhibition of partially purified EGFR tyrosine kinase from human A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Mus musculus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258162(US9493448, 64 | US9597330, Example 21 | US9845313,...)
Affinity DataIC50:  15nMAssay Description:Inhibition of mouse NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50222425(6,7-diethoxy-4-styrylquinazoline | CHEMBL250925)
Affinity DataIC50:  15nMAssay Description:Inhibition of partially purified EGFR tyrosine kinase from human A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM50613342(CHEMBL5286433)
Affinity DataIC50:  15nMAssay Description:Inhibition of human Nav1.7/beta1/2 transfected in HEK293-A cells assessed as inhibition of channel current incubated for 5.5 mins by high-throughput ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetSodium channel subunit beta-2(Mus musculus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50613344(CHEMBL5284082)
Affinity DataIC50:  15nMAssay Description:Inhibition of mouse Nav1.7/beta1/2 transfected in HEK293-A cells assessed as inhibition of channel current incubated for 5.5 mins by high-throughput ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50505257(CHEMBL4471012)
Affinity DataIC50:  15nMAssay Description:Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium channel subunit beta-2(Mus musculus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50613336(CHEMBL5276801)
Affinity DataIC50:  16nMAssay Description:Inhibition of mouse Nav1.7/beta1/2 transfected in HEK293-A cells assessed as inhibition of channel current incubated for 5.5 mins by high-throughput ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM258146(US9493448, 122 | US9493448, 154 | US9493448, 48 | ...)
Affinity DataIC50:  16nMAssay Description:Current recording was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. Th...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM217483(US9212182, 477 | US9212182, 478)
Affinity DataIC50:  17nMAssay Description:Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombinMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM258244(US9493448, 152 | US9597330, Example 52 | US9845313...)
Affinity DataIC50:  17nMAssay Description:Current recording was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM258106(US9493448, 8 | US9845313, Example 8)
Affinity DataIC50:  17nMAssay Description:Inhibition of human NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Mus musculus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258102(US9493448, 4 | US9845313, Example 4)
Affinity DataIC50:  17nMAssay Description:Inhibition of mouse NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM258231(US9493448, 138 | US9493448, 148 | US9597330, Examp...)
Affinity DataIC50:  18nMAssay Description:Current recording was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM50613336(CHEMBL5276801)
Affinity DataIC50:  19nMAssay Description:Inhibition of human Nav1.7/beta1/2 transfected in HEK293-A cells assessed as inhibition of channel current incubated for 5.5 mins by high-throughput ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM217483(US9212182, 477 | US9212182, 478)
Affinity DataIC50:  19nMAssay Description:Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombinMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM258146(US9493448, 122 | US9493448, 154 | US9493448, 48 | ...)
Affinity DataIC50:  20nMAssay Description:Current recording was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. Th...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM258220(US9493448, 127 | US9493448, 143 | US9597330, Examp...)
Affinity DataIC50:  21nMAssay Description:Current recording was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM258233(US9493448, 140 | US9493448, 150 | US9597330, Examp...)
Affinity DataIC50:  21nMAssay Description:Current recording was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50466964(Pf-05241328)
Affinity DataIC50:  22nMAssay Description:Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombinMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM258146(US9493448, 122 | US9493448, 154 | US9493448, 48 | ...)
Affinity DataIC50:  23nMAssay Description:Inhibition of human Nav1.7 expressed in CHO cells with -120 mV holding potential by whole cell manual patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM258141(US9493448, 43 | US9597330, Example 10 | US9845313,...)
Affinity DataIC50:  24nMAssay Description:Inhibition of human NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM258231(US9493448, 138 | US9493448, 148 | US9597330, Examp...)
Affinity DataIC50:  24nMAssay Description:Current recording was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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