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Found 111 with Last Name = 'klüter' and Initial = 's'
TargetEpidermal growth factor receptor [668-1210](Homo sapiens (Human))
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM4567(4-anilinoquinazoline deriv. 2 | BMC163482 Compound...)
Affinity DataIC50:  0.0800nMpH: 7.5 T: 2°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [668-1210](Homo sapiens (Human))
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM4583((2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4...)
Affinity DataIC50:  0.220nMpH: 7.5 T: 2°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataIC50:  0.400nM Kd:  11nMpH: 7.0 T: 2°CAssay Description:IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [668-1210](Homo sapiens (Human))
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM31826(4-aminoquinazoline, 2a | BMC163482 Compound 3 | CH...)
Affinity DataIC50:  0.430nMpH: 7.5 T: 2°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [696-1210,T790M](Homo sapiens (Human))
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM4567(4-anilinoquinazoline deriv. 2 | BMC163482 Compound...)
Affinity DataIC50:  1.20nMpH: 7.5 T: 2°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [696-1210,T790M](Homo sapiens (Human))
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM4583((2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4...)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor [668-1210](Homo sapiens (Human))
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)
Affinity DataIC50:  3.60nMpH: 7.5 T: 2°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM31829(RL46 | quinazoline-pyrazolourea hybrid compound, 3...)
Affinity DataIC50:  14nM Kd:  56nMpH: 7.0 T: 2°CAssay Description:IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM31828(quinazoline-pyrazolourea hybrid compound, 3b)
Affinity DataIC50:  21nM Kd:  73nMpH: 7.0 T: 2°CAssay Description:IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src [251-533,T338M](Gallus gallus (Chicken))
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM31829(RL46 | quinazoline-pyrazolourea hybrid compound, 3...)
Affinity DataIC50:  23nMpH: 7.0 T: 2°CAssay Description:IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataIC50:  27nMAssay Description:Displacemnt of N,N'-(2,2'-(3,3'-disulfanediylbis(2,5-dioxopyrrolidine-3,1-diyl))bis(ethane-2,1-diyl))bis(2-(3-(3-tert-butyl-5-(3-naphthalen-1-ylureid...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src [251-533,T338M](Gallus gallus (Chicken))
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM31828(quinazoline-pyrazolourea hybrid compound, 3b)
Affinity DataIC50:  34nMpH: 7.0 T: 2°CAssay Description:IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50303597((S)-2-(2-amino-3-phenylpropylamino)-3-methyl-5-(na...)
Affinity DataIC50:  35nMAssay Description:Inhibition of p38alpha active form expressed in Escherichia coli BL21(DE3) cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50266947(2-(6-chloro-5-((2R,5S)-4-(4-fluorobenzyl)-2,5-dime...)
Affinity DataIC50:  36nMAssay Description:Inhibition of p38alpha active form expressed in Escherichia coli BL21(DE3) cells by HTRF assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50303586(1-(3-tert-Butyl-1-(3-nitrophenyl)-1H-pyrazol-5-yl)...)
Affinity DataIC50:  45nMAssay Description:Displacemnt of N,N'-(2,2'-(3,3'-disulfanediylbis(2,5-dioxopyrrolidine-3,1-diyl))bis(ethane-2,1-diyl))bis(2-(3-(3-tert-butyl-5-(3-naphthalen-1-ylureid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM31825(1-(1-(3-Aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl)...)
Affinity DataIC50:  70nMAssay Description:Displacemnt of N,N'-(2,2'-(3,3'-disulfanediylbis(2,5-dioxopyrrolidine-3,1-diyl))bis(ethane-2,1-diyl))bis(2-(3-(3-tert-butyl-5-(3-naphthalen-1-ylureid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM31827(quinazoline-pyrazolourea hybrid compound, 3a)
Affinity DataIC50:  71nM Kd:  174nMpH: 7.0 T: 2°CAssay Description:IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50303597((S)-2-(2-amino-3-phenylpropylamino)-3-methyl-5-(na...)
Affinity DataIC50:  75nMAssay Description:Displacemnt of N,N'-(2,2'-(3,3'-disulfanediylbis(2,5-dioxopyrrolidine-3,1-diyl))bis(ethane-2,1-diyl))bis(2-(3-(3-tert-butyl-5-(3-naphthalen-1-ylureid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50303597((S)-2-(2-amino-3-phenylpropylamino)-3-methyl-5-(na...)
Affinity DataIC50:  76nMAssay Description:Inhibition of JNK2 active form by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM31825(1-(1-(3-Aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl)...)
Affinity DataIC50:  90nMAssay Description:Inhibition of p38alpha active form expressed in Escherichia coli BL21(DE3) cells by HTRF assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM31825(1-(1-(3-Aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl)...)
Affinity DataIC50:  90nMAssay Description:Inhibition of JNK2 active form by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50303594(1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(3-(6...)
Affinity DataIC50:  95nMAssay Description:Displacemnt of N,N'-(2,2'-(3,3'-disulfanediylbis(2,5-dioxopyrrolidine-3,1-diyl))bis(ethane-2,1-diyl))bis(2-(3-(3-tert-butyl-5-(3-naphthalen-1-ylureid...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50266947(2-(6-chloro-5-((2R,5S)-4-(4-fluorobenzyl)-2,5-dime...)
Affinity DataIC50:  96nMAssay Description:Displacemnt of N,N'-(2,2'-(3,3'-disulfanediylbis(2,5-dioxopyrrolidine-3,1-diyl))bis(ethane-2,1-diyl))bis(2-(3-(3-tert-butyl-5-(3-naphthalen-1-ylureid...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50303584(1-(3-tert-butyl-1-(3-nitrophenyl)-1H-pyrazol-5-yl)...)
Affinity DataIC50:  100nMAssay Description:Inhibition of p38alpha active form expressed in Escherichia coli BL21(DE3) cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50303591(1-(4-(6-aminoquinolin-4-ylamino)phenyl)-3-(3-tert-...)
Affinity DataIC50:  100nMAssay Description:Displacemnt of N,N'-(2,2'-(3,3'-disulfanediylbis(2,5-dioxopyrrolidine-3,1-diyl))bis(ethane-2,1-diyl))bis(2-(3-(3-tert-butyl-5-(3-naphthalen-1-ylureid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src [251-533,T338M](Gallus gallus (Chicken))
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM31827(quinazoline-pyrazolourea hybrid compound, 3a)
Affinity DataIC50:  101nMpH: 7.0 T: 2°CAssay Description:IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM14832(3-(4-fluorophenyl)-2-pyridin-4-yl-6-thia-1,4-diaza...)
Affinity DataIC50:  110nMAssay Description:Inhibition of p38alpha active form expressed in Escherichia coli BL21(DE3) cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50303585(1-(3-tert-butyl-1-(3-nitrophenyl)-1H-pyrazol-5-yl)...)
Affinity DataIC50:  120nMAssay Description:Inhibition of p38alpha active form expressed in Escherichia coli BL21(DE3) cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50303596(CHEMBL566100 | N-(4-(3-(3-(3-tert-butyl-1-p-tolyl-...)
Affinity DataIC50:  140nMAssay Description:Inhibition of p38alpha active form expressed in Escherichia coli BL21(DE3) cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM31831(quinazoline-pyrazolourea hybrid compound, 3e)
Affinity DataIC50:  150nMAssay Description:Inhibition of JNK2 active form by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50303586(1-(3-tert-Butyl-1-(3-nitrophenyl)-1H-pyrazol-5-yl)...)
Affinity DataIC50:  150nMAssay Description:Inhibition of p38alpha active form expressed in Escherichia coli BL21(DE3) cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50303594(1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(3-(6...)
Affinity DataIC50:  150nMAssay Description:Inhibition of p38alpha active form expressed in Escherichia coli BL21(DE3) cells by HTRF assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataIC50:  150nMAssay Description:Inhibition of JNK2 active form by HTRF assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM31825(1-(1-(3-Aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl)...)
Affinity DataIC50:  170nMAssay Description:Displacemnt of N,N'-(2,2'-(3,3'-disulfanediylbis(2,5-dioxopyrrolidine-3,1-diyl))bis(ethane-2,1-diyl))bis(2-(3-(3-tert-butyl-5-(3-naphthalen-1-ylureid...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM31830(quinazoline-pyrazolourea hybrid compound, 3d)
Affinity DataIC50:  207nM Kd:  256nMpH: 7.0 T: 2°CAssay Description:IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50303584(1-(3-tert-butyl-1-(3-nitrophenyl)-1H-pyrazol-5-yl)...)
Affinity DataIC50:  220nMAssay Description:Displacemnt of N,N'-(2,2'-(3,3'-disulfanediylbis(2,5-dioxopyrrolidine-3,1-diyl))bis(ethane-2,1-diyl))bis(2-(3-(3-tert-butyl-5-(3-naphthalen-1-ylureid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50303597((S)-2-(2-amino-3-phenylpropylamino)-3-methyl-5-(na...)
Affinity DataIC50:  220nMAssay Description:Displacemnt of N,N'-(2,2'-(3,3'-disulfanediylbis(2,5-dioxopyrrolidine-3,1-diyl))bis(ethane-2,1-diyl))bis(2-(3-(3-tert-butyl-5-(3-naphthalen-1-ylureid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50303585(1-(3-tert-butyl-1-(3-nitrophenyl)-1H-pyrazol-5-yl)...)
Affinity DataIC50:  220nMAssay Description:Displacemnt of N,N'-(2,2'-(3,3'-disulfanediylbis(2,5-dioxopyrrolidine-3,1-diyl))bis(ethane-2,1-diyl))bis(2-(3-(3-tert-butyl-5-(3-naphthalen-1-ylureid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataIC50:  220nMAssay Description:Displacemnt of N,N'-(2,2'-(3,3'-disulfanediylbis(2,5-dioxopyrrolidine-3,1-diyl))bis(ethane-2,1-diyl))bis(2-(3-(3-tert-butyl-5-(3-naphthalen-1-ylureid...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50303595(1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(3-(q...)
Affinity DataIC50:  230nMAssay Description:Displacemnt of N,N'-(2,2'-(3,3'-disulfanediylbis(2,5-dioxopyrrolidine-3,1-diyl))bis(ethane-2,1-diyl))bis(2-(3-(3-tert-butyl-5-(3-naphthalen-1-ylureid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM31831(quinazoline-pyrazolourea hybrid compound, 3e)
Affinity DataIC50:  235nM Kd:  239nMpH: 7.0 T: 2°CAssay Description:IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src [251-533,S345C](Gallus gallus (Chicken))
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM4583((2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4...)
Affinity DataIC50:  236nMpH: 7.5 T: 2°CAssay Description:IC50 values were determined with the Z lyte assay system (Invitrogen). The reactions were performed in 384-well small volume plates from Greiner (#7...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataIC50:  250nMAssay Description:Inhibition of p38alpha active form expressed in Escherichia coli BL21(DE3) cells by HTRF assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50303596(CHEMBL566100 | N-(4-(3-(3-(3-tert-butyl-1-p-tolyl-...)
Affinity DataIC50:  250nMAssay Description:Displacemnt of N,N'-(2,2'-(3,3'-disulfanediylbis(2,5-dioxopyrrolidine-3,1-diyl))bis(ethane-2,1-diyl))bis(2-(3-(3-tert-butyl-5-(3-naphthalen-1-ylureid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor [696-1210,T790M](Homo sapiens (Human))
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)
Affinity DataIC50:  260nMpH: 7.5 T: 2°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50303595(1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(3-(q...)
Affinity DataIC50:  290nMAssay Description:Inhibition of p38alpha active form expressed in Escherichia coli BL21(DE3) cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50303593(1-(3-(6-aminoquinolin-4-ylamino)phenyl)-3-(3-tert-...)
Affinity DataIC50:  290nMAssay Description:Inhibition of p38alpha active form expressed in Escherichia coli BL21(DE3) cells by HTRF assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50303593(1-(3-(6-aminoquinolin-4-ylamino)phenyl)-3-(3-tert-...)
Affinity DataIC50:  310nMAssay Description:Displacemnt of N,N'-(2,2'-(3,3'-disulfanediylbis(2,5-dioxopyrrolidine-3,1-diyl))bis(ethane-2,1-diyl))bis(2-(3-(3-tert-butyl-5-(3-naphthalen-1-ylureid...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society

Curated by ChEMBL
LigandPNGBDBM31831(quinazoline-pyrazolourea hybrid compound, 3e)
Affinity DataIC50:  320nMAssay Description:Inhibition of p38alpha active form expressed in Escherichia coli BL21(DE3) cells by HTRF assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src [251-533,S345C](Gallus gallus (Chicken))
Chemical Genomics Centre of The Max Planck Society

LigandPNGBDBM4567(4-anilinoquinazoline deriv. 2 | BMC163482 Compound...)
Affinity DataIC50:  340nMpH: 7.5 T: 2°CAssay Description:IC50 values were determined with the Z lyte assay system (Invitrogen). The reactions were performed in 384-well small volume plates from Greiner (#7...More data for this Ligand-Target Pair
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