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Found 96 with Last Name = 'kniess' and Initial = 't'
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataKi:  9nMAssay Description:Competitive inhibition of VEGFR2 by qPCR methodMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataKi:  9nMAssay Description:Competitive inhibition of recombinant GST-tagged VEGFR2 cytoplasmic domain in presence of ATPMore data for this Ligand-Target Pair
TargetNeurotensin receptor type 1(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50319376((S)-2-((S)-2-((S)-2-((S)-1-((S)-2-((S)-2-amino-5-g...)
Affinity DataIC50:  1nMAssay Description:Displacement of [3H]neurotensin from NTR1 in human HT29 cells after 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50029618(4-(2-(4-methoxyphenyl)cyclopent-1-enyl)benzenesulf...)
Affinity DataIC50:  2nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50029613(1-Methoxy-4-(2-(4-(methanesulfonyl)phenyl)cyclopen...)
Affinity DataIC50:  5nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM20607((2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}ethy...)
Affinity DataIC50:  5nMAssay Description:Antagonist activity at human full-length ERbeta expressed in non-human mammalian expression system assessed as inhibition of 17beta-estradiol-induced...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50272095(4-(3-(4-methoxyphenyl)-1H-indol-2-yl)benzenesulfon...)
Affinity DataIC50:  6nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50029613(1-Methoxy-4-(2-(4-(methanesulfonyl)phenyl)cyclopen...)
Affinity DataIC50:  7nMAssay Description:Inhibition of COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50272131(3-(4-fluorophenyl)-2-(4-(methylsulfonyl)phenyl)-1H...)
Affinity DataIC50:  20nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50272096(3-(4-methoxyphenyl)-2-(4-(methylsulfonyl)phenyl)-1...)
Affinity DataIC50:  20nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human recombinant COX-2 by fluorescence assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50266516(5-(4-Fluorophenyl)-1-(4-methanesulfonylphenyl)-1H-...)
Affinity DataIC50:  30nMAssay Description:Inhibition of COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50266515(5-(4-Chlorophenyl)-1-(4-methanesulfonylphenyl)-1H-...)
Affinity DataIC50:  40nMAssay Description:Inhibition of COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human recombinant COX2 by enzymatic fluorescence assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  70nMAssay Description:Inhibition of COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50266511(1-(4-Methanesulfonylphenyl)-5-phenyl-1H-[1,2,3]tri...)
Affinity DataIC50:  110nMAssay Description:Inhibition of COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM4810((3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-...)
Affinity DataIC50:  110nMAssay Description:Inhibition of FLK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50266512(1-(4-Methanesulfonyl-phenyl)-5-p-tolyl-1H-[1,2,3]t...)
Affinity DataIC50:  120nMAssay Description:Inhibition of COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  130nMAssay Description:Inhibition of recombinant human COX-2 assessed as reduction of prostaglandin-G2 to prostaglandin-H2 and oxidation of 10-acetyl-3,7-dihydroxyphenoxazi...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50266480(1-(4-Methanesulfonylphenyl)-4-phenyl-1H-[1,2,3]tri...)
Affinity DataIC50:  150nMAssay Description:Inhibition of COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50266513(5-(4-Methoxyphenyl)-1-(4-(methylsulfonyl)phenyl)-1...)
Affinity DataIC50:  170nMAssay Description:Inhibition of COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50514959(CHEMBL4592754)
Affinity DataIC50:  180nMAssay Description:Antagonist activity at human full-length ERbeta expressed in non-human mammalian expression system assessed as inhibition of 17beta-estradiol-induced...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50266484(4-(4-Chlorophenyl)-1-(4-methanesulfonylphenyl)-1H-...)
Affinity DataIC50:  190nMAssay Description:Inhibition of COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50029618(4-(2-(4-methoxyphenyl)cyclopent-1-enyl)benzenesulf...)
Affinity DataIC50:  200nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50514953(CHEMBL4582563)
Affinity DataIC50:  200nMAssay Description:Antagonist activity at human full-length ERbeta expressed in non-human mammalian expression system assessed as inhibition of 17beta-estradiol-induced...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50266485(4-(4-Fluorophenyl)-1-(4-methanesulfonylphenyl)-1H-...)
Affinity DataIC50:  210nMAssay Description:Inhibition of COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50106762(CHEMBL3601277)
Affinity DataIC50:  220nMAssay Description:Inhibition of recombinant human COX-2 assessed as reduction of prostaglandin-G2 to prostaglandin-H2 and oxidation of 10-acetyl-3,7-dihydroxyphenoxazi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50106760(CHEMBL3601279)
Affinity DataIC50:  280nMAssay Description:Inhibition of recombinant human COX-2 assessed as reduction of prostaglandin-G2 to prostaglandin-H2 and oxidation of 10-acetyl-3,7-dihydroxyphenoxazi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50266514(CHEMBL457331 | N,N-dimethyl-4-(1-(4-(methylsulfony...)
Affinity DataIC50:  360nMAssay Description:Inhibition of COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 1(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50319374((S)-2-((S)-1-((2S,5S,8S,11S)-8-(3-amino-3-oxopropy...)
Affinity DataIC50:  700nMAssay Description:Displacement of [3H]neurotensin from NTR1 in human HT29 cells after 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50266515(5-(4-Chlorophenyl)-1-(4-methanesulfonylphenyl)-1H-...)
Affinity DataIC50:  700nMAssay Description:Inhibition of COX1 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50266512(1-(4-Methanesulfonyl-phenyl)-5-p-tolyl-1H-[1,2,3]t...)
Affinity DataIC50:  780nMAssay Description:Inhibition of COX1 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50266511(1-(4-Methanesulfonylphenyl)-5-phenyl-1H-[1,2,3]tri...)
Affinity DataIC50:  810nMAssay Description:Inhibition of COX1 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50266513(5-(4-Methoxyphenyl)-1-(4-(methylsulfonyl)phenyl)-1...)
Affinity DataIC50:  830nMAssay Description:Inhibition of COX1 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50266514(CHEMBL457331 | N,N-dimethyl-4-(1-(4-(methylsulfony...)
Affinity DataIC50:  840nMAssay Description:Inhibition of COX1 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50106763(CHEMBL3601276)
Affinity DataIC50:  890nMAssay Description:Inhibition of recombinant human COX-2 assessed as reduction of prostaglandin-G2 to prostaglandin-H2 and oxidation of 10-acetyl-3,7-dihydroxyphenoxazi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50266516(5-(4-Fluorophenyl)-1-(4-methanesulfonylphenyl)-1H-...)
Affinity DataIC50:  910nMAssay Description:Inhibition of COX1 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50106761(CHEMBL3601278)
Affinity DataIC50:  970nMAssay Description:Inhibition of recombinant human COX-2 assessed as reduction of prostaglandin-G2 to prostaglandin-H2 and oxidation of 10-acetyl-3,7-dihydroxyphenoxazi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50272131(3-(4-fluorophenyl)-2-(4-(methylsulfonyl)phenyl)-1H...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of human recombinant COX2 by enzymatic fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50428519(CHEMBL2336619)
Affinity DataIC50:  1.27E+3nMAssay Description:Inhibition of recombinant human COX-2 assessed as reduction of prostaglandin-G2 to prostaglandin-H2 and oxidation of 10-acetyl-3,7-dihydroxyphenoxazi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50514956(CHEMBL4515823)
Affinity DataIC50:  1.30E+3nMAssay Description:Antagonist activity at human full-length ERbeta expressed in non-human mammalian expression system assessed as inhibition of 17beta-estradiol-induced...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50514958(CHEMBL4544403)
Affinity DataIC50:  1.40E+3nMAssay Description:Antagonist activity at human full-length ERbeta expressed in non-human mammalian expression system assessed as inhibition of 17beta-estradiol-induced...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50514954(CHEMBL4517877)
Affinity DataIC50:  1.50E+3nMAssay Description:Antagonist activity at human full-length ERbeta expressed in non-human mammalian expression system assessed as inhibition of 17beta-estradiol-induced...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM20607((2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}ethy...)
Affinity DataIC50:  1.70E+3nMAssay Description:Antagonist activity at human full-length ERalpha expressed in non-human mammalian expression system assessed as inhibition of 17beta-estradiol-induce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50338296(1-(4-methoxyphenyl)-5-(4-(methylsulfonyl)phenyl)-1...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human recombinant COX-2 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50266481(1-(4-Methanesulfonyl-phenyl)-4-p-tolyl-1H-[1,2,3]t...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50266482(1-(4-Methanesulfonyl-phenyl)-4-(4-methoxyphenyl)-1...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50514960(CHEMBL4537514)
Affinity DataIC50:  2.70E+3nMAssay Description:Antagonist activity at human full-length ERbeta expressed in non-human mammalian expression system assessed as inhibition of 17beta-estradiol-induced...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50338297(1-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)-1H...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of human recombinant COX-2 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Helmholtz-Zentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50514957(CHEMBL4447475)
Affinity DataIC50:  3.00E+3nMAssay Description:Antagonist activity at human full-length ERbeta expressed in non-human mammalian expression system assessed as inhibition of 17beta-estradiol-induced...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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