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Found 716 with Last Name = 'kondo' and Initial = 't'
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50083552(1,9-di{4-[5-amino(imino)methylbenzo[b]furan-2-ylca...)
Affinity DataKi:  0.0190nMAssay Description:Inhibition of tryptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50083561(1-{4-[5-amino(imino)methylbenzo[b]thiophen-2-ylcar...)
Affinity DataKi:  0.0280nMAssay Description:Inhibition of tryptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50083556(1-{4-[5-amino(imino)methylbenzo[b]furan-2-ylcarbon...)
Affinity DataKi:  0.0290nMAssay Description:Inhibition of tryptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50083541(1-{4-[5-amino(imino)methyl-4,5,6,7-tetrahydrothien...)
Affinity DataKi:  0.0460nMAssay Description:Inhibition of tryptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50083548(1-{4-[5-amino(imino)methylbenzo[b]furan-2-ylcarbon...)
Affinity DataKi:  0.0570nMAssay Description:Inhibition of tryptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50217306(CHEMBL112049)
Affinity DataKi:  0.120nMAssay Description:Inhibition of tryptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250631(CHEMBL4093489)
Affinity DataKi:  0.574nMAssay Description:Displacement of [33P]-S1P from human S1P5 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250631(CHEMBL4093489)
Affinity DataKi:  0.626nMAssay Description:Agonist activity at human S1P5 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins by E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Rattus norvegicus)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250631(CHEMBL4093489)
Affinity DataKi:  0.772nMAssay Description:Displacement of [33P]-S1P from human S1P2 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50087713((1-Ethyl-propyl)-[3-(4-methoxy-2-methyl-phenyl)-2,...)
Affinity DataKi:  1nMAssay Description:Displacement of [125I]CRF from human corticotropin-releasing factor receptor 1 expressed in CHO-K1 cells after 2 hrs by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50083549(1-{4-[5-amino(imino)methylbenzo[b]furan-2-ylcarbon...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of tryptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250631(CHEMBL4093489)
Affinity DataKi:  29nMAssay Description:Displacement of [33P]-S1P from human S1P4 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50217313(CHEMBL110856)
Affinity DataKi:  60nMAssay Description:Inhibition of tryptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50217310(CHEMBL109688)
Affinity DataKi:  67nMAssay Description:Inhibition of tryptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50217308(CHEMBL424436)
Affinity DataKi:  210nMAssay Description:Inhibition of tryptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50217305(CHEMBL323935)
Affinity DataKi:  460nMAssay Description:Inhibition of tryptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50217315(CHEMBL30862)
Affinity DataKi:  970nMAssay Description:Inhibition of tryptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50217312(CHEMBL324918)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of tryptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50083563(1-{4-[5-amino(imino)methylaminobenzo[b]furan-2-ylc...)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of tryptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50217317(CHEMBL109903)
Affinity DataKi:  3.00E+3nMAssay Description:Inhibition of tryptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50083562(2-(4-{2-[4-(5-Carbamimidoyl-benzofuran-2-carbonyl)...)
Affinity DataKi:  5.30E+3nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250631(CHEMBL4093489)
Affinity DataKi: >5.45E+3nMAssay Description:Displacement of [33P]-S1P from rat S1P1 receptor after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250631(CHEMBL4093489)
Affinity DataKi: >5.63E+3nMAssay Description:Displacement of [33P]-S1P from human S1P3 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50217309(CHEMBL111451)
Affinity DataKi:  6.60E+3nMAssay Description:Inhibition of tryptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50217314(CHEMBL112894)
Affinity DataKi:  1.30E+4nMAssay Description:Inhibition of tryptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50217307(CHEMBL112900)
Affinity DataKi:  1.30E+4nMAssay Description:Inhibition of tryptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50083556(1-{4-[5-amino(imino)methylbenzo[b]furan-2-ylcarbon...)
Affinity DataKi:  1.50E+4nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50083561(1-{4-[5-amino(imino)methylbenzo[b]thiophen-2-ylcar...)
Affinity DataKi:  2.20E+4nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50217316(CHEMBL113084)
Affinity DataKi:  2.30E+4nMAssay Description:Inhibition of tryptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50083547(1,5-di(4-(5-amino(imino)methylbenzo[b]furan-2-ylca...)
Affinity DataKi:  2.30E+4nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50083563(1-{4-[5-amino(imino)methylaminobenzo[b]furan-2-ylc...)
Affinity DataKi:  2.40E+4nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50083557(CHEMBL113531 | N-Benzyl-2-(4-{2-[4-(5-carbamimidoy...)
Affinity DataKi:  2.80E+4nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50083541(1-{4-[5-amino(imino)methyl-4,5,6,7-tetrahydrothien...)
Affinity DataKi:  2.90E+4nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50083542(1,5-di{4-[5-amino(imino)methylbenzo[b]furan-2-ylca...)
Affinity DataKi:  3.20E+4nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50083548(1-{4-[5-amino(imino)methylbenzo[b]furan-2-ylcarbon...)
Affinity DataKi:  3.20E+4nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50083543(1,4-di{4-[5-amino(imino)methylbenzo[b]furan-2-ylca...)
Affinity DataKi:  5.10E+4nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50217311(CHEMBL109660)
Affinity DataKi:  8.00E+4nMAssay Description:Inhibition of tryptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50083553(1,3-di{4-[5-amino(imino)methylbenzo[b]furan-2-ylca...)
Affinity DataKi:  8.20E+4nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50083545(1,7-di{4-[5-amino(imino)methylbenzo[b]furan-2-ylca...)
Affinity DataKi:  8.50E+4nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50083549(1-{4-[5-amino(imino)methylbenzo[b]furan-2-ylcarbon...)
Affinity DataKi:  8.80E+4nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50083552(1,9-di{4-[5-amino(imino)methylbenzo[b]furan-2-ylca...)
Affinity DataKi:  2.30E+5nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM335414(4-(2-{(3S)-8-chloro-7-[5-chloro-2-(1H-tetrazol-1-y...)
Affinity DataIC50:  1.10nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM335416(5-(2-{(3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]...)
Affinity DataIC50:  1.10nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM335416(5-(2-{(3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]...)
Affinity DataIC50:  1.10nMAssay Description:Human Factor XIa activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6000, 50 mM HEPES-NaOH (pH7.4) wit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM335414(4-(2-{(3S)-8-chloro-7-[5-chloro-2-(1H-tetrazol-1-y...)
Affinity DataIC50:  1.10nMAssay Description:Human Factor XIa activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6000, 50 mM HEPES-NaOH (pH7.4) wit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM294112(US10336741, Example 99 | US10882855, Example 99 | ...)
Affinity DataIC50:  1.20nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM294112(US10336741, Example 99 | US10882855, Example 99 | ...)
Affinity DataIC50:  1.20nMAssay Description:Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM294112(US10336741, Example 99 | US10882855, Example 99 | ...)
Affinity DataIC50:  1.20nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM238267(US9394250, 99)
Affinity DataIC50:  1.20nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM335412(4-(2-{(3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]...)
Affinity DataIC50:  1.40nMAssay Description:Human Factor XIa activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6000, 50 mM HEPES-NaOH (pH7.4) wit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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