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Found 475 with Last Name = 'kowalchick' and Initial = 'je'
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50371255(CHEMBL1203953)
Affinity DataIC50:  0.180nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232520((2R)-4-oxo-4-[3-(trifluoromethyl)-8-[2-(trifluorom...)
Affinity DataIC50:  0.310nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232520((2R)-4-oxo-4-[3-(trifluoromethyl)-8-[2-(trifluorom...)
Affinity DataIC50:  0.310nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232506(2-[7-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butano...)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232518((2R)-4-oxo-4-[8-(pyridin-2-ylmethyl)-3-(trifluorom...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232518((2R)-4-oxo-4-[8-(pyridin-2-ylmethyl)-3-(trifluorom...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232503((2R)-4-[8-(4-methoxybenzyl)-3-(trifluoromethyl)-5,...)
Affinity DataIC50:  0.430nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232503((2R)-4-[8-(4-methoxybenzyl)-3-(trifluoromethyl)-5,...)
Affinity DataIC50:  0.430nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232501((2R)-4-[8-(2-fluorobenzyl)-3-(trifluoromethyl)-5,6...)
Affinity DataIC50:  0.460nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232501((2R)-4-[8-(2-fluorobenzyl)-3-(trifluoromethyl)-5,6...)
Affinity DataIC50:  0.460nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232506(2-[7-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butano...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232506(2-[7-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butano...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232510((2R)-4-[8-benzyl-3-(trifluoromethyl)-5,6-dihydro[1...)
Affinity DataIC50:  0.660nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232510((2R)-4-[8-benzyl-3-(trifluoromethyl)-5,6-dihydro[1...)
Affinity DataIC50:  0.660nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221449((3R)-1-(8-((1H-imidazol-1-yl)methyl)-2-(trifluorom...)
Affinity DataIC50:  2nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221444((R)-1-((R)-8-((1H-1,2,4-triazol-1-yl)methyl)-2-(tr...)
Affinity DataIC50:  2nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232507(2-[7-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butano...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232507(2-[7-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butano...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221452((R)-1-((R)-8-(4-fluorobenzyl)-2-(trifluoromethyl)-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221442((3R)-1-(8-((1H-pyrazol-1-yl)methyl)-2-(trifluorome...)
Affinity DataIC50:  4nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221454((R)-1-((R)-8-(4-(trifluoromethyl)benzyl)-2-(triflu...)
Affinity DataIC50:  4nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232502((2R)-4-[(8S)-8-methyl-3-(trifluoromethyl)-5,6-dihy...)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232511((2R)-4-[8-ethyl-3-(trifluoromethyl)-5,6-dihydro[1,...)
Affinity DataIC50:  5nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232511((2R)-4-[8-ethyl-3-(trifluoromethyl)-5,6-dihydro[1,...)
Affinity DataIC50:  5nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221453((3R)-1-(8-((1H-1,2,4-triazol-1-yl)methyl)-2-(trifl...)
Affinity DataIC50:  5nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232508((2R)-4-[8-(2,2,2-trifluoroethyl)-3-(trifluoromethy...)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232508((2R)-4-[8-(2,2,2-trifluoroethyl)-3-(trifluoromethy...)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232519((2R)-4-[8-[3,5-bis(trifluoromethyl)benzyl]-3-(trif...)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232519((2R)-4-[8-[3,5-bis(trifluoromethyl)benzyl]-3-(trif...)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221451((R)-3-amino-1-((R)-8-(cyclopropylmethyl)-2-(triflu...)
Affinity DataIC50:  7nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232504((2R)-4-[5,8-dimethyl-3-(trifluoromethyl)-5,6-dihyd...)
Affinity DataIC50:  11nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232502((2R)-4-[(8S)-8-methyl-3-(trifluoromethyl)-5,6-dihy...)
Affinity DataIC50:  11nMAssay Description:Inhibition of mouse DPP4 at 1 mg/kgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221445((R)-3-amino-1-((R)-8-(cyclopropylfluoromethyl)-2-(...)
Affinity DataIC50:  11nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232504((2R)-4-[5,8-dimethyl-3-(trifluoromethyl)-5,6-dihyd...)
Affinity DataIC50:  11nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221445((R)-3-amino-1-((R)-8-(cyclopropylfluoromethyl)-2-(...)
Affinity DataIC50:  11nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232504((2R)-4-[5,8-dimethyl-3-(trifluoromethyl)-5,6-dihyd...)
Affinity DataIC50:  12nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221446((R)-3-amino-1-((R)-8-(cyclopropyl(hydroxy)methyl)-...)
Affinity DataIC50:  12nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221440((R)-3-amino-1-((R)-8-(cyclopropyl(hydroxy)methyl)-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM11162((1R)-3-oxo-3-[3-(trifluoroethyl)-5,6-dihydro[1,2,4...)
Affinity DataIC50:  18nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM11162((1R)-3-oxo-3-[3-(trifluoroethyl)-5,6-dihydro[1,2,4...)
Affinity DataIC50:  18nMpH: 7.5 T: 2°CAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM11162((1R)-3-oxo-3-[3-(trifluoroethyl)-5,6-dihydro[1,2,4...)
Affinity DataIC50:  18nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM11162((1R)-3-oxo-3-[3-(trifluoroethyl)-5,6-dihydro[1,2,4...)
Affinity DataIC50:  18nMAssay Description:Inhibition of DPP4 activityMore data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM15561((3R)-3-amino-4-(5-chloro-2-fluorophenyl)-1-[3-(tri...)
Affinity DataIC50:  21nMAssay Description:Inhibition of DPP4 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50210657((R)-3-amino-4-(2,4-dichlorophenyl)-1-(3-(trifluoro...)
Affinity DataIC50:  23nMAssay Description:Inhibition of DPP4 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221443((2R)-4-[(8R)-8-METHYL-2-(TRIFLUOROMETHYL)-5,6-DIHY...)
Affinity DataIC50:  25nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM11160((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Affinity DataIC50:  27nMpH: 7.5 T: 2°CAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM11160((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Affinity DataIC50:  27nMAssay Description:Inhibition of DPP4 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50210649((R)-3-amino-1-(3-(difluoromethyl)-5,6-dihydro-[1,2...)
Affinity DataIC50:  29nMAssay Description:Inhibition of DPP4 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50210647((R)-3-amino-1-(3-cyclopropyl-5,6-dihydro-[1,2,4]tr...)
Affinity DataIC50:  30nMAssay Description:Inhibition of DPP4 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50210668((3R)-3-amino-4-(2,5-difluorophenyl)-1-(3-(2,4-difl...)
Affinity DataIC50:  30nMAssay Description:Inhibition of DPP4 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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