Compile Data Set for Download or QSAR
maximum 50k data
Found 216 with Last Name = 'larsson' and Initial = 'lo'
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50214034((1S,3S)-N1-(7-methoxy-4-methylquinolin-2-yl)-N3-(t...)
Affinity DataIC50:  0.100nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50214034((1S,3S)-N1-(7-methoxy-4-methylquinolin-2-yl)-N3-(t...)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at human MCHR1 expressed in HEK293 cells assessed as [35S]GTPgammaS accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50214024((1S,3S)-N1-(6-methoxy-4-methylquinolin-2-yl)-N3-(t...)
Affinity DataIC50:  3nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50214036((1S,3S)-N1-((5-(difluoromethoxy)-1-methyl-1H-indol...)
Affinity DataIC50:  5nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50214037((1S,3S)-N1-(4-methylquinolin-2-yl)-N3-(thiophen-3-...)
Affinity DataIC50:  7nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50214052((1S,3S)-N1-(4-methoxyquinolin-2-yl)-N3-(thiophen-3...)
Affinity DataIC50:  8nMAssay Description:Antagonist activity at human MCHR1 expressed in HEK293 cells assessed as [35S]GTPgammaS accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50214052((1S,3S)-N1-(4-methoxyquinolin-2-yl)-N3-(thiophen-3...)
Affinity DataIC50:  9nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50214035((1S,3S)-N1-(7-methoxy-4-methylquinolin-2-yl)-N3-((...)
Affinity DataIC50:  9nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50534272(CHEMBL4593409)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant sPLA2-2A (unknown origin) using 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine as substrate preincubated for 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50214050((1S,3S)-N1-(benzo[c][1,2,5]thiadiazol-4-ylmethyl)-...)
Affinity DataIC50:  10nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50534275(CHEMBL4451830)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant sPLA2-2A (unknown origin) using 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine as substrate preincubated for 10 mins foll...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50534274(CHEMBL4457557)
Affinity DataIC50:  12nMAssay Description:Inhibition of recombinant sPLA2-2A (unknown origin) using 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine as substrate preincubated for 10 mins foll...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50214030((1S,3S)-N1-(3,4-dichlorobenzyl)-N3-(7-methoxy-4-me...)
Affinity DataIC50:  13nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGroup XIIB secretory phospholipase A2-like protein(Homo sapiens)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50534272(CHEMBL4593409)
Affinity DataIC50: <14nMAssay Description:Inhibition of sPLA2 in human HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50214046((1S,3S)-N1-(3-(trifluoromethoxy)benzyl)-N3-(7-meth...)
Affinity DataIC50:  15nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50214068(6-methoxy-4-methyl-N-(3-(thiophen-3-ylmethylamino)...)
Affinity DataIC50:  15nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50214061((1S,3S)-N1-(benzo[c][1,2,5]thiadiazol-5-ylmethyl)-...)
Affinity DataIC50:  16nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50534277(CHEMBL4453126)
Affinity DataIC50:  18nMAssay Description:Inhibition of recombinant sPLA2-2A (unknown origin) using 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine as substrate preincubated for 10 mins foll...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50214047(3-(((1S,3S)-3-(7-methoxy-4-methylquinolin-2-ylamin...)
Affinity DataIC50:  20nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50534278(CHEMBL4533403)
Affinity DataIC50:  21nMAssay Description:Inhibition of recombinant sPLA2-2A (unknown origin) using 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine as substrate preincubated for 10 mins foll...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50214032((1S,3S)-N1-(isoquinolin-4-ylmethyl)-N3-(7-methoxy-...)
Affinity DataIC50:  22nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50214053((1S,3S)-N1-(6-methoxyquinolin-2-yl)-N3-(thiophen-3...)
Affinity DataIC50:  25nMAssay Description:Antagonist activity at human MCHR1 expressed in HEK293 cells assessed as [35S]GTPgammaS accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50214049((1S,3S)-N1-(6-fluoro-4-methoxyquinolin-2-yl)-N3-(t...)
Affinity DataIC50:  26nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50214048((1S,3S)-N1-(2-bromo-5-methoxybenzyl)-N3-(7-methoxy...)
Affinity DataIC50:  28nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50055366((3-Aminooxalyl-1-benzyl-2-ethyl-1H-indol-4-yloxy)-...)
Affinity DataIC50:  28nMAssay Description:Inhibition of recombinant sPLA2-2A (unknown origin) using 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine as substrate preincubated for 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50214055(CHEMBL399244 | N4,N4-dimethyl-N2-((1S,3S)-3-(thiop...)
Affinity DataIC50:  29nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50214066((1S,3S)-N1-(7-methoxy-4-methylquinolin-2-yl)-N3-((...)
Affinity DataIC50:  29nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50214044(3-(((1S,3S)-3-(7-methoxy-4-methylquinolin-2-ylamin...)
Affinity DataIC50:  33nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50214045((1S,2S,4R,6S)-N2-(6-methoxy-4-methylquinolin-2-yl)...)
Affinity DataIC50:  35nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50214036((1S,3S)-N1-((5-(difluoromethoxy)-1-methyl-1H-indol...)
Affinity DataIC50:  35nMAssay Description:Antagonist activity at human MCHR1 expressed in HEK293 cells assessed as [35S]GTPgammaS accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50534276(CHEMBL4555962)
Affinity DataIC50:  38nMAssay Description:Inhibition of recombinant sPLA2-2A (unknown origin) using 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine as substrate preincubated for 10 mins foll...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50214041(3-(((1S,3S)-3-(7-methoxy-4-methylquinolin-2-ylamin...)
Affinity DataIC50:  39nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGroup 10 secretory phospholipase A2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50055366((3-Aminooxalyl-1-benzyl-2-ethyl-1H-indol-4-yloxy)-...)
Affinity DataIC50:  41nMAssay Description:Inhibition of recombinant sPLA2-10 (unknown origin) using 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine as substrate preincubated for 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50214023((1S,3S)-N1-(5-methoxyquinolin-2-yl)-N3-(thiophen-3...)
Affinity DataIC50:  42nMAssay Description:Antagonist activity at human MCHR1 expressed in HEK293 cells assessed as [35S]GTPgammaS accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50214021((1S,3S)-N1-(2-chloro-4-(methylsulfonyl)benzyl)-N3-...)
Affinity DataIC50:  50nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Astrazeneca Research And Development

Curated by ChEMBL
LigandPNGBDBM50350728(CHEMBL1818291)
Affinity DataIC50:  52nMAssay Description:Inhibition of human recombinant his-tagged ACC2 expressed in baculovirus/Sf9 cell assessed as inorganic phosphate formation preincubated for 15 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50214023((1S,3S)-N1-(5-methoxyquinolin-2-yl)-N3-(thiophen-3...)
Affinity DataIC50:  54nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGroup XIIB secretory phospholipase A2-like protein(Homo sapiens)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50534272(CHEMBL4593409)
Affinity DataIC50:  56nMAssay Description:Inhibition of sPLA2 in atherosclerotic plaque from coronary artery disease patientMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50214053((1S,3S)-N1-(6-methoxyquinolin-2-yl)-N3-(thiophen-3...)
Affinity DataIC50:  57nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50214038(5-chloro-3-(((1S,3S)-3-(7-methoxy-4-methylquinolin...)
Affinity DataIC50:  58nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50214037((1S,3S)-N1-(4-methylquinolin-2-yl)-N3-(thiophen-3-...)
Affinity DataIC50:  59nMAssay Description:Antagonist activity at human MCHR1 expressed in HEK293 cells assessed as [35S]GTPgammaS accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50214039((1S,3S)-N1-((5-bromo-1-methyl-1H-indol-3-yl)methyl...)
Affinity DataIC50:  61nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50214040((1S,3S)-N1-(6-methoxy-4-methylquinolin-2-yl)-N3-(t...)
Affinity DataIC50:  62nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50214025((1S,3S)-N1-(quinolin-2-yl)-N3-(thiophen-3-ylmethyl...)
Affinity DataIC50:  68nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50534279(CHEMBL4468927)
Affinity DataIC50:  70nMAssay Description:Inhibition of recombinant sPLA2-2A (unknown origin) using 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine as substrate preincubated for 10 mins foll...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50214057((1S,3S)-N1-(7-methoxy-4-methylquinolin-2-yl)-N3-((...)
Affinity DataIC50:  71nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50214065((1S,3S)-N1-((5-(benzyloxy)-1-methyl-1H-indol-3-yl)...)
Affinity DataIC50:  80nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50214066((1S,3S)-N1-(7-methoxy-4-methylquinolin-2-yl)-N3-((...)
Affinity DataIC50:  83nMAssay Description:Antagonist activity at human MCHR1 expressed in HEK293 cells assessed as [35S]GTPgammaS accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50214035((1S,3S)-N1-(7-methoxy-4-methylquinolin-2-yl)-N3-((...)
Affinity DataIC50:  85nMAssay Description:Antagonist activity at human MCHR1 expressed in HEK293 cells assessed as [35S]GTPgammaS accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Astrazeneca Research And Development

Curated by ChEMBL
LigandPNGBDBM50350748(CHEMBL1818297)
Affinity DataIC50:  89nMAssay Description:Inhibition of human recombinant his-tagged ACC2 expressed in baculovirus/Sf9 cell assessed as inorganic phosphate formation preincubated for 15 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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