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Found 3650 with Last Name = 'le' and Initial = 'q'
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50160917(3-(3-(2-(benzyloxy)-5-chlorophenyl)thiophen-2-yl)b...)
Affinity DataKi:  0.300nMAssay Description:Antagonist activity against PGE2 activated EP1 receptor assessed as ability to inhibit intracellular calcium mobilisation by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
University Of Southampton

Curated by ChEMBL
LigandPNGBDBM50399614(CHEMBL2181170)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]GR113808 from 5HT4R in guinea pig striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
University Of Southampton

Curated by ChEMBL
LigandPNGBDBM50443687(CHEMBL3093187)
Affinity DataKi:  4.20nMAssay Description:Displacement of [3H]GR113808 from 5HT4R in guinea pig striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))TBA
LigandPNGBDBM50608552(CHEMBL5269107)
Affinity DataKi:  5.10nMAssay Description:Inhibition of human GBA2 over-expressed in HEK293T cells using 4-methylumbeliferone as substrate incubated for 1 hrs by FluoPol-ABPP assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50564520(CHEMBL4796569)
Affinity DataKi:  5.10nMAssay Description:Inhibition of His-tagged human full length PI3Kalpha coexpressed with p85 alpha in baculovirus expression system using PIP2 peptide as substrate incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))TBA
LigandPNGBDBM50608553(CHEMBL5291161)
Affinity DataKi:  7.70nMAssay Description:Inhibition of human GBA2 over-expressed in HEK293T cells using 4-methylumbeliferone as substrate incubated for 1 hrs by FluoPol-ABPP assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
University Of Southampton

Curated by ChEMBL
LigandPNGBDBM50443688(CHEMBL3093186)
Affinity DataKi:  9nMAssay Description:Displacement of [3H]GR113808 from 5HT4R in guinea pig striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
University Of Southampton

Curated by ChEMBL
LigandPNGBDBM50443690(CHEMBL3093184)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]GR113808 from 5HT4R in guinea pig striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
University Of Southampton

Curated by ChEMBL
LigandPNGBDBM50399619(CHEMBL2181189)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]GR113808 from 5HT4R in guinea pig striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
University Of Southampton

Curated by ChEMBL
LigandPNGBDBM50443691(CHEMBL3093194)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]GR113808 from 5HT4R in guinea pig striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
University Of Southampton

Curated by ChEMBL
LigandPNGBDBM50399632(CHEMBL2177145)
Affinity DataKi:  52nMAssay Description:Displacement of [3H]GR113808 from 5HT4R in guinea pig striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50564520(CHEMBL4796569)
Affinity DataKi:  89nMAssay Description:Inhibition of N-terminal His6-tagged human recombinant full length PI3Kbeta co-expressed with human recombinant full length P85alpha in baculovirus i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
University Of Southampton

Curated by ChEMBL
LigandPNGBDBM50443689(CHEMBL3093185)
Affinity DataKi:  91nMAssay Description:Displacement of [3H]GR113808 from 5HT4R in guinea pig striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50564520(CHEMBL4796569)
Affinity DataKi:  193nMAssay Description:Inhibition of GST-tagged human recombinant PI3Kgamma catalytic domain (468 to 1203 residues) expressed in insect cells using PIP2 peptide as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50564520(CHEMBL4796569)
Affinity DataKi:  245nMAssay Description:Inhibition of N-terminal His6-tagged human recombinant full length PI3Kdelta co-expressed with human recombinant full length P85alpha in baculovirus ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
University Of Southampton

Curated by ChEMBL
LigandPNGBDBM50443688(CHEMBL3093186)
Affinity DataKi:  1.20E+3nMAssay Description:Binding affinity to human 5HT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
University Of Southampton

Curated by ChEMBL
LigandPNGBDBM50443687(CHEMBL3093187)
Affinity DataKi:  2.60E+3nMAssay Description:Binding affinity to human 5HT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM103683(US8563553, 108)
Affinity DataIC50:  0.0800nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM103702(US8563553, 127)
Affinity DataIC50:  0.0800nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM103684(US8563553, 109)
Affinity DataIC50:  0.100nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM103628(US8563553, 53)
Affinity DataIC50:  0.100nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM103629(US8563553, 54)
Affinity DataIC50:  0.100nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM103632(US8563553, 57)
Affinity DataIC50:  0.100nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM103681(US8563553, 106)
Affinity DataIC50:  0.100nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM103677(US8563553, 102)
Affinity DataIC50:  0.110nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM103699(US8563553, 124)
Affinity DataIC50:  0.110nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM103723(US8563553, 148)
Affinity DataIC50:  0.120nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM103715(US8563553, 140)
Affinity DataIC50:  0.130nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM103680(US8563553, 105)
Affinity DataIC50:  0.130nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM103721(US8563553, 146)
Affinity DataIC50:  0.130nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50585514(CHEMBL5086526)
Affinity DataIC50:  0.158nMAssay Description:Inhibition of GST-fused human JAK3 (810 to 1100 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50585527(CHEMBL5084861)
Affinity DataIC50: >0.158nMAssay Description:Inhibition of GST-tagged recombinant human JAK2 (808 to 1132 residues) expressed in baculovirus expression system using ULight-JAK-1 Tyr1023 peptide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM103717(US8563553, 142)
Affinity DataIC50:  0.160nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM103648(US8563553, 73)
Affinity DataIC50:  0.180nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM103647(US8563553, 72)
Affinity DataIC50:  0.180nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM103693(US8563553, 118)
Affinity DataIC50:  0.190nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50585515(CHEMBL5076189)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of GST-fused human JAK3 (810 to 1100 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM103694(US8563553, 119)
Affinity DataIC50:  0.200nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM103645(US8563553, 70)
Affinity DataIC50:  0.200nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM103625(US8563553, 50)
Affinity DataIC50:  0.200nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM103624(US8563553, 49)
Affinity DataIC50:  0.200nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM103686(US8563553, 111)
Affinity DataIC50:  0.220nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM103674(US8563553, 99)
Affinity DataIC50:  0.230nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM103695(US8563553, 120)
Affinity DataIC50:  0.230nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM103649(US8563553, 74)
Affinity DataIC50:  0.240nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM103690(US8563553, 115)
Affinity DataIC50:  0.25nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM103652(US8563553, 77)
Affinity DataIC50:  0.260nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM103691(US8563553, 116)
Affinity DataIC50:  0.260nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

LigandPNGBDBM35317(4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(...)
Affinity DataIC50:  0.270nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM103703(US8563553, 128)
Affinity DataIC50:  0.270nMpH: 7.5Assay Description:Raf/Mek amplified luminescence proximity homogeneous assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
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