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Found 756 with Last Name = 'leblond' and Initial = 'b'
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50176918((2S)-aminobutyryl-(2S)-indoline carboxylic acid pr...)
Affinity DataKi:  6nMAssay Description:Inhibition of TPPII in rat cererbral membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50121282((S)-1-((S)-2-aminobutanoyl)-N-butylindoline-2-carb...)
Affinity DataKi:  7nMAssay Description:Inhibition of TPPII in rat cererbral membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50176940((2S)-aminobutyryl-(2S)-indoline carboxylic acid et...)
Affinity DataKi:  12nMAssay Description:Inhibition of TPPII in rat cererbral membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50176934((2S)-aminobutyryl-L-proline n-butylamide | CHEMBL2...)
Affinity DataKi:  80nMAssay Description:Inhibition of TPPII in rat cererbral membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50176913((2S)-aminobutyryl-L-proline n-propylamide | CHEMBL...)
Affinity DataKi:  80nMAssay Description:Inhibition of TPPII in rat cererbral membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50176939((2S)-1-((S)-2-aminobutanoyl)-4-benzyl-N-butylpyrro...)
Affinity DataKi:  140nMAssay Description:Inhibition of TPPII in rat cererbral membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50176936((2S)-aminobutyryl-L-proline n-pentylamide | CHEMBL...)
Affinity DataKi:  270nMAssay Description:Inhibition of TPPII in rat cererbral membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50176927((2S)-aminobutyryl-L-proline 3-methylthiopropylamid...)
Affinity DataKi:  300nMAssay Description:Inhibition of TPPII in rat cererbral membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50176935((2S,4S)-1-((S)-2-aminobutanoyl)-N-butyl-4-fluoropy...)
Affinity DataKi:  320nMAssay Description:Inhibition of TPPII in rat cererbral membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50176945((2S)-aminobutyryl-L-proline isobutylamide | CHEMBL...)
Affinity DataKi:  320nMAssay Description:Inhibition of TPPII in rat cererbral membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50176922((2S)-aminobutyryl-(2S)-indoline carboxylic acid me...)
Affinity DataKi:  340nMAssay Description:Inhibition of TPPII in rat cererbral membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50176914((2S)-aminobutyryl-L-proline-(2S)-methylbutylamide ...)
Affinity DataKi:  500nMAssay Description:Inhibition of TPPII in rat cererbral membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50176920((S)-1-((S)-2-amino-3-methylbutanoyl)-N-butylpyrrol...)
Affinity DataKi:  570nMAssay Description:Inhibition of TPPII in rat cererbral membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50176932((2S)-aminobutyryl-L-prolinamide | CHEMBL224063)
Affinity DataKi:  570nMAssay Description:Inhibition of TPPII in rat cererbral membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50176928(CHEMBL375490 | L-valyl-L-proline hexylamide)
Affinity DataKi:  900nMAssay Description:Inhibition of TPPII in rat cererbral membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50176926(CHEMBL224628 | L-norvalyl-L-prolinamide)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of TPPII in rat cererbral membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50176919(CHEMBL388843 | L-norleucyl-L-prolinamide)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of TPPII in rat cererbral membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50176925(CHEMBL224340 | L-leucyl-L-prolinamide)
Affinity DataKi:  2.10E+3nMAssay Description:Inhibition of TPPII in rat cererbral membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50176943((S)-1-((S)-2-aminopropanoyl)pyrrolidine-2-carboxam...)
Affinity DataKi:  2.10E+3nMAssay Description:Inhibition of TPPII in rat cererbral membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50176931(CHEMBL376375 | L-valyl-L-proline benzylamide)
Affinity DataKi:  3.30E+3nMAssay Description:Inhibition of TPPII in rat cererbral membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50176924(CHEMBL224341 | L-isoleucyl-L-prolinamide)
Affinity DataKi:  4.30E+3nMAssay Description:Inhibition of TPPII in rat cererbral membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50176930((2S)-aminobutyryl-L-proline (R)-sec-butylamide | C...)
Affinity DataKi:  4.50E+3nMAssay Description:Inhibition of TPPII in rat cererbral membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50176938(CHEMBL388062 | alpha-methylalanyl-L-proline butyla...)
Affinity DataKi:  5.00E+3nMAssay Description:Inhibition of TPPII in rat cererbral membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50176929(CHEMBL375933 | L-valyl-L-prolinamide)
Affinity DataKi:  6.00E+3nMAssay Description:Inhibition of TPPII in rat cererbral membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50176944(1-((S)-2-aminobutanoyl)-N-butylazepane-2-carboxami...)
Affinity DataKi:  6.00E+3nMAssay Description:Inhibition of TPPII in rat cererbral membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50176923((2S)-aminobutyryl-(R)-pipecolinic acid amide | CHE...)
Affinity DataKi:  1.20E+4nMAssay Description:Inhibition of TPPII in rat cererbral membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50176921((2S)-aminobutyryl-(2S)-azetidine carboxamide | CHE...)
Affinity DataKi:  2.00E+4nMAssay Description:Inhibition of TPPII in rat cererbral membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50176915((2S)-aminobutyryl-L-proline (S)-sec-butylamide | C...)
Affinity DataKi:  2.00E+4nMAssay Description:Inhibition of TPPII in rat cererbral membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50176912(CHEMBL225596 | L-valyl-L-proline cyclohexylmethyla...)
Affinity DataKi:  3.40E+4nMAssay Description:Inhibition of TPPII in rat cererbral membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50176911((2S)-aminobutyryl-L-pipecolinic acid n-butylamide ...)
Affinity DataKi:  3.50E+4nMAssay Description:Inhibition of TPPII in rat cererbral membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50176916((2S)-aminobutyryl-(S)-nipecotamide | CHEMBL223665)
Affinity DataKi:  4.00E+4nMAssay Description:Inhibition of TPPII in rat cererbral membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50176942((2S)-aminobutyryl-4-thia-L-prolinamide | CHEMBL375...)
Affinity DataKi:  4.00E+4nMAssay Description:Inhibition of TPPII in rat cererbral membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50176933(CHEMBL390771 | L-valyl-L-proline piperidinylamide)
Affinity DataKi:  5.70E+4nMAssay Description:Inhibition of TPPII in rat cererbral membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50176941(CHEMBL224610 | L-phenylalanyl-L-prolinamide)
Affinity DataKi:  7.10E+4nMAssay Description:Inhibition of TPPII in rat cererbral membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50176937((R)-1-((S)-2-amino-3-methylbutanoyl)-N-butylpyrrol...)
Affinity DataKi:  1.90E+5nMAssay Description:Inhibition of TPPII in rat cererbral membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTripeptidyl-peptidase 2(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50176917(CHEMBL390838 | L-valyl-L-proline-N-naphthylamide)
Affinity DataKi:  8.60E+5nMAssay Description:Inhibition of TPPII in rat cererbral membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50380208(CHEMBL2011408)
Affinity DataIC50:  0.0100nMAssay Description:Inhibition of steroid sulfatase in human MCF7 cells using [3H]E1S as substrate after 20 hrs by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50380223(CHEMBL2011422)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of steroid sulfatase in human placental microsomes using [3H]E1S as substrate after 30 mins by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50380216(CHEMBL364332)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of steroid sulfatase in human MCF7 cells using [3H]E1S as substrate after 20 hrs by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM125523(US8772316, 6)
Affinity DataIC50:  0.120nMpH: 7.4Assay Description:The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM187126(US9670181, 6 4-(dibenzo[b,d]furan-2-ylmethyl)-1-et...)
Affinity DataIC50:  0.120nMpH: 7.4 T: 2°CAssay Description:The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Diaxonhit

US Patent
LigandPNGBDBM50434358(CHEMBL2386770 | US9446044, 68)
Affinity DataIC50:  0.160nMpH: 7.5 T: 2°CAssay Description:The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM194437(US9200016, 119 | US9902710, Compound 119)
Affinity DataIC50:  0.180nMpH: 7.4 T: 2°CAssay Description:The phosphodiesterase assay was developed using the LANCE cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1....More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM194437(US9200016, 119 | US9902710, Compound 119)
Affinity DataIC50:  0.180nMAssay Description:The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Diaxonhit

US Patent
LigandPNGBDBM50434353(CHEMBL2386747 | US9446044, 72)
Affinity DataIC50:  0.220nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Diaxonhit

US Patent
LigandPNGBDBM50434353(CHEMBL2386747 | US9446044, 72)
Affinity DataIC50:  0.220nMAssay Description:Inhibition of human DYRK1A using [33P]-ATP incubated for 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Diaxonhit

US Patent
LigandPNGBDBM50434353(CHEMBL2386747 | US9446044, 72)
Affinity DataIC50:  0.220nMpH: 7.5 T: 2°CAssay Description:The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Diaxonhit

US Patent
LigandPNGBDBM50434358(CHEMBL2386770 | US9446044, 68)
Affinity DataIC50:  0.240nMpH: 7.5 T: 2°CAssay Description:The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Diaxonhit

US Patent
LigandPNGBDBM50434353(CHEMBL2386747 | US9446044, 72)
Affinity DataIC50:  0.280nMpH: 7.5 T: 2°CAssay Description:The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Diaxonhit

US Patent
LigandPNGBDBM50434353(CHEMBL2386747 | US9446044, 72)
Affinity DataIC50:  0.280nMAssay Description:Inhibition of human DYRK1B using [33P]-ATP incubated for 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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