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Found 261 with Last Name = 'lehmann' and Initial = 'a'
LigandPNGBDBM24198(3-aminopropylphosphinic derivative, (R)-8 | [(2R)-...)
Affinity DataKi:  4.30nM ΔG°:  -47.3kJ/mole EC50:  14nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24195(3-aminopropylphosphinic derivative, (R)-7 | AZD335...)
Affinity DataKi:  5.10nM ΔG°:  -46.9kJ/mole EC50:  8.64nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24193((3-amino-2-fluoropropyl)phosphinic acid | 3-aminop...)
Affinity DataKi:  10nM ΔG°:  -45.2kJ/mole EC50:  15nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50271255(1-[(Imidazolidin-2-yl)imino]indazole hydrochloride...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenoceptor in Sprague-Dawley rat brain membranes after 45 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24196((3-amino-2-fluoropropyl)(methyl)phosphinic acid | ...)
Affinity DataKi:  14nM ΔG°:  -44.4kJ/mole EC50:  23nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24184((3-aminopropyl)phosphinic acid | 3-aminopropylphos...)
Affinity DataKi:  15nM ΔG°:  -44.2kJ/mole EC50:  19nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50497435(CHEMBL3343699)
Affinity DataKi:  26nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenoceptor in Sprague-Dawley rat brain membranes after 45 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50497438(CHEMBL3343704)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenoceptor in Sprague-Dawley rat brain membranes after 45 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNischarin(RAT)
Medical University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50334197(7-Chloro-3-[(imidazolidin-2-yl)imino]indazole hydr...)
Affinity DataKi:  30.8nMAssay Description:Displacement of [3H]2BFI from imidazoline I1 receptor in Sprague-Dawley rat brain membrane after 45 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50497439(CHEMBL3343700)
Affinity DataKi:  31nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenoceptor in Sprague-Dawley rat brain membranes after 45 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50497436(CHEMBL3343703)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenoceptor in Sprague-Dawley rat brain membranes after 45 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNischarin(RAT)
Medical University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50164835(CHEMBL3800398)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]clonidine from Imidazoline receptor 1 in Sprague-Dawley rat kidney P2 membranes after 45 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Medical University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50497435(CHEMBL3343699)
Affinity DataKi:  33nMAssay Description:Displacement of [3H]RS-79948-197 from human alpha2A adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM24185((3-aminopropyl)(methyl)phosphinic acid | 3-Apmpa |...)
Affinity DataKi:  33nM ΔG°:  -42.3kJ/mole EC50:  41nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
TargetNischarin(RAT)
Medical University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50334195(4-Chloro-3-[(imidazolidin-2-yl)imino]indazole hydr...)
Affinity DataKi:  45.2nMAssay Description:Displacement of [3H]2BFI from imidazoline I1 receptor in Sprague-Dawley rat brain membrane after 45 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24191((3-amino-2-oxopropyl)phosphinic acid | (3-amino-2-...)
Affinity DataKi:  48nM ΔG°:  -41.4kJ/mole EC50:  81nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM24186((3-amino-2-hydroxypropyl)phosphinic acid | 3-amino...)
Affinity DataKi:  50nM ΔG°:  -41.3kJ/mole EC50:  130nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Medical University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50271255(1-[(Imidazolidin-2-yl)imino]indazole hydrochloride...)
Affinity DataKi:  52nMAssay Description:Displacement of [3H]RS-79948-197 from human alpha2A adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50497440(CHEMBL3343698)
Affinity DataKi:  64nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenoceptor in Sprague-Dawley rat brain membranes after 45 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Medical University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50497439(CHEMBL3343700)
Affinity DataKi:  65nMAssay Description:Displacement of [3H]RS-79948-197 from human alpha2A adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM24194(3-aminopropylphosphinic derivative, (S)-7 | [(2S)-...)
Affinity DataKi:  70nM ΔG°:  -40.4kJ/mole EC50:  250nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
Medical University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50497435(CHEMBL3343699)
Affinity DataKi:  72nMAssay Description:Displacement of [3H]RS-79948-197 from human alpha2B adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNischarin(RAT)
Medical University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50164841(CHEMBL3798191)
Affinity DataKi:  79nMAssay Description:Displacement of [3H]clonidine from Imidazoline receptor 1 in Sprague-Dawley rat kidney P2 membranes after 45 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
Medical University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50271255(1-[(Imidazolidin-2-yl)imino]indazole hydrochloride...)
Affinity DataKi:  79nMAssay Description:Displacement of [3H]RS-79948-197 from human alpha2B adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24186((3-amino-2-hydroxypropyl)phosphinic acid | 3-amino...)
Affinity DataKi:  94nM ΔG°:  -39.7kJ/mole EC50:  220nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNischarin(RAT)
Medical University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50334196(3-[(Imidazolidin-2-yl)imino]-4-methylindazole hydr...)
Affinity DataKi:  133nMAssay Description:Displacement of [3H]2BFI from imidazoline I1 receptor in Sprague-Dawley rat brain membrane after 45 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNischarin(RAT)
Medical University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50334194(3-[(Imidazolidin-2-yl)imino]indazole hydrochloride...)
Affinity DataKi:  134nMAssay Description:Displacement of [3H]2BFI from imidazoline I1 receptor in Sprague-Dawley rat brain membrane after 45 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
Medical University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50497439(CHEMBL3343700)
Affinity DataKi:  158nMAssay Description:Displacement of [3H]RS-79948-197 from human alpha2B adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNischarin(RAT)
Medical University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50334206(3-[(Imidazolidin-2-yl)imino]-4-methoxyindazole hyd...)
Affinity DataKi:  167nMAssay Description:Displacement of [3H]2BFI from imidazoline I1 receptor in Sprague-Dawley rat brain membrane after 45 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24189(3-aminopropylphosphinic derivative, (R)-4 | 3-amin...)
Affinity DataKi:  180nM ΔG°:  -38.1kJ/mole EC50:  150nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50497433(CHEMBL3343702)
Affinity DataKi:  187nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenoceptor in Sprague-Dawley rat brain membranes after 45 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM24192((3-amino-2-oxopropyl)(methyl)phosphinic acid | (3-...)
Affinity DataKi:  200nM ΔG°:  -37.9kJ/mole EC50:  270nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM24182(4-amino-3-(4-chlorophenyl)butanoic acid | Baclofen...)
Affinity DataKi:  220nM ΔG°:  -37.6kJ/mole EC50:  750nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
TargetNischarin(RAT)
Medical University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50334204(3-[(Imidazolidin-2-yl)imino]-6-methylindazole hydr...)
Affinity DataKi:  325nMAssay Description:Displacement of [3H]2BFI from imidazoline I1 receptor in Sprague-Dawley rat brain membrane after 45 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNischarin(RAT)
Medical University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50334203(6-Chloro-3-[(imidazolidin-2-yl)imino]indazole hydr...)
Affinity DataKi:  410nMAssay Description:Displacement of [3H]2BFI from imidazoline I1 receptor in Sprague-Dawley rat brain membrane after 45 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50497434(CHEMBL3343697)
Affinity DataKi:  416nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenoceptor in Sprague-Dawley rat brain membranes after 45 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNischarin(RAT)
Medical University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50164834(CHEMBL3798638)
Affinity DataKi:  468nMAssay Description:Displacement of [3H]clonidine from Imidazoline receptor 1 in Sprague-Dawley rat kidney P2 membranes after 45 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Medical University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50497436(CHEMBL3343703)
Affinity DataKi:  476nMAssay Description:Displacement of [3H]prazosin from alpha1-adrenoceptor in Sprague-Dawley rat brain membranes after 45 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM24197(3-aminopropylphosphinic derivative, (S)-8 | [(2S)-...)
Affinity DataKi:  480nM ΔG°:  -35.7kJ/mole EC50:  1.70E+3nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Medical University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50497438(CHEMBL3343704)
Affinity DataKi:  518nMAssay Description:Displacement of [3H]prazosin from alpha1-adrenoceptor in Sprague-Dawley rat brain membranes after 45 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Medical University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50497433(CHEMBL3343702)
Affinity DataKi:  535nMAssay Description:Displacement of [3H]prazosin from alpha1-adrenoceptor in Sprague-Dawley rat brain membranes after 45 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Medical University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50497435(CHEMBL3343699)
Affinity DataKi:  600nMAssay Description:Displacement of [3H]RS-79948-197 from human alpha2C adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Medical University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50271255(1-[(Imidazolidin-2-yl)imino]indazole hydrochloride...)
Affinity DataKi:  640nMAssay Description:Displacement of [3H]RS-79948-197 from human alpha2C adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNischarin(RAT)
Medical University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50164837(CHEMBL3800446)
Affinity DataKi:  789nMAssay Description:Displacement of [3H]clonidine from Imidazoline receptor 1 in Sprague-Dawley rat kidney P2 membranes after 45 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24189(3-aminopropylphosphinic derivative, (R)-4 | 3-amin...)
Affinity DataKi:  840nM ΔG°:  -34.3kJ/mole EC50:  600nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Medical University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50497435(CHEMBL3343699)
Affinity DataKi:  918nMAssay Description:Displacement of [3H]prazosin from alpha1-adrenoceptor in Sprague-Dawley rat brain membranes after 45 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNischarin(RAT)
Medical University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50164842(CHEMBL3798387)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [3H]clonidine from Imidazoline receptor 1 in Sprague-Dawley rat kidney P2 membranes after 45 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Medical University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50497439(CHEMBL3343700)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of [3H]RS-79948-197 from human alpha2C adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Medical University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50497439(CHEMBL3343700)
Affinity DataKi:  1.63E+3nMAssay Description:Displacement of [3H]prazosin from alpha1-adrenoceptor in Sprague-Dawley rat brain membranes after 45 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM24186((3-amino-2-hydroxypropyl)phosphinic acid | 3-amino...)
Affinity DataKi:  2.10E+3nM ΔG°:  -32.1kJ/mole EC50:  1.10E+3nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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