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Found 78 with Last Name = 'liao' and Initial = 'p'
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataIC50: <3nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataIC50: <3nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM7478(2-chloro-4-[(2-{[(1R)-1-(hydroxymethyl)-2-methylpr...)
Affinity DataIC50:  6nMAssay Description:Inhibition of recombinant CDK5/p35 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM7478(2-chloro-4-[(2-{[(1R)-1-(hydroxymethyl)-2-methylpr...)
Affinity DataIC50:  6nMAssay Description:Inhibition of recombinant CDK2/CycA (unknown origin)More data for this Ligand-Target Pair
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063243(CHEMBL161499 | N-(2,6-Diisopropyl-phenyl)-2-pyridi...)
Affinity DataIC50:  8nMAssay Description:In vitro Acyl coenzyme A:cholesterol acyltransferase inhibition in hepatic microsomes isolated from cholesterol-fed ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Oryctolagus cuniculus (rabbit))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063239(CHEMBL161638 | N-(2,6-Diisopropyl-phenyl)-2-phenyl...)
Affinity DataIC50:  10nMAssay Description:Inhibition of Acyl coenzyme A:cholesterol acyltransferase by microsomal LAI assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063239(CHEMBL161638 | N-(2,6-Diisopropyl-phenyl)-2-phenyl...)
Affinity DataIC50:  10nMAssay Description:In vitro Acyl coenzyme A:cholesterol acyltransferase inhibition in hepatic microsomes isolated from cholesterol-fed ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 13(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50590457(CHEMBL5193291)
Affinity DataIC50:  10nMAssay Description:Irreversible inhibition of CDK13 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50367737(CHEMBL4173631)
Affinity DataIC50:  10nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 13(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50590457(CHEMBL5193291)
Affinity DataIC50:  10nMAssay Description:Inhibition of CDK13 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063226(CHEMBL160149 | N-(2,6-Diisopropyl-phenyl)-2-phenyl...)
Affinity DataIC50:  11nMAssay Description:In vitro Acyl coenzyme A:cholesterol acyltransferase inhibition in hepatic microsomes isolated from cholesterol-fed ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataIC50:  12nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063236(CHEMBL159871 | N-(2,6-Diisopropyl-phenyl)-2-phenyl...)
Affinity DataIC50:  12nMAssay Description:In vitro Acyl coenzyme A:cholesterol acyltransferase inhibition in hepatic microsomes isolated from cholesterol-fed ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063231(CHEMBL159621 | N-(2,6-Diisopropyl-phenyl)-2-phenyl...)
Affinity DataIC50:  12nMAssay Description:In vitro Acyl coenzyme A:cholesterol acyltransferase inhibition in hepatic microsomes isolated from cholesterol-fed ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063220(CHEMBL161270 | N-(2,6-Diisopropyl-phenyl)-2-phenyl...)
Affinity DataIC50:  13nMAssay Description:In vitro Acyl coenzyme A:cholesterol acyltransferase inhibition in hepatic microsomes isolated from cholesterol-fed ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063235(CHEMBL161798 | N-(2,6-Diisopropyl-phenyl)-2-phenyl...)
Affinity DataIC50:  13nMAssay Description:In vitro Acyl coenzyme A:cholesterol acyltransferase inhibition in hepatic microsomes isolated from cholesterol-fed ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063232(2-Phenyl-N-(2,4,6-trimethoxy-phenyl)-malonamic aci...)
Affinity DataIC50:  13nMAssay Description:In vitro Acyl coenzyme A:cholesterol acyltransferase inhibition in hepatic microsomes isolated from cholesterol-fed ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063229(CHEMBL161292 | N-(2,6-Diisopropyl-phenyl)-2-phenyl...)
Affinity DataIC50:  13nMAssay Description:In vitro Acyl coenzyme A:cholesterol acyltransferase inhibition in hepatic microsomes isolated from cholesterol-fed ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063221(CHEMBL161295 | N-(2,6-Diisopropyl-phenyl)-2-phenyl...)
Affinity DataIC50:  16nMAssay Description:In vitro Acyl coenzyme A:cholesterol acyltransferase inhibition in hepatic microsomes isolated from cholesterol-fed ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Oryctolagus cuniculus (rabbit))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063239(CHEMBL161638 | N-(2,6-Diisopropyl-phenyl)-2-phenyl...)
Affinity DataIC50:  20nMAssay Description:Inhibition of Acyl coenzyme A:cholesterol acyltransferase by microsomal MAI2 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063227(2-Phenyl-N-(2,4,6-trimethoxy-phenyl)-malonamic aci...)
Affinity DataIC50:  20nMAssay Description:In vitro Acyl coenzyme A:cholesterol acyltransferase inhibition in hepatic microsomes isolated from cholesterol-fed ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063230(CHEMBL159491 | N-(2,6-Diisopropyl-phenyl)-2,2-dime...)
Affinity DataIC50:  21nMAssay Description:In vitro Acyl coenzyme A:cholesterol acyltransferase inhibition in hepatic microsomes isolated from cholesterol-fed ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063224(CHEMBL159414 | N-(2,6-Diisopropyl-phenyl)-2-phenyl...)
Affinity DataIC50:  22nMAssay Description:In vitro Acyl coenzyme A:cholesterol acyltransferase inhibition in hepatic microsomes isolated from cholesterol-fed ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50:  30nMAssay Description:Inhibition of recombinant CDK1/CycB1 (unknown origin) using CTD as substrate incubated for 60 mins by Beckman scintillation counter analysisMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063237(2-Phenyl-N-(2,4,6-trimethoxy-phenyl)-malonamic aci...)
Affinity DataIC50:  30nMAssay Description:In vitro Acyl coenzyme A:cholesterol acyltransferase inhibition in hepatic microsomes isolated from cholesterol-fed ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063240(CHEMBL161639 | N-(2,6-Diisopropyl-phenyl)-2-fluoro...)
Affinity DataIC50:  32nMAssay Description:In vitro Acyl coenzyme A:cholesterol acyltransferase inhibition in hepatic microsomes isolated from cholesterol-fed ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063233(CHEMBL159597 | N-(2,6-Diisopropyl-phenyl)-2-phenyl...)
Affinity DataIC50:  37nMAssay Description:In vitro Acyl coenzyme A:cholesterol acyltransferase inhibition in hepatic microsomes isolated from cholesterol-fed ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063234(CHEMBL351398 | N-(2,6-Diisopropyl-phenyl)-2-phenyl...)
Affinity DataIC50:  40nMAssay Description:In vitro Acyl coenzyme A:cholesterol acyltransferase inhibition in hepatic microsomes isolated from cholesterol-fed ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataIC50:  42nMAssay Description:Inhibition of CDK7 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 12(Homo sapiens)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50590464(CHEMBL5179701)
Affinity DataIC50:  44nMAssay Description:Inhibition of CDK12 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCasein kinase I isoform delta(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50454220(CHEMBL4211454)
Affinity DataIC50:  44nMAssay Description:Inhibition of CK1 delta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063222(CHEMBL159993 | N-(2,6-Diisopropyl-phenyl)-2-phenyl...)
Affinity DataIC50:  50nMAssay Description:In vitro Acyl coenzyme A:cholesterol acyltransferase inhibition in hepatic microsomes isolated from cholesterol-fed ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 12(Homo sapiens)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataIC50:  50nMAssay Description:Inhibition of CDK12 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 12(Homo sapiens)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50590457(CHEMBL5193291)
Affinity DataIC50:  52nMAssay Description:Inhibition of CDK12 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063225(2-Phenyl-N-(2,4,6-triisopropyl-phenyl)-malonamic a...)
Affinity DataIC50:  56nMAssay Description:In vitro Acyl coenzyme A:cholesterol acyltransferase inhibition in hepatic microsomes isolated from cholesterol-fed ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 12(Homo sapiens)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50590461(CHEMBL5174472)
Affinity DataIC50:  59nMAssay Description:Inhibition of CDK12 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCyclin-dependent kinase 12(Homo sapiens)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50590459(CHEMBL5178679)
Affinity DataIC50:  63nMAssay Description:Inhibition of CDK12 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)
Affinity DataIC50:  70nMAssay Description:Inhibition of recombinant CDK2/CycA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063245(CHEMBL159694 | N-(2,6-Diisopropyl-phenyl)-2-phenyl...)
Affinity DataIC50:  72nMAssay Description:In vitro Acyl coenzyme A:cholesterol acyltransferase inhibition in hepatic microsomes isolated from cholesterol-fed ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)
Affinity DataIC50:  75nMAssay Description:Inhibition of recombinant CDK5/p35 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 12(Homo sapiens)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50454220(CHEMBL4211454)
Affinity DataIC50:  86nMAssay Description:Inhibition of CDK12 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 12(Homo sapiens)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50298225(CHEMBL2069955 | CHEMBL573578 | NM-PP1 | US10544104...)
Affinity DataIC50:  100nMAssay Description:Inhibition of CDK12 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50:  100nMAssay Description:Inhibition of recombinant CDK4/CycD1 (unknown origin) using CTD as substrate incubated for 60 mins by Beckman scintillation counter analysisMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetCyclin-dependent kinase 12(Homo sapiens)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50540077(CHEMBL4649135)
Affinity DataIC50:  103nMAssay Description:Inhibition of CDK12 (unknown origin) in presence of high ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCyclin-dependent kinase 12(Homo sapiens)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50590458(CHEMBL5202653)
Affinity DataIC50:  130nMAssay Description:Inhibition of CDK12 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50:  144nMAssay Description:Inhibition of recombinant CDK9/CycT1 (unknown origin) using CTD as substrate incubated for 60 mins by Beckman scintillation counter analysisMore data for this Ligand-Target Pair
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063238(2-Pyridin-2-yl-N-(2,4,6-triisopropyl-phenyl)-malon...)
Affinity DataIC50:  180nMAssay Description:In vitro Acyl coenzyme A:cholesterol acyltransferase inhibition in hepatic microsomes isolated from cholesterol-fed ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063223(CHEMBL159374 | N-(2,6-Diisopropyl-phenyl)-2-phenyl...)
Affinity DataIC50:  200nMAssay Description:In vitro Acyl coenzyme A:cholesterol acyltransferase inhibition in hepatic microsomes isolated from cholesterol-fed ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 12(Homo sapiens)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50590462(CHEMBL5187567)
Affinity DataIC50:  250nMAssay Description:Inhibition of CDK12 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCasein kinase I isoform epsilon(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50454220(CHEMBL4211454)
Affinity DataIC50:  260nMAssay Description:Inhibition of CK1 epsilon (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
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