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Found 61 with Last Name = 'liao' and Initial = 'r'
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM19023(1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-y...)
Affinity DataKi:  0.0800nMAssay Description:Inhibition of factor Xa (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50328731(CHEMBL1269025 | Edoxaban)
Affinity DataKi:  0.561nMAssay Description:Inhibition of factor Xa (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetMu-type opioid receptor(GUINEA PIG)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataKi:  38nMAssay Description:Binding affinity of the compound against mu opioid receptor was determined in brain membrane preparations from male Hartley guinea-pigsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50070947(2-ethyl-1'-methylspiro[2,3-dihydrobenzo[b]furan-3,...)
Affinity DataKi:  102nMAssay Description:Binding affinity of the compound against mu opioid receptor was determined in brain membrane preparations from male Hartley guinea-pigsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50070948(1',2-dimethylspiro[2,3-dihydrobenzo[b]furan-3,4'-(...)
Affinity DataKi:  124nMAssay Description:Binding affinity of the compound against mu opioid receptor was determined in brain membrane preparations from male Hartley guinea-pigsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50026752(1-Methyl-4-phenyl-piperidine-4-carboxylic acid eth...)
Affinity DataKi:  451nMAssay Description:Binding affinity of the compound against mu opioid receptor was determined in brain membrane preparations from male Hartley guinea-pigsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50070946(1',3'-dimethylspiro[2,3-dihydrobenzo[b]furan-3,4'-...)
Affinity DataKi:  505nMAssay Description:Binding affinity of the compound against Opioid receptor kappa 1 was determined in brain membrane preparations from male Hartley guinea-pigsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50070946(1',3'-dimethylspiro[2,3-dihydrobenzo[b]furan-3,4'-...)
Affinity DataKi:  505nMAssay Description:Binding affinity against Opioid receptor kappa 1 was determined in brain membrane preparations from male Hartley guinea-pigsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataKi:  510nMAssay Description:Binding affinity of the compound against Opioid receptor delta 1 was determined in brain membrane preparations from male Hartley guinea-pigsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDelta-type opioid receptor(Homo sapiens (Human))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50070947(2-ethyl-1'-methylspiro[2,3-dihydrobenzo[b]furan-3,...)
Affinity DataKi:  853nMAssay Description:Binding affinity of the compound against Opioid receptor delta 1 was determined in brain membrane preparations from male Hartley guinea-pigsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50070946(1',3'-dimethylspiro[2,3-dihydrobenzo[b]furan-3,4'-...)
Affinity DataKi:  1.01E+3nMAssay Description:Binding affinity against mu opioid receptor was determined in brain membrane preparations from male Hartley guinea-pigsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50070946(1',3'-dimethylspiro[2,3-dihydrobenzo[b]furan-3,4'-...)
Affinity DataKi:  1.02E+3nMAssay Description:Binding affinity of the compound against mu opioid receptor was determined in brain membrane preparations from male Hartley guinea-pigsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50070949(1'-methylspiro[2,3-dihydrobenzo[b]furan-3,4'-(hexa...)
Affinity DataKi:  1.65E+3nMAssay Description:Binding affinity of the compound against mu opioid receptor was determined in brain membrane preparations from male Hartley guinea-pigsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataKi:  1.87E+3nMAssay Description:Binding affinity of the compound against Opioid receptor kappa 1 was determined in brain membrane preparations from male Hartley guinea-pigsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50070948(1',2-dimethylspiro[2,3-dihydrobenzo[b]furan-3,4'-(...)
Affinity DataKi:  2.41E+3nMAssay Description:Binding affinity of the compound against Opioid receptor delta 1 was determined in brain membrane preparations from male Hartley guinea-pigsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50070949(1'-methylspiro[2,3-dihydrobenzo[b]furan-3,4'-(hexa...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity of the compound against Opioid receptor delta 1 was determined in brain membrane preparations from male Hartley guinea-pigsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50070947(2-ethyl-1'-methylspiro[2,3-dihydrobenzo[b]furan-3,...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity of the compound against Opioid receptor kappa 1 was determined in brain membrane preparations from male Hartley guinea-pigsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50026752(1-Methyl-4-phenyl-piperidine-4-carboxylic acid eth...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity of the compound against Opioid receptor kappa 1 was determined in brain membrane preparations from male Hartley guinea-pigsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50070948(1',2-dimethylspiro[2,3-dihydrobenzo[b]furan-3,4'-(...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity of the compound against Opioid receptor kappa 1 was determined in brain membrane preparations from male Hartley guinea-pigsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50070949(1'-methylspiro[2,3-dihydrobenzo[b]furan-3,4'-(hexa...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity of the compound against Opioid receptor kappa 1 was determined in brain membrane preparations from male Hartley guinea-pigsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM7840(RIVAROXABAN | US8822458, 44 | US8822458, 97)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of factor Xa (unknown origin)More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM20880((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM20880((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake preincubated for 10 mins followed by [14C]-AMG addition ...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50610336(CHEMBL5286692)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of factor Xa (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50386885(CANAGLIFLOZIN | CANAGLIFLOZIN HYDRATE | US10752604...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM19023(1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-y...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of factor Xa (unknown origin)More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50315426((1S)-1,5-Anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM150162(BI-10773 | Jardiance | US8980829, EMPAGLIFLOZIN | ...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50610335(CHEMBL5285200)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of factor Xa (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50396779(TOFOGLIFLOZIN)
Affinity DataIC50:  4nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50381554(CHEMBL2018096)
Affinity DataIC50:  8.40nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50462729(CHEMBL4238635)
Affinity DataIC50:  126nMAssay Description:Inhibition of human SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake preincubated for 10 mins followed by [14C]-AMG addition ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50462730(CHEMBL4248660)
Affinity DataIC50:  184nMAssay Description:Inhibition of human SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake preincubated for 10 mins followed by [14C]-AMG addition ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50462731(CHEMBL4238200)
Affinity DataIC50:  246nMAssay Description:Inhibition of human SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake preincubated for 10 mins followed by [14C]-AMG addition ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
National Formosa University

Curated by ChEMBL
LigandPNGBDBM50334076(CHEMBL1644792 | zhankuic acid A methyl ester)
Affinity DataIC50:  600nMAssay Description:Inhibition of iNOS in mouse BV2 microglial cells assessed as NO productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
National Formosa University

Curated by ChEMBL
LigandPNGBDBM50334075(CHEMBL1258116 | methyl 4alpha-methylergost-8,24(28...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of iNOS in mouse BV2 microglial cells assessed as NO productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
National Formosa University

Curated by ChEMBL
LigandPNGBDBM50334078(CHEMBL1641973 | Camphoratin J | methyl 3,11-dioxo-...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of iNOS in mouse BV2 microglial cells assessed as NO productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM20880((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Affinity DataIC50:  1.83E+3nMAssay Description:Inhibition of human SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake preincubated for 10 mins followed by [14C]-AMG addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
National Formosa University

Curated by ChEMBL
LigandPNGBDBM50334077(CHEMBL1641969 | Camphoratin F | methyl 7beta-hydro...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of iNOS in mouse BV2 microglial cells assessed as NO productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
National Formosa University

Curated by ChEMBL
LigandPNGBDBM50334079(CHEMBL1644795 | methyl antcinate H)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of iNOS in mouse BV2 microglial cells assessed as NO productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
National Formosa University

Curated by ChEMBL
LigandPNGBDBM50334061(CHEMBL1644789 | Zhankuic acid A)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of iNOS in mouse BV2 microglial cells assessed as NO productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
National Formosa University

Curated by ChEMBL
LigandPNGBDBM50334062(CHEMBL1644793 | antcin A)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of iNOS in mouse BV2 microglial cells assessed as NO productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
National Formosa University

Curated by ChEMBL
LigandPNGBDBM50334063(7beta,14alpha-dihydroxy-3,11-dioxo-4alpha-methyler...)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of iNOS in mouse BV2 microglial cells assessed as NO productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
National Formosa University

Curated by ChEMBL
LigandPNGBDBM50334064((1S,2R,5R,6R,9R,10R,13S,15S)-5-[(2R,3E,5R)-5,6-dim...)
Affinity DataIC50:  6.30E+3nMAssay Description:Inhibition of iNOS in mouse BV2 microglial cells assessed as NO productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
National Formosa University

Curated by ChEMBL
LigandPNGBDBM50334065(CHEMBL1644788 | antrocamphin A)
Affinity DataIC50:  7.20E+3nMAssay Description:Inhibition of iNOS in mouse BV2 microglial cells assessed as NO productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
National Formosa University

Curated by ChEMBL
LigandPNGBDBM50334066(CHEMBL1644790 | Zhankuic acid B)
Affinity DataIC50:  9.60E+3nMAssay Description:Inhibition of iNOS in mouse BV2 microglial cells assessed as NO productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50462731(CHEMBL4238200)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake preincubated for 10 mins followed by [14C]-AMG addition ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50462729(CHEMBL4238635)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake preincubated for 10 mins followed by [14C]-AMG addition ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50462730(CHEMBL4248660)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake preincubated for 10 mins followed by [14C]-AMG addition ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
National Formosa University

Curated by ChEMBL
LigandPNGBDBM50334067(Benzocamphorin B | CHEMBL1644787)
Affinity DataIC50:  1.21E+4nMAssay Description:Inhibition of iNOS in mouse BV2 microglial cells assessed as NO productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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