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Found 171 with Last Name = 'lim' and Initial = 'b'
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065136(CHEMBL81455 | N-(2-Azepan-1-yl-ethyl)-4-iodo-N-met...)
Affinity DataKi:  0.140nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065134(CHEMBL309983 | N-(2-Azepan-1-yl-ethyl)-4-bromo-N-m...)
Affinity DataKi:  0.180nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065140(4-Iodo-N-(2-piperidin-1-yl-ethyl)-benzenesulfonami...)
Affinity DataKi:  0.460nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065144(CHEMBL79660 | N-(2-Azepan-1-yl-ethyl)-4-bromo-benz...)
Affinity DataKi:  0.630nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50000069(CHEMBL20377 | [2-(3,4-Dichloro-phenyl)-ethyl]-meth...)
Affinity DataKi:  0.700nMAssay Description:Inhibition Constant for 4-[125I]-IPBS binding to sigma 1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065142(CHEMBL439765 | N-(2-Azepan-1-yl-ethyl)-4-iodo-benz...)
Affinity DataKi:  1.32nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065135(4-Iodo-N-(2-pyrrolidin-1-yl-ethyl)-benzenesulfonam...)
Affinity DataKi:  1.46nMAssay Description:Inhibition Constant for 4-[125I]-IPBS binding to sigma 1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065141(4-Bromo-N-(2-piperidin-1-yl-ethyl)-benzenesulfonam...)
Affinity DataKi:  1.54nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065143(CHEMBL83448 | N-(2-Azepan-1-yl-ethyl)-3-iodo-4-met...)
Affinity DataKi:  3.11nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  3.70nMAssay Description:Compound was evaluated for its invitro competition binding studies using sigma-ligand (0.05-10000 nM) - [3H]-(+)-pentazocine (sigma1 receptor) in gui...More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065135(4-Iodo-N-(2-pyrrolidin-1-yl-ethyl)-benzenesulfonam...)
Affinity DataKi:  4.30nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065138(CHEMBL81451 | N-(2-Diethylamino-ethyl)-4-iodo-benz...)
Affinity DataKi:  4.97nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065133(4-Bromo-N-(2-pyrrolidin-1-yl-ethyl)-benzenesulfona...)
Affinity DataKi:  6.65nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065139(4-Bromo-N-(2-diethylamino-ethyl)-benzenesulfonamid...)
Affinity DataKi:  10.1nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50010774(CHEMBL539782 | CHEMBL83430 | N,N'-Dibenzyl-guanidi...)
Affinity DataKi:  27.7nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065145(3-Iodo-4-methoxy-N-(2-piperidin-1-yl-ethyl)-benzen...)
Affinity DataKi:  41.8nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50035131((+)-(6R,11S)-6,11-dimethyl-3-(3-methyl-but-2-enyl)...)
Affinity DataKi:  152nMAssay Description:Compound was evaluated for its inhibition constant from the competition binding assays for sigma-1 receptor in guinea pig membranes.More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50035131((+)-(6R,11S)-6,11-dimethyl-3-(3-methyl-but-2-enyl)...)
Affinity DataKi:  152nMAssay Description:Compound was evaluated for its inhibition constant from the competition binding assays for sigma-1 receptor in guinea pig membranes.More data for this Ligand-Target Pair
TargetPancreatic alpha-amylase(Sus scrofa (Pig))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50499987(CHEMBL3742315)
Affinity DataKi:  1.17E+4nMAssay Description:Non-competitive inhibition of porcine pancreatic alpha-amylase by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandPNGBDBM50350458(CHEMBL1814333)
Affinity DataIC50:  0.100nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandPNGBDBM50350429(CHEMBL1814154)
Affinity DataIC50:  0.100nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandPNGBDBM50350447(CHEMBL1814329)
Affinity DataIC50:  0.100nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandPNGBDBM50200841(CHEMBL220360 | MK-0364 | MK-0634 | N-((2S,3S)-4-(4...)
Affinity DataIC50:  0.300nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandPNGBDBM50350449(CHEMBL1814331)
Affinity DataIC50:  0.400nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandPNGBDBM50350428(CHEMBL1814153)
Affinity DataIC50:  0.5nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50531540(CHEBI:75998 | GSK-1120212 | GSK1120212 | JTP 74057...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandPNGBDBM50350448(CHEMBL1814330)
Affinity DataIC50:  0.800nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandPNGBDBM50350450(CHEMBL1814335)
Affinity DataIC50:  1nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandPNGBDBM50350430(CHEMBL1814155)
Affinity DataIC50:  1.10nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandPNGBDBM50350436(CHEMBL1814316)
Affinity DataIC50:  2nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandPNGBDBM50350444(CHEMBL1814326)
Affinity DataIC50:  3nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandPNGBDBM50350452(CHEMBL1814338)
Affinity DataIC50:  3nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandPNGBDBM50350456(CHEMBL1814332)
Affinity DataIC50:  4nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50363397(CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandPNGBDBM50350432(CHEMBL1814157)
Affinity DataIC50:  5nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandPNGBDBM50350446(CHEMBL1814328)
Affinity DataIC50:  6nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandPNGBDBM50350445(CHEMBL1814327)
Affinity DataIC50:  6nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandPNGBDBM50350457(CHEMBL1814318)
Affinity DataIC50:  10nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandPNGBDBM50350440(CHEMBL1814322)
Affinity DataIC50:  11nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandPNGBDBM50350438(CHEMBL1814320)
Affinity DataIC50:  12nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandPNGBDBM50350454(CHEMBL1814340)
Affinity DataIC50:  13nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50531540(CHEBI:75998 | GSK-1120212 | GSK1120212 | JTP 74057...)
Affinity DataIC50:  15nMAssay Description:Inhibition of MEK2 (unknown origin)More data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandPNGBDBM50350435(CHEMBL1814315)
Affinity DataIC50:  15nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50250183(CHEMBL503188 | N-{3-[(4S)-4-Benzylamino-1-hydroxy-...)
Affinity DataIC50:  16nMAssay Description:Inhibition of HCV1b Con1 NS5B assessed as [3H]UTP incorporation into RNA by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandPNGBDBM50350455(CHEMBL1814158)
Affinity DataIC50:  17nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Affinity DataIC50:  18nMAssay Description:Inhibition of EGFR in human RPMI-8226 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandPNGBDBM21278(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl...)
Affinity DataIC50:  18nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50249586(CHEMBL504729 | N-{3-[4-[(2,6-Dimethylbenzyl)amino]...)
Affinity DataIC50:  19nMAssay Description:Inhibition of HCV1b Con1 NS5B assessed as [3H]UTP incorporation into RNA by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandPNGBDBM50350437(CHEMBL1814317)
Affinity DataIC50:  22nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Dr. Reddy'S Laboratories

Curated by ChEMBL
LigandPNGBDBM50350431(CHEMBL1814156)
Affinity DataIC50:  22nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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