TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center
Curated by ChEMBL
The George Washington University Medical Center
Curated by ChEMBL
Affinity DataKi: 0.140nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center
Curated by ChEMBL
The George Washington University Medical Center
Curated by ChEMBL
Affinity DataKi: 0.180nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center
Curated by ChEMBL
The George Washington University Medical Center
Curated by ChEMBL
Affinity DataKi: 0.460nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center
Curated by ChEMBL
The George Washington University Medical Center
Curated by ChEMBL
Affinity DataKi: 0.630nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center
Curated by ChEMBL
The George Washington University Medical Center
Curated by ChEMBL
Affinity DataKi: 0.700nMAssay Description:Inhibition Constant for 4-[125I]-IPBS binding to sigma 1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center
Curated by ChEMBL
The George Washington University Medical Center
Curated by ChEMBL
Affinity DataKi: 1.32nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center
Curated by ChEMBL
The George Washington University Medical Center
Curated by ChEMBL
Affinity DataKi: 1.46nMAssay Description:Inhibition Constant for 4-[125I]-IPBS binding to sigma 1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center
Curated by ChEMBL
The George Washington University Medical Center
Curated by ChEMBL
Affinity DataKi: 1.54nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center
Curated by ChEMBL
The George Washington University Medical Center
Curated by ChEMBL
Affinity DataKi: 3.11nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center
Curated by ChEMBL
The George Washington University Medical Center
Curated by ChEMBL
Affinity DataKi: 3.70nMAssay Description:Compound was evaluated for its invitro competition binding studies using sigma-ligand (0.05-10000 nM) - [3H]-(+)-pentazocine (sigma1 receptor) in gui...More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center
Curated by ChEMBL
The George Washington University Medical Center
Curated by ChEMBL
Affinity DataKi: 4.30nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center
Curated by ChEMBL
The George Washington University Medical Center
Curated by ChEMBL
Affinity DataKi: 4.97nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center
Curated by ChEMBL
The George Washington University Medical Center
Curated by ChEMBL
Affinity DataKi: 6.65nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center
Curated by ChEMBL
The George Washington University Medical Center
Curated by ChEMBL
Affinity DataKi: 10.1nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center
Curated by ChEMBL
The George Washington University Medical Center
Curated by ChEMBL
Affinity DataKi: 27.7nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center
Curated by ChEMBL
The George Washington University Medical Center
Curated by ChEMBL
Affinity DataKi: 41.8nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center
Curated by ChEMBL
The George Washington University Medical Center
Curated by ChEMBL
Affinity DataKi: 152nMAssay Description:Compound was evaluated for its inhibition constant from the competition binding assays for sigma-1 receptor in guinea pig membranes.More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center
Curated by ChEMBL
The George Washington University Medical Center
Curated by ChEMBL
Affinity DataKi: 152nMAssay Description:Compound was evaluated for its inhibition constant from the competition binding assays for sigma-1 receptor in guinea pig membranes.More data for this Ligand-Target Pair
Affinity DataKi: 1.17E+4nMAssay Description:Non-competitive inhibition of porcine pancreatic alpha-amylase by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 0.700nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 4.20nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Mansoura University
Curated by ChEMBL
Mansoura University
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of MEK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 15nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of HCV1b Con1 NS5B assessed as [3H]UTP incorporation into RNA by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of EGFR in human RPMI-8226 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of HCV1b Con1 NS5B assessed as [3H]UTP incorporation into RNA by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair