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Found 2770 with Last Name = 'maccoss' and Initial = 'm'
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289127((2S,4R)-4-(3-Methyl-1-phenylcarbamoyl-butylcarbamo...)
Affinity DataKi:  0.360nMAssay Description:Inhibition of matrix metalloproteinase-3(MMP-3).More data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50071484(CHEMBL308148 | N-[(R)-4-(4-Acetylamino-4-phenyl-pi...)
Affinity DataKi:  0.510nMAssay Description:Tested in vitro to inhibit the binding of [125I]-NKA to its receptor in rat duodenum membraneMore data for this Ligand-Target Pair
In DepthDetails Article
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50088301((E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-be...)
Affinity DataKi:  1.40nMAssay Description:Inhibitory activity of the compound against specific binding of [125I]-MIP-1 alpha to human CCR5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289128((R)-6-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-[(S)...)
Affinity DataKi:  1.90nMAssay Description:Inhibition of matrix metalloproteinase-3(MMP-3).More data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057050((2S,4R)-2-Butyl-4-[(S)-2,2-dimethyl-1-(pyridin-4-y...)
Affinity DataKi:  2nMAssay Description:Inhibition of human stromelysin-1 (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057073((2S,4R)-6-(4'-Fluoro-biphenyl-4-yl)-4-((S)-3-methy...)
Affinity DataKi:  2nMAssay Description:Inhibition of human stromelysin-1 (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285557((R)-2-[(S)-3-(4-butyl-phenyl)-1-((S)-4-guanidino-1...)
Affinity DataKi:  2.10nMAssay Description:Inhibitory activity against human gelatinase-A (MMP-2)More data for this Ligand-Target Pair
In DepthDetails Article
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289128((R)-6-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-[(S)...)
Affinity DataKi:  2.60nMAssay Description:Inhibition of matrix metalloproteinase-2(MMP-2)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282978(3-{(S)-2-[(S)-3-Methyl-2-(3-phenyl-propionylamino)...)
Affinity DataKi:  2.70nMAssay Description:Tested for inhibition of cysteine proteinase IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails Article
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285567((R)-2-[(S)-1-((S)-4-guanidino-1-phenylcarbamoyl-bu...)
Affinity DataKi:  3nMAssay Description:Inhibitory activity against human gelatinase-A (MMP-2)More data for this Ligand-Target Pair
In DepthDetails Article
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057090((R)-2-((S)-1-((S)-4-methyl-1-oxo-1-(phenylamino)pe...)
Affinity DataKi:  3.5nMAssay Description:Inhibitory activity against human gelatinase-A (MMP-2)More data for this Ligand-Target Pair
In DepthDetails Article
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057090((R)-2-((S)-1-((S)-4-methyl-1-oxo-1-(phenylamino)pe...)
Affinity DataKi:  3.5nMAssay Description:Inhibition of matrix metalloproteinase-2(MMP-2)More data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057063((2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-phenylcarbam...)
Affinity DataKi:  4nMAssay Description:Inhibition of human stromelysin-1 (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282981(3-{(S)-2-[(S)-3-Methyl-2-(3-phenyl-propionylamino)...)
Affinity DataKi:  4.70nMAssay Description:Tested for inhibition of cysteine proteinase IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057041((2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbam...)
Affinity DataKi:  5nMAssay Description:Inhibition of human stromelysin-1 (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289127((2S,4R)-4-(3-Methyl-1-phenylcarbamoyl-butylcarbamo...)
Affinity DataKi:  5.70nMAssay Description:Inhibition of matrix metalloproteinase-2(MMP-2)More data for this Ligand-Target Pair
In DepthDetails Article
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285573((R)-2-[(S)-3-(4-ethoxy-phenyl)-1-((S)-4-guanidino-...)
Affinity DataKi:  6.10nMAssay Description:Inhibitory activity against human gelatinase-A (MMP-2)More data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288702((R)-6-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-[(S)...)
Affinity DataKi:  8nMAssay Description:Inhibition of matrix metalloproteinase-3(MMP-3).More data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057061((2S,4R)-2-Butyl-6-(4'-cyano-biphenyl-4-yl)-4-((S)-...)
Affinity DataKi:  9nMAssay Description:Inhibition of human stromelysin-1 (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289123((R)-2-[(S)-1-(3-Methyl-1-phenylcarbamoyl-butylcarb...)
Affinity DataKi:  9.5nMAssay Description:Inhibition of matrix metalloproteinase-3(MMP-3).More data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057074((2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbam...)
Affinity DataKi:  10nMAssay Description:Inhibition of human stromelysin-1 (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057046((2S,4R)-2-Butyl-6-(2'-tert-butylsulfamoyl-biphenyl...)
Affinity DataKi:  10nMAssay Description:Inhibition of human stromelysin-1 (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057088((2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbam...)
Affinity DataKi:  11nMAssay Description:Inhibition of human stromelysin-1 (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282984(3-{(S)-2-[(S)-3-Methyl-2-(3-phenyl-propionylamino)...)
Affinity DataKi:  11nMAssay Description:Tested for inhibition of cysteine proteinase IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057062((2S,4R)-2-Butyl-4-[(S)-2,2-dimethyl-1-(pyridin-4-y...)
Affinity DataKi:  11nMAssay Description:Inhibition of human stromelysin-1 (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285559((R)-2-((S)-4-(4-isobutylphenyl)-1-((S)-4-methyl-1-...)
Affinity DataKi:  11nMAssay Description:Inhibitory activity against human gelatinase-A (MMP-2)More data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057039((2S,4R)-6-(4'-Bromo-biphenyl-4-yl)-2-butyl-4-((S)-...)
Affinity DataKi:  11nMAssay Description:Inhibition of human stromelysin-1 (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057054((2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbam...)
Affinity DataKi:  12nMAssay Description:Inhibition of human stromelysin-1 (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057076((2S,4R)-2-Butyl-6-(2',4'-dichloro-biphenyl-4-yl)-4...)
Affinity DataKi:  12nMAssay Description:Inhibition of human stromelysin-1 (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285564((R)-2-((S)-4-(4-ethylphenyl)-1-((S)-4-methyl-1-oxo...)
Affinity DataKi:  12nMAssay Description:Inhibitory activity against human gelatinase-A (MMP-2)More data for this Ligand-Target Pair
In DepthDetails Article
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057041((2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbam...)
Affinity DataKi:  13nMAssay Description:Inhibition of gelatinase A (Matrix metalloproteinase-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057075((2S,4R)-2-Butyl-6-(4'-chloro-biphenyl-4-yl)-4-((S)...)
Affinity DataKi:  13nMAssay Description:Inhibition of human stromelysin-1 (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057079((2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbam...)
Affinity DataKi:  13nMAssay Description:Inhibition of human stromelysin-1 (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057061((2S,4R)-2-Butyl-6-(4'-cyano-biphenyl-4-yl)-4-((S)-...)
Affinity DataKi:  14nMAssay Description:Inhibition of gelatinase A (Matrix metalloproteinase-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(BOVINE)
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50002151(8-Piperazin-1-yl-imidazo[1,2-a]pyrazine | CHEMBL33...)
Affinity DataKi:  15nMAssay Description:Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057067((2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbam...)
Affinity DataKi:  15nMAssay Description:Inhibition of human stromelysin-1 (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057081((2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbam...)
Affinity DataKi:  15nMAssay Description:Inhibition of human stromelysin-1 (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057067((2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbam...)
Affinity DataKi:  16nMAssay Description:Inhibition of gelatinase A (Matrix metalloproteinase-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057052((2S,4R)-6-(4-Benzyl-phenyl)-2-butyl-4-((S)-2,2-dim...)
Affinity DataKi:  16nMAssay Description:Inhibition of gelatinase A (Matrix metalloproteinase-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057039((2S,4R)-6-(4'-Bromo-biphenyl-4-yl)-2-butyl-4-((S)-...)
Affinity DataKi:  17nMAssay Description:Inhibition of gelatinase A (Matrix metalloproteinase-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057074((2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbam...)
Affinity DataKi:  17nMAssay Description:Inhibition of gelatinase A (Matrix metalloproteinase-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057090((R)-2-((S)-1-((S)-4-methyl-1-oxo-1-(phenylamino)pe...)
Affinity DataKi:  18nMAssay Description:Inhibition of human stromelysin-1 (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057090((R)-2-((S)-1-((S)-4-methyl-1-oxo-1-(phenylamino)pe...)
Affinity DataKi:  18nMAssay Description:Inhibitory activity against human stromelysin-3 (MMP-3)More data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057090((R)-2-((S)-1-((S)-4-methyl-1-oxo-1-(phenylamino)pe...)
Affinity DataKi:  18nMAssay Description:Inhibition of matrix metalloproteinase-3(MMP-3).More data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057072((2S,4R)-2-Butyl-6-(3'-chloro-4'-fluoro-biphenyl-4-...)
Affinity DataKi:  19nMAssay Description:Inhibition of human stromelysin-1 (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM12197((3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydr...)
Affinity DataKi:  19nMAssay Description:The compound was tested for its inhibitory activity against IL-1 beta converting enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057065((2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbam...)
Affinity DataKi:  19nMAssay Description:Inhibition of gelatinase A (Matrix metalloproteinase-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057079((2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbam...)
Affinity DataKi:  21nMAssay Description:Inhibition of gelatinase A (Matrix metalloproteinase-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057065((2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbam...)
Affinity DataKi:  21nMAssay Description:Inhibition of human stromelysin-1 (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057043((2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbam...)
Affinity DataKi:  21nMAssay Description:Inhibition of human stromelysin-1 (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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