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Found 248 with Last Name = 'man' and Initial = 'cc'
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50100949((7-Bromo-1,2,3,4-tetrahydro-isoquinolin-3-yl)-meth...)
Affinity DataKi:  12nMAssay Description:Binding affinity against Human phenylethanolamine N-methyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50077537((+)-(7-nitro-1,2,3,4-tetrahydroisoquinolin-3-yl)me...)
Affinity DataKi:  47nMAssay Description:Binding affinity against Human phenylethanolamine N-methyltransferaseMore data for this Ligand-Target Pair
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50160902(2-(7-Bromo-1,2,3,4-tetrahydro-isoquinolin-3-yl)-et...)
Affinity DataKi:  350nMAssay Description:Binding affinity against Human phenylethanolamine N-methyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50160904(2-(7-Nitro-1,2,3,4-tetrahydro-isoquinolin-3-yl)-et...)
Affinity DataKi:  510nMAssay Description:Binding affinity against Human phenylethanolamine N-methyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50160905(3-(7-Nitro-1,2,3,4-tetrahydro-isoquinolin-3-yl)-pr...)
Affinity DataKi:  1.40E+3nMAssay Description:Binding affinity against Human phenylethanolamine N-methyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50160903(3-(7-Bromo-1,2,3,4-tetrahydro-isoquinolin-3-yl)-pr...)
Affinity DataKi:  1.70E+3nMAssay Description:Binding affinity against Human phenylethanolamine N-methyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50080521(3-Fluoromethyl-7-nitro-1,2,3,4-tetrahydro-isoquino...)
Affinity DataKi:  3.20E+3nMAssay Description:Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]-RX-821002 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50072991(7-Nitro-1,2,3,4-tetrahydro-isoquinoline | 7-nitro-...)
Affinity DataKi:  3.20E+3nMAssay Description:Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]-RX-821002 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50079900(7-Nitro-3-trifluoromethyl-1,2,3,4-tetrahydro-isoqu...)
Affinity DataKi:  3.40E+3nMAssay Description:Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]-RX-821002 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM13017(1,2,3,4-tetrahydroisoquinoline-7-sulfonamide | CHE...)
Affinity DataKi:  3.40E+3nMAssay Description:Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]-RX-821002 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50160906((+/-)-3-difluoromethyl-7-nitro-1,2,3,4-tetrahydroi...)
Affinity DataKi:  3.60E+3nMAssay Description:Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]-RX-821002 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50077537((+)-(7-nitro-1,2,3,4-tetrahydroisoquinolin-3-yl)me...)
Affinity DataKi:  3.90E+3nMAssay Description:Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]-RX-821002 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50079902(7-Bromo-3-trifluoromethyl-1,2,3,4-tetrahydro-isoqu...)
Affinity DataKi:  4.35E+3nMAssay Description:Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]-RX-821002 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50077543(3-Methyl-7-nitro-1,2,3,4-tetrahydro-isoquinoline |...)
Affinity DataKi:  4.84E+3nMAssay Description:Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]-RX-821002 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM13014(7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydr...)
Affinity DataKi:  6.52E+3nMAssay Description:Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]-RX-821002 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM100340(US8501749, 40)
Affinity DataIC50:  0.300nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetChymase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM100336(US8501749, 36)
Affinity DataIC50:  0.400nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetChymase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM100338(US8501749, 38)
Affinity DataIC50:  0.700nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetChymase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM100335(US8501749, 35)
Affinity DataIC50:  0.700nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetChymase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM100324(US8501749, 24)
Affinity DataIC50:  0.900nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330100(CHEMBL1271550 | N-(4-(3-(pyridin-3-yl)-5-(trifluor...)
Affinity DataIC50:  1nMAssay Description:Displacement of [3H]-cDPPO from human Ephx2 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM100341(US8501749, 41)
Affinity DataIC50:  1.30nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetChymase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM100330(US8501749, 30)
Affinity DataIC50:  1.40nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetChymase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM100339(US8501749, 39)
Affinity DataIC50:  1.40nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM26831(N-[(2E)-5-[benzene(methyl)amido]-1-(2-carbamoyleth...)
Affinity DataIC50:  2nMpH: 7.0 T: 2°CAssay Description:Kinase is purified as a GST-fusion protein. The kinase activity is measured using DELFIA which utilizes europium chelate-labeled anti-phosphotyrosine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM26840(N-[(2E)-5-[benzene(methyl)amido]-1-(2-carbamoyleth...)
Affinity DataIC50:  2nMpH: 7.0 T: 2°CAssay Description:Kinase is purified as a GST-fusion protein. The kinase activity is measured using DELFIA which utilizes europium chelate-labeled anti-phosphotyrosine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM26843(N-[(2E)-5-[benzene(methyl)amido]-1-(2-carbamoyleth...)
Affinity DataIC50:  2nMAssay Description:Kinase is purified as a GST-fusion protein. The kinase activity is measured using DELFIA which utilizes europium chelate-labeled anti-phosphotyrosine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM26847(N-[(2E)-5-[benzene(methyl)amido]-1-(2-carbamoyleth...)
Affinity DataIC50:  2nMAssay Description:Kinase is purified as a GST-fusion protein. The kinase activity is measured using DELFIA which utilizes europium chelate-labeled anti-phosphotyrosine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM26857(N-[(2E)-5-[benzene(methyl)amido]-1-(2-carbamoyleth...)
Affinity DataIC50:  2nMAssay Description:Kinase is purified as a GST-fusion protein. The kinase activity is measured using DELFIA which utilizes europium chelate-labeled anti-phosphotyrosine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM100320(US8501749, 20)
Affinity DataIC50:  2.10nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetChymase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM100331(US8501749, 31)
Affinity DataIC50:  2.20nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetChymase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM100325(US8501749, 25)
Affinity DataIC50:  2.5nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetChymase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM100318(US8501749, 18)
Affinity DataIC50:  2.60nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetChymase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM100334(US8501749, 34)
Affinity DataIC50:  2.60nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetChymase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM100337(US8501749, 37)
Affinity DataIC50:  2.70nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetChymase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM100327(US8501749, 27)
Affinity DataIC50:  3nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM26854(N-[(2E)-5-[benzene(methyl)amido]-1-(2-carbamoyleth...)
Affinity DataIC50:  3nMAssay Description:Kinase is purified as a GST-fusion protein. The kinase activity is measured using DELFIA which utilizes europium chelate-labeled anti-phosphotyrosine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM100312(US8501749, 12)
Affinity DataIC50:  3.10nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetChymase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM100321(US8501749, 21)
Affinity DataIC50:  4nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297414(CHEMBL556234 | N-[3-(4-Fluorophenyl)-3-(4-methanes...)
Affinity DataIC50:  4nMAssay Description:Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330103(CHEMBL1271608 | N-(5-(3-(pyridin-3-yl)-5-(trifluor...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of human Ephx2 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM100322(US8501749, 22)
Affinity DataIC50:  4.80nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBifunctional epoxide hydrolase 2(Rattus norvegicus)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297413(CHEMBL560537 | N-(3,3-diphenyl-propyl)-nicotinamid...)
Affinity DataIC50:  4.80nMAssay Description:Displacement of rhodamine-labeled probe from rat soluble epoxide hydrolase by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297416(4-Cyano-N-[3,3-bis-(4-fluorophenyl)-propyl]-benzam...)
Affinity DataIC50:  5nMAssay Description:Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297415(CHEMBL564893 | N-[3,3-Bis-(4-fluorophenyl)-propyl]...)
Affinity DataIC50:  5nMAssay Description:Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297412(CHEMBL560740 | N-[3,3-Bis-(4-fluorophenyl)-propyl]...)
Affinity DataIC50:  5nMAssay Description:Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297402(CHEMBL563417 | N-[4,4-Bis-(4-fluorophenyl)-propyl]...)
Affinity DataIC50:  5nMAssay Description:Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM26856(N-[(2E)-5-[benzene(methyl)amido]-1-(2-carbamoyleth...)
Affinity DataIC50:  5nMAssay Description:Kinase is purified as a GST-fusion protein. The kinase activity is measured using DELFIA which utilizes europium chelate-labeled anti-phosphotyrosine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297417(CHEMBL551338 | N-[3,3-Bis-(4-fluorophenyl)-propyl]...)
Affinity DataIC50:  5nMAssay Description:Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM26839(N-[(2E)-5-[benzene(methyl)amido]-1-(2-carbamoyleth...)
Affinity DataIC50:  5nMpH: 7.0 T: 2°CAssay Description:Kinase is purified as a GST-fusion protein. The kinase activity is measured using DELFIA which utilizes europium chelate-labeled anti-phosphotyrosine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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