Compile Data Set for Download or QSAR
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Found 158 with Last Name = 'mani' and Initial = 'u'
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185909(2-(3-((1-(3-(2-chlorophenoxy)benzyl)piperidin-4-yl...)
Affinity DataKi:  6nMAssay Description:Displacement of [125I]I309 from human CCR8 expressed in L1.2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185912(2-(4-{1-[3-(2-chloro-phenoxy)-benzyl]-piperidin-4-...)
Affinity DataKi:  9nMAssay Description:Displacement of [125I]I309 from human CCR8 expressed in L1.2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185908(1-ethyl-4-phenyl-piperidine-4-carboxylic acid {1-[...)
Affinity DataKi:  11nMAssay Description:Displacement of [125I]I309 from human CCR8 expressed in L1.2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185910(1-ethyl-4-phenyl-piperidine-4-carboxylic acid {1-[...)
Affinity DataKi:  15nMAssay Description:Displacement of [125I]I309 from human CCR8 expressed in L1.2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185906(1-[3-(2-chlorophenoxy)benzyl]-4-{[(1-ethyl-4-pheny...)
Affinity DataKi:  23nMAssay Description:Displacement of [125I]I309 from human CCR8 expressed in L1.2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185904((+/-) 3-phenyl-pyrrolidine-3-carboxylic acid {1-[3...)
Affinity DataKi:  27nMAssay Description:Displacement of [125I]I309 from human CCR8 expressed in L1.2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185902(1-[3-(2-methoxy-phenoxy)-benzyl]-4-[(4-phenyl-pipe...)
Affinity DataKi:  60nMAssay Description:Displacement of [125I]I309 from human CCR8 expressed in L1.2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185905(4-phenyl-piperidine-4-carboxylic acid {1-[3-(2-met...)
Affinity DataKi:  62nMAssay Description:Displacement of [125I]I309 from human CCR8 expressed in L1.2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185915(1-(4-chloro-phenyl)-cyclohexanecarboxylic acid {1-...)
Affinity DataKi:  250nMAssay Description:Displacement of [125I]I309 from human CCR8 expressed in L1.2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185907(CHEMBL210322 | N-{1-[3-(2-methoxy-phenoxy)-benzyl]...)
Affinity DataKi:  250nMAssay Description:Displacement of [125I]I309 from human CCR8 expressed in L1.2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185905(4-phenyl-piperidine-4-carboxylic acid {1-[3-(2-met...)
Affinity DataKi:  800nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185911(CHEMBL205692 | N-[1-(3-phenoxy-benzyl)-piperidin-4...)
Affinity DataKi:  1.40E+3nMAssay Description:Displacement of [125I]I309 from human CCR8 expressed in L1.2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185903(1-(3-phenoxy-benzyl)-piperidine-4-carboxylic acid ...)
Affinity DataKi:  2.60E+3nMAssay Description:Displacement of [125I]I309 from human CCR8 expressed in L1.2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185916(1-(3-phenoxy-benzyl)-piperidine-4-carboxylic acid ...)
Affinity DataKi:  9.10E+3nMAssay Description:Displacement of [125I]I309 from human CCR8 expressed in L1.2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185913(CHEMBL381354 | N-[1-(3-phenoxy-benzyl)-piperidin-4...)
Affinity DataKi:  9.20E+3nMAssay Description:Displacement of [125I]I309 from human CCR8 expressed in L1.2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185902(1-[3-(2-methoxy-phenoxy)-benzyl]-4-[(4-phenyl-pipe...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185909(2-(3-((1-(3-(2-chlorophenoxy)benzyl)piperidin-4-yl...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185906(1-[3-(2-chlorophenoxy)benzyl]-4-{[(1-ethyl-4-pheny...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185914(1-(3-phenoxybenzyl)piperidine-4-carboxylic acid | ...)
Affinity DataKi: >3.00E+4nMAssay Description:Displacement of [125I]I309 from human CCR8 expressed in L1.2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185909(2-(3-((1-(3-(2-chlorophenoxy)benzyl)piperidin-4-yl...)
Affinity DataIC50:  1nMAssay Description:Inhibition of I309-induced chemotaxis in L1.2 cells expressing CCR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132322(({2-[(2-{4-[4-Amino-5-(3-hydroxy-phenyl)-pyrrolo[2...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibition of Src protein tryrosine kinase using the Scintillation proximity kinase assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185912(2-(4-{1-[3-(2-chloro-phenoxy)-benzyl]-piperidin-4-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of I309-induced chemotaxis in L1.2 cells expressing CCR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Cyclin-dependent kinase 2 (CDK2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Mus musculus (Mouse))
Orchid Chemicals & Pharmaceuticals

US Patent
LigandPNGBDBM97708(US8476255, 96)
Affinity DataIC50:  10nMT: 2°CAssay Description:Histone Deacetylase (HDAC) inhibition assay using Boc-Lys (Ac)-AMC substrate. The fluorometric assay provides a fast and fluorescence based method t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Mus musculus (Mouse))
Orchid Chemicals & Pharmaceuticals

US Patent
LigandPNGBDBM97707(US8476255, 95)
Affinity DataIC50:  10nMT: 2°CAssay Description:Histone Deacetylase (HDAC) inhibition assay using Boc-Lys (Ac)-AMC substrate. The fluorometric assay provides a fast and fluorescence based method t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185905(4-phenyl-piperidine-4-carboxylic acid {1-[3-(2-met...)
Affinity DataIC50:  11nMAssay Description:Inhibition of I309-induced chemotaxis in L1.2 cells expressing CCR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Mus musculus (Mouse))
Orchid Chemicals & Pharmaceuticals

US Patent
LigandPNGBDBM97695(US8476255, 55)
Affinity DataIC50:  20nMT: 2°CAssay Description:Histone Deacetylase (HDAC) inhibition assay using Boc-Lys (Ac)-AMC substrate. The fluorometric assay provides a fast and fluorescence based method t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50221656(CHEMBL3706663)
Affinity DataIC50:  20nMAssay Description:In vitro inhibition of Src protein tryrosine kinase using the Scintillation proximity kinase assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185904((+/-) 3-phenyl-pyrrolidine-3-carboxylic acid {1-[3...)
Affinity DataIC50:  22nMAssay Description:Inhibition of I309-induced chemotaxis in L1.2 cells expressing CCR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Mus musculus (Mouse))
Orchid Chemicals & Pharmaceuticals

US Patent
LigandPNGBDBM97703(US8476255, 89)
Affinity DataIC50:  30nMT: 2°CAssay Description:Histone Deacetylase (HDAC) inhibition assay using Boc-Lys (Ac)-AMC substrate. The fluorometric assay provides a fast and fluorescence based method t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 1(Mus musculus (Mouse))
Orchid Chemicals & Pharmaceuticals

US Patent
LigandPNGBDBM97698(US8476255, 59)
Affinity DataIC50:  30nMT: 2°CAssay Description:Histone Deacetylase (HDAC) inhibition assay using Boc-Lys (Ac)-AMC substrate. The fluorometric assay provides a fast and fluorescence based method t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 1(Mus musculus (Mouse))
Orchid Chemicals & Pharmaceuticals

US Patent
LigandPNGBDBM97685(US8476255, 28)
Affinity DataIC50:  36nMT: 2°CAssay Description:Histone Deacetylase (HDAC) inhibition assay using Boc-Lys (Ac)-AMC substrate. The fluorometric assay provides a fast and fluorescence based method t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132339(3-[4-Amino-7-(4-{2-[(2-hydroxy-ethyl)-methyl-amino...)
Affinity DataIC50:  40nMAssay Description:In vitro inhibition of Src protein tryrosine kinase using the Scintillation proximity kinase assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Mus musculus (Mouse))
Orchid Chemicals & Pharmaceuticals

US Patent
LigandPNGBDBM97697(US8476255, 58)
Affinity DataIC50:  40nMT: 2°CAssay Description:Histone Deacetylase (HDAC) inhibition assay using Boc-Lys (Ac)-AMC substrate. The fluorometric assay provides a fast and fluorescence based method t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Mus musculus (Mouse))
Orchid Chemicals & Pharmaceuticals

US Patent
LigandPNGBDBM97706(US8476255, 94)
Affinity DataIC50:  40nMT: 2°CAssay Description:Histone Deacetylase (HDAC) inhibition assay using Boc-Lys (Ac)-AMC substrate. The fluorometric assay provides a fast and fluorescence based method t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Mus musculus (Mouse))
Orchid Chemicals & Pharmaceuticals

US Patent
LigandPNGBDBM97704(US8476255, 90)
Affinity DataIC50:  40nMT: 2°CAssay Description:Histone Deacetylase (HDAC) inhibition assay using Boc-Lys (Ac)-AMC substrate. The fluorometric assay provides a fast and fluorescence based method t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 1(Mus musculus (Mouse))
Orchid Chemicals & Pharmaceuticals

US Patent
LigandPNGBDBM97694(US8476255, 53)
Affinity DataIC50:  40nMT: 2°CAssay Description:Histone Deacetylase (HDAC) inhibition assay using Boc-Lys (Ac)-AMC substrate. The fluorometric assay provides a fast and fluorescence based method t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132324(3-{4-Amino-7-[4-(2-hydroxy-ethyl)-phenyl]-7H-pyrro...)
Affinity DataIC50:  40nMAssay Description:In vitro inhibition of Src protein tryrosine kinase using the Scintillation proximity kinase assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50451556(CHEMBL3084838)
Affinity DataIC50:  41nMAssay Description:Inhibition of Src-mediated dentine resorption in rabbit-osteoclast assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Mus musculus (Mouse))
Orchid Chemicals & Pharmaceuticals

US Patent
LigandPNGBDBM97680(US8476255, 19)
Affinity DataIC50:  42nMT: 2°CAssay Description:Histone Deacetylase (HDAC) inhibition assay using Boc-Lys (Ac)-AMC substrate. The fluorometric assay provides a fast and fluorescence based method t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185910(1-ethyl-4-phenyl-piperidine-4-carboxylic acid {1-[...)
Affinity DataIC50:  43nMAssay Description:Inhibition of I309-induced chemotaxis in L1.2 cells expressing CCR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Mus musculus (Mouse))
Orchid Chemicals & Pharmaceuticals

US Patent
LigandPNGBDBM97700(US8476255, 77)
Affinity DataIC50:  50nMT: 2°CAssay Description:Histone Deacetylase (HDAC) inhibition assay using Boc-Lys (Ac)-AMC substrate. The fluorometric assay provides a fast and fluorescence based method t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Mus musculus (Mouse))
Orchid Chemicals & Pharmaceuticals

US Patent
LigandPNGBDBM97684(US8476255, 27)
Affinity DataIC50:  50nMT: 2°CAssay Description:Histone Deacetylase (HDAC) inhibition assay using Boc-Lys (Ac)-AMC substrate. The fluorometric assay provides a fast and fluorescence based method t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Mus musculus (Mouse))
Orchid Chemicals & Pharmaceuticals

US Patent
LigandPNGBDBM97688(US8476255, 32)
Affinity DataIC50:  52nMT: 2°CAssay Description:Histone Deacetylase (HDAC) inhibition assay using Boc-Lys (Ac)-AMC substrate. The fluorometric assay provides a fast and fluorescence based method t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Mus musculus (Mouse))
Orchid Chemicals & Pharmaceuticals

US Patent
LigandPNGBDBM97687(US8476255, 31)
Affinity DataIC50:  54nMT: 2°CAssay Description:Histone Deacetylase (HDAC) inhibition assay using Boc-Lys (Ac)-AMC substrate. The fluorometric assay provides a fast and fluorescence based method t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185907(CHEMBL210322 | N-{1-[3-(2-methoxy-phenoxy)-benzyl]...)
Affinity DataIC50:  55nMAssay Description:Inhibition of I309-induced chemotaxis in L1.2 cells expressing CCR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185908(1-ethyl-4-phenyl-piperidine-4-carboxylic acid {1-[...)
Affinity DataIC50:  56nMAssay Description:Inhibition of I309-induced chemotaxis in L1.2 cells expressing CCR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Mus musculus (Mouse))
Orchid Chemicals & Pharmaceuticals

US Patent
LigandPNGBDBM97686(US8476255, 29)
Affinity DataIC50:  57nMT: 2°CAssay Description:Histone Deacetylase (HDAC) inhibition assay using Boc-Lys (Ac)-AMC substrate. The fluorometric assay provides a fast and fluorescence based method t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132334(CHEMBL104215 | [(2-{4-[4-Amino-5-(3-hydroxy-phenyl...)
Affinity DataIC50:  60nMAssay Description:In vitro inhibition of Src protein tryrosine kinase using the Scintillation proximity kinase assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Mus musculus (Mouse))
Orchid Chemicals & Pharmaceuticals

US Patent
LigandPNGBDBM97699(BOC-LYS(AC)-AMC | US8476255, 76)
Affinity DataIC50:  60nMT: 2°CAssay Description:Histone Deacetylase (HDAC) inhibition assay using Boc-Lys (Ac)-AMC substrate. The fluorometric assay provides a fast and fluorescence based method t...More data for this Ligand-Target Pair
In DepthDetails US Patent
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