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Found 224 with Last Name = 'manning' and Initial = 'u'
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50175995(CHEMBL199986 | N-(2,4-difluorophenyl)-3-(5-(3-(dim...)
Affinity DataIC50:  0.600nMAssay Description:Inhibitory activity against murine p38alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50176013(3-(6-(2,4-difluorophenylamino)-1H-pyrazolo[3,4-b]p...)
Affinity DataIC50:  0.700nMAssay Description:Inhibitory activity against murine p38alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50176003(CHEMBL199993 | N-(2,4-difluorophenyl)-3-(2-methoxy...)
Affinity DataIC50:  0.900nMAssay Description:Inhibitory activity against murine p38alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148700(4-{4-(4-Fluoro-phenyl)-5-[2-((S)-1-phenyl-ethylami...)
Affinity DataIC50:  2nMAssay Description:Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148699(4-{2-(4-Fluoro-phenyl)-1-[2-((S)-1-phenyl-ethylami...)
Affinity DataIC50:  4nMAssay Description:Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50116031(3,5,6-Trifluoro-4-[4-(4-fluoro-phenyl)-5-pyridin-4...)
Affinity DataIC50:  4nMAssay Description:In vivo inhibition of murine Mitogen-activated protein kinase p38 alpha activity, GST-ATF-2 as substrate in the presence of 120 microM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148703(4-[5-(2-Cyclohexylamino-pyridin-4-yl)-4-(4-fluoro-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50116037(3,5-Difluoro-4-[5-(4-fluoro-phenyl)-4-pyridin-4-yl...)
Affinity DataIC50:  4nMAssay Description:In vivo inhibition of murine Mitogen-activated protein kinase p38 alpha activity, GST-ATF-2 as substrate in the presence of 120 microM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50175994(CHEMBL371756 | N-cyclopentyl-3-(6-(2,4-difluorophe...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against murine p38alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148691(4-{4-(4-Fluoro-phenyl)-5-[2-((S)-1-phenyl-ethylami...)
Affinity DataIC50:  5nMAssay Description:Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148702(CHEMBL415712 | Cyclohexyl-{4-[2-(4-fluoro-phenyl)-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50116038(4-(4-Benzofuran-2-yl-5-pyridin-4-yl-1H-imidazol-2-...)
Affinity DataIC50:  5nMAssay Description:In vivo inhibition of murine Mitogen-activated protein kinase p38 alpha activity, GST-ATF-2 as substrate in the presence of 120 microM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148696(CHEMBL119952 | {4-[(S)-2-(4-Fluoro-phenyl)-5-(4-me...)
Affinity DataIC50:  6nMAssay Description:Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50175998(4-(3-(6-(2,4-difluorophenylamino)-1H-pyrazolo[3,4-...)
Affinity DataIC50:  7nMAssay Description:Inhibitory activity against murine p38alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148693(4-{4-(4-Fluoro-phenyl)-5-[2-((S)-1-phenyl-ethylami...)
Affinity DataIC50:  7nMAssay Description:Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148698(CHEMBL333899 | Cyclohexyl-{4-[4-piperidin-4-yl-2-(...)
Affinity DataIC50:  8nMAssay Description:Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148695(4-{4-(4-Fluoro-phenyl)-5-[2-((S)-1-phenyl-ethylami...)
Affinity DataIC50:  9nMAssay Description:Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50176006(3-(5-(3-amino-3-methylbut-1-ynyl)-2-methoxyphenyl)...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against murine p38alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148697(4-{4-(4-Fluoro-phenyl)-5-[2-((S)-1-phenyl-ethylami...)
Affinity DataIC50:  11nMAssay Description:Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50176010(CHEMBL199319 | N-(2,4-difluorophenyl)-3-(5-(3-(dim...)
Affinity DataIC50:  11nMAssay Description:Inhibitory activity against murine p38alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50176000(3-(5-(3-amino-3-methylbut-1-ynyl)-2-methoxyphenyl)...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity against murine p38alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50176005(CHEMBL381457 | N-(2,4-difluorophenyl)-3-(2-methoxy...)
Affinity DataIC50:  14nMAssay Description:Inhibitory activity against murine p38alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148690(4-[5-(2-Cyclohexylamino-pyridin-4-yl)-4-(4-fluoro-...)
Affinity DataIC50:  15nMAssay Description:Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148692(CHEMBL120185 | Cyclopentyl-{4-[2-(4-fluoro-phenyl)...)
Affinity DataIC50:  15nMAssay Description:Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50116029(3,5-Difluoro-4-[4-(4-fluoro-phenyl)-5-pyridin-4-yl...)
Affinity DataIC50:  16nMAssay Description:In vivo inhibition of murine Mitogen-activated protein kinase p38 alpha activity, GST-ATF-2 as substrate in the presence of 120 microM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50404281(CHEMBL2111784)
Affinity DataIC50:  18nMAssay Description:Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50175999(4-(3-(6-(2,4-difluorophenylamino)-1H-pyrazolo[3,4-...)
Affinity DataIC50:  19nMAssay Description:Inhibitory activity against murine p38alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50089127(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Affinity DataIC50:  20nMAssay Description:Inhibition of murine p38 alpha MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50176007(3-(5-(3-amino-3-methylbut-1-ynyl)-2-methoxyphenyl)...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against murine p38alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50176001(4-(3-(6-(2,4-difluorophenylamino)-1H-pyrazolo[3,4-...)
Affinity DataIC50:  21nMAssay Description:Inhibitory activity against murine p38alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148694(4-[1-(2-Cyclopentylamino-pyrimidin-4-yl)-2-(3-trif...)
Affinity DataIC50:  29nMAssay Description:Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50176004(3-(5-(3-amino-3-methylbutyl)-2-methoxyphenyl)-N-(2...)
Affinity DataIC50:  29nMAssay Description:Inhibitory activity against murine p38alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50069336(CHEMBL439120 | NELNLGRREE | NQLPpYNELNLGRREEpYDVLD)
Affinity DataIC50:  30nMAssay Description:Antagonistic activity against SH2 domain of Zeta-chain (TCR) associated protein kinase, ZAP-70More data for this Ligand-Target Pair
In DepthDetails Article
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50069336(CHEMBL439120 | NELNLGRREE | NQLPpYNELNLGRREEpYDVLD)
Affinity DataIC50:  30nMAssay Description:Inhibition of binding to human ZAP-70 SH2 domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148690(4-[5-(2-Cyclohexylamino-pyridin-4-yl)-4-(4-fluoro-...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human c-Jun N-terminal kinase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50176002(3-(5-(3-amino-3-methylbutyl)-2-methoxyphenyl)-N-(2...)
Affinity DataIC50:  33nMAssay Description:Inhibitory activity against murine p38alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50176008(3-(5-(3-amino-3-methylbutyl)-2-methoxyphenyl)-N-(2...)
Affinity DataIC50:  43nMAssay Description:Inhibitory activity against murine p38alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148692(CHEMBL120185 | Cyclopentyl-{4-[2-(4-fluoro-phenyl)...)
Affinity DataIC50:  47nMAssay Description:Inhibition of human c-Jun N-terminal kinase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50176009(4-(3-(6-(2,4-difluorophenylamino)-1H-pyrazolo[3,4-...)
Affinity DataIC50:  47nMAssay Description:Inhibitory activity against murine p38alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50176011(3-(5-((cyclopentylamino)methyl)-2-methoxyphenyl)-N...)
Affinity DataIC50:  58nMAssay Description:Inhibitory activity against murine p38alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50089122(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Affinity DataIC50:  76nMAssay Description:Inhibition of murine p38 alpha MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50089123(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Affinity DataIC50:  80nMAssay Description:Inhibition of murine p38 alpha MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50089125(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-...)
Affinity DataIC50:  90nMAssay Description:Inhibition of murine p38 alpha MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50116025(2,3,5,6-Tetrafluoro-4-[4-(4-fluoro-phenyl)-5-pyrid...)
Affinity DataIC50:  90nMAssay Description:In vivo inhibition of murine Mitogen-activated protein kinase p38 alpha activity, GST-ATF-2 as substrate in the presence of 120 microM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50089125(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-...)
Affinity DataIC50:  90nMAssay Description:Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50175996(CHEMBL200017 | N-(2,4-difluorophenyl)-3-(2-methoxy...)
Affinity DataIC50:  94nMAssay Description:Inhibitory activity against murine p38alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50089130(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Affinity DataIC50:  120nMAssay Description:Inhibition of murine p38 alpha MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50089124(4-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol-2-...)
Affinity DataIC50:  130nMAssay Description:Inhibition of murine p38 alpha MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50116028(3,5-Difluoro-4-[4-(4-fluoro-phenyl)-5-pyridin-4-yl...)
Affinity DataIC50:  140nMAssay Description:In vivo inhibition of murine Mitogen-activated protein kinase p38 alpha activity, GST-ATF-2 as substrate in the presence of 120 microM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50089132(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Affinity DataIC50:  150nMAssay Description:Inhibition of murine p38 alpha MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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