TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: <9nMAssay Description:Inhibition of polo-like kinase 1 activityMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: <9nMAssay Description:Inhibition of polo-like kinase 1 activityMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: <9nMAssay Description:Inhibition of polo-like kinase 1 activityMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant full length His-tagged NEK2 expressed in baculovirus expression system assessed as inhibition of substrate phosphoryl...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant full length His-tagged NEK2 expressed in baculovirus expression system assessed as inhibition of substrate phosphoryl...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of human NEK2 by kinase-profiling analysisMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of Nek2 using 5-FAM-KKLNRTLSVA-COOH as substrate after 1 hr by caliper methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 26nMAssay Description:Inhibition of human recombinant full length His-tagged NEK2 expressed in baculovirus expression system assessed as inhibition of substrate phosphoryl...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of Nek2 using 5-FAM-KKLNRTLSVA-COOH as substrate after 1 hr by caliper methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 39nMAssay Description:Inhibition of human recombinant full length His-tagged NEK2 expressed in baculovirus expression system assessed as inhibition of substrate phosphoryl...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 42nMAssay Description:Inhibition of human recombinant full length His-tagged NEK2 expressed in baculovirus expression system assessed as inhibition of substrate phosphoryl...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 47nMAssay Description:Inhibition of Nek2 using 5-FAM-KKLNRTLSVA-COOH as substrate after 1 hr by caliper methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 47nMAssay Description:Inhibition of Nek2 using 5-FAM-KKLNRTLSVA-COOH as substrate after 1 hr by caliper methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of human recombinant full length His-tagged NEK2 expressed in baculovirus expression system assessed as inhibition of substrate phosphoryl...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of NEK2 autophosphorylation preincubated with compound by DELFIA assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 57nMAssay Description:Inhibition of human recombinant full length His-tagged NEK2 expressed in baculovirus expression system assessed as inhibition of substrate phosphoryl...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 57nMAssay Description:Inhibition of human recombinant full length His-tagged NEK2 expressed in baculovirus expression system assessed as inhibition of substrate phosphoryl...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 58nMAssay Description:Inhibition of Nek2 using 5-FAM-KKLNRTLSVA-COOH as substrate after 1 hr by caliper methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 59nMAssay Description:Inhibition of Nek2 using 5-FAM-KKLNRTLSVA-COOH as substrate after 1 hr by caliper methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 62nMAssay Description:Inhibition of human recombinant full length His-tagged NEK2 expressed in baculovirus expression system assessed as inhibition of substrate phosphoryl...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 64nMAssay Description:Inhibition of human recombinant full length His-tagged NEK2 expressed in baculovirus expression system assessed as inhibition of substrate phosphoryl...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 66nMAssay Description:Inhibition of polo-like kinase 1 activityMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 69nMAssay Description:Inhibition of polo-like kinase 1 activityMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of GSK3beta incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzymeMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 71nMAssay Description:Inhibition of human recombinant full length His-tagged NEK2 expressed in baculovirus expression system assessed as inhibition of substrate phosphoryl...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 72nMAssay Description:Inhibition of human recombinant full length His-tagged NEK2 expressed in baculovirus expression system assessed as inhibition of substrate phosphoryl...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 73nMAssay Description:Inhibition of Nek2 using 5-FAM-KKLNRTLSVA-COOH as substrate after 1 hr by caliper methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 76nMAssay Description:Inhibition of human recombinant full length His-tagged NEK2 expressed in baculovirus expression system assessed as inhibition of substrate phosphoryl...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 76nMAssay Description:Inhibition of human recombinant full length His-tagged NEK2 expressed in baculovirus expression system assessed as inhibition of substrate phosphoryl...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 79nMAssay Description:Inhibition of human recombinant full length His-tagged NEK2 expressed in baculovirus expression system assessed as inhibition of substrate phosphoryl...More data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibition of Aurora A (unknown origin) preincubated with enzyme for 15 mins followed by substrate/ATP challenge for 90 mins by ProfilerPro plate bas...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 88nMAssay Description:Inhibition of human recombinant full length His-tagged NEK2 expressed in baculovirus expression system assessed as inhibition of substrate phosphoryl...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 93nMAssay Description:Inhibition of Nek2 using 5-FAM-KKLNRTLSVA-COOH as substrate after 1 hr by caliper methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 93nMAssay Description:Inhibition of human recombinant full length His-tagged NEK2 expressed in baculovirus expression system assessed as inhibition of substrate phosphoryl...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant full length His-tagged NEK2 expressed in baculovirus expression system assessed as inhibition of substrate phosphoryl...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of human recombinant full length His-tagged NEK2 expressed in baculovirus expression system assessed as inhibition of substrate phosphoryl...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of human recombinant full length His-tagged NEK2 expressed in baculovirus expression system assessed as inhibition of substrate phosphoryl...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of LCK incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzymeMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 116nMAssay Description:Inhibition of human recombinant full length His-tagged NEK2 expressed in baculovirus expression system assessed as inhibition of substrate phosphoryl...More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of human NAUK1 by kinase-profiling analysisMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of Nek2 using 5-FAM-KKLNRTLSVA-COOH as substrate after 1 hr by caliper methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of human recombinant full length His-tagged NEK2 expressed in baculovirus expression system assessed as inhibition of substrate phosphoryl...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of human recombinant full length His-tagged NEK2 expressed in baculovirus expression system assessed as inhibition of substrate phosphoryl...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of human recombinant full length His-tagged NEK2 expressed in baculovirus expression system assessed as inhibition of substrate phosphoryl...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of human NEK2 by kinase-profiling analysisMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of human NEK2 by kinase-profiling analysisMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University
Curated by ChEMBL
Newcastle University
Curated by ChEMBL
TargetSerine/threonine-protein kinase Nek1(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 170nMT: 2°CAssay Description:Inhibition of NEK1 after 1 hr at room temperature by caliper methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Inhibition of polo-like kinase 1 activityMore data for this Ligand-Target Pair