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Found 197 with Last Name = 'mazzocco' and Initial = 'l'
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM30712(6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimet...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 1B receptor using [3H]-5-HT trifluoroacetate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM30712(6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimet...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]-5-HT trifluoroacetate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50088870(CHEMBL171129 | Dimethyl-[2-(5-thiophen-3-yl-1H-ind...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity for human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM30703(2-(4-tert-butyl-2,6-dimethyl-benzyl)-2-imidazoline...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]-5-HT trifluoroacetate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50088867(CHEMBL170192 | Dimethyl-[2-(5-thiophen-2-yl-1H-ind...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity for human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50064806(2-(4-Isopropyl-2,6-dimethyl-benzyl)-4,5-dihydro-1H...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]-5-HT trifluoroacetate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50152303(CHEMBL361035 | N-((S)-1-Benzyl-pyrrolidin-3-yl)-3-...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]spiperone from cloned human dopamine D4.2 receptor in HEK298 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50152303(CHEMBL361035 | N-((S)-1-Benzyl-pyrrolidin-3-yl)-3-...)
Affinity DataKi:  1.5nMAssay Description:Ability to displace [3H]-spiperone from human Dopamine receptor D4.2 stably transfected in human embryonic kidney 298 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50088863(2-(5-Thiophen-2-yl-1H-indol-3-yl)-ethylamine | CHE...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity for human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50152314((S)-N-(1-benzylpyrrolidin-3-yl)-4-(thiophen-2-yl)b...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]ketanserin from cloned human 5HT2A receptor in HEK298 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50088864(3-[2-((S)-2-Methoxymethyl-pyrrolidin-1-yl)-ethyl]-...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity for human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50152306(CHEMBL187122 | N-(1-Benzyl-pyrrolidin-3-yl)-4-thio...)
Affinity DataKi:  2nMAssay Description:Ability to displace [3H]-spiperone from human Dopamine receptor D4.2 stably transfected in human embryonic kidney 298 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50152298(CHEMBL426062 | N-((S)-1-Benzyl-pyrrolidin-3-yl)-3-...)
Affinity DataKi:  2nMAssay Description:Ability to displace [3H]-spiperone from human Dopamine receptor D4.2 stably transfected in human embryonic kidney 298 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50152296(CHEMBL364782 | N-((S)-1-Benzyl-pyrrolidin-3-yl)-4-...)
Affinity DataKi:  2nMAssay Description:Ability to displace [3H]-spiperone from human Dopamine receptor D4.2 stably transfected in human embryonic kidney 298 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50088869(3-[2-(2,5-Dimethyl-pyrrolidin-1-yl)-ethyl]-5-thiop...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity for human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50152305(Biphenyl-4-carboxylic acid (1-benzyl-pyrrolidin-3-...)
Affinity DataKi:  3nMAssay Description:Ability to displace [3H]-spiperone from human Dopamine receptor D4.2 stably transfected in human embryonic kidney 298 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50152314((S)-N-(1-benzylpyrrolidin-3-yl)-4-(thiophen-2-yl)b...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]spiperone from cloned human dopamine D4.2 receptor in HEK298 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50152314((S)-N-(1-benzylpyrrolidin-3-yl)-4-(thiophen-2-yl)b...)
Affinity DataKi:  3nMAssay Description:Ability to displace [3H]-spiperone from human Dopamine receptor D4.2 stably transfected in human embryonic kidney 298 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50152297(CHEMBL187236 | N-(1-Benzyl-pyrrolidin-3-yl)-4-thio...)
Affinity DataKi:  3nMAssay Description:Ability to displace [3H]-spiperone from human Dopamine receptor D4.2 stably transfected in human embryonic kidney 298 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50088866(CHEMBL174355 | Dimethyl-{2-[5-(5-methyl-thiophen-2...)
Affinity DataKi:  3.20nMAssay Description:Binding affinity for human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50152302(CHEMBL187113 | N-((R)-1-Benzyl-pyrrolidin-3-yl)-3-...)
Affinity DataKi:  3.40nMAssay Description:Ability to displace [3H]-spiperone from human Dopamine receptor D4.2 stably transfected in human embryonic kidney 298 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50174001(CHEMBL381019 | N-[(S)-1-(4-Methyl-benzyl)-pyrrolid...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]spiperone from cloned human dopamine D4.2 receptor in HEK298 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50152309(Biphenyl-3-carboxylic acid (1-benzyl-pyrrolidin-3-...)
Affinity DataKi:  4nMAssay Description:Ability to displace [3H]-spiperone from human Dopamine receptor D4.2 stably transfected in human embryonic kidney 298 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50088868(3-[2-(2,5-Dihydro-pyrrol-1-yl)-ethyl]-5-thiophen-2...)
Affinity DataKi:  4.5nMAssay Description:Binding affinity for human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50174000((S)-N-(1-(4-fluorobenzyl)pyrrolidin-3-yl)-4-(thiop...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]spiperone from cloned human dopamine D4.2 receptor in HEK298 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50152311(4''-Chloro-biphenyl-4-carboxylic acid (1-benzyl-py...)
Affinity DataKi:  5nMAssay Description:Ability to displace [3H]-spiperone from human Dopamine receptor D4.2 stably transfected in human embryonic kidney 298 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50064816(2-(4-tert-Butyl-2-methyl-benzyl)-4,5-dihydro-1H-im...)
Affinity DataKi:  6.80nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]-5-HT trifluoroacetate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50174006((S)-N-(1-(benzo[d][1,3]dioxol-5-ylmethyl)pyrrolidi...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]spiperone from cloned human dopamine D4.2 receptor in HEK298 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50088860(CHEMBL422737 | {2-[5-(5-Chloro-thiophen-2-yl)-1H-i...)
Affinity DataKi:  7.60nMAssay Description:Binding affinity for human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50152310(4''-Fluoro-biphenyl-4-carboxylic acid (1-benzyl-py...)
Affinity DataKi:  8nMAssay Description:Ability to displace [3H]-spiperone from human Dopamine receptor D4.2 stably transfected in human embryonic kidney 298 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50088865(CHEMBL174141 | {(S)-1-[2-(5-Thiophen-2-yl-1H-indol...)
Affinity DataKi:  8.20nMAssay Description:Binding affinity for human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50088864(3-[2-((S)-2-Methoxymethyl-pyrrolidin-1-yl)-ethyl]-...)
Affinity DataKi:  9.90nMAssay Description:Binding affinity for human 5-hydroxytryptamine 1B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  11nMAssay Description:Binding affinity for human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50064818(2-(4-tert-Butyl-2,6-dimethyl-phenyl)-acetamidine |...)
Affinity DataKi:  13nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]-5-HT trifluoroacetate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50174003((S)-N-(1-(3-methoxybenzyl)pyrrolidin-3-yl)-4-(thio...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]spiperone from cloned human dopamine D4.2 receptor in HEK298 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50174008((S)-N-(1-(3,4-difluorobenzyl)pyrrolidin-3-yl)-4-(t...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]spiperone from cloned human dopamine D4.2 receptor in HEK298 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM30703(2-(4-tert-butyl-2,6-dimethyl-benzyl)-2-imidazoline...)
Affinity DataKi:  14nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 1B receptor using [3H]-5-HT trifluoroacetate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50174000((S)-N-(1-(4-fluorobenzyl)pyrrolidin-3-yl)-4-(thiop...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]ketanserin from cloned human 5HT2A receptor in HEK298 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50174011((S)-N-(1-(4-(trifluoromethyl)benzyl)pyrrolidin-3-y...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]spiperone from cloned human dopamine D4.2 receptor in HEK298 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50174010((S)-N-(1-(3,4-dichlorobenzyl)pyrrolidin-3-yl)-4-(t...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]spiperone from cloned human dopamine D4.2 receptor in HEK298 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50174008((S)-N-(1-(3,4-difluorobenzyl)pyrrolidin-3-yl)-4-(t...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]ketanserin from cloned human 5HT2A receptor in HEK298 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50174004(CHEMBL197381 | N-((S)-1-(4-chlorobenzyl)pyrrolidin...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]spiperone from cloned human dopamine D4.2 receptor in HEK298 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50152308(4''-Methylsulfanyl-biphenyl-4-carboxylic acid (1-b...)
Affinity DataKi:  17nMAssay Description:Ability to displace [3H]-spiperone from human Dopamine receptor D4.2 stably transfected in human embryonic kidney 298 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50152313(4''-Trifluoromethyl-biphenyl-4-carboxylic acid (1-...)
Affinity DataKi:  17nMAssay Description:Ability to displace [3H]-spiperone from human Dopamine receptor D4.2 stably transfected in human embryonic kidney 298 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50152312(3''-Fluoro-biphenyl-4-carboxylic acid (1-benzyl-py...)
Affinity DataKi:  17nMAssay Description:Ability to displace [3H]-spiperone from human Dopamine receptor D4.2 stably transfected in human embryonic kidney 298 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50088870(CHEMBL171129 | Dimethyl-[2-(5-thiophen-3-yl-1H-ind...)
Affinity DataKi:  17nMAssay Description:Binding affinity for human 5-hydroxytryptamine 1B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50152301(CHEMBL366304 | N-((R)-1-Benzyl-pyrrolidin-3-yl)-4-...)
Affinity DataKi:  18nMAssay Description:Ability to displace [3H]-spiperone from human Dopamine receptor D4.2 stably transfected in human embryonic kidney 298 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50088861(3-(2-Pyrrolidin-1-yl-ethyl)-5-thiophen-2-yl-1H-ind...)
Affinity DataKi:  19nMAssay Description:Binding affinity for human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50174002(CHEMBL370652 | N-((S)-1-(4-(trifluoromethyl)benzyl...)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]spiperone from cloned human dopamine D4.2 receptor in HEK298 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50174010((S)-N-(1-(3,4-dichlorobenzyl)pyrrolidin-3-yl)-4-(t...)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]ketanserin from cloned human 5HT2A receptor in HEK298 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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