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Found 1657 with Last Name = 'merk' and Initial = 'd'
TargetCysteinyl leukotriene receptor 1(GUINEA PIG)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50009073(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]LTD4 from cysteinyl leukotriene receptor 1 in Hartley guinea pig parenchymal membrane after 30 mins by liquid scintillation count...More data for this Ligand-Target Pair
TargetAdenosine receptor A3(Homo sapiens (Human))
J. Uriach & Cía. S.A.

Curated by ChEMBL
LigandPNGBDBM50348176(CHEMBL1562432)
Affinity DataKi:  0.433nMAssay Description:Antagonistic activity of guinea pig Histamine H2 receptor expressed as pA2 at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
J. Uriach & Cía. S.A.

Curated by ChEMBL
LigandPNGBDBM21173(1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...)
Affinity DataKi:  0.460nMAssay Description:Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1(GUINEA PIG)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50227367(CHEMBL48435)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]LTD4 from cysteinyl leukotriene receptor 1 in Hartley guinea pig parenchymal membrane after 30 mins by liquid scintillation count...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
J. Uriach & Cía. S.A.

Curated by ChEMBL
LigandPNGBDBM50058235(8-(3-Oxa-tricyclo[3.2.1.0*2,4*]oct-6-yl)-1,3-dipro...)
Affinity DataKi:  0.950nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) enzyme from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50518072(CHEMBL4581645)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]-Way100635 from 5HT1A (unknown origin) expressed in CHO cell membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
J. Uriach & Cía. S.A.

Curated by ChEMBL
LigandPNGBDBM50003019(8-(Hexahydro-2,5-methano-pentalen-3a-yl)-1,3-dipro...)
Affinity DataKi:  1.30nMAssay Description:Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
J. Uriach & Cía. S.A.

Curated by ChEMBL
LigandPNGBDBM50086173(CHEMBL17002 | N-(4-Acetyl-phenyl)-2-[4-(2,6-dioxo-...)
Affinity DataKi:  1.40nMAssay Description:Antagonistic activity of guinea pig Histamine H2 receptor expressed as pA2 at pH 7.8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
J. Uriach & Cía. S.A.

Curated by ChEMBL
LigandPNGBDBM50086170((4-Cyano-phenyl)-carbamic acid 4-(2,6-dioxo-1,3-di...)
Affinity DataKi:  2nMAssay Description:Antagonistic activity against Histamine H2 receptor expressed as the charge of receptor sensitivity was determined at pH 7.8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50518072(CHEMBL4581645)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]-N-methylspiperone from dopamine D3 receptor (unknown origin) expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
J. Uriach & Cía. S.A.

Curated by ChEMBL
LigandPNGBDBM50116370(1-Benzyl-3-propyl-1H-1,3,4b,9-tetraaza-fluorene-2,...)
Affinity DataKi:  4nMAssay Description:Antagonistic activity against Histamine H2 receptor expressed as the charge of receptor sensitivity was determined at pH 7.0More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
J. Uriach & Cía. S.A.

Curated by ChEMBL
LigandPNGBDBM50233086(8-(1-((5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl)met...)
Affinity DataKi:  5.5nMAssay Description:Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50518072(CHEMBL4581645)
Affinity DataKi:  6.5nMAssay Description:Displacement of [3H]-N-methylspiperone from dopamine D4 receptor (unknown origin) expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
J. Uriach & Cía. S.A.

Curated by ChEMBL
LigandPNGBDBM50020986(CHEMBL11002 | N-(2-Dimethylamino-ethyl)-4-(2,6-dio...)
Affinity DataKi:  6.5nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) enzyme from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
J. Uriach & Cía. S.A.

Curated by ChEMBL
LigandPNGBDBM50227339(CHEMBL158077)
Affinity DataKi:  6.5nMAssay Description:Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
J. Uriach & Cía. S.A.

Curated by ChEMBL
LigandPNGBDBM50391223(CHEMBL355370)
Affinity DataKi:  18nMAssay Description:In vitro inhibitory activity against beta-1 adrenergic receptor measured by inhibition of positive chronotropic effect of isoproterenolin in isolated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(BOVINE)
J. Uriach & Cía. S.A.

Curated by ChEMBL
LigandPNGBDBM50391227(CHEMBL273671)
Affinity DataKi:  22nMAssay Description:Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
J. Uriach & Cía. S.A.

Curated by ChEMBL
LigandPNGBDBM50042209(4-(2,6-Dioxo-1-propyl-2,3,6,7-tetrahydro-1H-purin-...)
Affinity DataKi:  53nMAssay Description:In vitro inhibitory activity against beta-2 adrenergic receptor was measured by the inhibition of isoproterenol-induced relaxation of PGF2-alpha cont...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
J. Uriach & Cía. S.A.

Curated by ChEMBL
LigandPNGBDBM50037429(8-(3-chlorostyryl)caffeine | 8-[(E)-2-(3-chlorophe...)
Affinity DataKi:  54nMAssay Description:Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1(GUINEA PIG)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50015529(4-(5-Cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
Affinity DataKi:  157nMAssay Description:Displacement of [3H]LTD4 from cysteinyl leukotriene receptor 1 in Hartley guinea pig parenchymal membrane after 30 mins by liquid scintillation count...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
J. Uriach & Cía. S.A.

Curated by ChEMBL
LigandPNGBDBM50118811(5-(1,3-Dibutyl-2,6-dioxo-1,2,3,6-tetrahydro-purin-...)
Affinity DataKi:  229nMAssay Description:In vitro inhibitory activity against beta-1 adrenergic receptor measured by inhibition of positive chronotropic effect of isoproterenolin in isolated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 5 group A member 2(Homo sapiens (Human))TBA
LigandPNGBDBM50418303(CHEMBL1765959)
Affinity DataKi:  400nMAssay Description:Binding affinity to human LRH-1More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Homo sapiens (Human))TBA
LigandPNGBDBM50417870(CHEMBL5271417)
Affinity DataKi:  1.20E+3nMAssay Description:Binding affinity to human LRH-1More data for this Ligand-Target Pair
TargetAdenosine receptor A1(Homo sapiens (Human))
J. Uriach & Cía. S.A.

Curated by ChEMBL
LigandPNGBDBM50018159(4-(1,3-Dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-pu...)
Affinity DataKi:  3.00E+3nMAssay Description:Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
J. Uriach & Cía. S.A.

Curated by ChEMBL
LigandPNGBDBM50391228(8-(P-Sulfophenyl)Theophylline | 8-(P-Sulfophenyl)T...)
Affinity DataKi:  4.50E+3nMAssay Description:Antagonist activity against beta-1 adrenergic receptor in isolated guinea pig atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50530480(CHEMBL4445524)
Affinity DataKi:  4.80E+3nMAssay Description:Competitive inhibition of full length human soluble epoxide hydrolase pre-incubated for 30 mins before DiFMUP substrate addition by fluorescence base...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50530480(CHEMBL4445524)
Affinity DataKi:  4.80E+3nMAssay Description:Competitive inhibition of full length human soluble epoxide hydrolase pre-incubated for 30 mins before DiFMUP substrate addition by fluorescence base...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))
J. Uriach & Cía. S.A.

Curated by ChEMBL
LigandPNGBDBM50014260(3,7-dihydro-3,7-dimethyl-1H-purine-2,6-dione | 3,7...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) enzyme from chicken liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
J. Uriach & Cía. S.A.

Curated by ChEMBL
LigandPNGBDBM50014260(3,7-dihydro-3,7-dimethyl-1H-purine-2,6-dione | 3,7...)
Affinity DataKi:  1.03E+5nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) enzyme from chicken liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
J. Uriach & Cía. S.A.

Curated by ChEMBL
LigandPNGBDBM50014260(3,7-dihydro-3,7-dimethyl-1H-purine-2,6-dione | 3,7...)
Affinity DataKi:  1.05E+5nMAssay Description:Ability to inhibit U-46,619-induced contraction of isolated strips of rabbit thoracic aorta, which is the measure of thromboxane receptor antagonismMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAdenosine receptor A2a(Homo sapiens (Human))
J. Uriach & Cía. S.A.

Curated by ChEMBL
LigandPNGBDBM50014260(3,7-dihydro-3,7-dimethyl-1H-purine-2,6-dione | 3,7...)
Affinity DataKi: >2.50E+5nMAssay Description:Ability to inhibit U-46,619-induced contraction of isolated strips of guinea pig tracheal chain, which is the measure of thromboxane receptor antagon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPeptidylglycine alpha-amidating monooxygenase(Rattus norvegicus)
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50273316(CHEMBL509495 | N-dansyl-Tyr-Val-D-Ala)
Affinity DataKi:  4.70E+5nMAssay Description:Inhibition of rat recombinant peptidylglycine alpha-amidating monooxygenase assessed as inhibition of N-dansyl-Tyr-Val-Gly amidationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidylglycine alpha-amidating monooxygenase(Rattus norvegicus)
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50273962(CHEMBL445286 | Phenylthioacetylglycine)
Affinity DataKi:  3.80E+6nMAssay Description:Inhibition of rat recombinant peptidylglycine alpha-amidating monooxygenase assessed as inhibition of N-dansyl-Tyr-Val-Gly amidationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1(GUINEA PIG)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50023198(8-[4-(4-phenylbutyloxy)benzoyl]amino-2-(tetrazol-5...)
Affinity DataIC50:  0.0440nMAssay Description:Displacement of [3H]ICI from cysteinyl leukotriene receptor 1 in Hartley guinea pig lung membrane after 30 mins by liquid scintillation counting meth...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50241116(CHEMBL4066332)
Affinity DataIC50:  1nMAssay Description:Inhibition of sEH in human HepG2 cells using 14(15)-EET-d11 as substrate assessed as reduction in conversion of 14(15)-EET-d11 to 14(15)-DHET-d11 pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50463011(CHEMBL4241985)
Affinity DataIC50:  1.30nMAssay Description:Antagonist activity at full length human FXR expressed in HeLa cells co-expressing BSEP-pGL3/pSG5-hRXR after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50009073(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of cysteinyl leukotriene receptor 1 (unknown origin) expressed in HEK293 cell membranes after 45 mins by scintillation spectrometryMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50586964(CHEMBL5074984)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant human full length sEH assessed as reduction in 6-methoxy-2-naphthaldehyde formation using PHOME as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50586969(CHEMBL5088299)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant human full length sEH assessed as reduction in 6-methoxy-2-naphthaldehyde formation using PHOME as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50581277(CHEMBL5089068)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins by fl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50586961(CHEMBL5078180)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant human full length sEH assessed as reduction in 6-methoxy-2-naphthaldehyde formation using PHOME as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50586956(CHEMBL5075652)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant human full length sEH assessed as reduction in 6-methoxy-2-naphthaldehyde formation using PHOME as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50239015(CHEBI:6993 | MK-476 | Montelukast Sodium | Singula...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of cysteinyl leukotriene receptor 1 (unknown origin) expressed in HEK293 cell membranes after 45 mins by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50586954(CHEMBL5079563)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant human full length sEH assessed as reduction in 6-methoxy-2-naphthaldehyde formation using PHOME as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50586962(CHEMBL5081457)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant human full length sEH assessed as reduction in 6-methoxy-2-naphthaldehyde formation using PHOME as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50586945(CHEMBL5084314)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant human full length sEH assessed as reduction in 6-methoxy-2-naphthaldehyde formation using PHOME as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50586963(CHEMBL5090087)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant human full length sEH assessed as reduction in 6-methoxy-2-naphthaldehyde formation using PHOME as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50586965(CHEMBL5074074)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant human full length sEH assessed as reduction in 6-methoxy-2-naphthaldehyde formation using PHOME as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50581272(CHEMBL5086882)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins by fl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50586955(CHEMBL5090873)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant human full length sEH assessed as reduction in 6-methoxy-2-naphthaldehyde formation using PHOME as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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