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Found 760 with Last Name = 'moore' and Initial = 'ml'
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412728(CHEMBL521523)
Affinity DataKi:  0.0316nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M3 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412340(CHEMBL540359)
Affinity DataKi:  0.316nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic acetylcholine M1 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50291823(19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzyl)-...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity of compound towards Vasopressin receptor by binding [3H]-LVP to dog renal medullary preparation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50291822(19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzyl)-...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity of compound towards Vasopressin receptor by binding [3H]-LVP to dog renal medullary preparation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Smith Kline And French Laboratories

Curated by ChEMBL
LigandPNGBDBM50452590(CHEMBL3084309)
Affinity DataKi:  0.940nMAssay Description:The compound was tested for the ability to displace opioid receptor kappa specific radioligand [3H]DADLEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50291821(1-[19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzy...)
Affinity DataKi:  0.990nMAssay Description:Binding affinity of compound towards Vasopressin receptor by binding [3H]-LVP to dog renal medullary preparation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50291821(1-[19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzy...)
Affinity DataKi:  0.990nMAssay Description:Binding affinity of compound towards Vasopressin receptor by binding [3H]-LVP to dog renal medullary preparation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50291824(1-[19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzy...)
Affinity DataKi:  1nMAssay Description:Binding affinity of compound towards Vasopressin receptor by binding [3H]-LVP to dog renal medullary preparation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50020673(1-[19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzy...)
Affinity DataKi:  1nMAssay Description:Binding affinity of compound towards Vasopressin receptor by binding [3H]-LVP to dog renal medullary preparation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50020667(1-[19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzy...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity of compound towards Vasopressin receptor by binding [3H]-LVP to dog renal medullary preparation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50020671(13-(2-Amino-ethyl)-19-benzyl-22-(4-ethoxy-benzyl)-...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of LVP stimulated adenylate cyclase activity in pig kidney medullary membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016752(CHEMBL339943 | N*1*-[1-(1-Carbamoyl-4-guanidino-bu...)
Affinity DataKi:  1.5nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase (Vasopressin V2 receptor) of medullary membranes of human kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Smith Kline And French Laboratories

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  1.5nMAssay Description:The compound was tested for the ability to displace opioid receptor kappa specific radioligand [3H]DADLEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Smith Kline And French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016829(10-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-1...)
Affinity DataKi:  2.30nMAssay Description:The compound was tested for the ability to displace delta-receptor specific radioligand [3H]DSLETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Smith Kline And French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016829(10-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-1...)
Affinity DataKi:  2.30nMAssay Description:The compound was tested for the ability to displace opioid receptor delta specific radioligand [3H]-DSLETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50020669(13-(2-Amino-ethyl)-19-benzyl-22-(4-ethoxy-benzyl)-...)
Affinity DataKi:  2.5nMAssay Description:Inhibition of LVP stimulated adenylate cyclase activity in pig kidney medullary membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Smith Kline And French Laboratories

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  2.5nMAssay Description:The compound was tested for the ability to displace delta-receptor specific radioligand [3H]DSLETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50020665(13-(2-Amino-ethyl)-19-benzyl-22-(4-ethoxy-benzyl)-...)
Affinity DataKi:  2.70nMAssay Description:Inhibition of LVP stimulated adenylate cyclase activity in pig kidney medullary membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50016752(CHEMBL339943 | N*1*-[1-(1-Carbamoyl-4-guanidino-bu...)
Affinity DataKi:  2.90nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney (Vasopressin V2 receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412340(CHEMBL540359)
Affinity DataKi:  3.16nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Smith Kline And French Laboratories

Curated by ChEMBL
LigandPNGBDBM50452590(CHEMBL3084309)
Affinity DataKi:  3.30nMAssay Description:The compound was tested for the ability to displace delta-receptor specific radioligand [3H]DSLETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016760(19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzyl)-...)
Affinity DataKi:  3.30nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of human kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50220180(CHEMBL243669 | N-[3-fluoro-4'-(trifluoromethyl)-4-...)
Affinity DataKi:  3.5nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Smith Kline And French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016830(13-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-7...)
Affinity DataKi:  3.5nMAssay Description:The compound was tested for the ability to displace opioid receptor kappa specific radioligand [3H]DADLEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50452524(CHEMBL2372291)
Affinity DataKi:  3.60nMAssay Description:In vitro antagonist activity of the compound was measured by inhibition of vasopressin-stimulated adenylate cyclase in renal medullary preparation in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016756(CHEMBL265591 | c(Pmp-D-Tyr(Et)-Phe-Val-Asn-Cys)-Pr...)
Affinity DataKi:  3.70nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of human kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50020654(1-[19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzy...)
Affinity DataKi:  3.90nMAssay Description:Compound was tested for inhibition against V2 vasopressin receptor in pig renal medullary membrane preparations.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50020667(1-[19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzy...)
Affinity DataKi:  3.90nMAssay Description:Inhibition of LVP stimulated adenylate cyclase activity in pig kidney medullary membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016753(1-[20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzy...)
Affinity DataKi:  4.20nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of human kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50016753(1-[20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzy...)
Affinity DataKi:  4.20nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016757(1-[20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzy...)
Affinity DataKi:  4.40nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of human kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50016757(1-[20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzy...)
Affinity DataKi:  4.40nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50020655(CHEMBL408474 | [6-Amino-2-({1-[19-amino-13-benzyl-...)
Affinity DataKi:  4.60nMAssay Description:Tested for inhibition of [3H]-LVP binding to vasopressin receptor in medullary membranes of pig kidney.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50020655(CHEMBL408474 | [6-Amino-2-({1-[19-amino-13-benzyl-...)
Affinity DataKi:  4.60nMAssay Description:Compound was tested for inhibition of hog kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50016747(1-[20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzy...)
Affinity DataKi:  4.70nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016747(1-[20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzy...)
Affinity DataKi:  4.80nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of human kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50020675(1-[13-Benzyl-7-carbamoylmethyl-16-(4-ethoxy-benzyl...)
Affinity DataKi:  5.30nMAssay Description:Compound was tested for inhibition against V2 vasopressin receptor in pig renal medullary membrane preparations.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Smith Kline And French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016833(13-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-7...)
Affinity DataKi:  5.40nMAssay Description:The compound was tested for the ability to displace opioid receptor kappa specific radioligand [3H]DADLEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Smith Kline And French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016833(13-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-7...)
Affinity DataKi:  5.40nMAssay Description:The compound was tested for the ability to displace opioid receptor kappa specific radioligand [3H]DADLEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50016760(19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzyl)-...)
Affinity DataKi:  5.80nMAssay Description:Tested for inhibition of vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50020666(13-(2-Amino-ethyl)-19-benzyl-22-(4-ethoxy-benzyl)-...)
Affinity DataKi:  5.80nMAssay Description:Inhibition of LVP stimulated adenylate cyclase activity in pig kidney medullary membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50016760(19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzyl)-...)
Affinity DataKi:  5.80nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50016756(CHEMBL265591 | c(Pmp-D-Tyr(Et)-Phe-Val-Asn-Cys)-Pr...)
Affinity DataKi:  6nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50220182(CHEMBL390629 | N-[4'-(trifluoromethyl)-4-biphenyly...)
Affinity DataKi:  6.20nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50020673(1-[19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzy...)
Affinity DataKi:  6.40nMAssay Description:Inhibition of LVP stimulated adenylate cyclase activity in pig kidney medullary membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50020653(1-[19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzy...)
Affinity DataKi:  6.40nMAssay Description:Tested for inhibition of vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50020653(1-[19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzy...)
Affinity DataKi:  6.40nMAssay Description:Compound was tested for inhibition against V2 vasopressin receptor in pig renal medullary membrane preparations.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016755(20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzyl)-...)
Affinity DataKi:  6.60nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase (Vasopressin V2 receptor) of medullary membranes of human kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50016755(20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzyl)-...)
Affinity DataKi:  6.80nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney (Vasopressin V2 receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50016763(1-[20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzy...)
Affinity DataKi:  7.60nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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