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Found 347 with Last Name = 'myers' and Initial = 'sh'
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50248510(CHEMBL489326 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  0.0350nMAssay Description:Inhibition of human recombinant full length VEGFR2 using poly (Glu,Tyr) as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50565800(Azd-1390 | Azd1390)
Affinity DataIC50:  0.0900nMAssay Description:Inhibition of ATM (unknown origin) assessed as ATM-dependent phosphorylation using GST-p53 ser15 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50399540(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human full length MET by scintillation counting method in presence of 33P-gammaATPMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of wild-type human partial length AXL (R497 to Y821 residues) expressed in bacterial expression system using poly [Glu, Try] 4:1 as substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of wild-type human partial length FLT3 (V592 to Y969 residues) expressed in bacterial expression system using poly [Glu, Try] 4:1 as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50399540(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM144315(Gilteritinib | US11512074, Example T-9 | US8969336...)
Affinity DataIC50: <1nMAssay Description:Inhibition of AXL (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM4552(4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human ABL using EAIYAAPFAKKK as substrate after 40 mins by scintillation counting analysis in presence of [gamma-33P-ATP]More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM24498(3-(3-fluoro-4-{[2-(1-methyl-1H-imidazol-4-yl)thien...)
Affinity DataIC50:  1nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM24498(3-(3-fluoro-4-{[2-(1-methyl-1H-imidazol-4-yl)thien...)
Affinity DataIC50:  1nMAssay Description:Inhibition of MET (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM4552(4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human SRC (1 to 530 residues) using GGEEEEYFELVKKKK as substrate after 40 mins by scintillation counting analysis in presence of [gamma...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM4552(4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human BMX using poly(Glu,Tyr) 4:1 as substrate after 40 mins by scintillation counting analysis in presence of [gamma-33P-ATP]More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM4552(4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human MEK1 after 40 mins in presence of MgATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHepatocyte growth factor receptor(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50248510(CHEMBL489326 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human recombinant full length MET using poly (Glu,Tyr) as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50455346(CHEMBL4218175)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of wild-type human partial length FLT3 (V592 to Y969 residues) expressed in bacterial expression system using poly [Glu, Try] 4:1 as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50538983(CHEMBL3797933)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50248510(CHEMBL489326 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of VEGFR2 in human MDA-MB-231 cells assessed as receptor phosphorylation after 1 to 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489)
Affinity DataIC50:  2nMAssay Description:Inhibition of human partial length FLT3 D835Y mutant (Q580 to Y969 residues) expressed in bacterial expression system using poly [Glu, Try] 4:1 as su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172078(LY-2801653 | Merestinib)
Affinity DataIC50:  2nMAssay Description:Inhibition of human full length AXL after 4 hrs followed by stimulation with human recombinant Gas6 for 15 minutes by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50565801(CHEMBL4780868)
Affinity DataIC50:  2.80nMAssay Description:Displacement of kinase tracer178 from recombinant WEE1 (unknown origin) incubated for 1 hr by lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50384576(CHEMBL2036808)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of MER (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489)
Affinity DataIC50:  3nMAssay Description:Inhibition of wild-type human partial length RET (E713 to D1014 residues) expressed in bacterial expression system using poly [Glu, Try] 4:1 as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50110178(CHEMBL3603847 | US10787436, Compound I-23)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human CDK7 incubated for 180 mins by LanthaScreen Eu Kinase binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50538983(CHEMBL3797933)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50455346(CHEMBL4218175)
Affinity DataIC50:  4nMAssay Description:Inhibition of human partial length FLT3 D835Y mutant (Q580 to Y969 residues) expressed in bacterial expression system using poly [Glu, Try] 4:1 as su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50240826(AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of N-terminal GST-fused human WEE1 (215 to 646 residues) expressed in baculovirus expression system using poly(Lys,Tyr) as substrate incub...More data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50455346(CHEMBL4218175)
Affinity DataIC50:  6nMAssay Description:Inhibition of human partial length Aurora A (E122 to K401 residues) expressed in mammalian expression system using poly [Glu, Try] 4:1 as substrate i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50455346(CHEMBL4218175)
Affinity DataIC50:  6nMAssay Description:Inhibition of wild-type human partial length RET (E713 to D1014 residues) expressed in bacterial expression system using poly [Glu, Try] 4:1 as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489)
Affinity DataIC50:  6nMAssay Description:Inhibition of human partial length FLT3 ITD mutant expressed in bacterial expression system using poly [Glu, Try] 4:1 as substrate in presence of [ga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50565799(CHEMBL4780892)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of ATM (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM268079(2-[(3R)-3-methylmorpholin-4-yl]-4-(1-methyl-1H-pyr...)
Affinity DataIC50:  7nMAssay Description:Displacement of 5-TAMRA-labelled Tracer A from human GST-fused/FLAG-tagged full length ATR/human N-terminal FLAG-tagged full length ATRIP expressed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172080(CHEMBL3808948)
Affinity DataIC50:  7nMAssay Description:Inhibition of human AXL by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50248510(CHEMBL489326 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant full length AXL using poly (Glu,Tyr) as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50248510(CHEMBL489326 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of MET in human MDA-MB-231 cells assessed as receptor phosphorylation after 1 to 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50455354(CHEMBL4208852)
Affinity DataIC50:  8nMAssay Description:Inhibition of wild-type human partial length FLT3 (V592 to Y969 residues) expressed in bacterial expression system using poly [Glu, Try] 4:1 as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489)
Affinity DataIC50:  8nMAssay Description:Inhibition of wild-type human partial length VEGFR2 (R787 to P1253 residues) expressed in mammalian expression system using poly [Glu, Try] 4:1 as su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant AXL expressed in Escherichia coli BL21 infected with T7 phage by qPCR methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172077(CHEMBL3810063)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant AXL expressed in Escherichia coli BL21 infected with T7 phage by qPCR methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172078(LY-2801653 | Merestinib)
Affinity DataIC50:  11nMAssay Description:Inhibition of human full length AXL by scintillation counting method in presence of 33P-gammaATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50455346(CHEMBL4218175)
Affinity DataIC50:  11nMAssay Description:Inhibition of human partial length FLT3 ITD mutant expressed in bacterial expression system using poly [Glu, Try] 4:1 as substrate in presence of [ga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50399540(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Affinity DataIC50:  11nMAssay Description:Inhibition of AXL (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50455354(CHEMBL4208852)
Affinity DataIC50:  12nMAssay Description:Inhibition of human partial length FLT3 D835Y mutant (Q580 to Y969 residues) expressed in bacterial expression system using poly [Glu, Try] 4:1 as su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50208517(2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one | C...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human HeLa nuclear extract derived ATM using glutathioneS-transferase-p53N66 as substrate preincubated for 10 mins followed by ATP addi...More data for this Ligand-Target Pair
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50145038(CHEMBL2143829)
Affinity DataIC50:  13nMAssay Description:Inhibition of full length Flag-tagged ATM (unknown origin) using GST-p53(1 to 101 residues) as substrates incubated for 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50455346(CHEMBL4218175)
Affinity DataIC50:  13nMAssay Description:Inhibition of wild-type human partial length AXL (R497 to Y821 residues) expressed in bacterial expression system using poly [Glu, Try] 4:1 as substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489)
Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant AXL by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50384600(CHEMBL2036792 | US9744172, Compound UNC00000563A)
Affinity DataIC50:  14nMAssay Description:Inhibition of AXL (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM200300(5-[4-amino-1-(2,2-diethoxyethyl)pyrazolo[3,4-d]pyr...)
Affinity DataIC50:  15nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489)
Affinity DataIC50:  15nMAssay Description:Inhibition of wild-type human partial length MER (R557 to L884 residues) expressed in bacterial expression system using poly [Glu, Try] 4:1 as substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
University Of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489)
Affinity DataIC50:  17nMAssay Description:Inhibition of wild-type human partial length TYRO3 (S497 to T814 residues) expressed in bacterial expression system using poly [Glu, Try] 4:1 as subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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