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Found 236 with Last Name = 'naef' and Initial = 'r'
TargetAdenosine receptor A1(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207120(3-isobutyl-8-((6-methoxyisoquinolin-4-yl)methyl)-1...)
Affinity DataKi:  2.30E+3nMAssay Description:Inhibition of adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM651387((E)-2-(5-((4-(2-hydroxyethyl)piperidin-1-yl)sulfon...)
Affinity DataIC50:  0.160nMAssay Description:Experimental protocol: The test compound, i.e the compound of the present invention, reference compound or water (control) are added to a buffer cont...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM536301((E)-2-(2-ethoxy-5-((4-methylpiperazin-1-yl)sulfony...)
Affinity DataIC50:  0.25nMAssay Description:Experimental protocol: The test compound, i.e the compound of the present invention, reference compound or water (control) are added to a buffer cont...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM536314((E)-2-(2-ethoxy-5-((4-(3-hydroxypropyl)piperazin-1...)
Affinity DataIC50:  0.420nMAssay Description:Experimental protocol: The test compound, i.e the compound of the present invention, reference compound or water (control) are added to a buffer cont...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM651390((E)-2-(2-ethoxy-5-((4-(2-hydroxyethyl)piperidin-1l...)
Affinity DataIC50:  0.480nMAssay Description:Experimental protocol: The test compound, i.e the compound of the present invention, reference compound or water (control) are added to a buffer cont...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM536303((E)-5-methyl-2-(5-((4-methylpiperazin-1-yl)sulfony...)
Affinity DataIC50:  0.530nMAssay Description:Experimental protocol: The test compound, i.e the compound of the present invention, reference compound or water (control) are added to a buffer cont...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM536306(3-(2-(2-ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl...)
Affinity DataIC50:  1.5nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM536306(3-(2-(2-ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl...)
Affinity DataIC50:  1.5nMAssay Description:Experimental protocol: The test compound, i.e the compound of the present invention, reference compound or water (control) are added to a buffer cont...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM536304((E)-2-(5-((4-(2-hydroxyethyl)piperidin-1-yl)sulfon...)
Affinity DataIC50:  1.60nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM50207130(8-((6,7-dimethoxy-1-methylisoquinolin-4-yl)methyl)...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM50207120(3-isobutyl-8-((6-methoxyisoquinolin-4-yl)methyl)-1...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM536316(2-(2-ethoxy-5-((4-(3-hydroxypropyl)piperazin-1-yl)...)
Affinity DataIC50:  2.80nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM536316(2-(2-ethoxy-5-((4-(3-hydroxypropyl)piperazin-1-yl)...)
Affinity DataIC50:  2.80nMAssay Description:Experimental protocol: The test compound, i.e the compound of the present invention, reference compound or water (control) are added to a buffer cont...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP04972/P11541/P16586/P22571/P23439/Q95142(Bos taurus)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117721(3-Isobutyl-1-methyl-8-[5-(piperazin-1-ylmethanesul...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration against bovine retina phosphodiesterase 6 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM50117734(8-{5-[4-(2-Hydroxy-ethyl)-piperidine-1-sulfonyl]-2...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM50117719(4-[3-(3-Isobutyl-1-methyl-2,6-dioxo-2,3,6,7-tetrah...)
Affinity DataIC50:  3.5nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM50117711(8-{5-[4-(2-Hydroxy-ethyl)-piperazine-1-sulfonyl]-2...)
Affinity DataIC50:  3.5nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM536307(2-(2-ethoxy-5-((4-(2-hydroxyethyl)piperazin-1-yl)s...)
Affinity DataIC50:  4.10nMAssay Description:Experimental protocol: The test compound, i.e the compound of the present invention, reference compound or water (control) are added to a buffer cont...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM536307(2-(2-ethoxy-5-((4-(2-hydroxyethyl)piperazin-1-yl)s...)
Affinity DataIC50:  4.10nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM536314((E)-2-(2-ethoxy-5-((4-(3-hydroxypropyl)piperazin-1...)
Affinity DataIC50:  4.20nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM536310((E)-2-(2-ethoxy-5-((4-(2-hydroxyethyl)piperidin-1-...)
Affinity DataIC50:  4.80nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM50117724(3-(3-Isobutyl-1-methyl-2,6-dioxo-2,3,6,7-tetrahydr...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM50207121(CHEMBL245648 | N-(4-((8-((6,7-dimethoxyisoquinolin...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM536303((E)-5-methyl-2-(5-((4-methylpiperazin-1-yl)sulfony...)
Affinity DataIC50:  5.30nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Affinity DataIC50:  5.40nMAssay Description:TBDMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Affinity DataIC50:  5.40nMAssay Description:Experimental protocol: The test compound, i.e the compound of the present invention, reference compound or water (control) are added to a buffer cont...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM50117721(3-Isobutyl-1-methyl-8-[5-(piperazin-1-ylmethanesul...)
Affinity DataIC50:  5.5nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP04972/P11541/P16586/P22571/P23439/Q95142(Bos taurus)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117715(3-Isobutyl-1-methyl-8-[5-(4-methyl-piperazine-1-su...)
Affinity DataIC50:  6nMAssay Description:Inhibitory concentration against bovine retina phosphodiesterase 6 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM50207123(8-((6,7-dimethoxyisoquinolin-4-yl)methyl)-3-(3-hyd...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM50207127(8-((6,7-dimethoxyisoquinolin-4-yl)methyl)-1-methyl...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM50117707(8-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phe...)
Affinity DataIC50:  9nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM50207132(8-((6,7-dimethoxyisoquinolin-4-yl)methyl)-3-isobut...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM50117715(3-Isobutyl-1-methyl-8-[5-(4-methyl-piperazine-1-su...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM50117715(3-Isobutyl-1-methyl-8-[5-(4-methyl-piperazine-1-su...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM50117714(CHEMBL90164 | N-(2-Dimethylamino-ethyl)-N-ethyl-3-...)
Affinity DataIC50:  11nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM50117729(3-Isobutyl-8-{5-[4-(2-methoxy-ethyl)-piperazine-1-...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM536315((E)-3-(4-((4-ethoxy-3-(6-((hydroxyimino)methyl)-5-...)
Affinity DataIC50:  12nMAssay Description:Experimental protocol: The test compound, i.e the compound of the present invention, reference compound or water (control) are added to a buffer cont...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM536302(2-(2-ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)ph...)
Affinity DataIC50:  12nMAssay Description:Experimental protocol: The test compound, i.e the compound of the present invention, reference compound or water (control) are added to a buffer cont...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM536315((E)-3-(4-((4-ethoxy-3-(6-((hydroxyimino)methyl)-5-...)
Affinity DataIC50:  12nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM536302(2-(2-ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)ph...)
Affinity DataIC50:  12nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP04972/P11541/P16586/P22571/P23439/Q95142(Bos taurus)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117719(4-[3-(3-Isobutyl-1-methyl-2,6-dioxo-2,3,6,7-tetrah...)
Affinity DataIC50:  14nMAssay Description:Inhibitory concentration against bovine retina phosphodiesterase 6 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP04972/P11541/P16586/P22571/P23439/Q95142(Bos taurus)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117711(8-{5-[4-(2-Hydroxy-ethyl)-piperazine-1-sulfonyl]-2...)
Affinity DataIC50:  15nMAssay Description:Inhibitory concentration against bovine retina phosphodiesterase 6 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50072197(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethyl-6...)
Affinity DataIC50:  15nMAssay Description:Evaluated for the inhibition of [3H]rolipram binding to membrane-bound PDE4.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP04972/P11541/P16586/P22571/P23439/Q95142(Bos taurus)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117724(3-(3-Isobutyl-1-methyl-2,6-dioxo-2,3,6,7-tetrahydr...)
Affinity DataIC50:  16nMAssay Description:Inhibitory concentration against bovine retina phosphodiesterase 6 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM50117732(3-Isobutyl-8-[2-isopropoxy-5-(4-methyl-piperazine-...)
Affinity DataIC50:  16nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50072197(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethyl-6...)
Affinity DataIC50:  16nMAssay Description:Evaluated for its ability to inhibit PDE3.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM50117722(CHEMBL89239 | N-(2-Dimethylamino-ethyl)-3-(3-isobu...)
Affinity DataIC50:  16nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP04972/P11541/P16586/P22571/P23439/Q95142(Bos taurus)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117734(8-{5-[4-(2-Hydroxy-ethyl)-piperidine-1-sulfonyl]-2...)
Affinity DataIC50:  17nMAssay Description:Inhibitory concentration against bovine retina phosphodiesterase 6 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM50117736(8-{2-Ethoxy-5-[4-(2-hydroxy-ethyl)-piperazine-1-su...)
Affinity DataIC50:  19nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Topadur Pharma

US Patent
LigandPNGBDBM50117701(8-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phe...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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