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Found 211 with Last Name = 'narayana' and Initial = 'b'
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Nci-Fcrdc

LigandPNGBDBM200((2S)-N-[(2S,3R,5S)-3-hydroxy-5-[(2S)-3-methyl-2-{[...)
Affinity DataKi:  0.00400nM ΔG°:  -66.1kJ/molepH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay using the internally quenched fluorogenic substrate DABCYL-GABA-Ser-Gln-Tyr-P...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Nci-Fcrdc

LigandPNGBDBM198((2S)-N-[(2S,3S,4S,5S)-3,4-dihydroxy-5-[(2S)-3-meth...)
Affinity DataKi:  0.0110nM ΔG°:  -63.6kJ/molepH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay using the internally quenched fluorogenic substrate DABCYL-GABA-Ser-Gln-Tyr-P...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Nci-Fcrdc

LigandPNGBDBM199((2S)-N-[(2S,3R,4S,5S)-3,4-dihydroxy-5-[(2S)-3-meth...)
Affinity DataKi:  0.0120nM ΔG°:  -63.4kJ/molepH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay using the internally quenched fluorogenic substrate DABCYL-GABA-Ser-Gln-Tyr-P...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Nci-Fcrdc

LigandPNGBDBM197((2S)-N-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[(2S)-3-meth...)
Affinity DataKi:  0.112nM ΔG°:  -57.7kJ/molepH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay using the internally quenched fluorogenic substrate DABCYL-GABA-Ser-Gln-Tyr-P...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program

Curated by ChEMBL
LigandPNGBDBM18793(6,6-dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]...)
Affinity DataKi:  7.70nMAssay Description:Binding affinity to human recombinant DHFR expressed in Escherichia coli BL21(DE3) by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program

Curated by ChEMBL
LigandPNGBDBM50035483(5-Chloro-N*6*-(2,5-dimethoxy-benzyl)-quinazoline-2...)
Affinity DataKi:  10.2nMAssay Description:Binding affinity to human recombinant DHFR expressed in Escherichia coli BL21(DE3) by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program

Curated by ChEMBL
LigandPNGBDBM18512(5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)
Affinity DataKi:  30.8nMAssay Description:Binding affinity to human recombinant DHFR expressed in Escherichia coli BL21(DE3) by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDihydrofolate reductase(Homo sapiens (Human))
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program

Curated by ChEMBL
LigandPNGBDBM18792(1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-...)
Affinity DataKi:  55.6nMAssay Description:Binding affinity to human recombinant DHFR expressed in Escherichia coli BL21(DE3) by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxaloacetate decarboxylase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
University of Maryland Biotechnology Institute

LigandPNGBDBM92964(CHEMBL182928 | Oxalate)
Affinity DataKi:  4.30E+4nMAssay Description:Competitive inhibition constant determined for PA4872 catalyzed oxaloacetate decarboxylation.More data for this Ligand-Target Pair
TargetOxaloacetate decarboxylase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
University of Maryland Biotechnology Institute

LigandPNGBDBM92965(3,3-Difluoroxaloacetate)
Affinity DataKi:  4.50E+5nMAssay Description:Competitive inhibition constant determined for PA4872 catalyzed oxaloacetate decarboxylation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxaloacetate decarboxylase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
University of Maryland Biotechnology Institute

LigandPNGBDBM92966(Acetopyruvate)
Affinity DataKi:  5.60E+5nMAssay Description:Competitive inhibition constant determined for PA4872 catalyzed oxaloacetate decarboxylation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxaloacetate decarboxylase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
University of Maryland Biotechnology Institute

LigandPNGBDBM92966(Acetopyruvate)
Affinity DataKi:  1.09E+6nMAssay Description:Competitive inhibition constant determined for PA4872 catalyzed oxaloacetate decarboxylation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxaloacetate decarboxylase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
University of Maryland Biotechnology Institute

LigandPNGBDBM92967(Phosphonopyruvate)
Affinity DataKi:  3.00E+6nMAssay Description:Competitive inhibition constant determined for PA4872 catalyzed oxaloacetate decarboxylation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxaloacetate decarboxylase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
University of Maryland Biotechnology Institute

LigandPNGBDBM50273976(2-oxopentanoate | 2-oxovalerate | alpha-ketovalera...)
Affinity DataKi:  3.20E+6nMAssay Description:Competitive inhibition constant determined for PA4872 catalyzed oxaloacetate decarboxylation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxaloacetate decarboxylase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
University of Maryland Biotechnology Institute

LigandPNGBDBM50273976(2-oxopentanoate | 2-oxovalerate | alpha-ketovalera...)
Affinity DataKi:  6.70E+6nMAssay Description:Competitive inhibition constant determined for PA4872 catalyzed oxaloacetate decarboxylation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxaloacetate decarboxylase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
University of Maryland Biotechnology Institute

LigandPNGBDBM50159792(CHEMBL181886 | Natriumpyruvat | Pyruvate | pyruvic...)
Affinity DataKi:  7.20E+6nMAssay Description:Competitive inhibition constant determined for PA4872 catalyzed oxaloacetate decarboxylation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50603975(CHEMBL5201780)
Affinity DataIC50:  3nMAssay Description:Inhibition of human Haspin kinase domain using histone H3 biotin peptide as substrate preincubated with enzyme for 30 mins followed by substrate and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50603974(CHEMBL5201904)
Affinity DataIC50:  5nMAssay Description:Inhibition of human Haspin kinase domain using histone H3 biotin peptide as substrate preincubated with enzyme for 30 mins followed by substrate and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50603992(CHEMBL5179988)
Affinity DataIC50:  11nMAssay Description:Inhibition of human Haspin kinase domain using histone H3 biotin peptide as substrate preincubated with enzyme for 30 mins followed by substrate and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50603978(CHEMBL5187817)
Affinity DataIC50:  32nMAssay Description:Inhibition of human Haspin kinase domain using histone H3 biotin peptide as substrate preincubated with enzyme for 30 mins followed by substrate and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50603989(CHEMBL5192443)
Affinity DataIC50:  45nMAssay Description:Inhibition of human Haspin kinase domain using histone H3 biotin peptide as substrate preincubated with enzyme for 30 mins followed by substrate and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50603986(CHEMBL5187610)
Affinity DataIC50:  78nMAssay Description:Inhibition of human Haspin kinase domain using histone H3 biotin peptide as substrate preincubated with enzyme for 30 mins followed by substrate and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50603988(CHEMBL5170360)
Affinity DataIC50:  140nMAssay Description:Inhibition of human Haspin kinase domain using histone H3 biotin peptide as substrate preincubated with enzyme for 30 mins followed by substrate and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50603984(CHEMBL5195201)
Affinity DataIC50:  200nMAssay Description:Inhibition of human Haspin kinase domain using histone H3 biotin peptide as substrate preincubated with enzyme for 30 mins followed by substrate and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50603985(CHEMBL5207627)
Affinity DataIC50:  690nMAssay Description:Inhibition of human Haspin kinase domain using histone H3 biotin peptide as substrate preincubated with enzyme for 30 mins followed by substrate and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50603979(CHEMBL5204715)
Affinity DataIC50:  770nMAssay Description:Inhibition of human Haspin kinase domain using histone H3 biotin peptide as substrate preincubated with enzyme for 30 mins followed by substrate and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50603976(CHEMBL5200247)
Affinity DataIC50:  1.28E+3nMAssay Description:Inhibition of human Haspin kinase domain using histone H3 biotin peptide as substrate preincubated with enzyme for 30 mins followed by substrate and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50603983(CHEMBL5181699)
Affinity DataIC50:  1.33E+3nMAssay Description:Inhibition of human Haspin kinase domain using histone H3 biotin peptide as substrate preincubated with enzyme for 30 mins followed by substrate and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50347943(CHEMBL1800770)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by Q-patch assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50318672((1R,3S)-5'-Chloro-3-methyl-2,3,4,9-tetrahydrospiro...)
Affinity DataIC50:  1.51E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsome by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50318670((1R,3S)-5'-Chloro-6-fluoro-3-methyl-2,3,4,9-tetrah...)
Affinity DataIC50:  1.72E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsome by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50603977(CHEMBL5189523)
Affinity DataIC50:  1.74E+3nMAssay Description:Inhibition of human Haspin kinase domain using histone H3 biotin peptide as substrate preincubated with enzyme for 30 mins followed by substrate and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50347944(CHEMBL1800772)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by Q-patch assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50603977(CHEMBL5189523)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of hERG by Qpatch-clamp methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM597562(US11597733, Example 4-0)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of human FLT3More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50603987(CHEMBL5189235)
Affinity DataIC50:  4.04E+3nMAssay Description:Inhibition of human Haspin kinase domain using histone H3 biotin peptide as substrate preincubated with enzyme for 30 mins followed by substrate and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50318668((1R,3S)-5',7-Dichloro-3-methyl-2,3,4,9-tetrahydros...)
Affinity DataIC50:  4.11E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsome by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM597562(US11597733, Example 4-0)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50347945(CHEMBL1800774)
Affinity DataIC50:  4.80E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by Q-patch assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50603980(CHEMBL5173325)
Affinity DataIC50:  4.96E+3nMAssay Description:Inhibition of human Haspin kinase domain using histone H3 biotin peptide as substrate preincubated with enzyme for 30 mins followed by substrate and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50603981(CHEMBL5196893)
Affinity DataIC50:  5.31E+3nMAssay Description:Inhibition of human Haspin kinase domain using histone H3 biotin peptide as substrate preincubated with enzyme for 30 mins followed by substrate and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM597562(US11597733, Example 4-0)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50318666((1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-2,3,4,9-te...)
Affinity DataIC50:  5.42E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsome by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM597562(US11597733, Example 4-0)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of human Haspin kinase domain using histone H3 biotin peptide as substrate preincubated with enzyme for 30 mins followed by substrate and ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50347939(CHEMBL1800137)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by Q-patch assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50347947(CHEMBL1800776)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by Q-patch assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50347939(CHEMBL1800137)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of human ERG channel expressed in CHO cells by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50347941(CHEMBL1800768)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by Q-patch assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50388532(CHEMBL2058833)
Affinity DataIC50: >6.00E+3nMAssay Description:Inhibition of human CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50388532(CHEMBL2058833)
Affinity DataIC50: >6.00E+3nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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