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Found 108 with Last Name = 'newman' and Initial = 'me'
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  0.710nMAssay Description:Displacement of [3H]-NPA from rat brain Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50007692(8-[4-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-bu...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]-NPA from rat brain Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50048806(5-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-et...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]-NPA from rat brain Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50048807(5-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-et...)
Affinity DataKi:  3.10nMAssay Description:Displacement of [3H]-NPA from rat brain Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50001885((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Affinity DataKi:  3.70nMAssay Description:Displacement of [3H]-NPA from rat brain Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50048804(5-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-et...)
Affinity DataKi:  3.80nMAssay Description:Displacement of [3H]-NPA from rat brain Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50048805(5-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-et...)
Affinity DataKi:  4.20nMAssay Description:Displacement of [3H]-NPA from rat brain Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50048802(5'-[2-(4-benzo[d]isothiazol-3-ylhexahydro-1-pyrazi...)
Affinity DataKi:  4.20nMAssay Description:Displacement of [3H]-NPA from rat brain Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50048803(5-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)et...)
Affinity DataKi:  4.80nMAssay Description:Displacement of [3H]-NPA from rat brain Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50048800(6-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-et...)
Affinity DataKi:  5.10nMAssay Description:Displacement of [3H]-NPA from rat brain Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50048801(6-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-et...)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]-NPA from rat brain Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  45nMAssay Description:In vitro ability of the compound to displace [3H]-ketanserin from 5-hydroxytryptamine 2A receptor in rat brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataKi:  83nMAssay Description:Displacement of [3H]-NPA from rat brain Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50015711(3-(1,2,3,6-Tetrahydro-pyridin-4-yl)-1H-indole-5-ca...)
Affinity DataIC50:  0.800nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]-5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50015714(3-(1,2,3,6-Tetrahydro-pyridin-4-yl)-1H-indol-5-ol ...)
Affinity DataIC50:  1.20nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]-5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50015712(5-Fluoro-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-in...)
Affinity DataIC50:  1.90nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]-5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM81498(5-Methoxy-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-i...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]-5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50007558(6-[2-(4-Naphthalen-1-yl-piperazin-1-yl)-ethyl]-3H-...)
Affinity DataIC50:  2.20nMAssay Description:Binding affinity to 5-hydroxytryptamine 1A receptor in the rat brain using [3H]-8-hydroxy-2-(di-n-propylamine)tetralin as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50007563(1-Ethyl-5-[2-(4-naphthalen-1-yl-piperazin-1-yl)-et...)
Affinity DataIC50:  2.90nMAssay Description:Binding affinity to 5-hydroxytryptamine 1A receptor in the rat brain using [3H]-8-hydroxy-2-(di-n-propylamine)tetralin as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Affinity DataIC50:  3nMAssay Description:Binding affinity of the compound was measured against serotonin 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]-5-HT as the radioligandMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1D(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50039564(CHEMBL83597 | [3-((R)-1-Methyl-pyrrolidin-2-ylmeth...)
Affinity DataIC50:  3.10nMAssay Description:Binding affinity of the compound was measured against serotonin 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50:  3.10nMAssay Description:Compound was evaluated In vitro for its activity by binding to Dopamine receptor D2 in the rat brain using [3H]-NPA as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50015709(5-Bromo-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-ind...)
Affinity DataIC50:  3.20nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]-5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50015717(5-Chloro-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-in...)
Affinity DataIC50:  3.30nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]-5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50015718(5-Nitro-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-ind...)
Affinity DataIC50:  3.5nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]-5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM31023(3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole | CHE...)
Affinity DataIC50:  3.70nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]-5-HT as the radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50007559(5-[2-(4-Naphthalen-1-yl-piperazin-1-yl)-ethyl]-1,3...)
Affinity DataIC50:  4.87nMAssay Description:Binding affinity to 5-hydroxytryptamine 1A receptor in the rat brain using [3H]-8-hydroxy-2-(di-n-propylamine)tetralin as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]-5-HT as the radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Affinity DataIC50:  5.20nMAssay Description:Binding affinity of the compound was measured against serotonin 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Affinity DataIC50:  5.20nMAssay Description:Displacement of [3H]-8-OH-DPAT from rat cortex 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1D(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50039566((3-Nitro-pyridin-2-yl)-(3-(R)-1-pyrrolidin-2-ylmet...)
Affinity DataIC50:  6.20nMAssay Description:Binding affinity of the compound was measured against serotonin 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50007556(6-[2-(4-Naphthalen-1-yl-piperazin-1-yl)-ethyl]-3H-...)
Affinity DataIC50:  6.20nMAssay Description:Binding affinity to 5-hydroxytryptamine 1A receptor in the rat brain using [3H]-8-hydroxy-2-(di-n-propylamine)tetralin as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50007557(3,3-Dimethyl-5-[2-(4-naphthalen-1-yl-piperazin-1-y...)
Affinity DataIC50:  6.90nMAssay Description:Binding affinity to 5-hydroxytryptamine 1A receptor in the rat brain using [3H]-8-hydroxy-2-(di-n-propylamine)tetralin as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50039565(CHEMBL314213 | [3-(2-Dimethylamino-ethyl)-1H-indol...)
Affinity DataIC50:  10nMAssay Description:Binding affinity of the compound was measured against serotonin 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50007562(4-{4-[2-(4-Naphthalen-1-yl-piperazin-1-yl)-ethyl]-...)
Affinity DataIC50:  11nMAssay Description:Binding affinity to 5-hydroxytryptamine 1A receptor in the rat brain using [3H]-8-hydroxy-2-(di-n-propylamine)tetralin as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50015709(5-Bromo-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-ind...)
Affinity DataIC50:  13nMAssay Description:Displacement of [3H]-8-OH-DPAT from rat cortex 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM81498(5-Methoxy-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-i...)
Affinity DataIC50:  14nMAssay Description:Displacement of [3H]-8-OH-DPAT from rat cortex 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM84737(3-(1,2,3,6-Tetrahydro-pyridin-4-yl)-1,4-dihydro-py...)
Affinity DataIC50:  15nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50039567(CHEMBL84942 | [3-(1-Methyl-pyrrolidin-3-yl)-1H-ind...)
Affinity DataIC50:  15nMAssay Description:Binding affinity of the compound was measured against serotonin 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM81497(4-(4-Methyl-piperazin-1-yl)-7-trifluoromethyl-pyrr...)
Affinity DataIC50:  19nMAssay Description:Displacement of [3H]-8-OH-DPAT from rat cortex 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50015710(4-Piperazin-1-yl-7-trifluoromethyl-pyrrolo[1,2-a]q...)
Affinity DataIC50:  21nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]-5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50015717(5-Chloro-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-in...)
Affinity DataIC50:  26nMAssay Description:Displacement of [3H]-8-OH-DPAT from rat cortex 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50007406(1-(3-(trifluoromethyl)phenyl)piperazine | 1-(3-Tri...)
Affinity DataIC50:  27nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]-5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50015714(3-(1,2,3,6-Tetrahydro-pyridin-4-yl)-1H-indol-5-ol ...)
Affinity DataIC50:  30nMAssay Description:Displacement of [3H]-8-OH-DPAT from rat cortex 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50015711(3-(1,2,3,6-Tetrahydro-pyridin-4-yl)-1H-indole-5-ca...)
Affinity DataIC50:  32nMAssay Description:Displacement of [3H]-8-OH-DPAT from rat cortex 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50039564(CHEMBL83597 | [3-((R)-1-Methyl-pyrrolidin-2-ylmeth...)
Affinity DataIC50:  33nMAssay Description:Binding affinity of the compound was measured against serotonin 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM81497(4-(4-Methyl-piperazin-1-yl)-7-trifluoromethyl-pyrr...)
Affinity DataIC50:  35nMAssay Description:Compound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]-5-HT as the radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50015718(5-Nitro-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-ind...)
Affinity DataIC50:  36nMAssay Description:Displacement of [3H]-8-OH-DPAT from rat cortex 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50015710(4-Piperazin-1-yl-7-trifluoromethyl-pyrrolo[1,2-a]q...)
Affinity DataIC50:  37nMAssay Description:Displacement of [3H]-8-OH-DPAT from rat cortex 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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