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Found 402 with Last Name = 'nilsson' and Initial = 'i'
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50085448((S)-1-((R)-2-Amino-3-phenyl-propionyl)-pyrrolidine...)
Affinity DataKi:  1.5nMAssay Description:The compound was evaluated for binding affinity against ProthrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50085451((3S,6R,8aS)-6-Benzyl-6-hydroxy-5-oxo-octahydro-ind...)
Affinity DataKi:  9nMAssay Description:The compound was evaluated for binding affinity against ProthrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50085449((3S,6S,8S,8aS)-6-Benzyl-6-hydroxy-8-methoxy-5-oxo-...)
Affinity DataKi:  125nMAssay Description:Concentration required for 50 percent inhibition of ProthrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50085450((3S,6S,8aS)-6-Hydroxy-6-methyl-5-oxo-octahydro-ind...)
Affinity DataKi:  125nMAssay Description:The compound was evaluated for binding affinity against ProthrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50125842(5-amino(imino)methylamino-2-[1-[2-amino-3-phenyl-(...)
Affinity DataIC50:  0.00170nMAssay Description:In vitro inhibitory concentration of compound against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50301573((2S,3aS,7aS)-N-(4-carbamimidoylbenzyl)-1-((2S,3R)-...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50301562(CHEMBL584260 | N-(4-carbamimidoylbenzyl)-2-(1-(2-c...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50301571((2S,3aS,7aS)-N-(4-carbamimidoylbenzyl)-1-((2R,3R)-...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50301572((2S,3aS,7aS)-N-(4-carbamimidoylbenzyl)-1-((R)-3,3-...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University Of G£Teborg

Curated by ChEMBL
LigandPNGBDBM50017519(1,1-Diethyl-3-(7-methyl-4,6,6a,7,8,9,10,10a-octahy...)
Affinity DataIC50:  4nMAssay Description:In vitro binding activity against dopamine receptor D2 from homogenized rat brain, using [3H]spiperone as the radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
University Of G£Teborg

Curated by ChEMBL
LigandPNGBDBM21393(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Affinity DataIC50:  4.5nMAssay Description:In vitro binding activity against 5-hydroxytryptamine 1A receptor receptor from homogenized rat brain, using [3H]8-OH-DPAT as the radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM29388(Exanta | Melagatran | US11584714, Compound 999)
Affinity DataIC50:  4.70nMAssay Description:In vitro inhibitory concentration of compound against human thrombinMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50301574(CHEMBL568990 | Chlorodysinosin A)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50301559(CHEMBL569249 | N-(4-carbamimidoylbenzyl)-2-(1-(2,5...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50301561(CHEMBL565328 | N-(4-carbamimidoylbenzyl)-2-(1-(2,5...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50301558(CHEMBL565292 | N-(4-carbamimidoylbenzyl)-2-(1-(3-m...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50177433(CHEMBL535160 | N-(4-carbamimidoylbenzyl)-2-(2-hydr...)
Affinity DataIC50:  16nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50177436(CHEMBL557787 | N-(4-carbamimidoyl-benzyl)-2-[2-hyd...)
Affinity DataIC50:  17nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50085451((3S,6R,8aS)-6-Benzyl-6-hydroxy-5-oxo-octahydro-ind...)
Affinity DataIC50:  20nMAssay Description:Concentration required for 50 percent inhibition of ProthrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50119079((6R,8aS)-6-Benzyl-6-hydroxy-5-oxo-octahydro-indoli...)
Affinity DataIC50:  20nMAssay Description:Compound was tested for inhibitory activity against ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50119079((6R,8aS)-6-Benzyl-6-hydroxy-5-oxo-octahydro-indoli...)
Affinity DataIC50:  20nMAssay Description:Compound was tested for inhibitory activity against ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50235535(CHEMBL559192 | N-(4-carbamimidoyl-benzyl)-2-[4-met...)
Affinity DataIC50:  23nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
University Of G£Teborg

Curated by ChEMBL
LigandPNGBDBM50017519(1,1-Diethyl-3-(7-methyl-4,6,6a,7,8,9,10,10a-octahy...)
Affinity DataIC50:  25nMAssay Description:In vitro binding activity against 5-hydroxytryptamine 1A receptor from homogenized rat brain, using [3H]-8-OH-DPAT as the radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50177425(CHEMBL537420 | N-(4-carbamimidoylbenzyl)-2-(3-(2,5...)
Affinity DataIC50:  25nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50294877((2R,3AS,6R,7AS)-N-(2-{1-[AMINO(IMINO)METHYL]-2,5-D...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
University Of G£Teborg

Curated by ChEMBL
LigandPNGBDBM50044236(CHEMBL303339 | Dimethyl-(R)-6,7,8,9-tetrahydro-3H-...)
Affinity DataIC50:  31nMAssay Description:In vitro binding activity against 5-hydroxytryptamine 1A receptor from homogenized rat brain, using [3H]8-OH-DPAT as the radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50177421(CHEMBL558235 | N-(4-carbamimidoylbenzyl)-2-(3-(3,4...)
Affinity DataIC50:  39nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50301557(CHEMBL565291 | N-(4-carbamimidoylbenzyl)-2-(4-meth...)
Affinity DataIC50:  42nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50301563(CHEMBL568099 | N-(4-carbamimidoylbenzyl)-2-(1-(2-m...)
Affinity DataIC50:  44nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395351(CHEMBL2164363)
Affinity DataIC50:  45nMAssay Description:Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50269776(CHEMBL502639 | Dysinosin A)
Affinity DataIC50:  46nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395332(CHEMBL2164390)
Affinity DataIC50:  49nMAssay Description:Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50125849(CHEMBL17587 | Cyclopent-2-ene-1,2-dicarboxylic aci...)
Affinity DataIC50:  49nMAssay Description:In vitro inhibitory concentration of compound against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50177419(CHEMBL557779 | N-(4-carbamimidoylbenzyl)-2-(2-hydr...)
Affinity DataIC50:  50nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395345(CHEMBL2164369)
Affinity DataIC50:  51nMAssay Description:Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395333(CHEMBL2164389)
Affinity DataIC50:  53nMAssay Description:Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395373(CHEMBL2164041)
Affinity DataIC50:  64nMAssay Description:Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
University Of G£Teborg

Curated by ChEMBL
LigandPNGBDBM50017519(1,1-Diethyl-3-(7-methyl-4,6,6a,7,8,9,10,10a-octahy...)
Affinity DataIC50:  69nMAssay Description:In vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395356(CHEMBL2164356)
Affinity DataIC50:  73nMAssay Description:Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50125847(CHEMBL275154 | Cyclopent-2-ene-1,2-dicarboxylic ac...)
Affinity DataIC50:  73nMAssay Description:In vitro inhibitory concentration of compound against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Rattus norvegicus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395366(CHEMBL2164373)
Affinity DataIC50:  74nMAssay Description:Inhibition of recombinant rat NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Rattus norvegicus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395333(CHEMBL2164389)
Affinity DataIC50:  74nMAssay Description:Inhibition of recombinant rat NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395333(CHEMBL2164389)
Affinity DataIC50:  80nMAssay Description:Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -90 mV holding potential by patch clamp electrophysiological assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395333(CHEMBL2164389)
Affinity DataIC50:  80nMAssay Description:Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -90 mV holding potential by patch clamp electrophysiological assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395355(CHEMBL2164358)
Affinity DataIC50:  82nMAssay Description:Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
University Of G£Teborg

Curated by ChEMBL
LigandPNGBDBM50017520((+/-)-Dimethyl-(6,7,8,9-tetrahydro-3H-benzo[e]indo...)
Affinity DataIC50:  82nMAssay Description:In vitro binding activity against 5-hydroxytryptamine 1A receptor from homogenized rat brain, using [3H]8-OH-DPAT as the radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50177430(CHEMBL541383 | N-(4-carbamimidoylbenzyl)-2-(3-(4-c...)
Affinity DataIC50:  82nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395346(CHEMBL2164368)
Affinity DataIC50:  87nMAssay Description:Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50235527(CHEMBL535639 | N-(4-carbamimidoylbenzyl)-2-(4-meth...)
Affinity DataIC50:  91nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395366(CHEMBL2164373)
Affinity DataIC50:  92nMAssay Description:Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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