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Found 454 with Last Name = 'numa' and Initial = 'm'
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50041376((R)-6-Ethyl-10,13-dimethyl-1,6,7,8,9,10,11,12,13,1...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity for human placental microsome Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM9955((8S)-2,8,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{1...)
Affinity DataKi:  3.10nM ΔG°:  -50.5kJ/mole IC50:  37nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM9989((2S,6S,15S)-6-hydroxy-2-(hydroxymethyl)-15-methylt...)
Affinity DataKi:  3.40nM ΔG°:  -50.3kJ/mole IC50:  31nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50041369((R)-10,13-Dimethyl-6-propyl-1,6,7,8,9,10,11,12,13,...)
Affinity DataKi:  4.60nMAssay Description:Binding affinity for human placental microsome Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM9948((8R)-8-ethyl-2,15-dimethyltetracyclo[8.7.0.0^{2,7}...)
Affinity DataKi:  4.70nM ΔG°:  -49.4kJ/mole IC50:  54nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50041361((S)-6-Ethyl-10,13-dimethyl-1,6,7,8,9,10,11,12,13,1...)
Affinity DataKi:  4.70nMAssay Description:Binding affinity for human placental microsome Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM9951((8R)-2,15-dimethyl-8-pentyltetracyclo[8.7.0.0^{2,7...)
Affinity DataKi:  5nM ΔG°:  -49.3kJ/mole IC50:  54nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50041371((S)-10,13-Dimethyl-6-vinyl-1,6,7,8,9,10,11,12,13,1...)
Affinity DataKi:  5.10nMAssay Description:Binding affinity for human placental microsome aromatase Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM9960((8R)-2,8,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{1...)
Affinity DataKi:  5.30nM ΔG°:  -49.1kJ/mole IC50:  49nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50041362((S)-6,10,13-Trimethyl-1,6,7,8,9,10,11,12,13,14,15,...)
Affinity DataKi:  5.60nMAssay Description:Binding affinity for human placental microsome Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM9997((2S,15S)-2-(hydroxymethyl)-15-methyltetracyclo[8.7...)
Affinity DataKi:  5.80nM ΔG°:  -48.9kJ/mole IC50:  49nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM9994((2R,8R,15S)-8-hydroxy-2,15-dimethyltetracyclo[8.7....)
Affinity DataKi:  6nM ΔG°:  -48.8kJ/mole IC50:  50nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM9968((8R)-8-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,...)
Affinity DataKi:  6nM ΔG°:  -48.8kJ/mole IC50:  50nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50041366((S)-10,13-Dimethyl-6-propyl-1,6,7,8,9,10,11,12,13,...)
Affinity DataKi:  6.70nMAssay Description:Binding affinity for human placental microsome aromatase Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM9996((2R,15S)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{...)
Affinity DataKi:  6.80nM ΔG°:  -48.5kJ/mole IC50:  60nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM9981(2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]he...)
Affinity DataKi:  6.80nM IC50:  60nMAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM9949((8R)-2,15-dimethyl-8-propyltetracyclo[8.7.0.0^{2,7...)
Affinity DataKi:  7nM ΔG°:  -48.4kJ/mole IC50:  60nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM9953((8R)-8-heptyl-2,15-dimethyltetracyclo[8.7.0.0^{2,7...)
Affinity DataKi:  7.80nM ΔG°:  -48.1kJ/mole IC50:  60nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM9952((8R)-8-hexyl-2,15-dimethyltetracyclo[8.7.0.0^{2,7}...)
Affinity DataKi:  8nM ΔG°:  -48.1kJ/mole IC50:  76nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50041365((R)-6-Butyl-10,13-dimethyl-1,6,7,8,9,10,11,12,13,1...)
Affinity DataKi:  8.80nMAssay Description:Binding affinity for human placental microsome Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50041367((R)-6-Benzyl-10,13-dimethyl-1,6,7,8,9,10,11,12,13,...)
Affinity DataKi:  10nMAssay Description:Binding affinity for human placental microsome aromatase Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Yogi Vemana University

Curated by ChEMBL
LigandPNGBDBM50500457(CHEMBL3746815)
Affinity DataKi:  10nMAssay Description:Mixed-type inhibition of electric eel AChE using acetylthiocholine iodide as substrate assessed as free enzyme preincubated for 5 mins followed by su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM9944((8S)-2,15-dimethyl-8-pentyltetracyclo[8.7.0.0^{2,7...)
Affinity DataKi:  11nM ΔG°:  -47.3kJ/mole IC50:  140nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50041375((R)-6,10,13-Trimethyl-1,6,7,8,9,10,11,12,13,14,15,...)
Affinity DataKi:  11nMAssay Description:Binding affinity for human placental microsome Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM9967((8S)-8-methoxy-2,15-dimethyltetracyclo[8.7.0.0^{2,...)
Affinity DataKi:  12nM ΔG°:  -47.0kJ/mole IC50:  120nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM9970((8R)-8-methoxy-2,15-dimethyltetracyclo[8.7.0.0^{2,...)
Affinity DataKi:  12nM IC50:  130nMAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50041372((S)-6-Butyl-10,13-dimethyl-1,6,7,8,9,10,11,12,13,1...)
Affinity DataKi:  12nMAssay Description:Binding affinity for human placental microsome aromatase Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50332807((8R,9S,10R,13S,14S)-10,13-dimethyl-2,3,7,8,9,10,11...)
Affinity DataKi:  13nMAssay Description:The binding affinity was determined on Cytochrome P450 19A1 by analysis of Dixon plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50332808((8R,9S,10S,13S,14S)-10-(hydroxymethyl)-13-methyl-2...)
Affinity DataKi:  13nMAssay Description:Inhibition of 1 uM [1-beta-3H]-androstenedione binding to human placental microsome Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM9956((8S)-8-ethyl-2,15-dimethyltetracyclo[8.7.0.0^{2,7}...)
Affinity DataKi:  14nM ΔG°:  -46.6kJ/mole IC50:  110nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM9950((8R)-8-butyl-2,15-dimethyltetracyclo[8.7.0.0^{2,7}...)
Affinity DataKi:  14nM ΔG°:  -46.6kJ/mole IC50:  180nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B10(Homo sapiens (Human))
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50394657(CHEMBL270067)
Affinity DataKi:  15nMAssay Description:Inhibition of reductase activity of N-terminal 6His-tagged human AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as pyridine-3-aldehyde redu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM9943((8S)-8-butyl-2,15-dimethyltetracyclo[8.7.0.0^{2,7}...)
Affinity DataKi:  16nM ΔG°:  -46.3kJ/mole IC50:  200nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM9966((8S)-2,15-dimethyl-14-oxotetracyclo[8.7.0.0^{2,7}....)
Affinity DataKi:  18nM ΔG°:  -46.0kJ/mole IC50:  160nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM9941((8S)-8-ethyl-2,15-dimethyltetracyclo[8.7.0.0^{2,7}...)
Affinity DataKi:  19nM ΔG°:  -45.8kJ/mole IC50:  250nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Yogi Vemana University

Curated by ChEMBL
LigandPNGBDBM50500457(CHEMBL3746815)
Affinity DataKi:  19nMAssay Description:Mixed-type inhibition of electric eel AChE using acetylthiocholine iodide as substrate assessed as enzyme-substrate complex preincubated for 5 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM9946((8S)-8-heptyl-2,15-dimethyltetracyclo[8.7.0.0^{2,7...)
Affinity DataKi:  20nM ΔG°:  -45.7kJ/mole IC50:  250nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM8592((2R,15S)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{...)
Affinity DataKi:  20nM ΔG°:  -45.7kJ/mole IC50:  300nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50025428(10,13-Dimethyl-1,6,7,8,9,10,11,12,13,14,15,16-dode...)
Affinity DataKi:  20nMAssay Description:Binding affinity for aromatase cytochrome P45019A1 by analysis of Dixon plotMore data for this Ligand-Target Pair
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM9965((8S)-8-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,...)
Affinity DataKi:  21nM ΔG°:  -45.6kJ/mole IC50:  190nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM9992((2R,8S,15S)-8-hydroxy-2,15-dimethyltetracyclo[8.7....)
Affinity DataKi:  21nM ΔG°:  -45.6kJ/mole IC50:  190nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50041370((R)-10,13-Dimethyl-6-phenyl-1,6,7,8,9,10,11,12,13,...)
Affinity DataKi:  21nMAssay Description:Binding affinity for human placental microsome aromatase Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM9942((8S)-2,15-dimethyl-8-propyltetracyclo[8.7.0.0^{2,7...)
Affinity DataKi:  22nM ΔG°:  -45.5kJ/mole IC50:  270nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50041364((S)-6-Isopropyl-10,13-dimethyl-1,6,7,8,9,10,11,12,...)
Affinity DataKi:  22nMAssay Description:Binding affinity for human placental microsome aromatase Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM9969((8R)-2,15-dimethyl-14-oxotetracyclo[8.7.0.0^{2,7}....)
Affinity DataKi:  24nM IC50:  260nMAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM9987((2R,6S,15S)-6-hydroxy-2,15-dimethyltetracyclo[8.7....)
Affinity DataKi:  25nM ΔG°:  -45.1kJ/mole IC50:  280nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM9945((8S)-8-hexyl-2,15-dimethyltetracyclo[8.7.0.0^{2,7}...)
Affinity DataKi:  25nM ΔG°:  -45.1kJ/mole IC50:  280nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50008057(BMS-722782 | CHEBI:64153 | TANESPIMYCIN)
Affinity DataKi:  29nMAssay Description:Inhibition of FITC-GA binding to Hsp90alpha (unknown origin) ATPase site after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM9957((8S)-2,15-dimethyl-8-propyltetracyclo[8.7.0.0^{2,7...)
Affinity DataKi:  30nM ΔG°:  -44.7kJ/mole IC50:  230nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50041363((R)-6-Isopropyl-10,13-dimethyl-1,6,7,8,9,10,11,12,...)
Affinity DataKi:  31nMAssay Description:Binding affinity for human placental microsome aromatase Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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