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Found 918 with Last Name = 'oishi' and Initial = 's'
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM126083(US8779142, 102)
Affinity DataKi:  21nMAssay Description:Binding affinity to human HSP90-beta by fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM126083(US8779142, 102)
Affinity DataKi:  35nMAssay Description:Inhibition of FITC-GDA binding to human HSP90-alpha incubated for 2 hrs followed by FITC-GDA addition and measured after 5 hrs by fluorescence polari...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50175277(CHEMBL3809675)
Affinity DataKi:  40nMAssay Description:Inhibition of recombinant human SphK1 expressed in baculovirus infected sf9 cells using D-erythro-sphingosine as substrate in presence of [gamma-33P]...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 2(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM174110((S)-2-(3-(4-octylphenyl)-1,2,4- oxadiazol-5-yl)aze...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of recombinant human SphK2 expressed in baculovirus infected sf9 cells using D-erythro-sphingosine as substrate after 20 mins in presence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM174110((S)-2-(3-(4-octylphenyl)-1,2,4- oxadiazol-5-yl)aze...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of recombinant human SphK1 expressed in baculovirus infected sf9 cells using D-erythro-sphingosine as substrate after 20 mins in presence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50582399(CHEMBL5094983)
Affinity DataKi:  1.30E+4nMAssay Description:Inhibition of FITC-GDA binding to human HSP90-alpha incubated for 2 hrs followed by FITC-GDA addition and measured after 5 hrs by fluorescence polari...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingosine kinase 2(Mus musculus (Mouse))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50175277(CHEMBL3809675)
Affinity DataKi:  1.41E+4nMAssay Description:Inhibition of recombinant mouse SphK2 expressed in baculovirus infected sf9 cells using D-erythro-sphingosine as substrate in presence of [gamma-33P]...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50582399(CHEMBL5094983)
Affinity DataKi:  1.70E+4nMAssay Description:Binding affinity to human HSP90-beta by fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEndoplasmin(Homo sapiens (Human))
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM126083(US8779142, 102)
Affinity DataKi: >5.00E+4nMAssay Description:Binding affinity to GRP94 (unknown origin) by fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein 75 kDa, mitochondrial(Homo sapiens (Human))
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM126083(US8779142, 102)
Affinity DataKi: >5.00E+4nMAssay Description:Binding affinity to TRAP1 (unknown origin) by fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndoplasmin(Homo sapiens (Human))
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50582399(CHEMBL5094983)
Affinity DataKi: >3.00E+5nMAssay Description:Binding affinity to GRP94 (unknown origin) by fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein 75 kDa, mitochondrial(Homo sapiens (Human))
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50582399(CHEMBL5094983)
Affinity DataKi: >3.00E+5nMAssay Description:Binding affinity to TRAP1 (unknown origin) by fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKiSS-1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM26349((2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-(4-hydroxyp...)
Affinity DataIC50:  0.120nMAssay Description:Displacement of [125I]kisspeptin-15 from GPR54More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKiSS-1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM26339((2R,3E)-N-[(1S)-4-carbamimidamido-1-{[(1S)-1-carba...)
Affinity DataIC50:  0.120nMpH: 7.3 T: 2°CAssay Description:Membranes were incubated with [125I] kisspeptin-15 and increasing concentrations of test compound in binding buffer. The reaction mixtures were dilut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKiSS-1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM107307(US8592379, 19)
Affinity DataIC50:  0.120nMAssay Description:Binding inhibition assay using human GPR54.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKiSS-1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM26349((2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-(4-hydroxyp...)
Affinity DataIC50:  0.120nMpH: 7.3 T: 2°CAssay Description:Membranes were incubated with [125I] kisspeptin-15 and increasing concentrations of test compound in binding buffer. The reaction mixtures were dilut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKiSS-1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM26339((2R,3E)-N-[(1S)-4-carbamimidamido-1-{[(1S)-1-carba...)
Affinity DataIC50:  0.120nMAssay Description:Displacement of [125I]kisspeptin-15 from GPR54More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKiSS-1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM107314(US8592379, 36 | US8592379, 37)
Affinity DataIC50:  0.240nMAssay Description:Binding inhibition assay using human GPR54.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKiSS-1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM26347((2R,4S)-N-[(1S)-4-carbamimidamido-1-{[(1S)-1-carba...)
Affinity DataIC50:  0.240nMpH: 7.3 T: 2°CAssay Description:Membranes were incubated with [125I] kisspeptin-15 and increasing concentrations of test compound in binding buffer. The reaction mixtures were dilut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKiSS-1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM26338((2S)-N-[(1S)-4-carbamimidamido-1-{[(1S)-1-carbamoy...)
Affinity DataIC50:  0.710nMpH: 7.3 T: 2°CAssay Description:Membranes were incubated with [125I] kisspeptin-15 and increasing concentrations of test compound in binding buffer. The reaction mixtures were dilut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKiSS-1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM107306(US8592379, 1)
Affinity DataIC50:  0.710nMAssay Description:Binding inhibition assay using human GPR54.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKiSS-1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM26338((2S)-N-[(1S)-4-carbamimidamido-1-{[(1S)-1-carbamoy...)
Affinity DataIC50:  0.710nMAssay Description:Displacement of [125I]kisspeptin-15 from GPR54More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide FF receptor 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336911((S)-2-((S)-2-((S)-5-amino-2-((S)-1-((S)-2-((S)-2-(...)
Affinity DataIC50:  0.790nMAssay Description:Displacement of (D-[125I]Tyr1, MePhe3)-NPFF from NPFFR2 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKiSS-1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM107308(US8592379, 20)
Affinity DataIC50:  1.20nMAssay Description:Binding inhibition assay using human GPR54.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKiSS-1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM26340((2S)-N-[(1S)-4-carbamimidamido-1-{[(1S)-1-carbamoy...)
Affinity DataIC50:  1.20nMpH: 7.3 T: 2°CAssay Description:Membranes were incubated with [125I] kisspeptin-15 and increasing concentrations of test compound in binding buffer. The reaction mixtures were dilut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50432242(CHEMBL2347361)
Affinity DataIC50:  1.5nMAssay Description:Displacement of ([125I]-His3, MePhe7)-NKB from NK3R (unknown origin) transfected in CHO cells by gamma counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50432275(CHEMBL2347488)
Affinity DataIC50:  1.5nMAssay Description:Displacement of ([125I]-His3, MePhe7)-NKB from NK3R (unknown origin) transfected in CHO cells by gamma counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50180193(AZD-2624 | AZD2624)
Affinity DataIC50:  1.60nMAssay Description:Displacement of [125I]His3-MePhe7)-NKB from human NK3R expressed in CHO cell membranes by topcounting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50432267(CHEMBL2347496)
Affinity DataIC50:  1.70nMAssay Description:Displacement of ([125I]-His3, MePhe7)-NKB from NK3R (unknown origin) transfected in CHO cells by gamma counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50432241(CHEMBL2347362)
Affinity DataIC50:  1.80nMAssay Description:Displacement of ([125I]-His3, MePhe7)-NKB from NK3R (unknown origin) transfected in CHO cells by gamma counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide FF receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336911((S)-2-((S)-2-((S)-5-amino-2-((S)-1-((S)-2-((S)-2-(...)
Affinity DataIC50:  1.90nMAssay Description:Displacement of (D-[125I]Tyr1, MePhe3)-NPFF from NPFFR1 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50432245(CHEMBL2347511)
Affinity DataIC50:  2.5nMAssay Description:Displacement of ([125I]-His3, MePhe7)-NKB from NK3R (unknown origin) transfected in CHO cells by gamma counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50041978(CHEMBL3134157)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of recombinant C-terminal His6-tagged human SphK1 expressed in baculovirus infected sf21 cells using FITC-sphingosine as substrate after 1...More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50202356(CHEMBL218806 | cyclo(-D-Tyr-D-MeArg-L-Arg-L-Nal-Gl...)
Affinity DataIC50:  3nMAssay Description:Inhibition of [125I]SDF1 binding to CXCR4 transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50299467((5S,8S,14S,17S,20S,23S,26S,29S,32S)-26-((1H-imidaz...)
Affinity DataIC50:  3nMAssay Description:Displacement of ([125I]-His3, MePhe7)-NKB from NK3R (unknown origin) transfected in CHO cells by gamma counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50432269(CHEMBL2347494)
Affinity DataIC50:  3.60nMAssay Description:Displacement of ([125I]-His3, MePhe7)-NKB from NK3R (unknown origin) transfected in CHO cells by gamma counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50180171(CHEMBL3813763)
Affinity DataIC50:  3.90nMAssay Description:Displacement of [125I]His3-MePhe7)-NKB from human NK3R expressed in CHO cell membranes by topcounting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50202350(CHEMBL219474 | cyclo(-D-Tyr-L-Arg-L-Arg-L-Nal-Gly-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of [125I]SDF1 binding to CXCR4 transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50432273(CHEMBL2347490)
Affinity DataIC50:  4nMAssay Description:Displacement of ([125I]-His3, MePhe7)-NKB from NK3R (unknown origin) transfected in CHO cells by gamma counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50385614(CHEMBL2042118)
Affinity DataIC50:  4.20nMAssay Description:Displacement of [125I]-SDF-1alpha from CXCR4 receptor expressed in HEK293 cells after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50166087(CHEMBL436097 | N-{3-[(2R,5S,8S,14R)-5-(3-Guanidino...)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of [125I]-SDF-1 binding to C-X-C chemokine receptor type 4 (CXCR4) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50432268(CHEMBL2347495)
Affinity DataIC50:  4.30nMAssay Description:Displacement of ([125I]-His3, MePhe7)-NKB from NK3R (unknown origin) transfected in CHO cells by gamma counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50432272(CHEMBL2347491)
Affinity DataIC50:  4.40nMAssay Description:Displacement of ([125I]-His3, MePhe7)-NKB from NK3R (unknown origin) transfected in CHO cells by gamma counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKiSS-1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM26341((2E)-N-[(1S)-4-carbamimidamido-1-{[(1S)-1-carbamoy...)
Affinity DataIC50:  4.60nMpH: 7.3 T: 2°CAssay Description:Membranes were incubated with [125I] kisspeptin-15 and increasing concentrations of test compound in binding buffer. The reaction mixtures were dilut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase II subunit alpha'(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50144654(CHEMBL3760043)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of GST-tagged human CK2alpha' (1 to 350 residues) using CK2tide as substrate incubated for 1 hr by off-chip mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKiSS-1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM107309(US8592379, 21)
Affinity DataIC50:  4.60nMAssay Description:Binding inhibition assay using human GPR54.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuromedin-K receptor(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50432270(CHEMBL2347493)
Affinity DataIC50:  4.60nMAssay Description:Displacement of ([125I]-His3, MePhe7)-NKB from NK3R (unknown origin) transfected in CHO cells by gamma counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide FF receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM26349((2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-(4-hydroxyp...)
Affinity DataIC50:  4.70nMAssay Description:Displacement of (D-[125I]Tyr1, MePhe3)-NPFF from NPFFR1 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50385613(CHEMBL2042119)
Affinity DataIC50:  4.90nMAssay Description:Displacement of [125I]-SDF-1alpha from CXCR4 receptor expressed in HEK293 cells after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50432259(CHEMBL2347662)
Affinity DataIC50:  5.5nMAssay Description:Displacement of ([125I]-His3, MePhe7)-NKB from NK3R (unknown origin) transfected in CHO cells by gamma counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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