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Found 1117 with Last Name = 'okada' and Initial = 't'
TargetEndothelin receptor type B(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50000558(CHEMBL437472 | ET-1 | Endothelin -1 | Endothelin 1...)
Affinity DataKi:  0.00800nMAssay Description:Ability to inhibit [125I]ET-3 binding to the Endothelin B receptor from porcine lung membranes was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50000558(CHEMBL437472 | ET-1 | Endothelin -1 | Endothelin 1...)
Affinity DataKi:  0.0400nMAssay Description:Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin receptor type B(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50287890(CHEMBL427778 | Suc-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu...)
Affinity DataKi:  0.0770nMAssay Description:Ability to inhibit [125I]ET-3 binding to the Endothelin B receptor from porcine lung membranes was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50274347((2E)-N-[(5R,6R)-17-(cyclopropylmethyl)-4,5-epoxy-3...)
Affinity DataKi:  0.238nMAssay Description:Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cell membranes by micro-beta scintillation counting methodMore data for this Ligand-Target Pair
TargetEndothelin receptor type B(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50287885(CHEMBL405377 | Suc-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu...)
Affinity DataKi:  0.25nMAssay Description:Ability to inhibit [125I]ET-3 binding to the Endothelin B receptor from porcine lung membranes was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin receptor type B(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50287883(CHEMBL412003 | Suc-Glu-Ala-Gly-Tyr-Phe-Ala-His-Leu...)
Affinity DataKi:  0.910nMAssay Description:Ability to inhibit [125I]ET-3 binding to the Endothelin B receptor from porcine lung membranes was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin receptor type B(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50071433((S)-2-{(R)-3-Biphenyl-4-yl-2-[(3,5-dimethyl-benzoy...)
Affinity DataKi:  1nMAssay Description:Ability to inhibit [125I]ET-3 binding to the Endothelin B receptor from porcine lung membranes was evaluatedMore data for this Ligand-Target Pair
TargetEndothelin receptor type B(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50287882(CHEMBL412065 | Suc-Glu-Ala-Val-Tyr-Phe-Ala-Gly-Leu...)
Affinity DataKi:  1nMAssay Description:Ability to inhibit [125I]ET-3 binding to the Endothelin B receptor from porcine lung membranes was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50230035(CHEMBL4091544)
Affinity DataKi:  1.40nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular calcium level preincubated for 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50230164(CHEMBL4091834 | US10377763, Example 2)
Affinity DataKi:  1.70nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular calcium level preincubated for 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50230139(CHEMBL4105072 | US10377763, Example 8)
Affinity DataKi:  1.80nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular calcium level preincubated for 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50230138(CHEMBL4094318)
Affinity DataKi:  1.90nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular calcium level preincubated for 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50230161(CHEMBL4089496)
Affinity DataKi:  1.90nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular calcium level preincubated for 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50230158(CHEMBL4073947 | US10377763, Example 11)
Affinity DataKi:  2nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular calcium level preincubated for 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50230134(CHEMBL4087046)
Affinity DataKi:  2.10nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular calcium level preincubated for 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50230144(CHEMBL4081763 | US10377763, Example 5)
Affinity DataKi:  2.10nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular calcium level preincubated for 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50230141(CHEMBL4083587 | US10377763, Example 20)
Affinity DataKi:  2.10nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular calcium level preincubated for 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50230167(CHEMBL4071220 | US10377763, Example 21)
Affinity DataKi:  2.30nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular calcium level preincubated for 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50230160(CHEMBL4065120)
Affinity DataKi:  2.40nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular calcium level preincubated for 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50078977(1-(3-{3-[N'-(4-Hydroxy-phenyl)-guanidino]-2-oxo-2,...)
Affinity DataKi:  2.90nMAssay Description:In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblasto...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50230156(CHEMBL4097697 | US10377763, Example 3)
Affinity DataKi:  3nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular calcium level preincubated for 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50230136(CHEMBL4068322 | US10377763, Example 18)
Affinity DataKi:  3.5nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular calcium level preincubated for 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50230166(CHEMBL4079180)
Affinity DataKi:  4.10nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular calcium level preincubated for 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50230142(CHEMBL4099280 | US10377763, Example 23)
Affinity DataKi:  4.20nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular calcium level preincubated for 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50230029(CHEMBL4071362)
Affinity DataKi:  4.20nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular calcium level preincubated for 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50526575(CHEMBL4456012)
Affinity DataKi:  4.30nMAssay Description:Antagonist activity at human OX1 receptor expressed in CHOK1 cells assessed as inhibition of orexin-A-induced calcium mobilization preincubated for 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50287878(CGP-49941 | CHEMBL305615 | N-{(R)-1-[2-(1H-Indol-3...)
Affinity DataKi:  5nMAssay Description:Ability to inhibit [125I]ET-3 binding to the Endothelin B receptor from porcine lung membranes was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50078965(1-Benzothiazol-6-yl-3-{1-[3-(3-isopropyl-ureido)-b...)
Affinity DataKi:  5.10nMAssay Description:In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblasto...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50230145(CHEMBL4080833)
Affinity DataKi:  5.10nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular calcium level preincubated for 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50230148(CHEMBL4101590)
Affinity DataKi:  5.10nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular calcium level preincubated for 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50287888(CHEMBL407559 | Suc-Glu-Ala-Val-Tyr-Phe-Gly-His-Leu...)
Affinity DataKi:  5.30nMAssay Description:Ability to inhibit [125I]ET-3 binding to the Endothelin B receptor from porcine lung membranes was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50526577(CHEMBL4457194)
Affinity DataKi:  5.5nMAssay Description:Antagonist activity at human OX1 receptor expressed in CHOK1 cells assessed as inhibition of orexin-A-induced calcium mobilization preincubated for 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50287886(CHEMBL405796 | Suc-Glu-Ala-Val-Tyr-Phe-Ala-His-Gly...)
Affinity DataKi:  5.90nMAssay Description:Ability to inhibit [125I]ET-3 binding to the Endothelin B receptor from porcine lung membranes was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50230168(CHEMBL4079662 | US10377763, Example 4)
Affinity DataKi:  5.90nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular calcium level preincubated for 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50526573(CHEMBL4448949)
Affinity DataKi:  5.90nMAssay Description:Antagonist activity at human OX1 receptor expressed in CHOK1 cells assessed as inhibition of orexin-A-induced calcium mobilization preincubated for 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50230155(CHEMBL4094746 | US10377763, Example 27)
Affinity DataKi:  5.90nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular calcium level preincubated for 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50274347((2E)-N-[(5R,6R)-17-(cyclopropylmethyl)-4,5-epoxy-3...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cell membranes by micro-beta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50230146(CHEMBL4099781)
Affinity DataKi:  6.20nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular calcium level preincubated for 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50230163(CHEMBL4092034)
Affinity DataKi:  6.20nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular calcium level preincubated for 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50230162(CHEMBL4084072)
Affinity DataKi:  6.40nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular calcium level preincubated for 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50079009(1-(3-{3-[N'-(4-Hydroxy-phenyl)-N''-methyl-guanidin...)
Affinity DataKi:  7.30nMAssay Description:In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblasto...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50230165(CHEMBL4062575)
Affinity DataKi:  7.30nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular calcium level preincubated for 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50230137(CHEMBL4073714)
Affinity DataKi:  7.30nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular calcium level preincubated for 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50526576(CHEMBL4588327)
Affinity DataKi:  7.5nMAssay Description:Antagonist activity at human OX1 receptor expressed in CHOK1 cells assessed as inhibition of orexin-A-induced calcium mobilization preincubated for 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50078970(1-(2-Fluoro-phenyl)-3-{1-[3-(3-isopropyl-ureido)-b...)
Affinity DataKi:  7.60nMAssay Description:In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblasto...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50230154(CHEMBL4097196 | US10377763, Example 15)
Affinity DataKi:  7.60nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular calcium level preincubated for 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50079015(1-(2,4-Difluoro-phenyl)-3-{1-[3-(3-isopropyl-ureid...)
Affinity DataKi:  7.80nMAssay Description:In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblasto...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50079012(1-Benzo[b]thiophen-6-yl-3-{1-[3-(3-isopropyl-ureid...)
Affinity DataKi:  7.80nMAssay Description:In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblasto...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50079016(1-Benzofuran-6-yl-3-{1-[3-(3-isopropyl-ureido)-ben...)
Affinity DataKi:  7.80nMAssay Description:In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblasto...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50230031(CHEMBL4080914)
Affinity DataKi:  8.10nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular calcium level preincubated for 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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