Affinity DataKi: 1.40nMAssay Description:Displacement of [3H]NMS from muscarinic receptor M1 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 2.20nMAssay Description:Displacement of [3H]NMS from muscarinic receptor M5 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetAsparagine synthetase [glutamine-hydrolyzing](Homo sapiens (Human))
Kyoto University
Curated by ChEMBL
Kyoto University
Curated by ChEMBL
Affinity DataKi: 2.5nMAssay Description:Inhibition of human recombinant ASNS expressed in Sf9 cells assessed as assessed as overall inhibition constant for ammonia dependent production of i...More data for this Ligand-Target Pair
Affinity DataKi: 2.70nMAssay Description:Displacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 3.10nMAssay Description:Displacement of [3H]NMS from muscarinic receptor M4 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 3.60nMAssay Description:Displacement of [3H]NMS from muscarinic receptor M3 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 3.60nMAssay Description:Displacement of [3H]N-alpha-methyl-histamine from human histamine H3 receptor expressed in human HEK293-EBNA cellsMore data for this Ligand-Target Pair
Affinity DataKi: 4.60nMAssay Description:Displacement of [3H]NMS from muscarinic receptor M1 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 6.30nMAssay Description:Displacement of [3H]NMS from muscarinic receptor M4 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 6.70nMAssay Description:Displacement of [3H]N-alpha-methyl-histamine from human histamine H3 receptor expressed in human HEK293-EBNA cellsMore data for this Ligand-Target Pair
TargetAsparagine synthetase [glutamine-hydrolyzing](Homo sapiens (Human))
Kyoto University
Curated by ChEMBL
Kyoto University
Curated by ChEMBL
Affinity DataKi: 8nMAssay Description:Inhibition of human recombinant ASNS expressed in Sf9 cells assessed as overall inhibition constant for glutamine dependent production of inorganic p...More data for this Ligand-Target Pair
Affinity DataKi: 8.40nMAssay Description:Displacement of [3H]N-alpha-methyl-histamine from human histamine H3 receptor expressed in human HEK293-EBNA cellsMore data for this Ligand-Target Pair
Affinity DataKi: 9nMAssay Description:Displacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Displacement of [3H]NMS from muscarinic receptor M3 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 18nMAssay Description:Displacement of [3H]NMS from muscarinic receptor M5 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 19.8nMAssay Description:Displacement of [3H]N-alpha-methyl-histamine from human histamine H3 receptor expressed in human HEK293-EBNA cellsMore data for this Ligand-Target Pair
TargetAsparagine synthetase [glutamine-hydrolyzing](Homo sapiens (Human))
Kyoto University
Curated by ChEMBL
Kyoto University
Curated by ChEMBL
Affinity DataKi: 24nMAssay Description:Inhibition of human recombinant ASNS expressed in Sf9 cells assessed as overall inhibition constant for glutamine dependent production of inorganic p...More data for this Ligand-Target Pair
TargetAsparagine synthetase [glutamine-hydrolyzing](Homo sapiens (Human))
Kyoto University
Curated by ChEMBL
Kyoto University
Curated by ChEMBL
Affinity DataKi: 33nMAssay Description:Inhibition of human recombinant ASNS expressed in Sf9 cells assessed as assessed as overall inhibition constant for ammonia dependent production of i...More data for this Ligand-Target Pair
Affinity DataKi: 51.1nMAssay Description:Displacement of [3H]N-alpha-methyl-histamine from human histamine H3 receptor expressed in human HEK293-EBNA cellsMore data for this Ligand-Target Pair
Affinity DataKi: 63nMAssay Description:Displacement of [3H]N-alpha-methyl-histamine from human histamine H3 receptor expressed in human HEK293-EBNA cellsMore data for this Ligand-Target Pair
Affinity DataKi: 129nMAssay Description:Displacement of [3H]N-alpha-methyl-histamine from human histamine H3 receptor expressed in human HEK293-EBNA cellsMore data for this Ligand-Target Pair
TargetAsparagine synthetase [glutamine-hydrolyzing](Homo sapiens (Human))
Kyoto University
Curated by ChEMBL
Kyoto University
Curated by ChEMBL
Affinity DataKi: 280nMAssay Description:Inhibition of human recombinant ASNS expressed in Sf9 cells assessed as assessed as initial inhibition constant for ammonia dependent production of i...More data for this Ligand-Target Pair
TargetAsparagine synthetase [glutamine-hydrolyzing](Homo sapiens (Human))
Kyoto University
Curated by ChEMBL
Kyoto University
Curated by ChEMBL
Affinity DataKi: 310nMAssay Description:Inhibition of human recombinant ASNS expressed in Sf9 cells assessed as assessed as overall inhibition constant for ammonia dependent production of i...More data for this Ligand-Target Pair
Affinity DataKi: 400nMAssay Description:Inhibition of relaxation activities of DNA topoisomerase I with respect to pBR322 DNAMore data for this Ligand-Target Pair
TargetAsparagine synthetase [glutamine-hydrolyzing](Homo sapiens (Human))
Kyoto University
Curated by ChEMBL
Kyoto University
Curated by ChEMBL
Affinity DataKi: 450nMAssay Description:Inhibition of human recombinant ASNS expressed in Sf9 cells assessed as assessed as initial inhibition constant for ammonia dependent production of i...More data for this Ligand-Target Pair
TargetAsparagine synthetase [glutamine-hydrolyzing](Homo sapiens (Human))
Kyoto University
Curated by ChEMBL
Kyoto University
Curated by ChEMBL
Affinity DataKi: 490nMAssay Description:Inhibition of human recombinant ASNS expressed in Sf9 cells assessed as initial inhibition constant for glutamine dependent production of inorganic p...More data for this Ligand-Target Pair
TargetAsparagine synthetase [glutamine-hydrolyzing](Homo sapiens (Human))
Kyoto University
Curated by ChEMBL
Kyoto University
Curated by ChEMBL
Affinity DataKi: 840nMAssay Description:Inhibition of human recombinant ASNS expressed in Sf9 cells assessed as overall inhibition constant for glutamine dependent production of inorganic p...More data for this Ligand-Target Pair
TargetAsparagine synthetase [glutamine-hydrolyzing](Homo sapiens (Human))
Kyoto University
Curated by ChEMBL
Kyoto University
Curated by ChEMBL
Affinity DataKi: 1.00E+3nMAssay Description:Inhibition of human recombinant ASNS expressed in Sf9 cells assessed as initial inhibition constant for glutamine dependent production of inorganic p...More data for this Ligand-Target Pair
TargetAsparagine synthetase [glutamine-hydrolyzing](Homo sapiens (Human))
Kyoto University
Curated by ChEMBL
Kyoto University
Curated by ChEMBL
Affinity DataKi: 3.04E+3nMAssay Description:Inhibition of human recombinant ASNS expressed in Sf9 cells assessed as assessed as initial inhibition constant for ammonia dependent production of i...More data for this Ligand-Target Pair
TargetAsparagine synthetase [glutamine-hydrolyzing](Homo sapiens (Human))
Kyoto University
Curated by ChEMBL
Kyoto University
Curated by ChEMBL
Affinity DataKi: 4.50E+3nMAssay Description:Inhibition of human recombinant ASNS expressed in Sf9 cells assessed as initial inhibition constant for glutamine dependent production of inorganic p...More data for this Ligand-Target Pair
Affinity DataKi: 7.41E+4nMAssay Description:Inhibition of relaxation activities of DNA topoisomerase II with respect to pBR322 DNAMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 0.540nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 0.650nMAssay Description:Inhibition of recombinant human full length GST-tagged GRK3 expressed in baculovirus using ulight topo2alpha as substrate preincubated for 60 mins fo...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged GRK2 expressed in baculovirus expression system using ulight topo2alpha as substrate preincubat...More data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged GRK2 expressed in baculovirus expression system using ulight topo2alpha as substrate preincubat...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Inhibition of recombinant human full length GST-tagged GRK3 expressed in baculovirus using ulight topo2alpha as substrate preincubated for 60 mins fo...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged GRK2 expressed in baculovirus expression system using ulight topo2alpha as substrate preincubat...More data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair