Affinity DataKi: 0.340nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
Affinity DataKi: 0.630nM ΔG°: -52.5kJ/moleT: 2°CAssay Description:The inhibition of the HLE was studied at 25°C by continuously monitoring the absorbance at 410 nm for 20 min of a solution prepared by mixing 10 _...More data for this Ligand-Target Pair
Affinity DataKi: 0.710nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
Affinity DataKi: 0.820nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
Affinity DataKi: 0.850nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
Affinity DataKi: 1.21nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
Affinity DataKi: 1.80nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
Affinity DataKi: 2.20nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
Affinity DataKi: 3.90nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
Affinity DataKi: 7.60nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
Affinity DataKi: 23.8nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
Affinity DataKi: 33.9nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
Affinity DataKi: 34.4nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
Affinity DataKi: 63.5nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
Affinity DataKi: 99.3nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
Affinity DataKi: 114nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
Affinity DataKi: 127nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
Affinity DataKi: 203nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
Affinity DataKi: 219nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
Affinity DataKi: 233nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
Affinity DataKi: 1.40E+3nMAssay Description:Competitive inhibition of recombinant Trypanosoma cruzi cruzain by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 3.00E+3nMAssay Description:Competitive inhibition of recombinant Trypanosoma cruzi cruzain by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 4.45E+3nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Universidade Federal De Minas Gerais
Curated by ChEMBL
Universidade Federal De Minas Gerais
Curated by ChEMBL
Affinity DataKi: 1.00E+4nMAssay Description:Mixed inhibition of recombinant Trypanosoma brucei rhodesain expressed in Pichia pastoris by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 1.21E+4nMAssay Description:Competitive inhibition of recombinant Trypanosoma cruzi cruzain in presence of varying levels of Z-phe-Arg-amidomethylcoumarin substrate by Lineweave...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Universidade Federal De Mato Grosso Do Sul
Curated by ChEMBL
Universidade Federal De Mato Grosso Do Sul
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of AChE in rat brain HippocampusMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Universidade Federal De Mato Grosso Do Sul
Curated by ChEMBL
Universidade Federal De Mato Grosso Do Sul
Curated by ChEMBL
Affinity DataIC50: 240nMAssay Description:Inhibition of AChE in rat brain cortexMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Universidade Federal De Mato Grosso Do Sul
Curated by ChEMBL
Universidade Federal De Mato Grosso Do Sul
Curated by ChEMBL
Affinity DataIC50: 320nMAssay Description:Inhibition of AChE in rat brain HippocampusMore data for this Ligand-Target Pair
Affinity DataIC50: 450nMAssay Description:Inhibition of Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorimetric analysisMore data for this Ligand-Target Pair
Ligand Info
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Universidade Federal De Mato Grosso Do Sul
Curated by ChEMBL
Universidade Federal De Mato Grosso Do Sul
Curated by ChEMBL
Affinity DataIC50: 650nMAssay Description:Inhibition of AChE in rat brain cortexMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorimetric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-FR-AMC as substrate and measured at 12 sec interval for 5 mins without preincubation by f...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Irreversible inhibition of Trypanosoma cruzi cruzipainMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Universidade Federal De Mato Grosso Do Sul
Curated by ChEMBL
Universidade Federal De Mato Grosso Do Sul
Curated by ChEMBL
Affinity DataIC50: 3.17E+3nMAssay Description:Inhibition of AChE in rat brain StriatumMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
Affinity DataIC50: 7.30E+3nMpH: 8.0Assay Description:AChE enzymatic activity was measured using an adaptation of the method previously described [Ingkaninan et al., J. Ethnopharmacol., 89:261-264]; 98 &...More data for this Ligand-Target Pair
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Universidade Federal De Minas Gerais
Curated by ChEMBL
Universidade Federal De Minas Gerais
Curated by ChEMBL
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of human recombinant glutathione reductase using glutathione as substrate preincubated for 30 mins by colorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-FR-AMC as substrate and measured at 12 sec interval for 5 mins without preincubation by f...More data for this Ligand-Target Pair
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Universidade Federal De Minas Gerais
Curated by ChEMBL
Universidade Federal De Minas Gerais
Curated by ChEMBL
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of recombinant Trypanosoma brucei rhodesain expressed in Pichia pastoris using Z-FR-AMC as substrate preincubated for 10 mins followed by ...More data for this Ligand-Target Pair
TargetTrypanothione reductase(Trypanosoma cruzi)
Universidade Federal De Minas Gerais
Curated by ChEMBL
Universidade Federal De Minas Gerais
Curated by ChEMBL
Affinity DataIC50: 1.23E+4nMAssay Description:Inhibition of Trypanosoma cruzi trypanothione reductase expressed in Escherichia coli BL21(DE3) assessed as reduction of oxidized trypanothione prein...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 13(Mus musculus)
Universidade Federal Do Rio De Janeiro
Curated by ChEMBL
Universidade Federal Do Rio De Janeiro
Curated by ChEMBL
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of LPS-induced p38 MAPK activation in BALB/c mouse peritoneal macrophagesMore data for this Ligand-Target Pair
TargetTrypanothione reductase(Trypanosoma cruzi)
Universidade Federal De Minas Gerais
Curated by ChEMBL
Universidade Federal De Minas Gerais
Curated by ChEMBL
Affinity DataIC50: 1.47E+4nMAssay Description:Inhibition of Trypanosoma cruzi trypanothione reductase expressed in Escherichia coli BL21(DE3) assessed as reduction of oxidized trypanothione prein...More data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-phe-Arg-amidomethylcoumarin as substrate by fluorometric methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-phe-Arg-amidomethylcoumarin as substrate by fluorometric methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Universidade Federal De Mato Grosso Do Sul
Curated by ChEMBL
Universidade Federal De Mato Grosso Do Sul
Curated by ChEMBL
Affinity DataIC50: 1.86E+4nMAssay Description:Inhibition of AChE in rat brain CerebellumMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Universidade Federal De Mato Grosso Do Sul
Curated by ChEMBL
Universidade Federal De Mato Grosso Do Sul
Curated by ChEMBL
Affinity DataIC50: 1.91E+4nMAssay Description:Inhibition of AChE in rat brain CerebellumMore data for this Ligand-Target Pair