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Found 122 with Last Name = 'oliveira' and Initial = 'r'
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303364(1-(4-((Benzo[d]oxazol-2-ylthio)methyl)phenyl)-3,3-...)
Affinity DataKi:  0.340nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303371(1-(6-((Benzo[d]thiazol-2-ylthio)methyl)pyridin-3-y...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM234270(4-oxo-β-lactam (3))
Affinity DataKi:  0.630nM ΔG°:  -52.5kJ/moleT: 2°CAssay Description:The inhibition of the HLE was studied at 25°C by continuously monitoring the absorbance at 410 nm for 20 min of a solution prepared by mixing 10 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50235615(3,3-diethyl-1-(4-methoxyphenyl)azetidine-2,4-dione...)
Affinity DataKi:  0.710nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303369(1-(4-((Benzo[d]thiazol-2-ylthio)methyl)phenyl)-3,3...)
Affinity DataKi:  0.820nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303373(3-butyl-3-ethyl-1-phenylazetidine-2,4-dione | CHEM...)
Affinity DataKi:  0.850nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303363(2-(4-(3,3-Diethyl-2,4-dioxoazetidin-1-yl)benzylthi...)
Affinity DataKi:  1nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303370(1-(4-((5-Phenyl-1,3,4-oxadiazol-2-ylthio)methyl)ph...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50235613(3,3-diethyl-1-phenylazetidine-2,4-dione | CHEMBL27...)
Affinity DataKi:  1.21nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303357(3,3-Diethyl-1-(6-methylpyridin-3-yl)azetidine-2,4-...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303372(3,3-Diethyl-1-(4-((phenylthio)methyl)phenyl)azetid...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303356(3,3-Diethyl-1-(pyridin-3-yl)azetidine-2,4-dione | ...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303361(3-Ethyl-3-isobutyl-1-phenylazetidine-2,4-dione | C...)
Affinity DataKi:  3.90nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303365(1-(2-((Benzo[d]oxazol-2-ylthio)methyl)phenyl)-3,3-...)
Affinity DataKi:  7.60nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50235616(1-(4-chlorophenyl)-3,3-dimethylazetidine-2,4-dione...)
Affinity DataKi:  23.8nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303358(3,3-Diethyl-1-(naphthalen-1-yl)azetidine-2,4-dione...)
Affinity DataKi:  33.9nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50235610(1-benzyl-3,3-dimethylazetidine-2,4-dione | CHEMBL5...)
Affinity DataKi:  34.4nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50235611(4-(3,3-diethyl-2,4-dioxoazetidin-1-yl)benzonitrile...)
Affinity DataKi:  63.5nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303362(1-(2-((Benzo[d]thiazol-2-ylthio)methyl)phenyl)-3,3...)
Affinity DataKi:  99.3nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303359(1-benzyl-3,3-diethylazetidine-2,4-dione | CHEMBL27...)
Affinity DataKi:  114nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303374(3-Benzyl-3-ethyl-1-phenylazetidine-2,4-dione | CHE...)
Affinity DataKi:  127nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303368(1-(2-((1-Methyl-1H-imidazol-2-ylthio)methyl)phenyl...)
Affinity DataKi:  203nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303360(CHEMBL271820 | ethyl 2-(3,3-Diethyl-2,4-dioxoazeti...)
Affinity DataKi:  219nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303355(3,3-Diethyl-1-o-tolylazetidine-2,4-dione | CHEMBL5...)
Affinity DataKi:  233nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Minas Gerais

Curated by ChEMBL
LigandPNGBDBM50518231(CHEMBL597248 | GNF-Pf-4180 | MMV006169)
Affinity DataKi:  1.40E+3nMAssay Description:Competitive inhibition of recombinant Trypanosoma cruzi cruzain by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Minas Gerais

Curated by ChEMBL
LigandPNGBDBM50546138(CHEMBL4793916)
Affinity DataKi:  3.00E+3nMAssay Description:Competitive inhibition of recombinant Trypanosoma cruzi cruzain by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303366(3-Benzyl-3-methyl-1-phenylazetidine-2,4-dione | CH...)
Affinity DataKi:  4.45E+3nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Universidade Federal De Minas Gerais

Curated by ChEMBL
LigandPNGBDBM50546136(CHEMBL531738)
Affinity DataKi:  1.00E+4nMAssay Description:Mixed inhibition of recombinant Trypanosoma brucei rhodesain expressed in Pichia pastoris by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Minas Gerais

Curated by ChEMBL
LigandPNGBDBM50233289(CHEMBL1241726)
Affinity DataKi:  1.21E+4nMAssay Description:Competitive inhibition of recombinant Trypanosoma cruzi cruzain in presence of varying levels of Z-phe-Arg-amidomethylcoumarin substrate by Lineweave...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Universidade Federal De Mato Grosso Do Sul

Curated by ChEMBL
LigandPNGBDBM50022775((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)
Affinity DataIC50:  70nMAssay Description:Inhibition of AChE in rat brain HippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Universidade Federal De Mato Grosso Do Sul

Curated by ChEMBL
LigandPNGBDBM50571301(CHEMBL4861510)
Affinity DataIC50:  240nMAssay Description:Inhibition of AChE in rat brain cortexMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Universidade Federal De Mato Grosso Do Sul

Curated by ChEMBL
LigandPNGBDBM50571301(CHEMBL4861510)
Affinity DataIC50:  320nMAssay Description:Inhibition of AChE in rat brain HippocampusMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Minas Gerais

Curated by ChEMBL
LigandPNGBDBM50612895(CHEMBL5287453)
Affinity DataIC50:  450nMAssay Description:Inhibition of Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorimetric analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Universidade Federal De Mato Grosso Do Sul

Curated by ChEMBL
LigandPNGBDBM50022775((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)
Affinity DataIC50:  650nMAssay Description:Inhibition of AChE in rat brain cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Minas Gerais

Curated by ChEMBL
LigandPNGBDBM50114666(5-(4-chlorophenyl)-2-furaldehyde thiosemicarbazone...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Minas Gerais

Curated by ChEMBL
LigandPNGBDBM50546137(CHEMBL582420 | MMV019202 | TCMDC-123752)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-FR-AMC as substrate and measured at 12 sec interval for 5 mins without preincubation by f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Minas Gerais

Curated by ChEMBL
LigandPNGBDBM12042((2R,3R)-3-{[(1S)-1-[(4-carbamimidamidobutyl)carbam...)
Affinity DataIC50:  3.00E+3nMAssay Description:Irreversible inhibition of Trypanosoma cruzi cruzipainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Universidade Federal De Mato Grosso Do Sul

Curated by ChEMBL
LigandPNGBDBM50022775((m-Hydroxyphenyl)trimethylammonium dimethylcarbama...)
Affinity DataIC50:  3.17E+3nMAssay Description:Inhibition of AChE in rat brain StriatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Minas Gerais

Curated by ChEMBL
LigandPNGBDBM50546139(CHEMBL533921 | MMV666072 | TCMDC-124653)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Instituto Superior Técnico

LigandPNGBDBM234404(3,4-Dimethoxycinnamoylcholine chloride (1))
Affinity DataIC50:  7.30E+3nMpH: 8.0Assay Description:AChE enzymatic activity was measured using an adaptation of the method previously described [Ingkaninan et al., J. Ethnopharmacol., 89:261-264]; 98 &...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Universidade Federal De Minas Gerais

Curated by ChEMBL
LigandPNGBDBM50015950(1,3-bis(2-chloroethyl)-1-nitrosourea | Bicnu (TN) ...)
Affinity DataIC50:  8.10E+3nMAssay Description:Inhibition of human recombinant glutathione reductase using glutathione as substrate preincubated for 30 mins by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Minas Gerais

Curated by ChEMBL
LigandPNGBDBM50518231(CHEMBL597248 | GNF-Pf-4180 | MMV006169)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-FR-AMC as substrate and measured at 12 sec interval for 5 mins without preincubation by f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Universidade Federal De Minas Gerais

Curated by ChEMBL
LigandPNGBDBM50546139(CHEMBL533921 | MMV666072 | TCMDC-124653)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of recombinant Trypanosoma brucei rhodesain expressed in Pichia pastoris using Z-FR-AMC as substrate preincubated for 10 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Universidade Federal De Minas Gerais

Curated by ChEMBL
LigandPNGBDBM77970(3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11...)
Affinity DataIC50:  1.23E+4nMAssay Description:Inhibition of Trypanosoma cruzi trypanothione reductase expressed in Escherichia coli BL21(DE3) assessed as reduction of oxidized trypanothione prein...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 13(Mus musculus)
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50485275(CHEMBL2043204 | LASSBio-998)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of LPS-induced p38 MAPK activation in BALB/c mouse peritoneal macrophagesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Universidade Federal De Minas Gerais

Curated by ChEMBL
LigandPNGBDBM68089((2E,6E)-2,6-bis(4-pyridylmethylene)cyclohexanone |...)
Affinity DataIC50:  1.47E+4nMAssay Description:Inhibition of Trypanosoma cruzi trypanothione reductase expressed in Escherichia coli BL21(DE3) assessed as reduction of oxidized trypanothione prein...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Minas Gerais

Curated by ChEMBL
LigandPNGBDBM50233289(CHEMBL1241726)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-phe-Arg-amidomethylcoumarin as substrate by fluorometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Minas Gerais

Curated by ChEMBL
LigandPNGBDBM50322743(8-chloro-N-(3-morpholinopropyl)-5H-pyrimido[5,4-b]...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-phe-Arg-amidomethylcoumarin as substrate by fluorometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Universidade Federal De Mato Grosso Do Sul

Curated by ChEMBL
LigandPNGBDBM50571300(CHEMBL4859777)
Affinity DataIC50:  1.86E+4nMAssay Description:Inhibition of AChE in rat brain CerebellumMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Universidade Federal De Mato Grosso Do Sul

Curated by ChEMBL
LigandPNGBDBM50571301(CHEMBL4861510)
Affinity DataIC50:  1.91E+4nMAssay Description:Inhibition of AChE in rat brain CerebellumMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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