Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant HDAC6 incubated for 90 mins using fluorogenic substrate ZMAL (Z-Lys(Ac)-AMC) by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of HDAC6 (unknown origin) using acetyl-lysine tripeptide as substrate preincubated for 24 hrs followed by substrate addition and measured ...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Antagonist activity at 5-HT3 receptor in guinea pig ileum muscleMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf
Curated by ChEMBL
Heinrich Heine University D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 4.40nMAssay Description:Inhibition of chymotrypsin-like activity of 20S proteasome in human SEM cells using Suc-LLVY aminoluciferin as substrate after 2 hrs by proteasome-Gl...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of human HDAC6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of human N-terminal GST-tagged HDAC6 expressed in baculovirus infected insect cells using RHKKAc as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of human HDAC1More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf
Curated by ChEMBL
Heinrich Heine University D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 6.70nMAssay Description:Inhibition of chymotrypsin-like activity of 20S proteasome in human HL60 cells using Suc-LLVY aminoluciferin as substrate after 2 hrs by proteasome-G...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of human recombinant HDAC1 incubated for 90 mins using fluorogenic substrate ZMAL (Z-Lys(Ac)-AMC) by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8.5nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human HDAC6 expressed in baculovirus infected insect cells using RHKK(Ac)AMC as substrate by fluoresc...More data for this Ligand-Target Pair
Affinity DataIC50: 9.40nMAssay Description:Inhibition of C-terminal FLAG-His-tagged full length recombinant human HDAC1 expressed in Sf21 insect cells using RHKK(Ac)AMC as substrate by fluores...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant HDAC6 incubated for 90 mins using fluorogenic substrate ZMAL (Z-Lys(Ac)-AMC) by fluorescence based assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf
Curated by ChEMBL
Heinrich Heine University D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human HDAC3/NCOR2 expressed in baculovirus infected insect cells using RHKK(Ac)AMC as substrate by fluorescence-based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant HDAC6 using ZMAL (Z-Lys(Ac)-AMC) fluorogenic substrate incubated for 90 mins by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant HDAC6 incubated for 90 mins using fluorogenic substrate ZMAL (Z-Lys(Ac)-AMC) by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of human N-terminal GST-tagged HDAC6 expressed in baculovirus infected insect cells using RHKKAc as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant HDAC6 using ZMAL (Z-Lys(Ac)-AMC) fluorogenic substrate incubated for 90 mins by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant HDAC6 using ZMAL (Z-Lys(Ac)-AMC) fluorogenic substrate incubated for 90 mins by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of human HDAC6 after 30 mins by microplate reader analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf
Curated by ChEMBL
Heinrich Heine University D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Inhibition of C-terminal GST-tagged recombinant human HDAC2 expressed in baculovirus infected insect cells using RHKK(Ac)AMC as substrate by fluoresc...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf
Curated by ChEMBL
Heinrich Heine University D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 28nMAssay Description:Inhibition of chymotrypsin-like activity of 20S proteasome in imatinib-resistant human SUP-B15 cells using Suc-LLVY aminoluciferin as substrate after...More data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Antagonist activity at Alpha-1B adrenoceptor in Wistar rat spleen assessed as phenylephrine induced contractions after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of full length N-terminal GST-tagged human HDAC6 expressed in baculovirus expression system using ZMAL as substrate incubated for 90 mins ...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of human recombinant HDAC6 using ZMAL (Z-Lys(Ac)-AMC) fluorogenic substrate incubated for 90 mins by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of human recombinant HDAC6 using ZMAL (Z-Lys(Ac)-AMC) fluorogenic substrate incubated for 90 mins by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Antagonist activity at 5-HT3 receptor in guinea pig ileum muscleMore data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Antagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant HDAC6 using ZMAL (Z-Lys(Ac)-AMC) fluorogenic substrate incubated for 90 mins by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 42nMAssay Description:Inhibition of full length N-terminal GST-tagged human HDAC6 expressed in baculovirus expression system using ZMAL as substrate incubated for 90 mins ...More data for this Ligand-Target Pair
Affinity DataIC50: 42nMAssay Description:Antagonist activity at alpha1A adrenoceptor in Wistar rat vas deferans assessed as noradrenaline induced contractions after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 43nMAssay Description:Inhibition of C-terminal Flag-tagged HDAC1 (unknown origin) expressed in HEK293 cells or Sf21 cells using Ac-NH-GGK(Ac)-AMC peptide as substrate meas...More data for this Ligand-Target Pair
Affinity DataIC50: 49nMAssay Description:Inhibition of full length N-terminal GST-tagged human HDAC6 expressed in baculovirus expression system using ZMAL as substrate incubated for 90 mins ...More data for this Ligand-Target Pair
Affinity DataIC50: 56nMAssay Description:Inhibition of human HDAC6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant HDAC6 using ZMAL (Z-Lys(Ac)-AMC) fluorogenic substrate incubated for 90 mins by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant HDAC6 incubated for 90 mins using fluorogenic substrate ZMAL (Z-Lys(Ac)-AMC) by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 61nMAssay Description:Antagonist activity at 5-HT3 receptor in guinea pig ileum muscleMore data for this Ligand-Target Pair
Affinity DataIC50: 65nMAssay Description:Inhibition of human HDAC1 after 30 mins by microplate reader analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 67nMAssay Description:Antagonist activity at 5-HT3 receptor in guinea pig ileum muscleMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of human recombinant HDAC6 using ZMAL (Z-Lys(Ac)-AMC) fluorogenic substrate incubated for 90 mins by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 71nMAssay Description:Antagonist activity at 5-HT3 receptor in guinea pig ileum muscleMore data for this Ligand-Target Pair
Affinity DataIC50: 72nMAssay Description:Inhibition of C-terminal Flag-tagged HDAC6 (unknown origin) expressed in HEK293 cells or Sf21 cells using Ac-NH-GGK(Ac)-AMC peptide as substrate meas...More data for this Ligand-Target Pair
Affinity DataIC50: 72nMAssay Description:Inhibition of recombinant C-terminal FLAG-tagged HDAC6 (unknown origin) using Ac-NH-GGK(Ac)-AMC as substrate measured after 180 mins by fluorescence ...More data for this Ligand-Target Pair
Affinity DataIC50: 73nMAssay Description:Antagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibition of human recombinant HDAC1 incubated for 90 mins using fluorogenic substrate ZMAL (Z-Lys(Ac)-AMC) by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibition of human recombinant HDAC6 using ZMAL (Z-Lys(Ac)-AMC) fluorogenic substrate incubated for 90 mins by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 85nMAssay Description:Inhibition of human recombinant HDAC6 using ZMAL (Z-Lys(Ac)-AMC) fluorogenic substrate incubated for 90 mins by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 91nMAssay Description:Antagonist activity at 5-HT3 receptor in guinea pig ileum muscleMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant HDAC6 using ZMAL (Z-Lys(Ac)-AMC) fluorogenic substrate incubated for 90 mins by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant HDAC6 using ZMAL (Z-Lys(Ac)-AMC) fluorogenic substrate incubated for 90 mins by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of full length N-terminal GST-tagged human HDAC6 expressed in baculovirus expression system using ZMAL as substrate incubated for 90 mins ...More data for this Ligand-Target Pair