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Found 268 with Last Name = 'otsuka' and Initial = 'm'
TargetDNA topoisomerase 1(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50142519(CHEMBL47027 | N-[2-(3,4,5-triihydroxy-benzoylamino...)
Affinity DataKi:  400nMAssay Description:Inhibition of relaxation activities of DNA topoisomerase I with respect to pBR322 DNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50142519(CHEMBL47027 | N-[2-(3,4,5-triihydroxy-benzoylamino...)
Affinity DataKi:  7.41E+4nMAssay Description:Inhibition of relaxation activities of DNA topoisomerase II with respect to pBR322 DNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50142519(CHEMBL47027 | N-[2-(3,4,5-triihydroxy-benzoylamino...)
Affinity DataIC50:  9nMAssay Description:Inhibitory concentration against relaxation activity of DNA topoisomerase II by detecting the conversion of supercoiled pBR322 DNA to its relaxed for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))TBA
LigandPNGBDBM50152068(CHEMBL3781485)
Affinity DataIC50:  10nMAssay Description:Inhibition of SIRT2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))TBA
LigandPNGBDBM50540056(CHEMBL4638983)
Affinity DataIC50:  28nMAssay Description:Inhibition of human SIRT2 expressed in Escherichia coli BL21 using acetyl-H3K9 by HPLC based assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Anadolu University

Curated by ChEMBL
LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)
Affinity DataIC50:  50nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged EGFR (695 to end residues) expressed in baculovirus infected Sf9 insect cells using Poly (4:1 G...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))TBA
LigandPNGBDBM50610747(CHEMBL5274785)
Affinity DataIC50:  70nMAssay Description:Inhibition of human SIRT2 deacetylase activity using QPKKac as substrateMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))TBA
LigandPNGBDBM50610746(CHEMBL5286760)
Affinity DataIC50:  70nMAssay Description:Inhibition of human SIRT2 deacetylase activity using QPKKac as substrateMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))TBA
LigandPNGBDBM50610744(CHEMBL5267372)
Affinity DataIC50:  78nMAssay Description:Inhibition of human SIRT2 deacetylase activity measured after preincubation by HPLC methodMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))TBA
LigandPNGBDBM50610746(CHEMBL5286760)
Affinity DataIC50:  90nMAssay Description:Inhibition of human SIRT2 demyristoylation activity using ETDKac as substrateMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))TBA
LigandPNGBDBM50610745(CHEMBL5273182)
Affinity DataIC50:  93nMAssay Description:Inhibition of human SIRT2 deacetylase activity measured after preincubation by HPLC methodMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))TBA
LigandPNGBDBM50610745(CHEMBL5273182)
Affinity DataIC50:  110nMAssay Description:Inhibition of human SIRT2 defatty-acylase activity measured after preincubation by HPLC methodMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50142517(CHEMBL47885 | N-[4-(3,4,5-triihydroxy-benzoylamino...)
Affinity DataIC50:  150nMAssay Description:Inhibitory concentration against relaxation activity of DNA topoisomerase II by detecting the conversion of supercoiled pBR322 DNA to its relaxed for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))TBA
LigandPNGBDBM50610744(CHEMBL5267372)
Affinity DataIC50:  170nMAssay Description:Inhibition of human SIRT2 defatty-acylase activity measured after preincubation by HPLC methodMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))TBA
LigandPNGBDBM50610742(CHEMBL5273854)
Affinity DataIC50:  180nMAssay Description:Inhibition of recombinant SIRT2 (unknown origin) using (FAM)-labeled fluorescent peptide-RHKK(Ac)LM by electrophoretic mobility shift assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  190nMAssay Description:Inhibition of human whole blood COX-2 assessed as production of PGE2 after 24 hrs by EIAMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))TBA
LigandPNGBDBM50148781(CHEMBL3770903)
Affinity DataIC50:  210nMAssay Description:Inhibition of recombinant SIRT2 (unknown origin) using FAM-RHKK(Ac)LM as substrate measured after 60 mins by electrophoretic mobility shift assayMore data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50142507(CHEMBL47526 | N-[3-(3,4,5-triihydroxy-benzoylamino...)
Affinity DataIC50:  220nMAssay Description:Inhibitory concentration against relaxation activity of DNA topoisomerase II by detecting the conversion of supercoiled pBR322 DNA to its relaxed for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))TBA
LigandPNGBDBM50610743(CHEMBL5272503)
Affinity DataIC50:  460nMAssay Description:Inhibition of human GST-fused SIRT2 expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50330857(2-(2-fluoro-4-(((1,2-trans)-2-hydroxycyclopentyl)m...)
Affinity DataIC50:  600nMAssay Description:Inhibition of COX1 in human whole blood assessed as TXB2 biosynthesis after 24 hrs by EIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50142519(CHEMBL47027 | N-[2-(3,4,5-triihydroxy-benzoylamino...)
Affinity DataIC50:  900nMAssay Description:Inhibitory concentration against relaxation activity of DNA topoisomerase I by detecting the conversion of supercoiled pBR322 DNA to its relaxed formMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))TBA
LigandPNGBDBM50610738(CHEMBL5282160)
Affinity DataIC50:  980nMAssay Description:Inhibition of SIRT2 (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))TBA
LigandPNGBDBM50595087(CHEMBL5192844)
Affinity DataIC50:  1.17E+3nMAssay Description:Inhibition of human SIRT2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))TBA
LigandPNGBDBM50523795(CHEMBL4551537)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of recombinant SIRT2 (unknown origin) using FAM-RHKK(Ac)LM as substrate measured after 60 mins by electrophoretic mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50140317((R)-2-[4-((1R,2S)-2-Hydroxy-cyclopentylmethyl)-phe...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of human whole blood COX-1 assessed as production of TXB2 after 24 hrs by EIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50140321((S)-2-[4-((1R,2S)-2-Hydroxy-cyclopentylmethyl)-phe...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of COX1 in human whole blood assessed as TXB2 biosynthesis after 24 hrs by EIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))TBA
LigandPNGBDBM50610748(CHEMBL5266407)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of human SIRT2 using Ac-peptide as substrate assessed as fluorescence intensity by microplate readerMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50142517(CHEMBL47885 | N-[4-(3,4,5-triihydroxy-benzoylamino...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibitory concentration against relaxation activity of DNA topoisomerase I by detecting the conversion of supercoiled pBR322 DNA to its relaxed formMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50388963(CHEMBL2063732)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human whole blood COX-1 assessed as inhibition of TXB2 production by EIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Anadolu University

Curated by ChEMBL
LigandPNGBDBM50528844(CHEMBL4516916)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HER4 (682 to 993 residues) expressed in baculovirus infected Sf9 insect cells using Poly (4:1 G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))TBA
LigandPNGBDBM50610737(CHEMBL4444068)
Affinity DataIC50:  1.56E+3nMAssay Description:Inhibition of SIRT2 (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50142507(CHEMBL47526 | N-[3-(3,4,5-triihydroxy-benzoylamino...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibitory concentration against relaxation activity of DNA topoisomerase I by detecting the conversion of supercoiled pBR322 DNA to its relaxed formMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))TBA
LigandPNGBDBM50523787(CHEMBL4464347)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of recombinant SIRT2 (unknown origin) using RHKK(Ac)-MCA as substrate measured after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))TBA
LigandPNGBDBM50523787(CHEMBL4464347)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of recombinant SIRT2 (unknown origin) using FAM-RHKK(Ac)LM as substrate measured after 60 mins by electrophoretic mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50127228(2-({6-[(2-Mercapto-ethylamino)-methyl]-4-naphthale...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of [3H]-farnesyl pyrophosphate binding to human farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50349898(CHEMBL1814707)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human whole blood COX-2 assessed as production of PGE2 after 24 hrs by EIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug and toxin extrusion protein 1(Homo sapiens (Human))
Setsunan University

Curated by ChEMBL
LigandPNGBDBM50588370(CHEMBL5194558)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human MATE1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50330856(2-(2-bromo-4-(((1,2-trans)-2-hydroxycyclopentyl)me...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of COX1 in human whole blood assessed as TXB2 biosynthesis after 24 hrs by EIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug and toxin extrusion protein 1(Homo sapiens (Human))
Setsunan University

Curated by ChEMBL
LigandPNGBDBM50103595(Brumetadina | CHEBI:3699 | Cimetidine | Tagamet | ...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of human MATE1More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Anadolu University

Curated by ChEMBL
LigandPNGBDBM50528843(CHEMBL4516736)
Affinity DataIC50:  2.28E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HER2 (676 to end residues) expressed in baculovirus infected Sf9 insect cells using Poly (4:1 G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50140321((S)-2-[4-((1R,2S)-2-Hydroxy-cyclopentylmethyl)-phe...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of COX2 in human whole blood assessed as PGE2 biosynthesis after 24 hrs by EIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50140317((R)-2-[4-((1R,2S)-2-Hydroxy-cyclopentylmethyl)-phe...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of human whole blood COX-2 assessed as production of PGE2 after 24 hrs by EIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))TBA
LigandPNGBDBM50610750(CHEMBL5276776)
Affinity DataIC50:  2.47E+3nMAssay Description:Inhibition of human SIRT2 using Ac-Glu-Thr-Asp-Lys(Dec)-AMC as substrate by fluorogenic based methodMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM14454(1-(4-pyridylacetyl)-4-(8-chloro-5,6-dihydro-11H-be...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of [3H]-farnesyl pyrophosphate binding to human farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))TBA
LigandPNGBDBM50523797(CHEMBL4522115)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of recombinant SIRT2 (unknown origin) using FAM-RHKK(Ac)LM as substrate measured after 60 mins by electrophoretic mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Anadolu University

Curated by ChEMBL
LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)
Affinity DataIC50:  2.59E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HER4 (682 to 993 residues) expressed in baculovirus infected Sf9 insect cells using Poly (4:1 G...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50142526(CHEMBL44765 | N-[4-(3,4-dihydroxy-benzoylamino)-ph...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibitory concentration against relaxation activity of DNA topoisomerase I by detecting the conversion of supercoiled pBR322 DNA to its relaxed formMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50388964(CHEMBL2063734)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human whole blood COX-1 assessed as inhibition of TXB2 production by EIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50410165(CHEMBL372661)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibitory concentration against DNA topoisomerase I activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50330857(2-(2-fluoro-4-(((1,2-trans)-2-hydroxycyclopentyl)m...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of COX2 in human whole blood assessed as PGE2 biosynthesis after 24 hrs by EIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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