Compile Data Set for Download or QSAR
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Found 57 with Last Name = 'overhand' and Initial = 'm'
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50398211(CHEMBL2181036)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]chrysamine G from fibrillar amyloid beta (1 to 40) (unknown origin) after 1 hr by liquid scintillation spectrophotometric analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50002834(CHEMBL3233658)
Affinity DataKi:  39nMAssay Description:Displacement of [3H]chrysamine G from fibrillar amyloid beta (1 to 40) (unknown origin) after 1 hr by liquid scintillation spectrophotometric analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50002835(CHEMBL3233659)
Affinity DataKi:  56nMAssay Description:Displacement of [3H]chrysamine G from fibrillar amyloid beta (1 to 40) (unknown origin) after 1 hr by liquid scintillation spectrophotometric analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50002836(CHEMBL3233660)
Affinity DataKi:  84nMAssay Description:Displacement of [3H]chrysamine G from fibrillar amyloid beta (1 to 40) (unknown origin) after 1 hr by liquid scintillation spectrophotometric analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50002833(CHEMBL3233657)
Affinity DataKi:  244nMAssay Description:Displacement of [3H]chrysamine G from fibrillar amyloid beta (1 to 40) (unknown origin) after 1 hr by liquid scintillation spectrophotometric analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50299749((2R,3R,4R,5S)-1-[5-(Adamantan-1-ylmethoxy)-pentyl]...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human GBA2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290252(CHEMBL78510 | potassium; (3E,7E)-4,8,12-trimethyl-...)
Affinity DataIC50:  18nMAssay Description:Inhibition of Squalene SynthaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM18355((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human lysosomal alpha glucosidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM18355((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)
Affinity DataIC50:  230nMAssay Description:Inhibition of human GBA2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50150667((S)-2-({(2S,3S,6R)-6-[((R)-2-Amino-3-tert-butyldis...)
Affinity DataIC50:  250nMAssay Description:Inhibition of [3H]FPP incorporation by Protein FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50122992(CHEMBL2370448 | [(1R,15S,16R,17S)-11-(3-Guanidino-...)
Affinity DataIC50:  384nMAssay Description:Displacement of [125I]-echistatin from alphaIIb-beta3 integrin of human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50299749((2R,3R,4R,5S)-1-[5-(Adamantan-1-ylmethoxy)-pentyl]...)
Affinity DataIC50:  400nMAssay Description:Inhibition of human lysosomal alpha glucosidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50366346(CHEMBL1790477)
Affinity DataIC50:  420nMAssay Description:Inhibition of [3H]FPP incorporation by Protein FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290254(CHEMBL80021 | pentapotassium ({[(3E,7E)-4,8,12-tri...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of Squalene SynthaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50122992(CHEMBL2370448 | [(1R,15S,16R,17S)-11-(3-Guanidino-...)
Affinity DataIC50:  1.49E+3nMAssay Description:Displacement of [125I]-echistatin from alphaV-beta3 integrin of human skin fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human lysosomal alpha glucosidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50290254(CHEMBL80021 | pentapotassium ({[(3E,7E)-4,8,12-tri...)
Affinity DataIC50:  1.81E+3nMAssay Description:Inhibition of Farnesyl TransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50150666((S)-2-({(2S,3S,6R)-6-[((R)-2-Amino-3-tert-butyldis...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of [3H]FPP incorporation by Protein FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50290253(CHEMBL21986 | pentapotassium ({[(6E,10E,15E,19E)-2...)
Affinity DataIC50:  3.99E+3nMAssay Description:Inhibition of Farnesyl TransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50290252(CHEMBL78510 | potassium; (3E,7E)-4,8,12-trimethyl-...)
Affinity DataIC50:  1.35E+4nMAssay Description:Inhibition of Farnesyl TransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50150662((S)-2-({(2S,3S,6R)-6-[((R)-2-Amino-3-tert-butyldis...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of [3H]GGPP incorporation by Protein Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of human GBA2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290253(CHEMBL21986 | pentapotassium ({[(6E,10E,15E,19E)-2...)
Affinity DataIC50:  2.33E+4nMAssay Description:Inhibition of Squalene SynthaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50122993(CHEMBL2370452 | [(1R,18S,19R,20S)-14-(3-Guanidino-...)
Affinity DataIC50:  3.22E+4nMAssay Description:Displacement of [125I]-echistatin from alphaIIb-beta3 integrin of human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50290251(CHEMBL79827 | tripotassium 2,4,6-trioxo-3-[(2E,6E)...)
Affinity DataIC50:  3.42E+4nMAssay Description:Inhibition of Farnesyl TransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50150665((S)-2-({(2S,3S,6S)-6-[((R)-2-Amino-3-tert-butyldis...)
Affinity DataIC50:  4.20E+4nMAssay Description:Inhibition of [3H]FPP incorporation by Protein FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290251(CHEMBL79827 | tripotassium 2,4,6-trioxo-3-[(2E,6E)...)
Affinity DataIC50:  4.64E+4nMAssay Description:Inhibition of Squalene SynthaseMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50150665((S)-2-({(2S,3S,6S)-6-[((R)-2-Amino-3-tert-butyldis...)
Affinity DataIC50:  4.80E+4nMAssay Description:Inhibition of [3H]GGPP incorporation by Protein Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290250(CHEMBL81657 | tripotassium 2,4,6-trioxo-3,3-bis[(2...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Squalene SynthaseMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50290250(CHEMBL81657 | tripotassium 2,4,6-trioxo-3,3-bis[(2...)
Affinity DataIC50:  5.62E+4nMAssay Description:Inhibition of Farnesyl TransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50150662((S)-2-({(2S,3S,6R)-6-[((R)-2-Amino-3-tert-butyldis...)
Affinity DataIC50:  5.70E+4nMAssay Description:Inhibition of [3H]FPP incorporation by Protein FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50150664((S)-2-({(2S,3S,6S)-6-[((R)-2-Amino-3-tert-butyldis...)
Affinity DataIC50:  9.10E+4nMAssay Description:Inhibition of [3H]FPP incorporation by Protein FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50122993(CHEMBL2370452 | [(1R,18S,19R,20S)-14-(3-Guanidino-...)
Affinity DataIC50:  9.81E+4nMAssay Description:Displacement of [125I]-echistatin from alphaV-beta3 integrin of human skin fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50122991(CHEMBL113277 | [(1R,6S,7R,8S,9R,23S,24R,25S)-19-(3...)
Affinity DataIC50:  1.98E+5nMAssay Description:Displacement of [125I]-echistatin from alphaIIb-beta3 integrin of human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50150663((S)-2-({(2S,3S,6S)-6-[((R)-2-Amino-3-tert-butyldis...)
Affinity DataIC50:  2.06E+5nMAssay Description:Inhibition of [3H]GGPP incorporation by Protein Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50150671((S)-2-(1-{(2R,6R)-6-[((R)-2-Amino-3-tert-butyldisu...)
Affinity DataIC50:  2.61E+5nMAssay Description:Inhibition of [3H]GGPP incorporation by Protein Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50150669((S)-2-(1-{(2R,3S,6S)-6-[((R)-2-Amino-3-tert-butyld...)
Affinity DataIC50:  2.70E+5nMAssay Description:Inhibition of [3H]GGPP incorporation by Protein Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50150668((S)-2-(1-{(2R,3S,6S)-6-[((R)-2-Amino-3-tert-butyld...)
Affinity DataIC50:  3.11E+5nMAssay Description:Inhibition of [3H]GGPP incorporation by Protein Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50150663((S)-2-({(2S,3S,6S)-6-[((R)-2-Amino-3-tert-butyldis...)
Affinity DataIC50:  3.21E+5nMAssay Description:Inhibition of [3H]FPP incorporation by Protein FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50150670((S)-2-(1-{(2R,3S,6R)-6-[((R)-2-Amino-3-tert-butyld...)
Affinity DataIC50:  4.64E+5nMAssay Description:Inhibition of [3H]GGPP incorporation by Protein Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50150672((S)-2-(1-{(2R,3S,6R)-6-[((R)-2-Amino-3-tert-butyld...)
Affinity DataIC50:  5.00E+5nMAssay Description:Inhibition of [3H]GGPP incorporation by Protein Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50150664((S)-2-({(2S,3S,6S)-6-[((R)-2-Amino-3-tert-butyldis...)
Affinity DataIC50:  5.21E+5nMAssay Description:Inhibition of [3H]GGPP incorporation by Protein Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50122991(CHEMBL113277 | [(1R,6S,7R,8S,9R,23S,24R,25S)-19-(3...)
Affinity DataIC50:  5.97E+5nMAssay Description:Displacement of [125I]-echistatin from alphaV-beta3 integrin of human skin fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50150672((S)-2-(1-{(2R,3S,6R)-6-[((R)-2-Amino-3-tert-butyld...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of [3H]FPP incorporation by Protein FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50150671((S)-2-(1-{(2R,6R)-6-[((R)-2-Amino-3-tert-butyldisu...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of [3H]FPP incorporation by Protein FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50150666((S)-2-({(2S,3S,6R)-6-[((R)-2-Amino-3-tert-butyldis...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of [3H]GGPP incorporation by Protein Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50299752((1S,3R,4S,5R,6R,7S)-4,5-dihydroxy-3-(hydroxymethyl...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human lysosomal alpha glucosidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50299754(CHEMBL577370 | N-((1S,3R,4S,5R,6R,7S)-4,5-Dihydrox...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human lysosomal alpha glucosidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50299751((1S,3R,4S,5R,6R,7S)-N-butyl-4,5-dihydroxy-3-(hydro...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human lysosomal alpha glucosidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50299754(CHEMBL577370 | N-((1S,3R,4S,5R,6R,7S)-4,5-Dihydrox...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human GBA2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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