Compile Data Set for Download or QSAR
maximum 50k data
Found 134 with Last Name = 'pannifer' and Initial = 'a'
LigandPNGBDBM50387593(CHEMBL2057726)
Affinity DataKi:  0.436nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50387590(CHEMBL2057725 | US8633204, 111)
Affinity DataKi:  1.56nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50387582(CHEMBL2057736 | US8633204, 196)
Affinity DataKi:  2nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50387589(CHEMBL2057727 | US8633204, 206)
Affinity DataKi:  3.70nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50387588(CHEMBL2057728 | US8633204, 205)
Affinity DataKi:  7nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50387591(CHEMBL2057735 | US8633204, 195)
Affinity DataKi:  10nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50387583(CHEMBL2057734)
Affinity DataKi:  10.6nMAssay Description:Inhibition of human mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50387583(CHEMBL2057734)
Affinity DataKi:  12.5nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50387586(CHEMBL2057731 | US8633204, 208)
Affinity DataKi:  13.5nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50387593(CHEMBL2057726)
Affinity DataKi:  18.6nMAssay Description:Inhibition of human mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50387586(CHEMBL2057731 | US8633204, 208)
Affinity DataKi:  23.5nMAssay Description:Inhibition of human mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50387592(CHEMBL2057729 | US8633204, 212)
Affinity DataKi:  26nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50387587(CHEMBL2057730 | US8633204, 211)
Affinity DataKi:  36nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50387588(CHEMBL2057728 | US8633204, 205)
Affinity DataKi:  51.2nMAssay Description:Inhibition of human mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50387589(CHEMBL2057727 | US8633204, 206)
Affinity DataKi:  76.4nMAssay Description:Inhibition of human mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50387584(CHEMBL2057733)
Affinity DataKi:  123nMAssay Description:Inhibition of human mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50387585(CHEMBL2057732)
Affinity DataKi:  138nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50387590(CHEMBL2057725 | US8633204, 111)
Affinity DataKi:  142nMAssay Description:Inhibition of human mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50387587(CHEMBL2057730 | US8633204, 211)
Affinity DataKi:  190nMAssay Description:Inhibition of human mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50387582(CHEMBL2057736 | US8633204, 196)
Affinity DataKi:  272nMAssay Description:Inhibition of human mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50387585(CHEMBL2057732)
Affinity DataKi:  663nMAssay Description:Inhibition of human mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50387584(CHEMBL2057733)
Affinity DataKi:  827nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM12407(3-chloro-N-[5-({6-methoxy-7-[3-(morpholin-4-yl)pro...)
Affinity DataIC50: <0.100nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora A purified from Sf9 cells, was incubated at room temperature with substrate, and test compounds in the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM12408(3-chloro-4-fluoro-N-[5-({6-methoxy-7-[3-(morpholin...)
Affinity DataIC50:  0.150nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora A purified from Sf9 cells, was incubated at room temperature with substrate, and test compounds in the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM7671(4-[(4-{imidazo[1,2-a]pyridazin-3-yl}pyrimidin-2-yl...)
Affinity DataIC50: <3nMpH: 7.0 T: 2°CAssay Description:The kinase activity was assayed using an in vitro scintillation proximity assay (SPA) for measuring incorporation of [gamma-33P] ATP into GST-Rb.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM7672(4-[(4-{imidazo[1,2-a]pyridazin-3-yl}pyrimidin-2-yl...)
Affinity DataIC50: <3nMpH: 7.0 T: 2°CAssay Description:The kinase activity was assayed using an in vitro scintillation proximity assay (SPA) for measuring incorporation of [gamma-33P] ATP into GST-Rb.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM7673(4-[(4-{imidazo[1,2-a]pyridazin-3-yl}pyrimidin-2-yl...)
Affinity DataIC50: <3nMpH: 7.0 T: 2°CAssay Description:The kinase activity was assayed using an in vitro scintillation proximity assay (SPA) for measuring incorporation of [gamma-33P] ATP into GST-Rb.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM7669(4-({4-[6-(ethylsulfanyl)imidazo[1,2-a]pyridin-3-yl...)
Affinity DataIC50: <3nMpH: 7.0 T: 2°CAssay Description:The kinase activity was assayed using an in vitro scintillation proximity assay (SPA) for measuring incorporation of [gamma-33P] ATP into GST-Rb.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM7667(4-[(4-{6-bromoimidazo[1,2-a]pyridin-3-yl}pyrimidin...)
Affinity DataIC50: <3nMpH: 7.0 T: 2°CAssay Description:The kinase activity was assayed using an in vitro scintillation proximity assay (SPA) for measuring incorporation of [gamma-33P] ATP into GST-Rb.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM7668(4-[(4-{6-cyanoimidazo[1,2-a]pyridin-3-yl}pyrimidin...)
Affinity DataIC50: <3nMpH: 7.0 T: 2°CAssay Description:The kinase activity was assayed using an in vitro scintillation proximity assay (SPA) for measuring incorporation of [gamma-33P] ATP into GST-Rb.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM12405(CHEMBL381724 | N-[5-({6-methoxy-7-[3-(morpholin-4-...)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora A purified from Sf9 cells, was incubated at room temperature with substrate, and test compounds in the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM7679(Imidazo[1,2-b]pyridazine deriv. 4b | N-(2-methoxye...)
Affinity DataIC50:  3nMpH: 7.0 T: 2°CAssay Description:The kinase activity was assayed using an in vitro scintillation proximity assay (SPA) for measuring incorporation of [gamma-33P] ATP into GST-Rb.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM7675(Imidazo[1,2-b]pyridazine deriv. 2e | N-[3-(dimethy...)
Affinity DataIC50: <3nMpH: 7.0 T: 2°CAssay Description:The kinase activity was assayed using an in vitro scintillation proximity assay (SPA) for measuring incorporation of [gamma-33P] ATP into GST-Rb.More data for this Ligand-Target Pair
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50194411((S)-2,3-dichloro-N-(1-(dimethylamino)-1-oxo-3-phen...)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant human liver GPa by multienzyme coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM7674(CHEMBL484571 | Imidazo[1,2-b]pyridazine deriv. 2d ...)
Affinity DataIC50:  8nMpH: 7.0 T: 2°CAssay Description:The kinase activity was assayed using an in vitro scintillation proximity assay (SPA) for measuring incorporation of [gamma-33P] ATP into GST-Rb.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50194415(2,3-dichloro-N-((1R,2R)-1-hydroxy-2,3-dihydro-1H-i...)
Affinity DataIC50:  9nMAssay Description:Inhibition of recombinant human liver GPa by multienzyme coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM7670(Imidazo[1,2-a]pyridine deriv. 4g | N-(2-methoxyeth...)
Affinity DataIC50:  16nMpH: 7.0 T: 2°CAssay Description:The kinase activity was assayed using an in vitro scintillation proximity assay (SPA) for measuring incorporation of [gamma-33P] ATP into GST-Rb.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM12413(CHEMBL204318 | N-[5-({6-methoxy-7-[3-(morpholin-4-...)
Affinity DataIC50:  17nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora A purified from Sf9 cells, was incubated at room temperature with substrate, and test compounds in the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50194414((S)-2-chloro-N-(1-(dimethylamino)-1-oxo-3-phenylpr...)
Affinity DataIC50:  17nMAssay Description:Inhibition of recombinant human liver GPa by multienzyme coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50194420((S)-2,3-dibromo-N-(1-(dimethylamino)-1-oxo-3-pheny...)
Affinity DataIC50:  23nMAssay Description:Inhibition of recombinant human liver GPa by multienzyme coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50356930(CHEMBL1914475)
Affinity DataIC50:  25nMAssay Description:Inhibition of PI3Kalpha by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50189744((Z)-5-((5-(4-fluoro-2-hydroxyphenyl)furan-2-yl)met...)
Affinity DataIC50:  30nMAssay Description:Inhibition of recombinant human PI3Kgamma by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50194417((S)-2-bromo-N-(1-(dimethylamino)-1-oxo-3-phenylpro...)
Affinity DataIC50:  31nMAssay Description:Inhibition of recombinant human liver GPa by multienzyme coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50356930(CHEMBL1914475)
Affinity DataIC50:  34nMAssay Description:Inhibition of recombinant human PI3Kgamma by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM24363(2-chloro-N-(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)...)
Affinity DataIC50:  41nMAssay Description:Inhibition of recombinant human liver GPa by multienzyme coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50194410(2,3-dichloro-N-((1R,2R)-6-fluoro-1-hydroxy-2,3-dih...)
Affinity DataIC50:  49nMAssay Description:Inhibition of recombinant human liver GPa by multienzyme coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50065954((S)-5-chloro-N-(1-(dimethylamino)-1-oxo-3-phenylpr...)
Affinity DataIC50:  51nMAssay Description:Inhibition of recombinant human liver GPa by multienzyme coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM12409(3-bromo-N-[5-({6-methoxy-7-[3-(morpholin-4-yl)prop...)
Affinity DataIC50:  70nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora A purified from Sf9 cells, was incubated at room temperature with substrate, and test compounds in the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM12410(4-ethyl-N-[5-({6-methoxy-7-[3-(morpholin-4-yl)prop...)
Affinity DataIC50:  85nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora A purified from Sf9 cells, was incubated at room temperature with substrate, and test compounds in the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50136437(5-Chloro-1H-indole-2-carboxylic acid (2-oxo-1,2,3,...)
Affinity DataIC50:  86nMAssay Description:Inhibition of recombinant human liver GPa by multienzyme coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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