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Found 3105 with Last Name = 'pastor' and Initial = 'j'
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163477((3R,3aS)-7-(2-Methoxy-ethoxy)-3-[4-((E)-2-methyl-3...)
Affinity DataKi:  0.0300nMAssay Description:Binding affinity for alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)

Curated by ChEMBL
LigandPNGBDBM50145416(GSK2126458 | Omipalisib)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of human p110alpha/p85alpha using PIP2 as substrate in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)

Curated by ChEMBL
LigandPNGBDBM50570237(CHEMBL4864407)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of human p110delta/p85alpha using PIP2 as substrate in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)

Curated by ChEMBL
LigandPNGBDBM50145416(GSK2126458 | Omipalisib)
Affinity DataKi:  0.0700nMAssay Description:Inhibition of human p110delta/p85alpha using PIP2 as substrate in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)

Curated by ChEMBL
LigandPNGBDBM50579634(CHEMBL4860369)
Affinity DataKi:  0.0800nMAssay Description:Inhibition of human PI3K p110delta/p85alpha by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163479(CHEMBL176261 | Dimethyl-(2-{(3R,3aS)-3-[4-((E)-2-m...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity for alpha-2A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163477((3R,3aS)-7-(2-Methoxy-ethoxy)-3-[4-((E)-2-methyl-3...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity for alpha-2A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50131346((3R,3aS)-7,8-Dimethoxy-3-[4-((E)-2-methyl-3-phenyl...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of [3H]- rauwolscine binding to alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163479(CHEMBL176261 | Dimethyl-(2-{(3R,3aS)-3-[4-((E)-2-m...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity for alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50024301(CHEMBL2112985)
Affinity DataKi:  0.100nMAssay Description:Binding affinity for alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163468((3R,3aS)-3-[4-((E)-2-Methyl-3-phenyl-allyl)-pipera...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity for alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)

Curated by ChEMBL
LigandPNGBDBM50570237(CHEMBL4864407)
Affinity DataKi:  0.100nMAssay Description:Inhibition of p110alpha H1047R mutant/p85alpha (unknown origin) using PIP2:3PS lipid kinase as substrate in presence of ATP measured by ADP-Glo lipid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)

Curated by ChEMBL
LigandPNGBDBM50579637(CHEMBL4878958)
Affinity DataKi:  0.130nMAssay Description:Inhibition of human PI3K p110delta/p85alpha by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)

Curated by ChEMBL
LigandPNGBDBM50570237(CHEMBL4864407)
Affinity DataKi:  0.160nMAssay Description:Inhibition of human p110alpha/p85alpha using PIP2 as substrate in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)

Curated by ChEMBL
LigandPNGBDBM50579637(CHEMBL4878958)
Affinity DataKi:  0.170nMAssay Description:Inhibition of human PI3Kgamma by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50131353(7,8-Dimethoxy-3-[4-((E)-2-methyl-3-phenyl-allyl)-p...)
Affinity DataKi:  0.200nMAssay Description:In vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]-rauwolscineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50146506((3R,3aS)-3-{4-[3-(3-Fluoro-phenyl)-2-methyl-allyl]...)
Affinity DataKi:  0.200nMAssay Description:In vitro binding affinity to human alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50146510((3R,3aS)-7,8-Dimethoxy-3-[4-(2-methyl-3-thiophen-3...)
Affinity DataKi:  0.200nMAssay Description:In vitro binding affinity to human alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50131346((3R,3aS)-7,8-Dimethoxy-3-[4-((E)-2-methyl-3-phenyl...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity for alpha-2C-adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163475((3R,3aS)-7-[2-(2-Ethoxy-ethoxy)-ethoxy]-3-[4-((E)-...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity for alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University of Agricultural Sciences and Veterinary Medicine

LigandPNGBDBM11626(β-CA inhibitor, 2 | 2-N-(4-amino-3-bromo-5-fl...)
Affinity DataKi:  0.200nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163489(Acetic acid (3R,3aS)-3-[4-((E)-2-methyl-3-phenyl-a...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity for alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50146498((3R,3aS)-7,8-Dimethoxy-3-[4-(2-methyl-3-thiophen-2...)
Affinity DataKi:  0.200nMAssay Description:In vitro binding affinity to human alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50131347((3R,3aS)-7,8-Dimethoxy-3-[4-((E)-3-phenyl-but-2-en...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of [3H]- rauwolscine binding to alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50146502((3R,3aS)-7,8-Dimethoxy-3-[4-(3-thiophen-2-yl-but-2...)
Affinity DataKi:  0.200nMAssay Description:In vitro binding affinity to human alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50146501((3R,3aS)-3-{4-[3-(2,5-Difluoro-phenyl)-2-methyl-al...)
Affinity DataKi:  0.200nMAssay Description:In vitro binding affinity to human alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50131347((3R,3aS)-7,8-Dimethoxy-3-[4-((E)-3-phenyl-but-2-en...)
Affinity DataKi:  0.200nMAssay Description:In vitro binding affinity to human alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163494((3R,3aS)-7-Methoxy-3-[4-((E)-2-methyl-3-phenyl-all...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity for alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163468((3R,3aS)-3-[4-((E)-2-Methyl-3-phenyl-allyl)-pipera...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity for alpha-2A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50131346((3R,3aS)-7,8-Dimethoxy-3-[4-((E)-2-methyl-3-phenyl...)
Affinity DataKi:  0.200nMAssay Description:In vitro binding affinity to human alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163491(CHEMBL175853 | Methoxy-acetic acid (3R,3aS)-3-[4-(...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity for alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)

Curated by ChEMBL
LigandPNGBDBM50579634(CHEMBL4860369)
Affinity DataKi:  0.25nMAssay Description:Inhibition of human PI3K p110alpha/p85alpha by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)

Curated by ChEMBL
LigandPNGBDBM50570237(CHEMBL4864407)
Affinity DataKi:  0.270nMAssay Description:Inhibition of p110alpha E542K mutant/p85alpha (unknown origin) using PIP2:3PS lipid kinase as substrate in presence of ATP measured by ADP-Glo lipid ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)

Curated by ChEMBL
LigandPNGBDBM50579637(CHEMBL4878958)
Affinity DataKi:  0.270nMAssay Description:Inhibition of human PI3K p110alpha/p85alpha by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50131347((3R,3aS)-7,8-Dimethoxy-3-[4-((E)-3-phenyl-but-2-en...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM10860(4-(aminomethyl)benzene-1-sulfonamide | CHEMBL419 |...)
Affinity DataKi:  0.300nMAssay Description:Ki value against human carbonic anhydrase XII (hCA XII)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50131347((3R,3aS)-7,8-Dimethoxy-3-[4-((E)-3-phenyl-but-2-en...)
Affinity DataKi:  0.300nMAssay Description:In vitro binding affinity to the human alpha-2A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50146501((3R,3aS)-3-{4-[3-(2,5-Difluoro-phenyl)-2-methyl-al...)
Affinity DataKi:  0.300nMAssay Description:In vitro binding affinity to the human alpha-2A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163483(CHEMBL175911 | Cyclopropanecarboxylic acid (3R,3aS...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity for alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50146502((3R,3aS)-7,8-Dimethoxy-3-[4-(3-thiophen-2-yl-but-2...)
Affinity DataKi:  0.300nMAssay Description:In vitro binding affinity to the human alpha-2A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University of Agricultural Sciences and Veterinary Medicine

LigandPNGBDBM11627(β-CA inhibitor, 3 | 2-N-(4-amino-3-fluoro-5-i...)
Affinity DataKi:  0.300nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University of Agricultural Sciences and Veterinary Medicine

LigandPNGBDBM11625(2-N-(4-amino-3-chloro-5-fluorobenzene)-1,3,4-thiad...)
Affinity DataKi:  0.300nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50131346((3R,3aS)-7,8-Dimethoxy-3-[4-((E)-2-methyl-3-phenyl...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University of Agricultural Sciences and Veterinary Medicine

LigandPNGBDBM11625(2-N-(4-amino-3-chloro-5-fluorobenzene)-1,3,4-thiad...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50146513((3R,3aS)-7,8-Dimethoxy-3-[4-(3-thiophen-3-yl-but-2...)
Affinity DataKi:  0.300nMAssay Description:In vitro binding affinity to human alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50146512((3R,3aS)-3-{4-[3-(4-Fluoro-phenyl)-but-2-enyl]-pip...)
Affinity DataKi:  0.300nMAssay Description:In vitro binding affinity to human alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)

Curated by ChEMBL
LigandPNGBDBM50579637(CHEMBL4878958)
Affinity DataKi:  0.310nMAssay Description:Inhibition of human PI3K p110beta/p85alpha by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)

Curated by ChEMBL
LigandPNGBDBM50579634(CHEMBL4860369)
Affinity DataKi:  0.370nMAssay Description:Inhibition of human PI3K p110beta/p85alpha by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50146515((3R,3aS)-7,8-Dimethoxy-3-{4-[3-(2-methoxy-phenyl)-...)
Affinity DataKi:  0.400nMAssay Description:In vitro binding affinity to human alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163489(Acetic acid (3R,3aS)-3-[4-((E)-2-methyl-3-phenyl-a...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity for alpha-2A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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