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Found 1218 with Last Name = 'petrassi' and Initial = 'hm'
TargetCathepsin S(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50243232(CHEMBL486232 | GNF-PF-5434 | N-((S)-4-methyl-1-oxo...)
Affinity DataKi: <0.100nMAssay Description:Inhibition of human recombinant cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50243232(CHEMBL486232 | GNF-PF-5434 | N-((S)-4-methyl-1-oxo...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of human recombinant cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50247192((S)-2-amino-N-((S)-5-phenyl-1-(phenylsulfonyl)pent...)
Affinity DataKi:  5.5nMAssay Description:Inhibition of human recombinant cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50186088((S)-2-amino-N-((S)-2-(biphenyl-4-yl)-1-cyanoethyl)...)
Affinity DataKi: >10nMAssay Description:Inhibition of human recombinant cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50186088((S)-2-amino-N-((S)-2-(biphenyl-4-yl)-1-cyanoethyl)...)
Affinity DataKi: >10nMAssay Description:Inhibition of human recombinant cathepsin B by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstasin(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50246998(CHEMBL505558 | benzyl (R)-1-((2S,4R)-2-(((S)-6-ami...)
Affinity DataKi:  12nMAssay Description:Binding affinity to human prostasinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstasin(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50246999(CHEMBL500474 | benzyl (R)-1-((2S,4R)-2-(((S)-6-ami...)
Affinity DataKi:  19nMAssay Description:Binding affinity to human prostasinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstasin(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50246997(CHEMBL505738 | benzyl (R)-1-((2S,4R)-2-(((S)-6-ami...)
Affinity DataKi:  27nMAssay Description:Binding affinity to human prostasinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstasin(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50246995(CHEMBL505048 | benzyl (R)-1-((2S,4R)-2-(((S)-6-ami...)
Affinity DataKi:  28nMAssay Description:Binding affinity to human prostasinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstasin(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50247004((3R,5S)-5-(((S)-6-amino-1-(benzo[d]oxazol-2-yl)-1-...)
Affinity DataKi:  29nMAssay Description:Binding affinity to human prostasinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstasin(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50246992(CHEMBL498914 | benzyl (R)-1-((2S,4R)-2-(((S)-6-ami...)
Affinity DataKi:  40nMAssay Description:Binding affinity to human prostasinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstasin(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50246994(CHEMBL443101 | benzyl (R)-1-((2S,4R)-2-(((S)-6-ami...)
Affinity DataKi:  41nMAssay Description:Binding affinity to human prostasinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstasin(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50246996(CHEMBL506226 | {(R)-1-[(2S,4R)-2-[(S)-5-Amino-1-(b...)
Affinity DataKi:  45nMAssay Description:Binding affinity to human prostasinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstasin(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50246991(CHEMBL509770 | benzyl (R)-1-((2S,3S)-2-(((S)-6-ami...)
Affinity DataKi:  49nMAssay Description:Binding affinity to human prostasinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstasin(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50247002(((R)-1-{(2S,4R)-2-[(S)-5-Amino-1-(benzooxazole-2-c...)
Affinity DataKi:  60nMAssay Description:Binding affinity to human prostasinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50243232(CHEMBL486232 | GNF-PF-5434 | N-((S)-4-methyl-1-oxo...)
Affinity DataKi:  64nMAssay Description:Inhibition of human recombinant cathepsin B by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstasin(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50247000(CHEMBL446259 | benzyl (R)-1-((2S,4R)-2-(((S)-6-ami...)
Affinity DataKi:  65nMAssay Description:Binding affinity to human prostasinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstasin(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50247005((3R,5S)-5-(((S)-6-amino-1-(benzo[d]oxazol-2-yl)-1-...)
Affinity DataKi:  101nMAssay Description:Binding affinity to human prostasinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50247192((S)-2-amino-N-((S)-5-phenyl-1-(phenylsulfonyl)pent...)
Affinity DataKi:  120nMAssay Description:Inhibition of human recombinant cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstasin(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50247001(CHEMBL448873 | Phenyl-carbamic acid (3R,5S)-5-[(S)...)
Affinity DataKi:  130nMAssay Description:Binding affinity to human prostasinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50247192((S)-2-amino-N-((S)-5-phenyl-1-(phenylsulfonyl)pent...)
Affinity DataKi:  137nMAssay Description:Inhibition of human recombinant cathepsin H by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstasin(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50247003(CHEMBL501945 | {(R)-1-[(2S,4R)-2-[(S)-5-Amino-1-(b...)
Affinity DataKi:  176nMAssay Description:Binding affinity to human prostasinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstasin(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50246990(CHEMBL454436 | benzyl (R)-1-((2S,3R)-2-(((S)-6-ami...)
Affinity DataKi:  267nMAssay Description:Binding affinity to human prostasinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstasin(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50247006((3R,5S)-5-((S)-6-amino-1-(benzo[d]oxazol-2-yl)-1-o...)
Affinity DataKi:  510nMAssay Description:Binding affinity to human prostasinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstasin(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50246993(CHEMBL507245 | benzyl (R)-1-((2S,4R)-2-(((S)-6-ami...)
Affinity DataKi:  1.04E+3nMAssay Description:Binding affinity to human prostasinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50247192((S)-2-amino-N-((S)-5-phenyl-1-(phenylsulfonyl)pent...)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of human recombinant cathepsin B by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50243232(CHEMBL486232 | GNF-PF-5434 | N-((S)-4-methyl-1-oxo...)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibition of human recombinant cathepsin H by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstasin(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50246989(CHEMBL501802 | benzyl (R)-1-((S)-2-(((S)-6-amino-1...)
Affinity DataKi:  1.40E+3nMAssay Description:Binding affinity to human prostasinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstasin(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50247007(((R)-1-{(2S,4R)-2-[(S)-5-Amino-1-(benzooxazole-2-c...)
Affinity DataKi:  1.55E+3nMAssay Description:Binding affinity to human prostasinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstasin(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50246988(CHEMBL503925 | benzyl (S)-1-((S)-1-((S)-6-amino-1-...)
Affinity DataKi:  2.10E+3nMAssay Description:Binding affinity to human prostasinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50186088((S)-2-amino-N-((S)-2-(biphenyl-4-yl)-1-cyanoethyl)...)
Affinity DataKi:  3.70E+3nMAssay Description:Inhibition of human recombinant cathepsin H by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstasin(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50246986(CHEMBL507205 | benzyl (S)-1-((S)-1-((S)-6-amino-1-...)
Affinity DataKi:  5.72E+3nMAssay Description:Binding affinity to human prostasinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstasin(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50246987(CHEMBL504394 | benzyl (S)-6-amino-1-((S)-1-((S)-6-...)
Affinity DataKi:  5.78E+3nMAssay Description:Binding affinity to human prostasinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstasin(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50246985(CHEMBL507704 | benzyl (S)-6-amino-1-((S)-1-((S)-6-...)
Affinity DataKi:  1.52E+4nMAssay Description:Binding affinity to human prostasinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50186088((S)-2-amino-N-((S)-2-(biphenyl-4-yl)-1-cyanoethyl)...)
Affinity DataKi:  1.80E+4nMAssay Description:Inhibition of human recombinant cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstasin(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50246983(CHEMBL509923 | benzyl (S)-1-((S)-6-amino-1-(benzo[...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity to human prostasinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstasin(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50246984(CHEMBL508055 | benzyl (S)-1-((S)-6-amino-1-(benzo[...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity to human prostasinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1 [866-1154](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM294911(US10112907, Example 00020 | US10766894, Compound T...)
Affinity DataIC50:  0.200nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM294911(US10112907, Example 00020 | US10766894, Compound T...)
Affinity DataIC50:  0.200nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1 [866-1154](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM294911(US10112907, Example 00020 | US10766894, Compound T...)
Affinity DataIC50:  0.200nMpH: 7.5Assay Description:A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1 [866-1154](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50021656(BARICITINIB | INCB-028050 | LY-3009104 | US1011290...)
Affinity DataIC50:  0.700nMpH: 7.5Assay Description:A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM294911(US10112907, Example 00020 | US10766894, Compound T...)
Affinity DataIC50:  0.700nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50021656(BARICITINIB | INCB-028050 | LY-3009104 | US1011290...)
Affinity DataIC50:  0.700nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1 [866-1154](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50021656(BARICITINIB | INCB-028050 | LY-3009104 | US1011290...)
Affinity DataIC50:  0.700nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [808-1132](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM294911(US10112907, Example 00020 | US10766894, Compound T...)
Affinity DataIC50:  0.700nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [808-1132](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM294911(US10112907, Example 00020 | US10766894, Compound T...)
Affinity DataIC50:  0.700nMpH: 7.5Assay Description:A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1 [866-1154](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50402074(CHEMBL2206059 | US10112907, Example 00024 | US1076...)
Affinity DataIC50:  1nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1 [866-1154](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50355501(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)
Affinity DataIC50:  1nMpH: 7.5Assay Description:A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1 [866-1154](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM294916(US10112907, Example 00027 | US10206907, Compound 1...)
Affinity DataIC50:  1nMpH: 7.5Assay Description:A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1 [866-1154](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50355501(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)
Affinity DataIC50:  1nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails US Patent
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