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Found 544 with Last Name = 'pissarnitski' and Initial = 'da'
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM14776(2-{2-ethoxy-5-[(4-ethylpiperazine-1-)sulfonyl]phen...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human phosphodiesterase 5More data for this Ligand-Target Pair
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50220297(1-((2R,6S)-1-(4-chlorophenylsulfonyl)-6-(3,5-diflu...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of gamma-secretase assessed as reduction of membrane Abeta40 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50477384(CHEMBL248276)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of gamma-secretase mediated amyloid beta-40 production in HEK293 cell membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50140583(5-ethyl-3-(4-hydroxybenzyl)-2-(2-phenyl-1-ethynyl)...)
Affinity DataIC50:  0.300nMAssay Description:Inhibitory concentration against human phosphodiesterase 5 (PDE5) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM119782(US8691832, 1)
Affinity DataIC50:  0.380nMpH: 7.5 T: 2°CAssay Description:DPP4 activity was measured using a continuous fluorometric assay. The substrate, Gly-Pro-AMC, was cleaved by DPP4 to release the fluorescent AMC grou...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM119782(US8691832, 1)
Affinity DataIC50:  0.420nMAssay Description:Inhibition of DPP4 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 30 mins followed by substrate addition measured after 50 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50140608(2-azido-5-ethyl-3-(4-hydroxybenzyl)-(6aR,9aS)-3,4,...)
Affinity DataIC50:  0.610nMAssay Description:Inhibitory concentration against human phosphodiesterase 5 (PDE5) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50477389(CHEMBL248285)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of gamma-secretase mediated amyloid beta-40 production in HEK293 cell membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50477366(CHEMBL537890)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of gamma-secretase mediated amyloid beta-40 production in HEK293 cell membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50140624(3-(3-bromo-4-hydroxybenzyl)-5-ethyl-4-oxo-(6aR,9aS...)
Affinity DataIC50:  0.900nMAssay Description:Inhibitory concentration against human phosphodiesterase 5 (PDE5) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50477377(CHEMBL248070)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of gamma-secretase mediated amyloid beta-40 production in HEK293 cell membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50140619(2-ethoxy-5-ethyl-3-(4-hydroxybenzyl)-(6aR,9aS)-3,4...)
Affinity DataIC50:  0.900nMAssay Description:Inhibitory concentration against human phosphodiesterase 5 (PDE5) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM119801(US8691832, 20)
Affinity DataIC50:  1nMpH: 7.5 T: 2°CAssay Description:DPP4 activity was measured using a continuous fluorometric assay. The substrate, Gly-Pro-AMC, was cleaved by DPP4 to release the fluorescent AMC grou...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM103948(US8569521, 144)
Affinity DataIC50:  1nMAssay Description:Gamma-secretase activity was determined as described by Zhang et al. (Biochemistry, 40(16), 5049-5055, 2001).More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50140593(3-(3-chloro-4-hydroxybenzyl)-5-ethyl-4-oxo-(6aR,9a...)
Affinity DataIC50:  1.10nMAssay Description:Inhibitory concentration against human phosphodiesterase 5 (PDE5) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50477372(CHEMBL245413)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of gamma-secretase mediated amyloid beta-40 production in HEK293 cell membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM119786(US8691832, 5)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of DPP4 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 30 mins followed by substrate addition measured after 50 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM119786(US8691832, 5)
Affinity DataIC50:  1.30nMpH: 7.5 T: 2°CAssay Description:DPP4 activity was measured using a continuous fluorometric assay. The substrate, Gly-Pro-AMC, was cleaved by DPP4 to release the fluorescent AMC grou...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50140590(2N-methyl-3-(3-chloro-4-hydroxybenzyl)-5-ethyl-4-o...)
Affinity DataIC50:  1.30nMAssay Description:Inhibitory concentration against human phosphodiesterase 5 (PDE5) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50140582((R)-3-(3-bromo-4-hydroxybenzyl)-7-benzyl-5-ethyl-2...)
Affinity DataIC50:  1.30nMAssay Description:Inhibitory concentration against human phosphodiesterase 5 (PDE5) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50140580(3-(3-bromo-4-methoxybenzyl)-5-ethyl-4-oxo-(6aR,9aS...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory concentration against human phosphodiesterase 5 (PDE5) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM119788(US8691832, 7)
Affinity DataIC50:  1.60nMpH: 7.5 T: 2°CAssay Description:DPP4 activity was measured using a continuous fluorometric assay. The substrate, Gly-Pro-AMC, was cleaved by DPP4 to release the fluorescent AMC grou...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM119788(US8691832, 7)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of DPP4 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 30 mins followed by substrate addition measured after 50 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50140603(3-(3-bromo-4-hydroxybenzyl)-5-ethyl-2-methoxy-(6aR...)
Affinity DataIC50:  1.60nMAssay Description:Inhibitory concentration against human phosphodiesterase 5 (PDE5) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50140620(7-benzyl-3-(3-chloro-4-methoxybenzyl)-5-ethyl-2-me...)
Affinity DataIC50:  1.60nMAssay Description:Inhibitory concentration against human phosphodiesterase 5 (PDE5) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50140598(5-ethyl-2-ethylsulfanyl-3-(4-hydroxybenzyl)-(6aR,9...)
Affinity DataIC50:  1.80nMAssay Description:Inhibitory concentration against human phosphodiesterase 5 (PDE5) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50140585((R)-3-(3-chloro-4-hydroxybenzyl)-7-benzyl-5-ethyl-...)
Affinity DataIC50:  1.90nMAssay Description:Inhibitory concentration against human phosphodiesterase 5 (PDE5) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50477363(CHEMBL248275)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of gamma-secretase mediated amyloid beta-40 production in HEK293 cell membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50140584(3-(3-chloro-4-hydroxybenzyl)-5-ethyl-2-methoxy-(6a...)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration against human phosphodiesterase 5 (PDE5) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129274(CHEMBL3629745)
Affinity DataIC50:  2nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 40 afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129274(CHEMBL3629745)
Affinity DataIC50:  2nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 42 afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50140579(5-ethyl-3-(4-hydroxybenzyl)-4-oxo-(6aR,9aS)-3,4,5,...)
Affinity DataIC50:  2.10nMAssay Description:Inhibitory concentration against human phosphodiesterase 5 (PDE5) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50477371(CHEMBL393712)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of gamma-secretase mediated amyloid beta-40 production in HEK293 cell membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50140605(3-(3-chloro-4-hydroxybenzyl)-2-ethoxy-5-ethyl-(6aR...)
Affinity DataIC50:  2.10nMAssay Description:Inhibitory concentration against human phosphodiesterase 5 (PDE5) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50140614((R)-3-(3-chloro-4-hydroxybenzyl)-7-benzyl-2-(benzy...)
Affinity DataIC50:  2.10nMAssay Description:Inhibitory concentration against human phosphodiesterase 5 (PDE5) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50140611((R)-3-(3-bromo-4-methoxybenzyl)-7-benzyl-5-ethyl-2...)
Affinity DataIC50:  2.20nMAssay Description:Inhibitory concentration against human phosphodiesterase 5 (PDE5) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50477392(CHEMBL247869)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of gamma-secretase mediated amyloid beta-40 production in HEK293 cell membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50140616(2N-methyl-3-(3-chloro-4-methoxybenzyl)-5-ethyl-4-o...)
Affinity DataIC50:  2.30nMAssay Description:Inhibitory concentration against human phosphodiesterase 5 (PDE5) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50165781((R)-7-Benzyl-2-chloro-5-ethyl-3-(4-hydroxy-benzyl)...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50220270(1-((2R,6S)-1-(4-chlorophenylsulfonyl)-6-(3,5-diflu...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of gamma-secretase assessed as reduction of membrane Abeta40 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50477365(CHEMBL245414)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of gamma-secretase mediated amyloid beta-40 production in HEK293 cell membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50165771((R)-7-Benzyl-2-bromo-5-ethyl-3-(4-hydroxy-benzyl)-...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50220288(1-((2R,6R)-1-(4-chlorophenylsulfonyl)-6-propylpipe...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of gamma-secretase assessed as reduction of membrane Abeta40 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50477386(CHEMBL392075)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of gamma-secretase mediated amyloid beta-40 production in HEK293 cell membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50477369(CHEMBL248477)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of gamma-secretase mediated amyloid beta-40 production in HEK293 cell membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50220271(1-((2R,6S)-1-(4-chlorophenylsulfonyl)-6-cyclopropy...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of gamma-secretase assessed as reduction of membrane Abeta40 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50140578((R)-3-(3-chloro-4-methoxybenzyl)-7-benzyl-5-ethyl-...)
Affinity DataIC50:  2.80nMAssay Description:Inhibitory concentration against human phosphodiesterase 5 (PDE5) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50140613(3-(3-bromo-4-methoxybenzyl)-5-ethyl-2-methoxy-(6aR...)
Affinity DataIC50:  2.80nMAssay Description:Inhibitory concentration against human phosphodiesterase 5 (PDE5) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50476438(CHEMBL233298)
Affinity DataIC50:  3nMAssay Description:Inhibition of gamma secretase-mediated amyloid-beta peptid aggregationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50140623((R)-3-(3-chloro-4-hydroxybenzyl)-7-benzyl-5-ethyl-...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration against human phosphodiesterase 5 (PDE5) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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