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Found 569 with Last Name = 'pryde' and Initial = 'dc'
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50066789(3-((S)-1-Azetidin-2-ylmethoxy)-5-iodo-pyridine | A...)
Affinity DataKi:  0.0500nMAssay Description:Displacement of [3H]epibatidine from alpha4beta2 nAChR in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50166908(5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca...)
Affinity DataKi:  0.0600nMAssay Description:Binding affinity to alpha4beta2 nAChR in rat cortexMore data for this Ligand-Target Pair
LigandPNGBDBM144227(US8952008, 4)
Affinity DataKi:  0.180nMAssay Description:Displacement of [3H]-flumazenil from human GABAA alpha1beta3gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50067424((S)-9-Methoxy-7-oxo-3b,4,5,6-tetrahydro-7H-2,6a,11...)
Affinity DataKi:  0.450nMAssay Description:Positive allosteric modulation of GABAA alpha5 (unknown origin)More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50142570(9-(4-Methyl-thiazol-2-yl)-11-pyridin-4-yl-6,7-dihy...)
Affinity DataKi:  0.5nMAssay Description:Positive allosteric modulation of GABAA alpha3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM430025(4-(4′-Ethanesulfonyl-6-fluoro-2′-metho...)
Affinity DataKi: <0.600nMAssay Description:The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM50142570(9-(4-Methyl-thiazol-2-yl)-11-pyridin-4-yl-6,7-dihy...)
Affinity DataKi:  0.600nMAssay Description:Positive allosteric modulation of GABAA alpha2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50512947(CHEMBL4545044)
Affinity DataKi:  0.640nMAssay Description:Displacement of [3H]-flumazenil from human GABAA alpha1beta3gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50179998(7-tert-butyl-3-(2,5-difluorophenyl)-6-((2-methyl-2...)
Affinity DataKi:  0.700nMAssay Description:Positive allosteric modulation of GABAA alpha3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM50179998(7-tert-butyl-3-(2,5-difluorophenyl)-6-((2-methyl-2...)
Affinity DataKi:  0.700nMAssay Description:Positive allosteric modulation of GABAA alpha2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50156083(3-tert-Butyl-7-(5-methyl-isoxazol-3-yl)-2-(2-methy...)
Affinity DataKi:  0.800nMAssay Description:Positive allosteric modulation of GABAA alpha1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM50156083(3-tert-Butyl-7-(5-methyl-isoxazol-3-yl)-2-(2-methy...)
Affinity DataKi:  0.800nMAssay Description:Positive allosteric modulation of GABAA alpha2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50156083(3-tert-Butyl-7-(5-methyl-isoxazol-3-yl)-2-(2-methy...)
Affinity DataKi:  0.800nMAssay Description:Positive allosteric modulation of GABAA alpha3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM144227(US8952008, 4)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]-flumazenil from human GABAA alpha3beta3gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50142570(9-(4-Methyl-thiazol-2-yl)-11-pyridin-4-yl-6,7-dihy...)
Affinity DataKi:  1.30nMAssay Description:Positive allosteric modulation of GABAA alpha1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50156083(3-tert-Butyl-7-(5-methyl-isoxazol-3-yl)-2-(2-methy...)
Affinity DataKi:  1.40nMAssay Description:Positive allosteric modulation of GABAA alpha5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50179998(7-tert-butyl-3-(2,5-difluorophenyl)-6-((2-methyl-2...)
Affinity DataKi:  2.30nMAssay Description:Positive allosteric modulation of GABAA alpha5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM144227(US8952008, 4)
Affinity DataKi: <2.47nMAssay Description:The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50512947(CHEMBL4545044)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]-flumazenil from human GABAA alpha3beta3gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM144226(US8952008, 3)
Affinity DataKi:  5.08nMAssay Description:The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM144239(US8952008, 32)
Affinity DataKi:  5.82nMAssay Description:The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM352410(5′-(7-Ethyl-7H-imidazo[4,5-c]pyridazin-4-yl)...)
Affinity DataKi:  6.30nMAssay Description:The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM352391(5-{2-Fluoro-5-[7-(propan-2-yl)-7H-imidazo[4,5-c]py...)
Affinity DataKi:  6.40nMAssay Description:The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM352390(5-[5-(7-Ethyl-7H-imidazo[4,5-c]pyridazin-4-yl)-2-f...)
Affinity DataKi:  6.60nMAssay Description:The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM352405(US9802945, 16)
Affinity DataKi:  6.70nMAssay Description:The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM352398(US9802945, 9)
Affinity DataKi:  6.80nMAssay Description:The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM144252(US8952008, 8)
Affinity DataKi:  7.45nMAssay Description:The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM144256(US8952008, 12)
Affinity DataKi:  7.48nMAssay Description:The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM352403(US9802945, 14)
Affinity DataKi:  7.5nMAssay Description:The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM144270(US8952008, 38)
Affinity DataKi:  8.56nMAssay Description:The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM144229(US8952008, 6)
Affinity DataKi:  9.51nMAssay Description:The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM144230(US8952008, 7)
Affinity DataKi:  9.71nMAssay Description:The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM352401(2′-Fluoro-5′-[7-(propan-2-yl)-7H-imida...)
Affinity DataKi:  10.7nMAssay Description:The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM144225(US8952008, 2)
Affinity DataKi:  10.9nMAssay Description:The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM144257(US8952008, 13)
Affinity DataKi:  11.7nMAssay Description:The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM430027(5-[5-(1-Ethyl-1H-pyrazolo[3,4-c]pyridazin-4-yl)-2-...)
Affinity DataKi:  11.8nMAssay Description:The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM352392(US9802945, 3)
Affinity DataKi:  12.8nMAssay Description:The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM144272(US8952008, 40)
Affinity DataKi:  14nMAssay Description:The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM144271(US8952008, 39)
Affinity DataKi:  14.4nMAssay Description:The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM144240(US8952008, 33)
Affinity DataKi:  16.4nMAssay Description:The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM430026(4-(4′-Ethanesulfonyl-6-fluorobiphenyl-3-yl)-...)
Affinity DataKi:  17.5nMAssay Description:The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM144253(US8952008, 9)
Affinity DataKi:  17.7nMAssay Description:The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM144227(US8952008, 4)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]-flumazenil from human GABAA alpha5beta2gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM144259(US8952008, 15)
Affinity DataKi:  18.2nMAssay Description:The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM144262(US8952008, 20)
Affinity DataKi:  19nMAssay Description:The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM144269(US8952008, 37)
Affinity DataKi:  19.1nMAssay Description:The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM352407(US9802945, 18)
Affinity DataKi:  19.3nMAssay Description:The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM352404(US9802945, 15)
Affinity DataKi:  20.3nMAssay Description:The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM352400(5′-(7-Cyclopropyl-7H-imidazo[4,5-c]pyridazin...)
Affinity DataKi:  20.5nMAssay Description:The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM352394(US9802945, 5)
Affinity DataKi:  21.7nMAssay Description:The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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