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Found 86 with Last Name = 'rajapakse' and Initial = 'r'
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50187673(5-(3,3,6-trimethyl-indan-5-yloxy)-furan-2-carboxyl...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to human recombinant GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50187673(5-(3,3,6-trimethyl-indan-5-yloxy)-furan-2-carboxyl...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to rat pituitary GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277947(CHEMBL482559 | N-(4-(4-(2-(cyclopentylamino)pyrimi...)
Affinity DataKi:  9nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Nicox Research Institute

Curated by ChEMBL
LigandPNGBDBM10884((2S,4S)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H...)
Affinity DataKi:  9nMAssay Description:Inhibition of human carbonic anhydrase 2 by CO2 hydrase stopped flow assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277909(CHEMBL483741 | N-cyclopentyl-4-(3-(tetrahydro-2H-p...)
Affinity DataKi:  12nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277910(4-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyraz...)
Affinity DataKi:  12nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Nicox Research Institute

Curated by ChEMBL
LigandPNGBDBM50303032(CHEMBL584939 | Ethyl-((4S,6S)-6-methyl-7,7-dioxo-2...)
Affinity DataKi:  13nMAssay Description:Inhibition of human carbonic anhydrase 2 by CO2 hydrase stopped flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Nicox Research Institute

Curated by ChEMBL
LigandPNGBDBM50303030(6-Nitrooxy-hexanoic acid ethyl-((4S,6S)-6-methyl-7...)
Affinity DataKi:  14nMAssay Description:Inhibition of human carbonic anhydrase 2 by CO2 hydrase stopped flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277869(4-(3-(4-chlorophenyl)-1H-pyrazol-4-yl)-N-cyclopent...)
Affinity DataKi:  26nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277838(4-(3-(4-chlorophenyl)-1H-pyrazol-4-yl)-N-cyclohexy...)
Affinity DataKi:  27nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277948(CHEMBL482753 | N-(4-(4-(2-(cyclopentylamino)pyrimi...)
Affinity DataKi:  28nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277946(3-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyraz...)
Affinity DataKi:  36nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277873(CHEMBL485365 | N-isopropyl-4-(3-(tetrahydro-2H-pyr...)
Affinity DataKi:  43nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 4(Homo sapiens (Human))
Nicox Research Institute

Curated by ChEMBL
LigandPNGBDBM10884((2S,4S)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H...)
Affinity DataKi:  43nMAssay Description:Inhibition of human carbonic anhydrase 4 by CO2 hydrase stopped flow assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 4(Homo sapiens (Human))
Nicox Research Institute

Curated by ChEMBL
LigandPNGBDBM50303031(CHEMBL570894 | N-Ethyl-N-((4S,6S)-6-methyl-7,7-dio...)
Affinity DataKi:  46nMAssay Description:Inhibition of human carbonic anhydrase 4 by CO2 hydrase stopped flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277836(4-(3-(4-chlorophenyl)-1H-pyrazol-4-yl)-N-isopropyl...)
Affinity DataKi:  48nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Nicox Research Institute

Curated by ChEMBL
LigandPNGBDBM50303034(CHEMBL571337 | Ethyl-((4S,6S)-6-methyl-7,7-dioxo-2...)
Affinity DataKi:  63nMAssay Description:Inhibition of human carbonic anhydrase 2 by CO2 hydrase stopped flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Nicox Research Institute

Curated by ChEMBL
LigandPNGBDBM50303031(CHEMBL570894 | N-Ethyl-N-((4S,6S)-6-methyl-7,7-dio...)
Affinity DataKi:  71nMAssay Description:Inhibition of human carbonic anhydrase 2 by CO2 hydrase stopped flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Nicox Research Institute

Curated by ChEMBL
LigandPNGBDBM50303033(CHEMBL585756 | Ethyl-((4S,6S)-6-methyl-7,7-dioxo-2...)
Affinity DataKi:  76nMAssay Description:Inhibition of human carbonic anhydrase 2 by CO2 hydrase stopped flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277907(CHEMBL520488 | N-isopropyl-4-(3-(1-(methylsulfonyl...)
Affinity DataKi:  101nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277837(4-(3-(4-chlorophenyl)-1H-pyrazol-4-yl)-N-cycloprop...)
Affinity DataKi:  151nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277908(CHEMBL518996 | N-(1-methylpiperidin-4-yl)-4-(3-(6-...)
Affinity DataKi:  162nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277905(CHEMBL520332 | N-isopropyl-4-(3-(tetrahydro-2H-pyr...)
Affinity DataKi:  169nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 4(Homo sapiens (Human))
Nicox Research Institute

Curated by ChEMBL
LigandPNGBDBM50303032(CHEMBL584939 | Ethyl-((4S,6S)-6-methyl-7,7-dioxo-2...)
Affinity DataKi:  181nMAssay Description:Inhibition of human carbonic anhydrase 4 by CO2 hydrase stopped flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277868((R)-3-(4-(3-(4-chlorophenyl)-1H-pyrazol-4-yl)pyrim...)
Affinity DataKi:  315nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 4(Homo sapiens (Human))
Nicox Research Institute

Curated by ChEMBL
LigandPNGBDBM50303033(CHEMBL585756 | Ethyl-((4S,6S)-6-methyl-7,7-dioxo-2...)
Affinity DataKi:  339nMAssay Description:Inhibition of human carbonic anhydrase 4 by CO2 hydrase stopped flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277872(CHEMBL485364 | N-isopropyl-4-(3-(tetrahydro-2H-pyr...)
Affinity DataKi:  381nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Nicox Research Institute

Curated by ChEMBL
LigandPNGBDBM50303032(CHEMBL584939 | Ethyl-((4S,6S)-6-methyl-7,7-dioxo-2...)
Affinity DataKi:  410nMAssay Description:Inhibition of human carbonic anhydrase 1 by CO2 hydrase stopped flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Nicox Research Institute

Curated by ChEMBL
LigandPNGBDBM50303031(CHEMBL570894 | N-Ethyl-N-((4S,6S)-6-methyl-7,7-dio...)
Affinity DataKi:  470nMAssay Description:Inhibition of human carbonic anhydrase 1 by CO2 hydrase stopped flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277906(CHEMBL484326 | N-isopropyl-4-(3-(piperidin-3-yl)-1...)
Affinity DataKi:  530nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50187673(5-(3,3,6-trimethyl-indan-5-yloxy)-furan-2-carboxyl...)
Affinity DataKi:  583nMAssay Description:Binding affinity to human 5HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50187673(5-(3,3,6-trimethyl-indan-5-yloxy)-furan-2-carboxyl...)
Affinity DataKi:  628nMAssay Description:Binding affinity to human A3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Nicox Research Institute

Curated by ChEMBL
LigandPNGBDBM50303033(CHEMBL585756 | Ethyl-((4S,6S)-6-methyl-7,7-dioxo-2...)
Affinity DataKi:  705nMAssay Description:Inhibition of human carbonic anhydrase 1 by CO2 hydrase stopped flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50187673(5-(3,3,6-trimethyl-indan-5-yloxy)-furan-2-carboxyl...)
Affinity DataKi:  964nMAssay Description:Binding affinity to human 5HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277870(4-(3-(4-chlorophenyl)-1H-pyrazol-4-yl)-N-(1-methyl...)
Affinity DataKi:  1.02E+3nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50187673(5-(3,3,6-trimethyl-indan-5-yloxy)-furan-2-carboxyl...)
Affinity DataKi:  1.06E+3nMAssay Description:Binding affinity to PAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50187673(5-(3,3,6-trimethyl-indan-5-yloxy)-furan-2-carboxyl...)
Affinity DataKi:  1.18E+3nMAssay Description:Binding affinity to human D3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50187673(5-(3,3,6-trimethyl-indan-5-yloxy)-furan-2-carboxyl...)
Affinity DataKi:  1.22E+3nMAssay Description:Binding affinity to H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50187673(5-(3,3,6-trimethyl-indan-5-yloxy)-furan-2-carboxyl...)
Affinity DataKi:  1.25E+3nMAssay Description:Binding affinity to human NK1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50187673(5-(3,3,6-trimethyl-indan-5-yloxy)-furan-2-carboxyl...)
Affinity DataKi:  1.40E+3nMAssay Description:Binding affinity to human mu opiate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50187673(5-(3,3,6-trimethyl-indan-5-yloxy)-furan-2-carboxyl...)
Affinity DataKi:  1.43E+3nMAssay Description:Binding affinity to human 5HT transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Nicox Research Institute

Curated by ChEMBL
LigandPNGBDBM50303034(CHEMBL571337 | Ethyl-((4S,6S)-6-methyl-7,7-dioxo-2...)
Affinity DataKi:  1.52E+3nMAssay Description:Inhibition of human carbonic anhydrase 1 by CO2 hydrase stopped flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277870(4-(3-(4-chlorophenyl)-1H-pyrazol-4-yl)-N-(1-methyl...)
Affinity DataKi:  1.57E+3nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50187673(5-(3,3,6-trimethyl-indan-5-yloxy)-furan-2-carboxyl...)
Affinity DataKi:  1.62E+3nMAssay Description:Binding affinity to human D1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50187673(5-(3,3,6-trimethyl-indan-5-yloxy)-furan-2-carboxyl...)
Affinity DataKi:  1.75E+3nMAssay Description:Binding affinity to human 5HT7 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50187673(5-(3,3,6-trimethyl-indan-5-yloxy)-furan-2-carboxyl...)
Affinity DataKi:  1.80E+3nMAssay Description:Binding affinity to human DA transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50187673(5-(3,3,6-trimethyl-indan-5-yloxy)-furan-2-carboxyl...)
Affinity DataKi:  1.96E+3nMAssay Description:Binding affinity to kappa opiate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277835(4-methylpyrimidine-2-thiol | CHEMBL455772)
Affinity DataKi:  2.06E+3nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50187673(5-(3,3,6-trimethyl-indan-5-yloxy)-furan-2-carboxyl...)
Affinity DataKi:  2.51E+3nMAssay Description:Binding affinity to human D4.4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277871(CHEMBL485193 | N-isopropyl-4-(1H-pyrazol-4-yl)pyri...)
Affinity DataKi:  2.73E+3nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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