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Found 236 with Last Name = 'rano' and Initial = 'ta'
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116913((S)-4-(1-Furo[3,2-c]pyridin-2-yl-1-methyl-ethyl)-1...)
Affinity DataIC50:  0.0750nMAssay Description:Inhibitory concentration required to inhibit cleavage of a substrate by the wild-type HIV-1 protease enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50219019(CHEMBL422323)
Affinity DataIC50: <0.100nMAssay Description:Tested in vitro for the ability to inhibit cleavage of a substrate by the wild type HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50219020(CHEMBL421786)
Affinity DataIC50: <0.100nMAssay Description:Tested in vitro for the ability to inhibit cleavage of a substrate by the wild type HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM9142((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(3S,4S)-3-h...)
Affinity DataIC50:  0.100nMpH: 5.5 T: 2°CAssay Description:Assay of HIV protease inhibition was performed by peptide cleavage using the substrate Val-Ser-Gln-Asn-beta-naphthylalanine*Pro-Ile-Val. Products of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50219021(CHEMBL1203459)
Affinity DataIC50: <0.100nMAssay Description:In vitro inhibitory activity of the compound against mutant HIV-1 (A-44)proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116914((S)-4-(1-Furo[3,2-c]pyridin-2-yl-1-methyl-ethyl)-1...)
Affinity DataIC50:  0.150nMAssay Description:Inhibitory concentration required to inhibit cleavage of a substrate by the wild-type HIV-1 ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109710((S)-4-(2-Dimethylamino-quinoline-7-sulfonyl)-1-[(2...)
Affinity DataIC50:  0.220nMAssay Description:In vitro inhibitory activity of the compound against wild type HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116915((S)-4-Furo[3,2-c]pyridin-2-ylmethyl-1-[(2S,4R)-2-h...)
Affinity DataIC50:  0.230nMAssay Description:Inhibitory concentration required to inhibit cleavage of a substrate by the wild-type HIV-1 ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM9142((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(3S,4S)-3-h...)
Affinity DataIC50:  0.300nMpH: 5.5 T: 2°CAssay Description:Assay of HIV protease inhibition was performed by peptide cleavage using the substrate Val-Ser-Gln-Asn-beta-naphthylalanine*Pro-Ile-Val. Products of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM9144((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(3S,4S)-3-h...)
Affinity DataIC50:  0.300nMpH: 5.5 T: 2°CAssay Description:Assay of HIV protease inhibition was performed by peptide cleavage using the substrate Val-Ser-Gln-Asn-beta-naphthylalanine*Pro-Ile-Val. Products of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM9145((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(3S,4S)-3-h...)
Affinity DataIC50:  0.400nMpH: 5.5 T: 2°CAssay Description:Assay of HIV protease inhibition was performed by peptide cleavage using the substrate Val-Ser-Gln-Asn-beta-naphthylalanine*Pro-Ile-Val. Products of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109714((S)-4-Benzofuran-2-ylmethyl-1-[(2S,4R)-2-hydroxy-4...)
Affinity DataIC50:  0.490nMAssay Description:In vitro inhibitory activity of the compound against wild type HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109714((S)-4-Benzofuran-2-ylmethyl-1-[(2S,4R)-2-hydroxy-4...)
Affinity DataIC50:  0.490nMAssay Description:In vitro inhibitory activity of the compound against wild type HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM9145((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(3S,4S)-3-h...)
Affinity DataIC50:  0.5nMpH: 5.5 T: 2°CAssay Description:Assay of HIV protease inhibition was performed by peptide cleavage using the substrate Val-Ser-Gln-Asn-beta-naphthylalanine*Pro-Ile-Val. Products of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM517((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-h...)
Affinity DataIC50:  0.590nMAssay Description:Tested in vitro for the ability to inhibit cleavage of a substrate by the wild type HIV-1 proteaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM517((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-h...)
Affinity DataIC50:  0.590nMAssay Description:In vitro inhibitory concentration of the compound to prevent cleavage of a substrate by the protease enzymeMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM517((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-h...)
Affinity DataIC50:  0.590nMAssay Description:Inhibitory concentration required to inhibit cleavage of a substrate by the wild-type HIV-1 ProteaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109706((S)-1-[(2S,4R)-2-Hydroxy-4-((R)-(R)-2-hydroxy-inda...)
Affinity DataIC50:  0.600nMAssay Description:In vitro inhibitory activity of the compound against mutant HIV-1 (A-44)proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50219020(CHEMBL421786)
Affinity DataIC50: <0.600nMAssay Description:Tested in vitro for the ability to inhibit cleavage of a substrate by the wild type HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50219019(CHEMBL422323)
Affinity DataIC50: <0.600nMAssay Description:In vitro inhibitory activity of the compound against mutant HIV-1 (A-44)proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50219021(CHEMBL1203459)
Affinity DataIC50: <0.600nMAssay Description:In vitro inhibitory activity of the compound against wild type HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109706((S)-1-[(2S,4R)-2-Hydroxy-4-((R)-(R)-2-hydroxy-inda...)
Affinity DataIC50:  0.600nMAssay Description:In vitro inhibitory activity of the compound against wild type HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM9143((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(3S,4S)-3-h...)
Affinity DataIC50:  0.600nMpH: 5.5 T: 2°CAssay Description:Assay of HIV protease inhibition was performed by peptide cleavage using the substrate Val-Ser-Gln-Asn-beta-naphthylalanine*Pro-Ile-Val. Products of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM9145((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(3S,4S)-3-h...)
Affinity DataIC50:  0.700nMpH: 5.5 T: 2°CAssay Description:Assay of HIV protease inhibition was performed by peptide cleavage using the substrate Val-Ser-Gln-Asn-beta-naphthylalanine*Pro-Ile-Val. Products of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM9144((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(3S,4S)-3-h...)
Affinity DataIC50:  0.700nMpH: 5.5 T: 2°CAssay Description:Assay of HIV protease inhibition was performed by peptide cleavage using the substrate Val-Ser-Gln-Asn-beta-naphthylalanine*Pro-Ile-Val. Products of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM9143((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(3S,4S)-3-h...)
Affinity DataIC50:  0.800nMpH: 5.5 T: 2°CAssay Description:Assay of HIV protease inhibition was performed by peptide cleavage using the substrate Val-Ser-Gln-Asn-beta-naphthylalanine*Pro-Ile-Val. Products of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109705((S)-4-(5-Fluoro-benzofuran-2-ylmethyl)-1-[(2S,4R)-...)
Affinity DataIC50:  0.940nMAssay Description:In vitro inhibitory activity of the compound against wild type HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090147((S)-4-(3,4-Dichloro-benzyl)-1-[(2S,4R)-2-hydroxy-4...)
Affinity DataIC50:  1.10nMAssay Description:In vitro inhibitory concentration of the compound to prevent cleavage of a substrate by the protease enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM9142((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(3S,4S)-3-h...)
Affinity DataIC50:  1.20nMpH: 5.5 T: 2°CAssay Description:Assay of HIV protease inhibition was performed by peptide cleavage using the substrate Val-Ser-Gln-Asn-beta-naphthylalanine*Pro-Ile-Val. Products of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116916((S)-1-[(2S,4R)-2-Hydroxy-4-((1S,2R)-2-hydroxy-inda...)
Affinity DataIC50:  1.20nMAssay Description:Inhibitory concentration required to inhibit cleavage of a substrate by the wild-type HIV-1 ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109709((S)-4-Benzo[d]isoxazol-3-ylmethyl-1-[(2S,4R)-2-hyd...)
Affinity DataIC50:  1.20nMAssay Description:In vitro inhibitory activity of the compound against wild type HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109708((S)-4-Benzooxazol-2-ylmethyl-1-[(2S,4R)-2-hydroxy-...)
Affinity DataIC50:  1.20nMAssay Description:In vitro inhibitory activity of the compound against wild type HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109708((S)-4-Benzooxazol-2-ylmethyl-1-[(2S,4R)-2-hydroxy-...)
Affinity DataIC50:  1.20nMAssay Description:In vitro inhibitory activity of the compound against wild type HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM9143((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(3S,4S)-3-h...)
Affinity DataIC50:  1.30nMpH: 5.5 T: 2°CAssay Description:Assay of HIV protease inhibition was performed by peptide cleavage using the substrate Val-Ser-Gln-Asn-beta-naphthylalanine*Pro-Ile-Val. Products of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM9141((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(3S,4S)-3-h...)
Affinity DataIC50:  1.60nMpH: 5.5 T: 2°CAssay Description:Assay of HIV protease inhibition was performed by peptide cleavage using the substrate Val-Ser-Gln-Asn-beta-naphthylalanine*Pro-Ile-Val. Products of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090146((S)-1-[(2S,4R)-2-Hydroxy-4-((1S,2R)-2-hydroxy-inda...)
Affinity DataIC50:  1.60nMAssay Description:In vitro inhibitory concentration of the compound to prevent cleavage of a substrate by the protease enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM517((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-h...)
Affinity DataIC50:  1.60nMAssay Description:In vitro inhibitory activity of the compound against wild type HIV-1 proteaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109712((S)-1-[(2S,4R)-2-Hydroxy-4-((R)-(R)-2-hydroxy-inda...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibitory activity of the compound against mutant HIV-1 (A-44)proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109712((S)-1-[(2S,4R)-2-Hydroxy-4-((R)-(R)-2-hydroxy-inda...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibitory activity of the compound against wild type HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109698((S)-1-[(2S,4R)-2-Hydroxy-4-((R)-(R)-2-hydroxy-inda...)
Affinity DataIC50:  2.20nMAssay Description:In vitro inhibitory activity of the compound against mutant HIV-1 (A-44)proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109710((S)-4-(2-Dimethylamino-quinoline-7-sulfonyl)-1-[(2...)
Affinity DataIC50:  2.20nMAssay Description:In vitro inhibitory activity of the compound against mutant HIV-1 (A-44)proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174861(US9102669, 24)
Affinity DataIC50:  4nMT: 2°CAssay Description:The SCD1 enzymatic assay was done in a volume of 50 μL using 10 μg of RLM (prepared as described above) in a 96-well polypropylene plate (e...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM9141((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(3S,4S)-3-h...)
Affinity DataIC50:  5.20nMpH: 5.5 T: 2°CAssay Description:Assay of HIV protease inhibition was performed by peptide cleavage using the substrate Val-Ser-Gln-Asn-beta-naphthylalanine*Pro-Ile-Val. Products of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM9141((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(3S,4S)-3-h...)
Affinity DataIC50:  5.80nMpH: 5.5 T: 2°CAssay Description:Assay of HIV protease inhibition was performed by peptide cleavage using the substrate Val-Ser-Gln-Asn-beta-naphthylalanine*Pro-Ile-Val. Products of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174891(US9102669, 83)
Affinity DataIC50:  6nMT: 2°CAssay Description:The SCD1 enzymatic assay was done in a volume of 50 μL using 10 μg of RLM (prepared as described above) in a 96-well polypropylene plate (e...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM60550(BDBM50448682 | US9102669, 53)
Affinity DataIC50:  6nMT: 2°CAssay Description:The SCD1 enzymatic assay was done in a volume of 50 μL using 10 μg of RLM (prepared as described above) in a 96-well polypropylene plate (e...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109711((S)-1-[(2S,4R)-2-Hydroxy-4-((R)-(R)-2-hydroxy-inda...)
Affinity DataIC50:  6.70nMAssay Description:In vitro inhibitory activity of the compound against wild type HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109699((S)-1-[(2S,4R)-2-Hydroxy-4-((R)-(R)-2-hydroxy-inda...)
Affinity DataIC50:  6.70nMAssay Description:In vitro inhibitory activity of the compound against wild type HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50443712(CHEMBL3093861 | US9238658, 33)
Affinity DataIC50:  7nMT: 2°CAssay Description:The SCD1 enzymatic assay was done in a volume of 50 uL using 10 ug of RLM (prepared as described above) in a 96-well polypropylene plate (enzyme reac...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50448657(CHEMBL3127530 | US9102669, 29)
Affinity DataIC50:  7nMT: 2°CAssay Description:The SCD1 enzymatic assay was done in a volume of 50 μL using 10 μg of RLM (prepared as described above) in a 96-well polypropylene plate (e...More data for this Ligand-Target Pair
In DepthDetails US Patent
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