Affinity DataIC50: 3.09E+3nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 4.94E+3nMAssay Description:Inhibition of PDE11A4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 185nMAssay Description:Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 273nMAssay Description:Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 371nMAssay Description:Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 478nMAssay Description:Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 63nMAssay Description:Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 112nMAssay Description:Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 175nMAssay Description:Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 248nMAssay Description:Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 258nMAssay Description:Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 500nMAssay Description:Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 163nMAssay Description:Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 4.50E+3nMAssay Description:Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 215nMAssay Description:Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 55nMAssay Description:Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 293nMAssay Description:Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 211nMAssay Description:Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 9nMAssay Description:Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 65nMAssay Description:Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3.90E+3nMAssay Description:Partial agonist activity at muscarinic M1 receptor (unknown origin) assessed as recruitment of beta-arrestin by Path Hunter assayMore data for this Ligand-Target Pair
Affinity DataEC50: 365nMAssay Description:Positive allosteric modulation of muscarinic M1 receptor (unknown origin) assessed as increase in Ach-induced recruitment of beta-arrestin by Path Hu...More data for this Ligand-Target Pair
Affinity DataEC50: 447nMAssay Description:Positive allosteric modulation of muscarinic M1 receptor (unknown origin) expressed in CHO cells assessed as increase in Ach-induced accumulation of ...More data for this Ligand-Target Pair
Affinity DataEC50: 60nMAssay Description:Positive allosteric modulation of human muscarinic M1 receptor stably expressed in CHO cells assessed as increase in Ach-induced intracellular calciu...More data for this Ligand-Target Pair
Affinity DataEC50: 144nMAssay Description:Positive allosteric modulation of human muscarinic M1 receptor stably expressed in CHO cells assessed as increase in Ach-induced intracellular calciu...More data for this Ligand-Target Pair
Affinity DataEC50: >9.00E+3nMAssay Description:Positive allosteric modulation of human muscarinic M1 receptor stably expressed in CHO cells assessed as increase in Ach-induced intracellular calciu...More data for this Ligand-Target Pair
Affinity DataEC50: 92nMAssay Description:Positive allosteric modulation of human muscarinic M1 receptor stably expressed in CHO cells assessed as increase in Ach-induced intracellular calciu...More data for this Ligand-Target Pair
Affinity DataEC50: >9.00E+3nMAssay Description:Positive allosteric modulation of human muscarinic M1 receptor stably expressed in CHO cells assessed as increase in Ach-induced intracellular calciu...More data for this Ligand-Target Pair
Affinity DataEC50: 392nMAssay Description:Positive allosteric modulation of human muscarinic M1 receptor stably expressed in CHO cells assessed as increase in Ach-induced intracellular calciu...More data for this Ligand-Target Pair
Affinity DataEC50: 208nMAssay Description:Positive allosteric modulation of human muscarinic M1 receptor stably expressed in CHO cells assessed as increase in Ach-induced intracellular calciu...More data for this Ligand-Target Pair
Affinity DataEC50: 115nMAssay Description:Positive allosteric modulation of human muscarinic M1 receptor stably expressed in CHO cells assessed as increase in Ach-induced intracellular calciu...More data for this Ligand-Target Pair
Affinity DataEC50: 109nMAssay Description:Positive allosteric modulation of human muscarinic M1 receptor stably expressed in CHO cells assessed as increase in Ach-induced intracellular calciu...More data for this Ligand-Target Pair
Affinity DataEC50: 1.69E+3nMAssay Description:Positive allosteric modulation of human muscarinic M1 receptor stably expressed in CHO cells assessed as increase in Ach-induced intracellular calciu...More data for this Ligand-Target Pair
Affinity DataEC50: 166nMAssay Description:Positive allosteric modulation of human muscarinic M1 receptor stably expressed in CHO cells assessed as increase in Ach-induced intracellular calciu...More data for this Ligand-Target Pair
Affinity DataEC50: 102nMAssay Description:Positive allosteric modulation of human muscarinic M1 receptor stably expressed in CHO cells assessed as increase in Ach-induced intracellular calciu...More data for this Ligand-Target Pair
Affinity DataEC50: 38nMAssay Description:Positive allosteric modulation of human muscarinic M1 receptor stably expressed in CHO cells assessed as increase in Ach-induced intracellular calciu...More data for this Ligand-Target Pair
Affinity DataEC50: 20nMAssay Description:Positive allosteric modulation of human muscarinic M1 receptor stably expressed in CHO cells assessed as increase in Ach-induced intracellular calciu...More data for this Ligand-Target Pair
Affinity DataEC50: 29nMAssay Description:Positive allosteric modulation of human muscarinic M1 receptor stably expressed in CHO cells assessed as increase in Ach-induced intracellular calciu...More data for this Ligand-Target Pair
Affinity DataEC50: 89nMAssay Description:Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 101nMAssay Description:Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair