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Found 897 with Last Name = 'rigollier' and Initial = 'p'
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18313((2R,4S,5S,7S)-5-amino-N-(2-acetamidoethyl)-4-hydro...)
Affinity DataIC50:  0.300nMAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Novartis

US Patent
LigandPNGBDBM110357(US8613914, 125 | US9206232, 129)
Affinity DataIC50: <0.300nMAssay Description:The inhibitory activity of certain compounds against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length NS3-4A prot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Novartis

US Patent
LigandPNGBDBM196124(US9206232, 125)
Affinity DataIC50: <0.300nMAssay Description:The inhibitory activity of certain compounds of Table A against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18288((2R,4S,5S,7S)-5-amino-4-hydroxy-7-{[4-methoxy-3-(3...)
Affinity DataIC50:  0.400nMpH: 7.2 T: 2°CAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18342((2S,4S,5S,7S)-5-amino-4-hydroxy-7-{[4-methoxy-3-(3...)
Affinity DataIC50:  0.400nMAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18337((2S,4S,5S,7S)-5-amino-N-[2,2-dimethyl-2-(methylcar...)
Affinity DataIC50:  0.400nMAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Novartis

US Patent
LigandPNGBDBM110396(US8613914, 170 | US9206232, 170)
Affinity DataIC50:  0.5nMAssay Description:The inhibitory activity of certain compounds against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length NS3-4A prot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Novartis

US Patent
LigandPNGBDBM110396(US8613914, 170 | US9206232, 170)
Affinity DataIC50:  0.5nMAssay Description:The inhibitory activity of certain compounds of Table A against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18278((2R,4S,5S,7S)-5-amino-7-{[3-(benzyloxy)-4-methoxyp...)
Affinity DataIC50:  0.600nMpH: 7.2 T: 2°CAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18340((2S,4S,5S,7S)-5-amino-4-hydroxy-7-{[4-methoxy-3-(3...)
Affinity DataIC50:  0.600nMAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Novartis

US Patent
LigandPNGBDBM110393(US8613914, 167 | US9206232, 167)
Affinity DataIC50:  0.600nMAssay Description:The inhibitory activity of certain compounds of Table A against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus)
Novartis

US Patent
LigandPNGBDBM110400(US8613914, 174 | US9206232, 174)
Affinity DataIC50:  0.600nMAssay Description:The inhibitory activity of certain compounds against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length NS3-4A prot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18344((2S,4S,5S,7S)-5-amino-4-hydroxy-7-{[4-methoxy-3-(3...)
Affinity DataIC50:  0.600nMAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Novartis

US Patent
LigandPNGBDBM110400(US8613914, 174 | US9206232, 174)
Affinity DataIC50:  0.600nMAssay Description:The inhibitory activity of certain compounds of Table A against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus)
Novartis

US Patent
LigandPNGBDBM110393(US8613914, 167 | US9206232, 167)
Affinity DataIC50:  0.600nMAssay Description:The inhibitory activity of certain compounds against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length NS3-4A prot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM17950((2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethyle...)
Affinity DataIC50:  0.600nMAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50089055(CHEMBL273811 | N*2*-(4-Ethanesulfonylmethyl-phenyl...)
Affinity DataIC50:  0.600nMAssay Description:Antagonistic activity against neuropeptide Y receptor type 5 subtype stably expressed in LM(tk-)cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18323((2S,4S,5S,7S)-5-amino-N-(3-carbamoylpropyl)-4-hydr...)
Affinity DataIC50:  0.700nMpH: 7.2 T: 2°CAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18338((2S,4S,5S,7S)-5-amino-4-hydroxy-7-{[4-methoxy-3-(3...)
Affinity DataIC50:  0.800nMAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Novartis

US Patent
LigandPNGBDBM110388(US8613914, 162 | US9206232, 162)
Affinity DataIC50:  0.800nMAssay Description:The inhibitory activity of certain compounds of Table A against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18326((2S,4S,5S,7S)-5-amino-N-[(1S)-1-carbamoylpropyl]-4...)
Affinity DataIC50:  0.800nMpH: 7.2 T: 2°CAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18289((2R,4S,5S,7S)-5-amino-4-hydroxy-N-(4-hydroxybutyl)...)
Affinity DataIC50:  0.800nMpH: 7.2 T: 2°CAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50089048(CHEMBL18163 | N,N-Dimethyl-C-[4-(4-phenylamino-qui...)
Affinity DataIC50:  0.900nMAssay Description:Antagonistic activity against neuropeptide Y receptor type 5 subtype stably expressed in LM(tk-)cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Novartis

US Patent
LigandPNGBDBM110388(US8613914, 162 | US9206232, 162)
Affinity DataIC50:  0.900nMAssay Description:The inhibitory activity of certain compounds of Table A against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Novartis

US Patent
LigandPNGBDBM196120(US9206232, 77)
Affinity DataIC50:  0.900nMAssay Description:The inhibitory activity of certain compounds of Table A against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Novartis

US Patent
LigandPNGBDBM110280(US8613914, 48 | US9206232, 48)
Affinity DataIC50:  0.900nMAssay Description:The inhibitory activity of certain compounds of Table A against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Novartis

US Patent
LigandPNGBDBM110273(US8613914, 41 | US9206232, 41)
Affinity DataIC50:  0.900nMAssay Description:The inhibitory activity of certain compounds of Table A against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus)
Novartis

US Patent
LigandPNGBDBM110388(US8613914, 162 | US9206232, 162)
Affinity DataIC50:  0.900nMAssay Description:The inhibitory activity of certain compounds against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length NS3-4A prot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus)
Novartis

US Patent
LigandPNGBDBM110280(US8613914, 48 | US9206232, 48)
Affinity DataIC50:  0.900nMAssay Description:The inhibitory activity of certain compounds against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length NS3-4A prot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus)
Novartis

US Patent
LigandPNGBDBM110273(US8613914, 41 | US9206232, 41)
Affinity DataIC50:  0.900nMAssay Description:The inhibitory activity of certain compounds against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length NS3-4A prot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18336((2S,4S,5S,7S)-5-amino-4-hydroxy-7-{[4-methoxy-3-(3...)
Affinity DataIC50:  0.900nMpH: 7.2 T: 2°CAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18334((2S,4S,5S,7S)-5-amino-N-[(2R)-2-carbamoyl-2-methyl...)
Affinity DataIC50:  0.900nMpH: 7.2 T: 2°CAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Novartis

US Patent
LigandPNGBDBM110309(US8613914, 77)
Affinity DataIC50:  0.900nMAssay Description:The inhibitory activity of certain compounds against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length NS3-4A prot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18308((2R,4S,5S,7S)-5-amino-N-(3-carbamoylpropyl)-4-hydr...)
Affinity DataIC50:  1nMAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Novartis

US Patent
LigandPNGBDBM110383(US8613914, 157 | US9206232, 157)
Affinity DataIC50:  1nMAssay Description:The inhibitory activity of certain compounds against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length NS3-4A prot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18304(8-phenyl-octanecarboxamide peptidomimetic, 61 | me...)
Affinity DataIC50:  1nMAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM17949((2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-{[4-meth...)
Affinity DataIC50:  1nMpH: 7.2 T: 2°CAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145270(CHEMBL81994 | {4-[(9-Fluoro-5,6-dihydro-4H-3-thia-...)
Affinity DataIC50:  1nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18350((2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethyle...)
Affinity DataIC50:  1nMAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18339((2S,4S,5S,7S)-5-amino-N-[3-(dimethylcarbamoyl)prop...)
Affinity DataIC50:  1nMAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Novartis

US Patent
LigandPNGBDBM110383(US8613914, 157 | US9206232, 157)
Affinity DataIC50:  1nMAssay Description:The inhibitory activity of certain compounds of Table A against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18335((2S,4S,5S,7S)-5-amino-4-hydroxy-7-{[4-methoxy-3-(3...)
Affinity DataIC50:  1nMpH: 7.2 T: 2°CAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Novartis

US Patent
LigandPNGBDBM110397(US8613914, 171 | US9206232, 171)
Affinity DataIC50:  1nMAssay Description:The inhibitory activity of certain compounds of Table A against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18333((2S,4S,5S,7S)-5-amino-N-[(2S)-2-carbamoyl-2-methyl...)
Affinity DataIC50:  1nMpH: 7.2 T: 2°CAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Novartis

US Patent
LigandPNGBDBM110277(US8613914, 45 | US9206232, 45)
Affinity DataIC50:  1nMAssay Description:The inhibitory activity of certain compounds of Table A against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18331((2S,4S,5S,7S)-5-amino-N-[(2S)-1-carbamoylpropan-2-...)
Affinity DataIC50:  1nMpH: 7.2 T: 2°CAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18322((2S,4S,5S,7S)-5-amino-N-(2-carbamoylethyl)-4-hydro...)
Affinity DataIC50:  1nMpH: 7.2 T: 2°CAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Novartis

US Patent
LigandPNGBDBM110294(US8613914, 62 | US9206232, 62)
Affinity DataIC50:  1nMAssay Description:The inhibitory activity of certain compounds of Table A against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRenin(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM18321((2S,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-{[4-meth...)
Affinity DataIC50:  1nMpH: 7.2 T: 2°CAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Novartis

US Patent
LigandPNGBDBM110294(US8613914, 62 | US9206232, 62)
Affinity DataIC50:  1nMAssay Description:The inhibitory activity of certain compounds against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length NS3-4A prot...More data for this Ligand-Target Pair
In DepthDetails US Patent
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