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LigandPNGBDBM50482773(CHEMBL1253513)
Affinity DataKi:  1.92E+3nMAssay Description:Displacement of [3H]RX821002 from alpha2 adrenergic receptor in rat brain membraneMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50482766(CHEMBL1254501)
Affinity DataKi:  2.08E+3nMAssay Description:Displacement of [3H]RX821002 from alpha2 adrenergic receptor in rat brain membraneMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50482769(CHEMBL1253486)
Affinity DataKi:  2.95E+3nMAssay Description:Displacement of [3H]RX821002 from alpha2 adrenergic receptor in rat brain membraneMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50482770(CHEMBL1253511)
Affinity DataKi:  3.64E+3nMAssay Description:Displacement of [3H]RX821002 from alpha2 adrenergic receptor in rat brain membraneMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50086502(2-BFi | 2-Benzofuran-2-yl-4,5-dihydro-1H-imidazole...)
Affinity DataKi:  3.98E+3nMAssay Description:Displacement of [3H]RX821002 from alpha2 adrenergic receptor in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50482764(CHEMBL1254500)
Affinity DataKi:  4.39E+3nMAssay Description:Displacement of [3H]RX821002 from alpha2 adrenergic receptor in rat brain membraneMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50482768(CHEMBL1254502)
Affinity DataKi:  4.43E+3nMAssay Description:Displacement of [3H]RX821002 from alpha2 adrenergic receptor in rat brain membraneMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50482767(CHEMBL1253584)
Affinity DataKi:  1.02E+4nMAssay Description:Displacement of [3H]RX821002 from alpha2 adrenergic receptor in rat brain membraneMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50482765(CHEMBL1253512)
Affinity DataKi:  1.10E+4nMAssay Description:Displacement of [3H]RX821002 from alpha2 adrenergic receptor in rat brain membraneMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50482771(CHEMBL1253583)
Affinity DataKi:  2.42E+4nMAssay Description:Displacement of [3H]RX821002 from alpha2 adrenergic receptor in rat brain membraneMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50482772(CHEMBL1253510)
Affinity DataKi:  2.55E+4nMAssay Description:Displacement of [3H]RX821002 from alpha2 adrenergic receptor in rat brain membraneMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50399922(CHEMBL2180974)
Affinity DataIC50:  0.200nMAssay Description:Competitive inhibition of biotinylated vitronectin to integrin alphaVbeta3 receptor after 3 hrs by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50399922(CHEMBL2180974)
Affinity DataIC50:  0.200nMAssay Description:Competitive inhibition of biotinylated vitronectin to integrin alphaVbeta3 receptor after 3 hrs by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50399923(CHEMBL2180979)
Affinity DataIC50:  0.200nMAssay Description:Competitive inhibition of biotinylated vitronectin to integrin alphaVbeta3 receptor after 3 hrs by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50399919(CHEMBL2180983)
Affinity DataIC50:  0.900nMAssay Description:Competitive inhibition of biotinylated vitronectin to integrin alphaVbeta3 receptor after 3 hrs by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50177879(CHEMBL200182 | ST-1646)
Affinity DataIC50:  1nMAssay Description:Competitive inhibition of biotinylated vitronectin to integrin alphaVbeta3 receptor after 3 hrs by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBaculoviral IAP repeat-containing protein 2(Human)
Istituto Di Scienze E Tecnologie Molecolari (Istm)

Curated by ChEMBL
LigandPNGBDBM50240586(CHEMBL4098982)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of SMAC derived peptide abuRPF-K(5-Fam)-NH2 interaction with recombinant human C-terminal 6His-tagged cIAP1 BIR3 domain (245 to 357 residu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50399918(CHEMBL2180982)
Affinity DataIC50:  1.10nMAssay Description:Competitive inhibition of biotinylated vitronectin to integrin alphaVbeta3 receptor after 3 hrs by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50233956(CHEMBL4075011)
Affinity DataIC50:  1.20nMAssay Description:Displacement of biotinylated vitronectin from recombinant human integrin alphaVbeta3 dark incubated for 3 hrs by solid-phase receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBaculoviral IAP repeat-containing protein 2(Human)
Istituto Di Scienze E Tecnologie Molecolari (Istm)

Curated by ChEMBL
LigandPNGBDBM50240587(CHEMBL4070316)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of SMAC derived peptide abuRPF-K(5-Fam)-NH2 interaction with recombinant human C-terminal 6His-tagged cIAP1 BIR3 domain (245 to 357 residu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBaculoviral IAP repeat-containing protein 2(Human)
Istituto Di Scienze E Tecnologie Molecolari (Istm)

Curated by ChEMBL
LigandPNGBDBM32609(1-aza-2-oxobicyclo[5.3.0]decane scaffold, 36b)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of SMAC derived peptide abuRPF-K(5-Fam)-NH2 interaction with recombinant human C-terminal 6His-tagged cIAP1 BIR3 domain (245 to 357 residu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50177879(CHEMBL200182 | ST-1646)
Affinity DataIC50:  1.40nMAssay Description:Competitive inhibition of biotinylated vitronectin to integrin alphaVbeta5 receptor after 3 hrs by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBaculoviral IAP repeat-containing protein 2(Human)
Istituto Di Scienze E Tecnologie Molecolari (Istm)

Curated by ChEMBL
LigandPNGBDBM50240589(CHEMBL4091245)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of SMAC derived peptide abuRPF-K(5-Fam)-NH2 interaction with recombinant human C-terminal 6His-tagged cIAP1 BIR3 domain (245 to 357 residu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBaculoviral IAP repeat-containing protein 2(Human)
Istituto Di Scienze E Tecnologie Molecolari (Istm)

Curated by ChEMBL
LigandPNGBDBM50240592(CHEMBL4097534)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of SMAC derived peptide abuRPF-K(5-Fam)-NH2 interaction with recombinant human C-terminal 6His-tagged cIAP1 BIR3 domain (245 to 357 residu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Human)
University of Parma

Curated by ChEMBL
LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataIC50:  2nMAssay Description:Inhibition of PDGFRbeta (unknown origin) phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetIntegrin alpha-V/beta-3(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50399912(CHEMBL2180973)
Affinity DataIC50:  2.10nMAssay Description:Competitive inhibition of biotinylated vitronectin to integrin alphaVbeta3 receptor after 3 hrs by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50237601(CHEMBL411941 | CycloRGDfV | [(2S,5R,8S,11S)-5-Benz...)
Affinity DataIC50:  3.20nMAssay Description:Competitive inhibition of biotinylated vitronectin to integrin alphaVbeta3 receptor after 3 hrs by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50399915(CHEMBL2180976)
Affinity DataIC50:  3.20nMAssay Description:Competitive inhibition of biotinylated vitronectin to integrin alphaVbeta3 receptor after 3 hrs by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50237601(CHEMBL411941 | CycloRGDfV | [(2S,5R,8S,11S)-5-Benz...)
Affinity DataIC50:  3.20nMAssay Description:Displacement of biotinylated vitronectin from human integrin alphaVbeta3 measured after 3 hrs by solid-phase receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50233954(CHEMBL4066412)
Affinity DataIC50:  3.80nMAssay Description:Displacement of biotinylated vitronectin from recombinant human integrin alphaVbeta3 dark incubated for 3 hrs by solid-phase receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50399924(CHEMBL2180975)
Affinity DataIC50:  3.90nMAssay Description:Competitive inhibition of biotinylated vitronectin to integrin alphaVbeta3 receptor after 3 hrs by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50399916(CHEMBL2180980)
Affinity DataIC50:  4.10nMAssay Description:Competitive inhibition of biotinylated vitronectin to integrin alphaVbeta3 receptor after 3 hrs by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50399914(CHEMBL2180977)
Affinity DataIC50:  4.5nMAssay Description:Competitive inhibition of biotinylated vitronectin to integrin alphaVbeta3 receptor after 3 hrs by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50233955(CHEMBL4095441)
Affinity DataIC50:  5.10nMAssay Description:Displacement of biotinylated vitronectin from recombinant human integrin alphaVbeta3 dark incubated for 3 hrs by solid-phase receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50399920(CHEMBL2180984)
Affinity DataIC50:  5.20nMAssay Description:Competitive inhibition of biotinylated vitronectin to integrin alphaVbeta3 receptor after 3 hrs by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin-H2 D-isomerase(Mouse)
Sterling Research Group

Curated by ChEMBL
LigandPNGBDBM50009854(CHEMBL13078 | [1-(2-Morpholin-4-yl-ethyl)-1H-indol...)
Affinity DataIC50:  6nMAssay Description:Concentration required to inhibit 50% activity of prostaglandin synthetase was determined in vitro in mouse brain microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBaculoviral IAP repeat-containing protein 2(Human)
Istituto Di Scienze E Tecnologie Molecolari (Istm)

Curated by ChEMBL
LigandPNGBDBM50240588(CHEMBL4079500)
Affinity DataIC50:  6.10nMAssay Description:Inhibition of SMAC derived peptide abuRPF-K(5-Fam)-NH2 interaction with recombinant human C-terminal 6His-tagged cIAP1 BIR3 domain (245 to 357 residu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50233958(CHEMBL4087743)
Affinity DataIC50:  6.10nMAssay Description:Displacement of biotinylated vitronectin from human integrin alphaVbeta3 measured after 3 hrs by solid-phase receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50402996(CHEMBL2207440)
Affinity DataIC50:  6.40nMAssay Description:Inhibition of human recombinant C-terminal His-tagged PYK2 using ATP as substrate incubated for 1 hr prior to substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50237601(CHEMBL411941 | CycloRGDfV | [(2S,5R,8S,11S)-5-Benz...)
Affinity DataIC50:  7.5nMAssay Description:Competitive inhibition of biotinylated vitronectin to integrin alphaVbeta5 receptor after 3 hrs by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50399913(CHEMBL2180978)
Affinity DataIC50:  7.60nMAssay Description:Competitive inhibition of biotinylated vitronectin to integrin alphaVbeta3 receptor after 3 hrs by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50399921(CHEMBL2180985)
Affinity DataIC50:  8.5nMAssay Description:Competitive inhibition of biotinylated vitronectin to integrin alphaVbeta3 receptor after 3 hrs by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Human)
University of Parma

Curated by ChEMBL
LigandPNGBDBM50233954(CHEMBL4066412)
Affinity DataIC50:  9nMAssay Description:Inhibition of recombinant human PDGFRbeta expressed in insect cells using Ulight-Poly GAT[EAY(1:1:1)]n as substrate measured after 30 mins by LANCE m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
University of Naples Federico II

Curated by ChEMBL
LigandPNGBDBM50582862(CHEMBL5081456)
Affinity DataIC50:  9.10nMAssay Description:Inhibition of PD-1/PDL-1 (unknown origin) bindingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
University of Naples Federico II

Curated by ChEMBL
LigandPNGBDBM50582861(CHEMBL5093056)
Affinity DataIC50:  12nMAssay Description:Inhibition of PD-1/PDL-1 (unknown origin) bindingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50402999(CHEMBL2207441)
Affinity DataIC50:  13nMAssay Description:Inhibition of human recombinant C-terminal His-tagged PYK2 using ATP as substrate incubated for 1 hr prior to substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin-H2 D-isomerase(Mouse)
Sterling Research Group

Curated by ChEMBL
LigandPNGBDBM50009864(CHEMBL274833 | [2-Methyl-1-(2-morpholin-4-yl-ethyl...)
Affinity DataIC50:  15nMAssay Description:Concentration required to inhibit 50% activity of prostaglandin synthetase was determined in vitro in mouse brain microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
University of Naples Federico II

Curated by ChEMBL
LigandPNGBDBM50582860(CHEMBL5078455)
Affinity DataIC50:  15nMAssay Description:Inhibition of PD-1/PDL-1 (unknown origin) bindingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
University of Naples Federico II

Curated by ChEMBL
LigandPNGBDBM50239947(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)
Affinity DataIC50:  18nMAssay Description:Inhibition of PD-1/PDL-1 (unknown origin) bindingMore data for this Ligand-Target Pair
TargetProstaglandin-H2 D-isomerase(Mouse)
Sterling Research Group

Curated by ChEMBL
LigandPNGBDBM50009871(Benzo[b]thiophen-3-yl-[2-methyl-1-(2-morpholin-4-y...)
Affinity DataIC50:  18nMAssay Description:Concentration required to inhibit 50% activity of prostaglandin synthetase was determined in vitro in mouse brain microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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