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Found 392 with Last Name = 'saniere' and Initial = 'l'
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50548385(Glpg-1205 | Glpg1205)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]-9-(2-phenylethyl)-2-(2-pyrazin-2-yloxyethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one from recombinant FLAG-tagged GPR84 (un...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328879(CHEMBL1234898 | N-benzyl-3-(2-cyano-6-propylpyrimi...)
Affinity DataKi:  120nMAssay Description:Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313476(4-(3-(piperidin-1-yl)propyl)-6-(3-(trifluoromethyl...)
Affinity DataKi:  160nMAssay Description:Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313477(4-(3-(pentan-3-ylamino)propyl)-6-(3-(trifluorometh...)
Affinity DataKi:  320nMAssay Description:Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328887(4-(3-morpholinopropyl)-6-(3-(trifluoromethyl)pheny...)
Affinity DataKi:  320nMAssay Description:Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328880(CHEMBL1271174 | N-benzyl-3-(2-cyano-6-propylpyrimi...)
Affinity DataKi:  370nMAssay Description:Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328890(4-(3-(pyridin-2-ylamino)propyl)-6-(3-(trifluoromet...)
Affinity DataKi:  400nMAssay Description:Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328885(4-(3-(2,2,2-trifluoroethylamino)propyl)-6-(3-(trif...)
Affinity DataKi:  500nMAssay Description:Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328888(4-(3-(2-methoxyethylamino)propyl)-6-(3-(trifluorom...)
Affinity DataKi:  560nMAssay Description:Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328884(4-(3-(methylamino)propyl)-6-(3-(trifluoromethyl)ph...)
Affinity DataKi:  630nMAssay Description:Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313479(4-cycloheptyl-6-(3-(piperidin-1-yl)propyl)pyrimidi...)
Affinity DataKi:  700nMAssay Description:Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328878(3-(2-cyano-6-propylpyrimidin-4-yl)-N-(2-(dimethyla...)
Affinity DataKi:  710nMAssay Description:Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328886(4-(3-(4-methylpiperazin-1-yl)propyl)-6-(3-(trifluo...)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328889(4-(3-(4-hydroxypiperidin-1-yl)propyl)-6-(3-(triflu...)
Affinity DataKi:  1.12E+3nMAssay Description:Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328895(1-(3-(2-cyano-6-(3-(trifluoromethyl)phenyl)pyrimid...)
Affinity DataKi:  1.58E+3nMAssay Description:Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328896(1-(3-(2-cyano-6-(3-(trifluoromethyl)phenyl)pyrimid...)
Affinity DataKi:  2.51E+3nMAssay Description:Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328894(2-(3-(2-cyano-6-(3-(trifluoromethyl)phenyl)pyrimid...)
Affinity DataKi:  3.00E+3nMAssay Description:Inhibition of human ERG channel expressed in HEK293 cells by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328894(2-(3-(2-cyano-6-(3-(trifluoromethyl)phenyl)pyrimid...)
Affinity DataKi:  3.16E+3nMAssay Description:Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328883(3-(2-cyano-6-(3-(trifluoromethyl)phenyl)pyrimidin-...)
Affinity DataKi:  3.16E+3nMAssay Description:Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328893(2-(3-(2-cyano-6-(3-(trifluoromethyl)phenyl)pyrimid...)
Affinity DataKi:  3.98E+3nMAssay Description:Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328898((S)-4-(3-(2-cyano-6-(3-(trifluoromethyl)phenyl)pyr...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328897(4-(3-(2-cyano-6-(3-(trifluoromethyl)phenyl)pyrimid...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328891(2-(3-(2-cyano-6-(3-(trifluoromethyl)phenyl)pyrimid...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328877(3-(2-cyano-6-propylpyrimidin-4-yl)-N,N-dimethyl-5-...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328882(3-(2-cyano-6-(3-(trifluoromethyl)phenyl)pyrimidin-...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328892(4-(3-((1H-tetrazol-5-yl)methylamino)propyl)-6-(3-(...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328881(4-(3-hydroxypropyl)-6-(3-(trifluoromethyl)phenyl)p...)
Affinity DataKi:  3.10E+4nMAssay Description:Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50548398(CHEMBL3718309)
Affinity DataIC50:  0.600nMAssay Description:Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328879(CHEMBL1234898 | N-benzyl-3-(2-cyano-6-propylpyrimi...)
Affinity DataIC50: <1nMAssay Description:Inhibition of human recombinant cathepsin K using Z-Phe-Arg-MCA substrate by fluorimetric assayMore data for this Ligand-Target Pair
TargetCathepsin K(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313480(4-(cyclohexylamino)-6-(piperazin-1-yl)-1,3,5-triaz...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
TargetCathepsin K(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328894(2-(3-(2-cyano-6-(3-(trifluoromethyl)phenyl)pyrimid...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant cathepsin K using Z-Phe-Arg-MCA substrate by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328890(4-(3-(pyridin-2-ylamino)propyl)-6-(3-(trifluoromet...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant cathepsin K using Z-Phe-Arg-MCA substrate by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323087(2-(4-ethoxy-3-(trifluoromethyl)phenyl)-9H-purine-6...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of human recombinant cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313477(4-(3-(pentan-3-ylamino)propyl)-6-(3-(trifluorometh...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant cathepsin K using Z-Phe-Arg-MCA substrate by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328896(1-(3-(2-cyano-6-(3-(trifluoromethyl)phenyl)pyrimid...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant cathepsin K using Z-Phe-Arg-MCA substrate by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328878(3-(2-cyano-6-propylpyrimidin-4-yl)-N-(2-(dimethyla...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant cathepsin K using Z-Phe-Arg-MCA substrate by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313476(4-(3-(piperidin-1-yl)propyl)-6-(3-(trifluoromethyl...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant cathepsin K using Z-Phe-Arg-MCA substrate by fluorimetric assayMore data for this Ligand-Target Pair
TargetCathepsin K(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313477(4-(3-(pentan-3-ylamino)propyl)-6-(3-(trifluorometh...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313476(4-(3-(piperidin-1-yl)propyl)-6-(3-(trifluoromethyl...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
TargetCathepsin S(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323088(2-(4-ethoxy-3-(trifluoromethyl)phenyl)-9-(2-hydrox...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of human recombinant cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328897(4-(3-(2-cyano-6-(3-(trifluoromethyl)phenyl)pyrimid...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant cathepsin K using Z-Phe-Arg-MCA substrate by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50548387(CHEMBL4794652)
Affinity DataIC50:  5nMAssay Description:Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50548393(CHEMBL3716446)
Affinity DataIC50:  6nMAssay Description:Antagonist activity at recombinant human GPR84 receptor expressed in HEK293 cells co-expressing GNAO1 transcription variant 1 assessed as reduction i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50322917(4-(4-ethoxy-3-(trifluoromethyl)phenyl)-6-propylpyr...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328884(4-(3-(methylamino)propyl)-6-(3-(trifluoromethyl)ph...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant cathepsin K using Z-Phe-Arg-MCA substrate by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323089(9-(3-(dimethylamino)propyl)-2-(4-ethoxy-3-(trifluo...)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of human recombinant cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323092(2-(4-ethoxy-3-(trifluoromethyl)phenyl)-9-ethyl-9H-...)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of human recombinant cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328893(2-(3-(2-cyano-6-(3-(trifluoromethyl)phenyl)pyrimid...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human recombinant cathepsin K using Z-Phe-Arg-MCA substrate by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50548412(CHEMBL4776061)
Affinity DataIC50:  8nMAssay Description:Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50328881(4-(3-hydroxypropyl)-6-(3-(trifluoromethyl)phenyl)p...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human recombinant cathepsin K using Z-Phe-Arg-MCA substrate by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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